The accessible literature sources do not give an integrated register of non-native tree species in Bosnia and Herzegovina and western Balkans floras. Therefore, the focus of this study was on an inventory of allochthonous dendroflora in the territory of Bosnia and Herzegovina (B&H) by 2023. Numerous literature sources, the herbarium collection of the National Museum of Bosnia and Herzegovina (SARA) and the authors' field investigations were used to create the allochthonous B&H dendroflora list. The inventory list comprises dendro species of trees, shrubs and lianas. The survey consists of 552 non-native dendro taxa, associated with family, geographic origin, residence time status, degree of naturalization, zone of resistance, and abundance of the investigated taxa. A total of 82 families, 208 genera, and 552 taxa, which included species level, subspecies, varieties, and hybrids were recorded. The B&H allochthonous dendroflora generally originate from Asia (260 taxa) and North America (128), with a significant share of hybrids (81). Only 19 archaeophytes were registered. According to the degree of naturalization, it was observed that as many as 451 taxa are casual and 13 invasive. The non-native dendro species in B&H mainly belong to the USDA Hardiness Zones 4-9, 5-9 and 6-9. The alien dendroflora of B&H includes 152 occasional, 142 rare, 198 abundant and only 60 taxa with massive abundance. The presented results give a detailed insight into the allochthonous dendroflora of B&H, which is also the first such presentation for the Western Balkans.

Starting from the metabolic profile of type 2 diabetes mellitus (T2DM), we hypothesized that the mechanisms of ¹³¹I-induced cardiotoxicity differ between patients diagnosed with differentiated thyroid cancer (DTC) with/without T2DM, with metformin potentially acting as a cardioprotective agent by mitigating inflammation in patients with T2DM. To address this hypothesis, we quantified, using ELISA, the serum concentration of several key biomarkers that reflect cardiac injury (NT-proBNP, NT-proANP, ST2/IL-33R, and cTn I) in 74 female patients with DTC/−T2DM and 25 with DTC/+T2DM treated with metformin. All patients received a cumulative oral dose of 131I exceeding 150 mCi (5.55 GBq) over approximately 53 months. Our results showed the following: (i) In DTC/−T2DM patients, high-cumulative 131I doses promote a pro-inflammatory state that accelerates the development of cardiotoxicity. Monitoring NT-proBNP, ST2/IL-33R, and cTn I in these patients may help identify those at risk of developing cardiac complications. (ii) In patients with DTC/+T2DM, high-cumulative 131I doses lead to the release of NT-proANP (r = 0.63), which signals that the atria are under significant stress. (iii) In patients with DTC/+T2DM, metformin suppresses inflammation, leading to a dose-dependent reduction in cTn I (r = −0.59). Monitoring cTn I and NT-proANP, and considering the use of metformin as part of the therapeutic strategy, could help manage cardiotoxicity in T2DM patients undergoing 131I therapy.

Goal: The paper will present the library collection of the Babusaade Ahmed Agha based on one of the three existing waqfiyas of this benefactor, preserved in the Topkapi Palace Museum in Istanbul (TS.MA.d. 6927). The waqfiya describes the establishment of a madrasa and its accompanying library in Mostar in the mid-17th century. The work will also offer a comparison of this collection with the Gazi Husrev-beg Library collection in Sarajevo, as the majority of the preserved titles from the mentioned collection can be found in this central heritage institution. Approach/Methodology: Using the identification method, we determined the exact titles and authors of the endowed books and manuscripts, for which numerous lexicographical dictionaries and manuscript catalogs were consulted. The classification of works by subject areas was based on the Flügel and Ahlwardt models. Regarding the presence of works from the original collection established by the Babusaade Ahmed Agha, the main research base was the Gazi Husrev-beg Library collection in Sarajevo, which provided direct access to works from the mentioned collection, as well as published catalogs of manuscripts in Oriental languages from this institution. Results: The paper highlights data related to the titles and authors of works from the library collection that was part of this educational institution. Based on this information, insight was provided into the thematic and content diversity of the mentioned library. Particularly interesting is the fact that this waqfiya contains the oldest mention of a librarian (1653) in Mostar, along with his duties and responsibilities regarding the preservation of the manuscript collection. In addition to this, the paper discusses the current state of the collection, aiming to determine the extent of preservation of the manuscript holdings from this 17th-century Mostar library. Originality/Value: In scientific and expert circles, it was known that there was a waqf established by the Babusaade Ahmed Agha, but it was not widely known what he left behind as a legacy for his fellow citizens in Mostar. This paper specifically discusses his legacy in Mostar based on primary sources, as well as the provisions he established to specify how this waqf would function. The waqf of Ahmed Agha was very important for the cultural life of Mostar in the second half of the 17th century.

