To keep internet based services available despite inevitable local internet and power outages, their data must be replicated to one or more other sites. For most systems using the store-and-forward architecture, data loss can also be prevented by using end-to-end acknowledgements. So far we have not found any sufficiently good solutions for replication of data in store-and-forward systems without acknowledgements and with geographically separated system nodes. We therefore designed a new replication protocol, which could take advantage of the lack of a global order between the messages and the acceptance of a slightly higher risk for duplicated deliveries than existing protocols. We tested a proof-of-concept implementation of the protocol for throughput and latency in a controlled experiment using 7 nodes in 4 geographically separated areas, and observed the throughput increasing superlinearly with the number of nodes up to almost 3500 messages per second. It is also, to the best of our knowledge, the first replication protocol with a bandwidth usage that scales according to the number of nodes allowed to fail and not the total number of nodes in the system.

Earnings management literature extensively explores tax regime and debt contracting as possible incentives in financial reporting. Firms engage with aggressive financial reporting to bias earnings in periods when the need for external financing increases. Contrary to this, the tax burden represents incentive for more conserva tive reporting. We argue that the level of firm’s financial reporting aggressiveness is not constant but rather floating from period to period, directly affecting the quality of financial reports. We assume that firm’s management on its own discretion determines the level of conservatism, balancing between these two incentives. The prevailing of two incentives, the need for external financing and the tax burden, determines the level of conservatism in particular reporting period. We hypothesised that the reduction in tax burden incentive overcomes the debt contracting incentive in the years of decreasing external financing need, implying more conservative accounting to balance between economic and taxable income. The total accruals are used as a measure of earnings management reflected to working capital accruals. The data analysis conducted on financial reports of 297 firms in the time-series of five years shows a significant correlation between total accruals, external financing needs and difference between economic and taxable income. This study provides an evidence on the association between conditional conservatism and external financing needs against anticipated tax sheltering activities in the economy with rather weak legal enforcement and widely spread use of accoun-ting-based covenants in debt contracting, proposing that the conditional conservatism may rather not reduce the cost of debt with the diminishing role of accounting in the debt contracting.

Introduction. Cellulose nanocrystals (CNCs) as attractive natural materials,have numerous applications in the biomedical field. Their unique biomechanicalcharacteristics, surface chemistry, low cost and sustainable naturemake them an engaging alternative to conventional materials and potentiatetheir use as progressive material. Therefore, it is critical to evaluate thecytocompatibility and immunomodulatory properties of nCNCs, which havenot been completely explored. The objective of this study was to examinea dose-dependent effect of native (n)CNCs on cytotoxicity and proliferativeactivity of human peripheral blood mononuclear cells (PBMNCs) in vitro.Methods. PBMNCs, obtained from the healthy blood donors, were cultivatedwith nCNCs. Cell viability was analyzed by flow cytometry assay, whileproliferative activity was determined by MTT, [3H]-thymidine uptake assayand detection of IL-2 production.Results. The cytotoxicity results suggested that no concentration of nCNCs(50-400 μg/ml) affected necrosis of PBMNCs, whereas apoptosis was inducedby the highest concentration of nCNCs compared to control (p<0.05).Unexpectedly, the highest concentration of nCNCs increased the metabolicactivity of PHA-stimulated cells compared to control (p<0.05). In contrastto these findings, lower concentrations of nCNCs (50 μg/ml and 100 μg/ml)stimulated proliferation of PBMNCs (p<0.05 and p<0.001). It was followedby increased production of IL-2 (100 μg/ml) (p<0.001).Conclusion. The results suggest that non-cytotoxic concentrations of nCNCsmodulate the proliferative activity of human PBMNCs, a phenomenon whichhas not been published up to now and which is relevant for further studies.

Context Neoangiogenesis and lymphangio-genesis are essential for the growth of tumor and progression of malignancy. Objective The study examined the significance of VEGF-C expression in comparison to classical prognostic factors in differentiated thyroid carcinoma (DTC), as well as an independent prognostic marker in DTC. Design The study included 81 patients with DTC allocated in two groups according to the type of cancer (follicular versus papillary) and then compared to expression of VEGF-C and clinicopathological features. Methods Expression of VEGF-C was identified with anti-VEGF-C antibody using tris-EDTA buffer Antigen Retrieval Protocol. Each specimen was scored with a semi-quantitative score system (H-score). Results The analysis of T staging system showed a linear correlation between the size of a tumor, expression of VEGF-C and recurrence of a disease, with a statistical significance (p < 0.0001). There was a clear and significant correlation between VEGF-C expression and T stage in patients with papillary carcinoma (p = 0.0294). Analysis of invasion of a surgical margin demonstrated significant positivity in patients with papillary thyroid cancers who expressed VEGF-C (p = 0.0207) indicating the worse prognosis of a disease. Also a statistically significant correlation was between VEGF-C and extrathyroid extension, indicating the worse prognosis (p = 0.0133) in papillary cancers. The level of VEGF-C expression was statistically significant in patients with papillary thyroid cancer (p = 0.039). Conclusions This study undoubtedly demonstrates that VEGF-C expression is an evident negative prognostic factor in patients with papillary thyroid carcinoma, along with the classic prognostic factors, such as a larger tumor size, tumor margin involvement, extrathyroid extension, i.e. local aggressiveness.

The internal market, which encompasses the free movement of goods, persons, services and capital, is at the heart of European cooperation. The Treaty on the Functioning of the European Union (TFEU) prohibits Member States, and in some cases private organisations, from introducing measures that impede free movement. In addition, there are provisions in the Treaty that prohibit companies from obstructing competition in the internal market.

Human migration is an outstanding example of a policy domain in which the links between European countries and their surroundings are revealed. The policy domains of asylum, migration and border control touch on international mobility, the protection of fundamental human rights, and international security all around Europe and within it. They also provoke intense debate among populations.

The previous chapter described how globalisation, the erosion of embedded liberalism and social protection, and pressure on mutual solidarity between Member States have led to growing frictions in the European Union. These frictions have usually had a combination of causes: external events, internal choices, or the unforeseen consequences of compromises that turned out better for one country or one segment of the population than for another.

Since the early years of the common market, the Community legal order has focused on removing obstacles to the free movement of goods, persons, services and capital; in other words, on creating a single market. Social protection remained in place in national legislation; harmonisation was sought where politically feasible, but ‘Europeanisation’ has remained limited in this domain. Free competition was promoted through a European-level anti-trust policy and by counteracting preferential treatment by national governments. As a Member State of the European Union, the Netherlands is part of an internal and external economy of unprecedented power, with more than half a billion consumers and a combined Gross Domestic Product (GDP) of 14,714 billion euros (2015), the largest GDP in the world. Two thirds of the EU’s trade in goods takes place between EU countries, with a volume of 3070 billion euros (2015). Approximately 72% of Dutch goods exports (measured in terms of their value) go to EU countries, and more than half of its imports come from EU countries (2015). With the removal of barriers as the starting point, the Netherlands, like its neighbouring countries, is closely intertwined with its European biotope. Dutch legislation is embedded in European legislation in almost every area, and in fact it must be, because differences would be susceptible to exploitation in the single market. Even technical requirements for appliances must not differ too much from country to country, as they would otherwise create an obstacle to European trade or give one or other country an undesirable competitive advantage. Since the reforms of recent decades, virtually all relevant legislation is the result of joint decision-making by the European Parliament and the Council of the European Union, at the initiative of the European Commission. The Member States are represented in the Council by a minister; decisions are taken by qualified majority, which means that for a decision to pass, at least 55% of the Member States, representing at least 65% of the population, must be in favour of it. The weekly