It's common for the syndromes indicate to the author or authors who discovered them. The paper aims to show the image of X-rays and ophthalmic syndrome and to point out to those who can be recognized by the proper radiological and ophthalmologic examination. The work is based on knowledge and experience of the author and co-author of the acquired long experience in the profession, acquired many years of ophthalmology and radiological material, the papers presented in the relevant national and international journals, history and local and foreign literary press. Are shown in - Syndrom Stuger-Weber-Krabbe, Syndrome Wyburn-Mason, Syndrome Von Hippel-Lindau, Syndrome Crouzon, Syndrome Apertand Syndrome Saethre-Chotzen. The authors conclude that ophthalmic syndromes have their own specificity in radiologically-ophthalmologic image.

Mind colonization has been a burning issue in the last few decades in the fields of science and humanities. It is argued that mind colonization of the indigenous populations has been conducted via education and language in the mission of ‘civilizing’ since education and language carry culture specific sets of meaning, including knowledge and truth which condition our perception of the world. Zitkala-Ša is one of the earliest Native American authors and activists who sought to subvert the epistemological hierarchy imposed through mind colonization. Zitkala-Ša’s autobiographical collection of short stories titled American Indian Stories (1921) documents her boarding school experience and the acquisition of the colonizer’s education and language. The present paper seeks to address mind colonization through language and education on the example of Zitkala-Ša’s American Indian Stories relying on a number of theories and approaches. The paper also reflects on the importance of Zitkala-Ša mastery of the colonizer’s language

Today’s changing and developing level of competition and power, continuous learning, knowledge and technology management, transformation in the production process, marketoriented-based innovation and knowledge as communication applications, companies are routed to make more resources and research about the ability of innovation. The innovation factor has enabled new processes, products, ideas to adapt successfully for the production and market structure, and correspondingly implementation of them. In this point of view, innovation ability is the integration of new information resulting in product and process innovation by activating the power that a company provides to its employees. This ability has referred to the information between internal knowledge and external market demands. Accordingly, the factors affecting the innovation capability dimensions have a vital importance for companies. The fact that there exist limited number of studies on the weighting of the factors affecting the dimensions of innovation ability in the comprehensive literature review, is another factor increasing the importance of the subject. In this study, the innovation ability dimensions have been weighted in corporate logistics companies in Sakarya. Plithogenic set based CRITIC method, which is one of the multi criteria decision making techniques, has been used. The most important factor in the study was determined to be ability of accessing information resources.

The management of manufacturing companies faces a number of decisions, and one of the most important is the selection of distribution channels. A large number of these companies do not sell their products directly to end consumers. For this reason, there are marketing intermediaries between manufacturers and end consumers whose primary function is to connect manufacturers and consumers. Their task is to provide the goods from manufacturers to consumers with the satisfaction of logistics characteristics: at the right time, at the right place and in a form that is convenient to use, and certainly with minimal costs. Distribution is one of four marketing mix instruments without which the optimal combination of the instruments would not be obtained. Thus, the decision on selecting distribution channels is as important as the decisions regarding products, prices and promotion. Based on the set criteria and the evaluation of certain distribution channels by the criteria, the management of the company will be able to make the best decision. The evaluation of distribution channels based on the set criteria was performed by marketing experts and experts in certain markets using an integrated multi-criteria model. The FUCOM method was applied to determine the significance of the criteria, and then the distribution channels were evaluated by applying the new MARCOS method. Thereafter, a sensitivity analysis was performed using other MCDM methods to verify the results previously obtained.

Cost rationalization has become imperative in every economic system in order to create adequate foundations for its efficient and sustainable management. Competitiveness in the global market is extremely high and it is challenging to manage business and logistics systems, especially in regards to financial parameters. The presence of inventories is inevitability in every logistics system, and it tends to create adequate policies for their efficient and sustainable management. In order to be able to do this, it is necessary to determine which products represent the largest percentage share in the value of procurement, and which are the most represented quantitatively. In this paper, the warehouse of construction material that represents the wholesale system is considered. Taking into account that it is wholesale, it is necessary to determine what the procurement costs are and what the demand is for certain products. The grouping of products into three categories A, B and C was performed, after which it is necessary to identify appropriate suppliers for each category in order to rationalize procurement costs. Financial, logistical and quality parameters are taken into account. The FUCOM method has been used to determine the significance of these parameters and ARAS method is applied for supplier evaluation and selection.

Introduction/Objective. Tonsillitis is a very common condition found in the pediatric population but also in adult patients. One of the consequences of such conditions is poor voice quality. Hoarseness, poor voice impostation, interruption, and hypernazalization are just some of the differences in patient voice quality. The objective of this paper was to examine the effects of tonsillectomy on the voice quality. Methods. The sample included 37 patients, 17 female and 20 male, ranging in age 3?39 years. The method involved recording patients one month before and one month after tonsillectomy with a digital sound recorder, with recordings analyzed in the Praat program. The variables monitored in the basic voice were as follows: voice pitch, standard deviation of voice, degree of voice interruption, jitter, shimmer, and signal-to-noise ratio. In the statistical analysis, in addition to standard descriptive analyzes, t-test and ACNOVA were also used. Results. The results showed that there are effects of tonsillectomy on standard deviation of baseline voice (p = 0.002), shimmer (p = 0.002), baseline voice interruption rate (p = 0.023), signal to noise ratio (p = 0.003). There were no differences in the effects of tonsillectomy with respect to the sex of the subjects. Conclusion. Based on the conducted research, there were some methodological conclusions that could be considered as a recommendation for future research: increase the number of persons in the sample, introduce a variable of chronological age, type of surgical intervention, and gradation of size of the tonsil and adenoid tissue.

