Abstract Relying on conceptualization of sexting as a deviant behavior, which appear to be related with mental health problems, we examined the relationship between sexting and psychological distress. A one-year longitudinal study was performed among 216 girls and 143 boys, aged from 15 to 17 years (M = 16.32, SD = .64). Participants completed the Sexting Behavior Questionnaire and the Depression Anxiety and Stress Scale at both time points of the study. The results showed that the prevalence for receiving sexts between the two time points was around 30%, and for sending sexts around 60%. The prevalence rates of receiving and sending sexually explicit context were quite stable over time, though they varied significantly across gender. Participants usually had sexted with a current or (ex)partner or friends. The number of person with whom participants exchange sexts did not exceed five. Anxiety and stress symptoms were more prevalent among sexters who receive sexts at the baseline than follow-up study (p < .05). Stress has been found to be significant predictors of sending sext at the baseline study (p < .05), while depression of receiving and sending at the follow-up study (p < .001). This study confirms that sexting is common among youth, and appears to be associated with negative consequences.

Abstract Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-β ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-α, IL-1β and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1β were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-β and TNF-α in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.

Scientific disciplines face concerns about replicability and statistical inference, and these concerns are also relevant in animal cognition research. This paper presents a first attempt to assess how researchers make and publish claims about animal physical cognition, and the statistical inferences they use to support them. We surveyed 116 published experiments from 63 papers on physical cognition, covering 43 different species. The most common tasks in our sample were trap-tube tasks (14 papers), other tool use tasks (13 papers), means-end understanding and string-pulling tasks (11 papers), object choice and object permanence tasks (9 papers) and access tasks (5 papers). This sample is not representative of the full scope of physical cognition research; however, it does provide data on the types of statistical design and publication decisions researchers have adopted. Across the 116 experiments, the median sample size was 7. Depending on the definitions we used, we estimated that between 44% and 59% of our sample of papers made positive claims about animals' physical cognitive abilities, between 24% and 46% made inconclusive claims, and between 10% and 17% made negative claims. Several failures of animals to pass physical cognition tasks were reported. Although our measures had low inter-observer reliability, these findings show that negative results can and have been published in the field. However, publication bias is still present, and consistent with this, we observed a drop in the frequency of p-values above .05. This suggests that some non-significant results have not been published. More promisingly, we found that researchers are likely making many correct statistical inferences at the individual-level. The strength of evidence of statistical effects at the group-level was weaker, and its p-value distribution was consistent with some effect sizes being overestimated. Studies such as ours can form part of a wider investigation into statistical reliability in comparative cognition. However, future work should focus on developing the validity and reliability of the measurements they use, and we offer some starting points.

The expectation for survival in patients with advanced melanoma now exceeds 50% at 5 years in patients treated with first-line combination ipilimumab and nivolumab, despite this regimen being associated with substantial toxicity. We discuss the latest updates from the Checkmate-067 study, framing the role of this combination in practice today.

Hydrogen evolution reaction (HER) is one of the most important reactions in electrochemistry. This is not only because it is the simplest way to produce high purity hydrogen and the fact that it is the side reaction in many other technologies. HER actually shaped current electrochemistry because it was in focus of active research for so many years (and it still is). The number of catalysts investigated for HER is immense, and it is not possible to overview them all. In fact, it seems that the complexity of the field overcomes the complexity of HER. The aim of this review is to point out some of the latest developments in HER catalysis, current directions and some of the missing links between a single crystal, nanosized supported catalysts and recently emerging, single-atom catalysts for HER.

Research subjects of this study are four representative locations in the industrial complex, in the city of Banja Luka, Republic of Srpska, Bosnia and Herzegovina. 16 polycyclic aromatic hydrocarbons (PAHs) (∑16PAHs), humus and pH were determined. The main objective of the paper is to determine the concentration levels, to assess the probable sources of PAHs contamination in soil and groundwater and to determine the ecological risk. The ∑16PAHs in soil (at depths of 30 cm, 100 cm, 200 cm, 300 cm and 400 cm) ranged from 0.99 to 2.24 mg/kg, from 0.34 to 0.46, from 0.24 to 0.32, from 0.13 to 0.27 and from 0.13 to 0.47, with mean values of 1.70 mg/kg, 0.40 mg/kg, 0.28 mg/kg, 0.20 mg/kg and 0.26 mg/kg, respectively. The ∑16PAHs in groundwater ranged from 0.23 to 4.50 mg/m3, with a mean value of 1.42 mg/m3. Surface soil and groundwater are heavily contaminated. All values of ∑PAHs in soil layers were lower in the depths of the soil. Factor analysis indicates three sources of contamination, i.e. principal component (PC) PC1 (pyrogenic), PC2 (petrogenic) and PC3 (biomass), with 52.39%, 26.14% and 8.46% of the total variance, respectively. ∑PAH and PAHs indicate high ecological risk for most PAHs, which decreases with soil depth.

This paper explores ethno-villages in Bosnia and Herzegovina as an important element of rural and cultural tourism. The attractiveness of natural and cultural heritage is very important for sustainable rural tourism development. In order to improve the process of decision making to enable the sustainable development of ethno-villages, a multi-criteria assessment model has been developed. The methodology is based on qualitative modeling using a multi-criteria analysis via the DEXi software. The model is based on hierarchical relations consisting of three main criteria that are the basis of sustainable tourism development: economic, social, and environmental criteria. The ultimate goal of the model in this study was to evaluate ethno-villages, namely six ethno-villages in Bosnia and Herzegovina. The results of the study show how ethno-villages contribute to sustainable development.

Background: The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage healthy lifestyle choices.Methods: 16 participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological state of stress and to assess biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Blood pressure and weight were tracked 3 times per month. At least once a week, but on average 6 times per month, participants also led the food diary. Univariate analysis compared the continuous variables by Student's t-test for the data that were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables.Results: Participants used the app with a compliance rate of 100%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to 4 kg of body mass. Physical readiness has significantly improved.Conclusions: Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients’ pockets where they can monitor their disease and increase the ability of self-care.