Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina KeYWORdS: carotid artery stenosis, peak-systolic velocity, multiple risk factors. citAtiON: Cardiol Croat. 2018;13(11-12):443. | https://doi.org/10.15836/ccar2018.443 *AddReSS fOR cORReSpONdeNce: Amina Bičo, Clinic of Heart and Blood Vessel Diseases, Clinical Center University of Sarajevo, Bolnička 25, 71000 Sarajevo, Bosnia and Herzegovina. / Phone: +387-61-348-688 / Email: amina.osmanagic@yahoo.com ORcid: Amina Bičo, https://orcid.org/0000-0001-6937-1772 • Alden Begić, https://orcid.org/0000-0002-5374-0892 Dževdet Radončić, https://orcid.org/0000-0001-5917-2956 • Mirza Dilić, https://orcid.org/0000-0002-7309-1455

1Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina 2University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina KeYWORdS: natriuretic peptides, brain natriuretic peptide, biomarker of myocardial infarction, Alzheimer’s disease. citAtiON: Cardiol Croat. 2018;13(11-12):435. | https://doi.org/10.15836/ccar2018.435 *AddReSS fOR cORReSpONdeNce: Edin Begic, Sarajevo School of Science and Technology, Sarajevo Medical School, Department of Pharmacology, Hrasnicka cesta 3a, 71000 Sarajevo, Bosnia and Herzegovina. / Phone: +38761303375 / E-mail: edinbegic90@gmail.com ORcid: Edin Begic, https://orcid.org/0000-0001-6842-262X • Suncica Hadzidedic, https://orcid.org/0000-0001-9026-8737 Ajla Kulaglic, https://orcid.org/0000-0003-3410-7079 • Belma Ramic-Brkic, https://orcid.org/0000-0002-8205-0137 Zijo Begic, https://orcid.org/0000-0002-1863-5755 • Mirsada Causevic, https://orcid.org/0000-0002-6099-6415

The past decade was marked, among other things, by the rapid growth of social networks. These networks collect personal data about their users - their photographs, interests, friends, locations, website visits, clicks, status updates and much more. A large number of users and a big collection of various data collected about the users make social media networks an abundant source of data that can be analyzed and used for targeted marketing, social phenomena analysis, generating different statistics and so on. In this paper we will use the potential of the tool RapidMiner in order to collect data from the social media network Twitter using the AYLIEN extension, preparing the data and applying sentiment analysis, which will give insight into the general atmosphere surrounding the actions of the current USA president Donald Trump

The buildings of architectural and cultural heritage are mostly built with stone or brick wall elements, which are connected using limestone or limestone cement mortar, without a full knowledge of the mechanical properties of masonry structures. The compatibility of heritage masonry buildings with valid technical specifications and the rules for earthquake resistance implies the need for construction work such as repairs, strengthening or reconstruction. By strengthening the masonry buildings, ductility and bearing capacity are increased to a level, which, in the case of the earthquake design, allows for some damage to happen, however the structure retains sufficient usability and bearing capacity without the possibility of collapse. Comparison between traditional and modern techniques for seismic strengthening of masonry buildings is given according to their effects, benefits and disadvantages. Recent Croatian provisions provided for heritage buildings enabling deviation of technical specifications are discussed.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) account for 2-5% of all ovarian cancers and among them pure embryonal cell cancer is rare condition (1, 2, 3, 4). Aim: To show successful pregnancy after unilateral salpingooopherectomy and chemotherapy in a girl with embryonal carcinoma of ovary (ECO). Case report: Patient had FIGO stage III c disease. After the surgical removal of the tumour, the patient underwent six cycles of adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP). Eight years after chemotherapy she conceived spontaneously. The patient went through regular antenatal checkups in a consultation with a gynecological oncologist. In addition to all regular examinations and controls, monthly monitoring of carbohydrate antigen (CA) 125, human epididymis protein 4 (HE 4), Roma Index is also recommended. Congenital malformation excluded at 20 weeks of gestation by level III ultrasonography. At 39th gestational week, laparotomy as well as a C-section was done and the patient was managed successfully in giving birth to a healthy female baby. Three months after delivery, the woman was recurrence free and the infant did not show any problems. At the last follow-up visit (May 5, 2018), all the tumor markers were negative, and the control MRI and ultrasound examinations did not reveal tumor recurrence or pathological lymph nodes. Conclusion Normal gonadal function and fertility are possible after fertility preservation surgery for ovarian germ cell malignancies, even with adjuvant chemotherapy.

Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson’s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD and major depressive disorder, we show evidence that some of our loci may be specific to PTSD. These results demonstrate the role of genetic variation contributing to the biology of differential risk for PTSD and the necessity of expanding GWAS beyond European ancestry.

This article presents a new approach to detect coiled coil and leucine zipper (L-Zip) motifs in protein sequences. The approach is based on protein scale calculation and sequence analysis. For this purpose, the wavelet-based local extrema extraction is employed, and window-based variations of local extrema afterward. This, in turn, provided a way to distinguish coiled coil subsequences and potential L-Zip motifs. The approach is validated on carefully chosen protein sequences that return inconclusive results within known frameworks for L-Zip detection, for example, 2ZIP. The results show that this new approach represents an improvement over previously presented approaches.

Introduction: Schizophrenia(SCZ) and Bipolar disorder (BD) are frequently occurring and impairing disorders that affect around 1% of the population. Important endophenotypes in the genetic research of SCZ and BD are cognitive functions. Core symptoms for SCZ and BD are impairments in working memory, declarative memory and attention, all of which fulfill the criteria for an endophenotype. The FK506 Binding Protein 5 (FKBP5) gene codes for a co-chaperone of the glucocorticoid receptor and has been reported to be associated with cognition. Aim: The aims of our research were to determine the degree of cognitive impairment in patients suffering from SCZ and BD and to explore the association of the FKBP5 variant rs3800373 genotype with the cognitive endophenotypes. Material and Methods: Patients and healthy controls were recruited over a period of two years from the Psychiatric Clinic, Clinical Center University of Sarajevo. Genotyping and neuropsychological assessments were performed for 263 subjects (129 SCZ, 53 BD, and 81 healthy controls [HC]). Neuropsychological assessments were performed for all patients with the Trail Making Test-A&B (TMT-A&B) and Digit-span forward&backwards tasks. The single nucleotide polymorphism (SNP) rs3800373 in the FKBP5 gene was genotyped using Infinium PsychArray Bead Chips. Results and Conclusion: SCZ and BD patients performed lower than HC in the TMT-A&B and in the Digit-span backwards task, while no differences were observed between SCZ and BD patients. While SCZ patients performed lower than HC in the Digit-span forwards task, there were no differences between BD and HC or between BD and SCZ. Rs 3800373 was not associated with performance in the TMT-A&B or Digit-span forwards&backwards tasks. SCZ and BD share largely overlapping neurocognitive characteristics. Rs3800373 was not associated with performance in the neuropsychological tests. However, given the limited sample size, the results do not exclude an association with the rs3800373 variant in a larger sample. Furthermore, as the analysis was limited to one SNP, the results cannot be generalized to other genetic variants in FKBP5.