Goal: Legal deposit is a complex system of multiple benefits, and by mapping adapted legal deposit regulations from 1945 to 1995 in Yugoslavia and Bosnia and Herzegovina, the aim of this research is to look at the development of the legal deposit in the context of redefining its coverage and the legislatively defined goals of the legal deposit. Approach/methodology/design: By researching the previous literature and reviewing official publications, that is examining the titles and full texts of published regulations in the printed editions of official publications, the relevant regulations related to the legal deposit in Yugoslavia, Bosnia and Herzegovina, federal and republican decrees, decisions, orders, laws for legal deposit were mapped. Results: The analysis of the mapped sixteen regulations, indicates the expansion of legal deposit coverage on a continuous basis, and reveals changes in the perception of the legal deposit values. Legal deposit was initially reduced in the regulations to its function of building library collections, which, however, must be viewed critically in the context of censorship background, while newer regulations respect its values in terms of building of national bibliographies, preservation and protection of cultural heritage, and more important, use of materials that have the designation of public good. Originality/value: This research thematizes the development of the legal deposit system in Bosnia and Herzegovina, from 1945 to 1995, by gathering selected regulations related to legal deposit, adopted in this time period, for the first time in one place, as a basis for further research of this institution in Bosnia and Herzegovina.

Goal: The goal of this research is to explore the patterns related to authorship and collaboration of authors of the papers published in the journal Bosniaca: Journal of National and University Library of Bosnia and Herzegovina in the period from 1996 to 2023. Approach/Methodology: During the selection and preparation of the corpus for analysis, bibliographic identifiers of published papers were analysed, and Subramanyam K. formula was used for calculation of the degree of collaboration. A total of 328 papers and 392 authors by occurrence were analyzed (227 unique authors). Results: Identification data of published papers in the period from 1996 to 2023 are gradually stabilizing, and standardization of bibliographic data is accompanied by the strengthening of the international network of authors, and the indexing of the Journal in bibliographic and citation databases. The number of single-authored papers published in the Journal is 85.98%, while the degree of collaboration in Bosniaca from 1996 to 2023 is 0.14, with the number of co-authored papers increasing from 2019. Of those analyzed, the largest number of unique authors comes from Bosnia and Herzegovina (132), followed by the countries of the region (69), and when it comes to the gender structure of unique authors, women are far more represented (159 authors, 70.04%), of which the majority, 88 female authors, also come from Bosnia and Herzegovina. Limitations: This research does not have firm criteria for selecting papers for analysis, also, nonstandardized listing of identification data of paper published in the first issues of the Journal, and manual entry of collected data can affect the research results and possible errors. Originality/value: So far in Bosnia and Herzegovina no bibliometric analysis of Bosnian and Herzegovinian journals in the field of library and information sciences have been conducted. As a contribution to such analysis, this paper presents the first bibliometric analysis of journal Bosniaca: Journal of the National and University Library of Bosnia and Herzegovina.

