Introduction: There are appreciable concerns among European health authorities with growing expenditure on cancer medicines and issues of sustainability. The enhanced use of low cost generics could help. Aims: Consequently, there is a need to comprehensively document current and future arrangements regarding the pricing of generic cancer medicines across Europe, and whether these are indication specific, as well as how this translates into actual prices to provide future direction. Methodology: Mixed method approach with qualitative research among senior health authority personnel and their advisers. Quantitative research via health authority databases to ascertain current prices for oral cancer medicines that had lost their patent and the influence of population size and economics on prices. Results: 25 European countries participated. Currently we see (a) variable approaches to the pricing of generic cancer medicines, which will continue; (b) no concerns with substitution for oral generic cancer medicines; (c) substantial price reductions versus originators for generic capecitabine (up to -93.1%), generic imatinib (up to -97.8%) and generic temozolomide (up to -80.7%). Prices for oncology medicines are not indication specific, and are not affected by population size although influenced by pricing approaches. There have also been price increases for some non-patented cancer medicines following manufacturer changes although now stabilising. Conclusion: The considerable price reductions seen for some generics means health authorities should further encourage the use of generic oncology medicines when they become available to fund increased volumes and new valued cancer medicines. Countries are also starting to address price increases for generics following changes in the manufacturer

BACKGROUND This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. METHODS Forty Caucasian subjects, mean age 63.5 ± 7.6, with significant coronary artery lesions (≥50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 ± 10 months. RESULTS Mean left ventricular ejection fraction was 56.7 ± 9.6%. TM CPET exhibited a higher occurrence of ST segment depression ≥ 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (∆VO2/∆WR) during RE predicted cumulative cardiac events (p < 0.01). CONCLUSIONS CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.

BackgroundSevere mental illness (SMI) presents a major burden to societies worldwide. Low- and middle-income countries (LMICs) often do not have sufficient financial resources and qualified staff to provide extensive specialised services for outpatients with SMI. Our research therefore aims to explore and test low-cost interventions that use existing resources in routine patient-clinician meetings, families and communities.MethodsIn Bosnia-Herzegovina, Colombia and Uganda, three psychosocial interventions will be tested, i.e. making patient-clinician meetings therapeutically effective through DIALOG+, family involvement in multi-family group meetings, and support for patients in befriending schemes with volunteers. All interventions will be provided to patients with SMI, delivered over a six-month period and evaluated with assessments at baseline and after six and 12 months. We will conduct nine trials including non-controlled trials, non-randomised controlled trials and randomised controlled trials (RCTs). Core outcome criteria will be used across all studies. However, details of study delivery and additional outcome criteria vary to accommodate local contexts, interests and priorities. The studies will be analysed separately, but with the option to compare and combine findings.DiscussionThe approach provides the opportunity to learn from commonalities and differences in the results and experiences across the three resource-oriented approaches and the three countries. If successfully implemented the studies can lead to more extensive research and are expected to inform health policies and clinical practice of community care for patients with SMI in the three participating countries and other LMICs.Trial registrationAll RCTs were registered prospectively and non-randomised trials retrospectively within the ISRCTN Registry.DIALOG+ in Uganda: ISRCTN25146122 (Date of Registration: 20/11/2018, prospective); DIALOG+ in Colombia: ISRCTN83333181 (Date of Registration: 20/11/2018, prospective); DIALOG+ in Bosnia-Herzegovina: ISRCTN13347129 (Date of Registration: 20/11/2018, prospective); Volunteer Support in Uganda: ISRCTN86689958 (Date of Registration: 04/03/2019, retrospective); Volunteer Support in Colombia: ISRCTN72241383 (Date of Registration: 04/03/2019, retrospective);Volunteer Support in Bosnia-Herzegovina: ISRCTN51290984 (Date of Registration: 20/11/2018, prospective); Family Involvement in Uganda: ISRCTN78948497 (Date of Registration: 04/03/2019, retrospective); Family Involvement in Colombia: ISRCTN11440755 (Date of Registration: 04/03/2019, retrospective); Family Involvement in Bosnia-Herzegovina: ISRCTN13347355 (Date of Registration: 20/11/2018, prospective).

The purpose of the present study was to examine the effectiveness of 23 different synthesized ionic liquids (ILs) on Fusarium culmorum and Fusarium oxysporum growth rate. The strategy of IL synthesis was a structural modification of ionic liquids through changing the polarity of imidazolium and pycolinium cations and replacing halide anions with well known antifungal anions (cinnamate, caffeate and mandelate). The findings clearly suggest that the type of alkyl chain on the cation is the most determining factor for IL toxicity. In order to examine how IL structure affects their toxicity towards Fusarium genus, lipophilic descriptor A log P is calculated from density functional theory and correlated with Fusarium growth rate. All these results demonstrate the high level of the interdependency of lipophilicity and toxicity for investigated ILs towards the Fusarium genus. The data collected in this research suggest that the inhibitory influence of ILs is more pronounced in the case of F. oxysporum.

