: Medicinal nail lacquers are the most effective topical treatment of nail diseases. These formulations generally are organic solutions of the active substance as well as film-forming polymer and plasticizer, which affects the characteristics of the film formed after application and solvent evaporation. The aim of this work was to test the effects of plasticizer present in nail lacquer formulations on permeation kinetics of fluconazole through the bovine hoof membrane in a novel in vitro test. The formulations contained Eudragit RS100 dis- solved in acetone, and dibutyl-phthalate, PEG 400 or propylene glycol as plasticizers present in two different concentrations. Permeation studies were carried out during the 7-day period, and the obtained permeability pro- files analyzed using similarity and difference factors, and by model-dependent permeation kinetics. When analyzed within the same strength, the highest extent of fluconazole permeation was obtained from the formula- tion with a lower concentration of propylene glycol at 0.9% fluconazole concentration, while for formulations with 1.8% and 2.7% of fluconazole, the highest permeation was achieved from the formulation with the high- er content of PEG400. The permeation profiles showed a greater difference within one formulation of different fluconazole content than with the same plasticizer present in different concentrations, when using dibutyl- phthalate and PEG400. The permeation profiles were similar when using propylene glycol. When comparing formulations with the same concentrations of plasticizers, there were differences in formulations with the high- er fluconazole concentrations. Permeation kinetics depended on fluconazole concentration as well as the path length the active substance had to pass to reach the receptor solution.

Brucellosis is an emergent and endemic zoonotic disease in Bosnia and Herzegovina. In this report we have diagnosed the first case of human brucellosis in Bosnia and Herzegovina, using molecular and microbiological tests, caused by live attenuated Brucella melitensis Rev.1 strain. The infection was caused through unintentional exposure to vaccination of small ruminants in Bosnia and Herzegovina and without any prior accidental self-injection of vaccine suspension.

REST HTTP is the communication protocol of choice for software developers today. In IoT systems with unreliable connectivity, however, a stateless protocol like REST HTTP needs to send a request message multiple times, and it only stops the retransmissions when an acknowledgement arrives at the sender. In our previous work, we studied the usage of random linear network coding (RLNC) for REST HTTP protocol to reducing the amount of unnecessarily retransmissions. In this paper, we experimentally validate the study and analyze REST HTTP with and without RLNC in a simple testbed in dynamic IoT systems. The measurements show notable improvements in bandwidth utilization in terms of reducing the retransmissions and delay when using network-coded REST HTTP.

Istraživana je morfološka varijabilnost lista 25 populacija klena (Acer campestre L.) na području Bosne i Hercegovine. Morfometrijsko istraživanje unutarpopulacijske i međupopulacijske varijabilnosti provedeno je na temelju 19 morfoloških svojstava lista, pri čemu su korištene deskriptivne i univarijatne statističke analize. Najveću varijabilnost pokazalo je svojstvo dužina peteljke lista, dok je najmanja varijabilnost utvrđena kod izvedenog svojstva odnos maksimalne dužine plojke lista i maksimalne širine plojke lista. Izvedena svojstva lista bila su manje varijabilna od mjernih, što upućuje na manje variranje svojstava oblika u odnosu na svojstva dimenzija lista. Analiza varijance pokazala je statistički značajne razlike između populacija za sva analizirana svojstva lista. Multipla testiranja pokazala su veću međupopulacijsku nego unutarpopulacijsku varijabilnost za sva istraživana svojstva osim dva svojstva geometrijske skale podataka (kutovi žila). Za razliku od mjerenih svojstava lista, sva izvedena svojstva pokazala su veću unutarpopulacijsku nego međupopulacijsku varijabilnost. Najdivergentnija populacija, s jedne strane, bila je populacija Trebinje, s najvećim brojem minimalnih vrijednosti svojstava lista, dok je s druge strane najdivergentnija populacija Banja Luka, s najvećim brojem maksimalnih vrijednosti svojstava lista. Dobiveni rezultati mogu služiti kao temelj za dalja istraživanja u drugim dijelovima areala vrste, u svrhu determiniranja utjecaja interakcije ekoloških, geografskih, klimatskih i migracijskih čimbenika na morfološku varijabilnost populacija klena.

The new challenging trends such as globalisation, liberalisation and privatisation of the postal sector, the emergence of the internet commerce, as well as the demands for high quality commercial postal services operators, create a new ambience for the ways business is conducted by commercial postal services operators which demands innovative approaches. The growing pressure regarding the costs of commercial postal services operators and the increase in volume for pick-up and delivery leads to changes from fixed into variable costs by means of different outsourcing models. This paper proposes a model of calculating the outsourcing services of the technological phases regarding parcel delivery and pick-up, while it is not focusing on the details of the partnership contract. For cost calculation, the model utilizes calculation factors based on the kilometres covered for different categories of vehicles that may take part in the parcel pick-up and delivery phases.

Wide GNSS (Global Navigation Satellite System) availability has its advantages, however, in that case the system is exposed to a large number of external influences, from interference with other signals to deliberate blocking and jamming. There is also a huge increase in GNSS user number for both professional and private purposes. The technology of protection and regulation is partly behind the technological development and leaves room for undesired impacts from both natural and artificial causes. Through this paper GNSS errors are described using an android mobile application, "GNSS Analysis Tool", that allows observation of the GNSS signal characteristics.