U ovom se radu analizira sintaksički status akuzativnih klitika u bosanskom jeziku i njihovo pomjeranje u tzv. drugu poziciju (engl. second position clitics / Wackernagel clitics) s teorijskog polazišta tzv. minimalističkog programa (engl. Minimalist Program, Chomsky 1995; 2000; 2001). Derivacija sintaksičkih struktura posmatra se kroz djelovanje sintaksičke operacije spajanja (engl. Merge) i sintaksičke operacije slaganja (engl. Agree). Pri tome, u radu se slijedi tzv. teorija faza (engl. Phase Theory, Chomsky 2001), koja postulira da se derivacija sintaksičke strukture odvija u fazama koje omogućavaju da se minimalni dijelovi strukture sukcesivno šalju u tzv. Spell-out, odnosno u interfejs u kojem dolazi do razdvajanja informacija relevantnih za nivo fonetskog (engl. Phonetic form, PF) i logičkog predstavljanja (engl. Logical form, LF). U radu se zastupa hipoteza da se akuzativne klitike izvorno generiraju u poziciji komplementa glagola za koji su tematski vezane te da, budući da nemaju status fraznih afiksa, ne mogu biti sintaksički spojene s tim glagolom. U tom se smislu transfer akuzativnih klitika u PF komponentu dešava već u vP fazi, dok glagol za koji je klitika tematski vezana nije obuhvaćen ovim transferom jer se pomjera u tzv. rubnu poziciju (engl. edge position) vP faze. Cilj je ovoga rada pokazati da je tzv. druga pozicija akuzativnih klitika rezultat njihovog postsintaksičkog pomjeranja koje slijedi nakon prozodijskog organiziranja strukturnih elemenata na PF nivou. Akuzativne klitike pomjeraju se u tzv. drugu poziciju u svojoj intonacijskoj frazi (engl. Intonation phrase, IP), pri čemu intonacijska fraza korespondira s granicama CP domene klauze koja sadrži akuzativne klitike. Pozicija akuzativnih klitika iza prve naglašene riješi (engl. first word position, 1W) ili iza prvog sintaksičkog konstituenta (engl. first constituent position, 1C) u vezi je s (ne)postojanjem prozodijskih barijera.

Abstract Study Objectives To examine (1) multidimensional sleep profiles in preschoolers (3–6 years) across geocultural regions and (2) differences in sleep characteristics and family practices between Majority World regions (Pacific Islands, Sub-Saharan Africa, Eastern Europe, Northeast Asia, Southeast Asia, South Asia, the Middle East and North Africa, and Latin America) and the Minority World (the Western world). Methods Participants were 3507 preschoolers from 37 countries. Nighttime sleep characteristics and nap duration (accelerometer: n = 1950) and family practices (parental questionnaire) were measured. Mixed models were used to estimate the marginal means of sleep characteristics by region and examine the differences. Results Geocultural region explained up to 30% of variance in sleep characteristics. A pattern of short nighttime sleep duration, low sleep efficiency, and long nap duration was observed in Eastern Europe, Northeast Asia, and Southeast Asia. The second pattern, with later sleep midpoints and greater night-to-night sleep variability, was observed in South Asia, the Middle East and North Africa, and Latin America. Compared to the Minority World, less optimal sleep characteristics were observed in several Majority World regions, with medium-to-large effect sizes (∣d∣=0.48–2.35). Several Majority World regions reported more frequent parental smartphone use during bedtime routines (Northeast Asia, Southeast Asia: 0.77–0.99 units) and were more likely to have electronic devices in children’s bedroom (Eastern Europe, Latin America, South Asia: OR = 5.97–16.57) and co-sleeping arrangement (Asia, Latin America: OR = 7.05–49.86), compared to the Minority World. Conclusions Preschoolers’ sleep profiles and related family practices vary across geocultural regions, which should be considered in sleep health promotion initiatives and policies.

Brain natriuretic peptide (BNP) serves as a crucial cardiac biomarker in human and small animal veterinary medicine, yet its role in equine cardiology remains underexplored.This study aimed to investigate the influence of different exercise types on BNP concentrations and single brief echocardiographic parameters in two distinct horse populations, while also examining potential correlations between BNP concentrations and echocardiographic variables.Forty clinically healthy horses, categorised into working and sports groups, underwent exercise testing exercise to their purposes. BNP concentrations were measured using a horse‐specific ELISA kit, and brief echocardiographic examinations were conducted 24 h post‐exercise.Blood samples were collected before, after exercises, and at rest to determine plasma BNP concentrations. The brief echocardiographic examinations looked only at M‐mode imaging from the right parasternal window, and assessed cardiac chambers and ventricular diameters. BNP concentrations and echocardiographic variables were compared between the two groups.Exercise did not significantly increase BNP concentrations in either group, with sports horses exhibiting higher basal BNP values (18.0–1973.0 pg/mL) compared to work horses (14.4–1074.5 pg/mL). No significant differences in BNP concentrations were observed between breeds, sexes, or pregnancy statuses. Brief echocardiographic examinations using M‐mode imaging from the right parasternal window revealed significant differences in right ventricular dimensions in diastole and relative wall thickness between the groups. A low negative correlation (r = −0.329, p = 0.038) was observed between BNP concentration and fractional shortening.Single pre‐exercise blood sampling, brief M‐mode echocardiography, and lack of exercise standardisation in the endurance horse group limited assessing high biological variability on BNP concentration and echocardiographic parameters in the tested horses.Assessing BNP concentrations and echocardiographic parameters during different exercises can be helpful in examining the functional status of the equine cardiovascular system, guiding tailored exercise regimens for optimal equine well‐being.