The purpose of this paper is to research how to improve loyalty to the dark chocolate brand Dorina through interaction created in the model composed of constructs such as brand image, brand impact, brand satisfaction and brand value. The data for this research have been gathered by an online survey. The total of 448 questionnaires have been collected in the territory of Bosnia and Herzegovina (B&H). The respondents to the survey were consumers of dark chocolate Dorina. The results indicate that consumer satisfaction is the most important factor for the brand loyalty on the dark chocolate market, followed by the impact and value, while the brand image does not significantly affect the loyalty of the consumers. Furthermore, the results indicate that the brand image significantly affects the customer satisfaction. A limitation of this research is that only one country has been taken as a sample, which could lead to generalization of results. New functions of chocolate, such as a health function, provide a new segment of food industry analysed in this paper. Companies should pay attention to the improvement of their brand image in order to affect consumer satisfaction which is the most important prerequisite for the creation of loyalty among the consumers. The developed model has provided instructions for the dark chocolate EKON. MISAO I PRAKSA DBK. GOD XXVIII. (2019.) BR. 1. (245-266) A. Puška et al: CONSUMERS .̀.. 246 manufacturers on how to improve loyalty of consumers and how to influence the very purchase.

Magnesium is an essential element and the intracellular divalent cation involved in many biochemical functions. People with magnesium deficiency must increase their intake of magnesium, usually in the form of various supplements. A common form of magnesium supplement widely available in pharmacies is magnesium oxide (MgO). In this work, the content of MgO was determined in pharmaceutical supplementations using spectrophotometry, based on the reaction between magnesium ions and eriochrome black T at a wavelength of 535 nm. The analysed content of MgO ranged from 360.5 to 386.5 mg MgO, which corresponds to the daily Mg recommended values (300 to 400 mg).

Presently, almost all human activities (agriculture, transport, industry, construction sector, etc.) have an adverse impact on the environment. The construction sector in the EU alone accounts for a big part of the total energy consumption and emission of CO2. Two-thirds of the energy used in the construction sector in Europe goes to housing. As the number of residents grows, the requirements for new housing increase, causing an additional increase in energy consumption and new CO2 emissions for construction, maintenance, lighting, ventilation, cooling, and heating. Benefits of detailed planning of sustainable development of the construction sector are manifold. The most important benefits are sustainable use of resources, economic and social development of communities, increasing employment rates, improvements of living conditions and protection of the environment. Two scenarios for the development of an energy-efficient construction sector in Bosnia and Herzegovina with a focus on housing facilities are developed, in order to address the needs and benefits of detailed planning. Both scenarios analyze the effects on job creation, the impact of used construction materials on the environment and eco balance of local products. The difference in the solutions confirms the benefits of an interdisciplinary approach to the planning of sustainable systems so that not only technical, but also economic and social benefits can be evaluated thanks to the combination of methods used.

The freedom of services by correspondence should be one of the most important market freedoms in the EU legislative politics and the CJEU jurisprudence. The announcement of the establishment of a fifth market freedom on data flow is directly addressed by the freedom of services by correspondence. The growing importance of the freedom of services in general is in line with the rise of the EU service sector as the main contributor to growth and employment in the EU, accounting for about two thirds of both EU employment and value added. In addition, since 2015 the Digital Single Market is one of European Commission’s political priority that aims at providing free access to online services. Online services are in most part services by correspondence, where neither provider nor recipient travels cross border. The truth is that the freedom of services by correspondence is barely ever mentioned explicitly neither by EU legislator nor by the CJEU. The EU legislator has rather chosen a sectoral approach to the Digital Single Market, fragmenting the fifth market freedom to several narrow pieces of legislation. The paper deals with the question why the freedom of services by correspondence has not acquired the same position as the freedom of goods. The analysis will focus on answering this question on the grounds of the theory of convergence of market freedoms and its limits.

Bosnia and Herzegovina is a place of meeting of different peoples and religions, which has contributed, according to the religious and cultural heritage, to be one of the richest countries in Europe. Four large religious communities in Bosnia and Herzegovina have significant shrines that are visited by tourists from all over the world, although neither the entities nor the states have a strategy for promoting religious tourism. In this paper we will present the representation of religious objects and manifestations of West Herzegovina tourism-geographic region, their tourist valorization and proposal in order to improve this specific form of tourism.