Contemporary dynamic market conditions are characterized by high levels of competition. Businesses are forced to make continuous changes in order to maintain a high level of customer’s satisfaction. Contact centers are part of the global economy and a key channel for communication with customers. Access to the contact centers is realized through several channels (telephone, e-mail, fax, web forms, etc.), but the primary method is still a phone call. Most call centers use Interactive Voice Response (IVR) to route users with a particular problem for directing the user to an agent with appropriate capabilities (Skill-based routing – SBR). This type of contact center operation can have a negative impact on the quality considering customer’s experience, due to the complexity and length of the process, which often results in directing calls to the inadequate agent and describing the problem multiple times to reach the right agent. This paper aims at applying machine learning methods based on prior experience with matching customers and agents in order to reduce time and target agents with adequate problem-solving abilities.

Background: This research was done as continuation of research made previously on male population. The goal of this research is to determine „differences between morphological characteristics and motoric capabilities of physically active and inactive female students “. Methods: Sample of physically inactive female students was made of 54 examinees and sample for active students was made of 52 girls. Average age was 12. All girls were primary school students. Physically inactive students regularly attended PE lessons and active students were involved in training process of basketball, volleyball, football and handball teams. Additional practice was done two times a week for 90 minutes. Morphological space is set by 15 variables and motoric space is set with 24 variables. Results: Statistical difference was determined by T-test on level (p<0.05). Significance given by T-test was checked by calculating Eta coefficient. Such data has differences in Chest Width (.00/.00 and η2=0,33), Weight (.00/.00 and η2=0,34), Stomach Skin Curves (.00/.00 and η2=0,37) and Back Skin Curves (.05/.05 and η2=0,16). Motoric space has differences in: Slalom with Three Medicine Balls (.00/.00 and η2=0.01), Throwing medicine ball from the chest (.00/.00 and η2=0,10), Long Jump (.00/.00 and η2=0,17), Push-ups (.02/.02 and η2=0.05), Sit-and-Reach (.04/.04 and η2=0.00) and 20m low start run (.00/.00 and. η2=0,14). Conclusions: After analysis it can be stated the aim of the research was completed and differences of anthropological status of physically active and inactive female students were determined. Students of age 12 can be recommended additional training activity to positively transform anthropological spaces with no transformation. Research with same or similar variables should be done on different age categories when compared to this one or to analyze quality of influence that specific sports have on transformation in this age category.

The aim of the paper was to examine the effect of noise on the blood flow velocity through a period of three years on workers who work on press machine. It was proven that continuous exposure to noise affects the blood flow velocity through the aorta and increases the diameter of ascending aorta and this, consequently, leads to an increase in cardiovascular risk. Prevention of changes in the cardiovascular system is considered to be imperative, and the limitation of noise levels and the length of exposure to noise must be established as factors that must be planned during the construction of the work environment.

A major research area in non-human social cognition is the investigation of cooperative problem solving, i.e. the cognition involved in situations when animals cooperate with each other. Social cognition is thought to have evolved due to the demands of social living, and is often thought to present an adaptive specialisation for living in groups. A previous analysis of social learning, another area of social cognition, has highlighted how this has consequently led to two overarching biases in the literature: firstly, a bias towards testing only social species, and secondly, an a priori assumption that social learning is qualitatively different from learning involved in non-social situations. The problem of these biases may not restricted to social learning but be present also in other areas of social cognition research. Applying an equivalent analysis to cooperative problem solving shows that here too both biases are present. Firstly, empirical studies on cooperative problem solving primarily conducted with social species and species that exhibit cooperative behaviours in the wild. Secondly, the assumption that cooperative problem solving relies on a distinctly socialcognitive ability can, at least implicitly, be observed throughout the literature. Thismay be the result of confounding different components of the cognitive process involved in cooperation: what information is required to successfully cooperate and how this information is acquired. While the former needs to involve information about another individual, there is no indication that the latter is required to differ from any known, domain-general cognitive mechanism. These two biases make it difficult to systematically test whether and how cooperation differs between species, and as such impede investigations into the evolution of cooperative problem solving.

Polycrystalline advanced ceramics are synthetic products produced by sintering together selected ceramics grains in a metal matrix serving as a binder. In order to be able to propose their optimisation, achieving high performance cutting and leading to reduced operating costs and improved working environment, relevant fracture mechanisms involved in their failure need to be determined. In this work, experimental results of plane strain fracture toughness obtained earlier on single-edge-V-notched-beam specimens were supported with microscopy analysis. These findings establish a clear connection between the fracture toughness results and the fracture mechanisms visible on and beneath the fracture surfaces, revealing adiabatic conditions that occur at the crack tip during fracture.

Research on how to implement blockchain technology within governance has avoided to further explore on the possibilities of the technology to replace standard nation state architectures. This in turn has created a wave of technological questions directed to better enforce decentralization and security within the popular networks, rather than proposing normative possibilities to be implemented into the institutional framework of the state. This article addresses this issue by analyzing a set of functional areas with the aim of replacing processes, institutions and actors that are often considered as part of the modern bureaucratic nation state. It also drafts functional concepts and recommendations on security issues that should be addressed in any attempt to implement blockchain solutions at the national level.