AIMS Clustering algorithms have been widely applied to tumor DNA methylation datasets to define methylation-based cancer subtypes. This study aimed to evaluate the agreement between subtypes obtained from common clustering strategies. MATERIALS & METHODS We used tumor DNA methylation data from 409 women with breast cancer from the Melbourne Collaborative Cohort Study (MCCS) and 781 breast tumors from The Cancer Genome Atlas (TCGA). Agreement was assessed using the adjusted Rand index for various combinations of number of CpGs, number of clusters and clustering algorithms (hierarchical, K-means, partitioning around medoids, and recursively partitioned mixture models). RESULTS Inconsistent agreement patterns were observed for between-algorithm and within-algorithm comparisons, with generally poor to moderate agreement (ARI <0.7). Results were qualitatively similar in the MCCS and TCGA, showing better agreement for moderate number of CpGs and fewer clusters (K = 2). Restricting the analysis to CpGs that were differentially-methylated between tumor and normal tissue did not result in higher agreement. CONCLUSION Our study highlights that common clustering strategies involving an arbitrary choice of algorithm, number of clusters and number of methylation sites are likely to identify different DNA methylation-based breast tumor subtypes.

Bosnia and Herzegovina is a country rich in natural resources and geo-strategically positioned in the heartland of the Balkans, which through its turbulent and inspiring history was the desired goal of various conquering empires. From the ancient Romans, through the Ottomans, Austro-Hungarians, Germans and all the way to the closest neighbours. On that difficult path of building a thousand-year statehood, it was affected by various socio-political crises that left a mark and, as a rule, slowed down its economic growth and self-sustainability of both the socio-political system and the general state of security of its critical subjects and infrastructures. In its different stages of statehood and statehood, Bosnia and Herzegovina faced different types of threats, from passive to active resistance, from frequent riots to open wars and opposition to invaders and usurpers of its territory and its wealth. Looking at our history, we learn from our ancestors, preparing based on their experience for the modern challenges of today. It is of great importance for scientists, researchers and practitioners to apply analytical - synthetic and general - social methods of data collection, in order to properly set themselves according to the definition of research problems and objectives, and to determine the methodology that will lead to effective and applicable solutions satisfying social and scientific objectives. Analysing the problem of determining and organizing the area of protection of critical subjects and infrastructures, we cannot help but notice one of the biggest threats to the vital lifeblood of the Bosnian society, namely its complex socio-political organization and the influence it generates as such on all segments of sustainability and security. This work contributes to the development and strengthening of the preventive security awareness of all those who in the future will deal with strengthening the capacity to protect critical entities in Bosnia and Herzegovina.

Introduction Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the generic genotyping workflows are unable to accurately infer copy numbers and complete genotypes of individual KIR genes from next-generation sequencing data. Thus, specialized genotyping tools are needed to genotype this complex region. Methods Here, we introduce Geny, a new computational tool for precise genotyping of KIR genes. Geny utilizes available KIR allele databases and proposes a novel combination of expectation-maximization filtering schemes and integer linear programming-based combinatorial optimization models to resolve ambiguous reads, provide accurate copy number estimation, and estimate the correct allele of each copy of genes within the KIR region. Results & Discussion We evaluated Geny on a large set of simulated short-read datasets covering the known validated KIR region assemblies and a set of Illumina short-read samples sequenced from 40 validated samples from the Human Pangenome Reference Consortium collection and showed that it outperforms the existing state-of-the-art KIR genotyping tools in terms of accuracy, precision, and recall. We envision Geny becoming a valuable resource for understanding immune system response and consequently advancing the field of patient-centric medicine.