Introduction. Matrix metalloproteinase-9 (MMP-9) plays one of the key roles in the migration of inflammatory cells and the destructive behavior of acquired middle ear cholesteatoma. The aim of the study was to determine the expression levels of MMP-9 in chronic otitis media, with and without acquired cholesteatoma, as well as to determine the correlation between them and the pathomorphological changes in the tympanic membrane (TM). Methods. Immunohistochemical study included 178 patients of both sexes, aged 5-75 years, who underwent microsurgical treatment of chronic otitis media (COM) at the Ear, Nose and Throat Department of the University Clinical Center of the Republic of Srpska in Banja Luka from 2015 to 2018. Patients were divided into two groups on the basis of the presence or absence of acquired cholesteatoma: 97 (CCOM) and 81 (COMWC). The samples of the perimatrix of acquired cholesteatoma (n=97) and inflamed middle ear mucosa (n=81) were taken intraoperatively. The presence of retraction and certain types and subtypes of TM perforations were examined by intraoperative exploration. MMP-9 expression levels were determined by immunohistochemical analysis. Results. In the presence of cholesteatoma and highly positive expression of MMP-9, the marginal type of TM perforation was more likely to occur (p<0.01) while in negative expression of MMP-9 in the COMWC group, the central type was more likely to occur (p<0.01). There was a higher probability of the presence of attic subtype of TM perforation in patients with cholesteatoma and moderate positive expression of MMP-9 (p<0.01). There was not a statistically significant contribution of any of the factors in the prediction of the influence on the occurrence of TM retraction. Conclusion. The presence of acquired middle ear cholesteatoma and highly positive expression of MMP-9 are statistically significant predictors of the presence of marginal type and attic subtype of TM perforation. Expression levels of MMP-9 may have potential clinical significance in the development of irreversible pathomorphological changes on TM in middle ear cholesteatoma.

Introduction. Acute rhinosinusitis (ARS) encompasses a heterogeneous group of inflammatory disorders affecting nasal mucosa and paranasal sinuses. Rhinosinusitis is the most common condition in the United States. It is estimated that over 30 million people annually visit the doctor due to this condition, while every sixth adult suffers from ARS. Among all ARS complications, over 91% are orbital complications (OC) with an average prevalence of 6% and a higher incidence in children compared to adults. Case report. Twelve-year-old boy, accompanied by his mother, was urgently referred to the Department of Otorhinolaryngology at the University Hospital in Foca due to a sudden red and painful left periorbital edema, pain in the left eye and a fever reaching 38.5ºC. After laboratory and CT scan diagnostics, an ophthalmologic examination and inpatient clinical findings after 36 hours of parenteral triple antibiotic therapy, the patient was referred to a tertiary-type institution for further treatment. The same procedure was performed conservatively during the hospitalization within 6 days. Conclusion. The initial treatment of orbital complications in children is conservative. Treatment should be started empirically, using triple antibiotic therapy. The choice of antibiotics and treatment protocols among pediatric population have not been agreed yet. If 36-48 hours after the beginning of the conservative treatment, there is lack of the clinical response, surgical treatment is absolutely indicated, regardless of the stage of orbital complication.

Uvod. Matriks metaloproteinaza 9 (MMP-9) ima jednu od kljucnih uloga umigraciji inflamatornih celija i destruktivnom ponasanju stecenog holesteatomasrednjeg uha. Cilj studije je bio da se utvrde nivoi ekspresije MMP-9 kod hronicnog otitis media, sa i bez stecenog holesteatoma i njihovakorelacija sa patomorfoloskim promjenama na membrani timpani (MT).Metode. Imunohistohemijska studija je ukljucila 178 ispitanika oba pola,od 5 do 75 godina, koji su podvrgnuti mikrohirurskom lijecenju hronicnogotitis media (HOM) u Klinici za bolesti uha, grla i nosa, Univerzitetskog klinickogcentra RS, Banja Luka od 2015. do 2018. godine. Ispitanici su podijeljeniu dvije grupe na osnovu prisustva ili odsustva stecenog holesteatoma:97 (HHOM) i 81 (HOM). Uzorci perimatriksa stecenog holesteatoma(n=97) i inflamirane sluznice srednjeg uha (n=81) su uzeti intraoperativno.Intraoperativnom eksploracijom je ispitivano prisustvo retrakcije i pojedinihtipova i podtipova perforacije MT. Nivoi ekspresije MMP-9 su određeniimunohistohemijskom analizom.Rezultati. U prisustvu holesteatoma i visoko pozitivne ekspresije MMP-9,veca je vjerovatnoca pojave ivicnog tipa perforacije MT (p<0,01), dok je kodnegativne ekspresije MMP-9 u HOM grupi, veca vjerovatnoca centralnogtipa perforacije MT (p<0,01). Veca je vjerovatnoca prisustva atik podtipaperforacije MT kod ispitanika s holesteatomom i umjereno pozitivne ekspresijeMMP-9 (p<0,01). Nije dokazan statisticki znacajan doprinos nijednogod faktora u predikciji uticaja na pojavu retrakcije MT.Zakljucak. Prisustvo stecenog holesteatoma srednjeg uha i visoko pozitivnaekspresija MMP-9 cine statisticki znacajne prediktore ivicnog tipa i atikpodtipa perforacije MT. Nivoi ekspresije MMP-9 mogu da imaju potencijalniklinicki znacaj u nastanku ireverzibilnih patomorfoloskih promjena na MTkod holesteatoma srednjeg uha.