Two highly invasive plant species, Lysimachia vulgaris and Lythrum salicaria are well-known for its anti-inflammatory, hemostatic, and antidiaroic activity. These plants are most widespread on the territory of Euroasia, where their traditional medicinal use has been reported. Due to their invasiveness, they are undesirable plants in  other parts of the world. Till this day, many studies were conducted regarding the biological and pharmacological activity of L. salicaria. In this study, the polyphenol content of plant extracts was examined using the Folin-Ciocalteou method. Antioxidant activity of selected plant species was also determined, using DPPH and FRAP methods. Extracts of different polarities were prepared using methanol, water, and acetone. Extraction was performed by maceration and ultrasonic extraction. The results of the study show that both plant species possess antioxidant activity. Lythrum salicaria extracts show a significant polyphenol content and antioxidant capacity, with results notably higher than the results of studies conducted so far. The different antioxidant activity of the prepared extracts confirms the influence of solvents and extraction methods on the utilization of the antioxidant potential of plants. Additionally, for the aqueous extracts prepared by ultrasonic extraction method, an in vitro study of antibacterial activity was conducted. Both plant species show antibacterial activity, with an emphasis on the very strong antibacterial activity of L. salicaria extracts against selected bacterial strains.

Bitter and sweet wormwoods are traditional plant species in the Asteraceae (Compositae). Their use in traditional medicine has long been known. Numerous preparations of bitter and sweet wormwood (teas, tinctures) are used in the treatment of diseases of the digestive system. The content of bioactive components (polyphenols and flavonoids) and antioxidant activity of Artemisia absinthium L. (bitter wormwood) and Artemisia annua L. (sweet wormwood) were examined in this paper. Extract's series were prepared by mixing selected organic solvents (methanol, ethanol and acetone) and water in different volume ratios for both analyzed species. Antioxidant activity was tested using FRAP and DPPH methods. Extracts of sweet wormwood contain more bioactive components and have a higher antioxidant capacity compared to extracts of bitter wormwood. In terms of extraction efficiency, the mixture of acetone and water (20:30 v/v) proved to be the most efficient. Regarding pure organic solvents, the most effective for the bioactive components isolation is ethanol, while acetone showed the weakest extraction power.

Cirsium (thistle) is one of the most taxonomically demanding genera within the Compositae. These taxonomic difficulties are hypothesized to result from limited morphological differentiation, incipient speciation and/or hybridization among taxa, and misinterpretations of faded and incomplete herbarium specimens. According to the latest data, the Dinarides and the Eastern Alps are inhabited by the endemic, diploid, newly described species Cirsium greimleri, which often occurs in sympatry with C. rivulare and C. erisithales. The area of the related, vicarious, tetraploid, and endemic species C. waldsteinii is limited to the southeastern Carpathians. Considering that the new knowledge refutes the existence of C. waldsteinii in Bosnia and Herzegovina, it was necessary to review all C. waldsteinii data discovered so far in Bosnia and Herzegovina. The results obtained from the distribution of the species, the predictive modelling of its ecological niche, and the analysis of the genome size confirmed the existence of the species C. greimleri in Bosnia and Herzegovina and its potential hybridization. This study indicates the need for further research into the sympatry of C. greimleri and its relatives, as well as the essential taxonomic revision of this complex.

Introduction: The early adolescence period represents a phase of turbulent physical development, characterized by disproportion in the musculoskeletal system, where the muscular system's inability to maintain a normal relationship between certain body segments results in poor posture among adolescents. Back pain is an increasing health problem among children and adolescents. Postural deviations and back pain are common issues among children, caused by the long-term effects of various risk factors associated with modern lifestyles. Methods: This study is a non-experimental (qualitative) research, specifically a scientific literature review. For the purposes of this paper, a search of relevant databases including Web of Science, Scopus, PubMed, and Med-Line was conducted for articles published between 2011 and 2024. Results: A significant number of articles were published between 2011 and 2024 in relevant scientific databases. After removing duplicates and irrelevant studies, 13 studies were included in the research. The studies used in this paper were published in Poland, the Czech Republic, Portugal, Tunisia, China, Egypt, Turkey, Pakistan, Brazil, Lebanon, Bosnia and Herzegovina, and Slovenia. Conclusion: Based on the review of scientific literature, it can be concluded that early identification of risk factors is essential, as it will reduce the frequency of postural deviations and back pain in children during early adolescence. Timely implementation of educational preventive programs on exercises, education about proper posture, sitting techniques, correct school bag carrying, the use of ergonomically adjusted school furniture, and promoting an active lifestyle at home and school, along with regular physical activity, is necessary.