Već sedamdesetih godina dvadesetoga stoljeća razvijeni su prvi koncepti suvremenoga pojma medijske pismenosti. Nakon toga uslijedilo je nekoliko inicijativa da bi se bolje prepoznala važnost učenja i nužnost razvoja medijske pismenosti. Devedesetih godina dolazi do institucionalizacije medijske pismenosti i do definiranja osnovnih smjernica i elemenata potrebnih za razvoj i implementaciju medijske pismenosti u društvu. Otada pa sve do danas koncept medijske pismenosti ubrzano se mijenjao. Dinamičan i ubrzan razvoj informacijskih i komunikacijskih tehnologija, pojava novih medija i medijskih navika konzumenata doveli su do promjene samoga koncepta i razumijevanja medijske pismenosti. Dotad se medijska pismenost prepoznavala kao instrument za zaštitu konzumenata od negativnih medijskih poruka i sadržaja (najčešće djece i mladih), a potom i kao instrument za zaštitu konzumenata od tehnologije te kao preduvjet za bolju građansku participaciju. Danas tumačenje pojma medijske pismenosti promatramo i u zavisnosti od društva i konteksta u kojem se medijska pismenost koristi i na način kako se razvija. Prema tome, koncept i primjena u ovisnosti su o geografskom i tehnološkom pristupu medijima, a samim time i o evaluaciji i načinu na koji komuniciramo preko različitih medija. Stoga bi današnji koncept medijske pismenosti predstavljao oružje ili oruđe za borbu protiv negativnih medijskih sadržaja, manipulacije, lažnih vijesti, obmana, propagande, dezinformacija, a u svrhu kritičkoga i kreativnog izražavanja i bolje građanske participacije.

The present study was conducted to investigate the water quality of the Trstionica River, Bosnia and Herzegovina. The physicochemical properties (temperature, pH, conductivity, total solids after evaporation at 105 °C), content of metals (calcium (Ca), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), sodium (Na), nickel (Ni), lead (Pb) and zinc (Zn)), and anions (chloride (Cl−), and phosphate (PO4)) were determined in water samples collected at seven locations during two sampling periods: unstable weather conditions (precipitation), and stable weather conditions (without precipitation). There was a significant difference in the content of individual parameters in the river water depending on the sampling time. For determination of metals concentrations, which were below the limit of detection, a preconcentration method using an ion-exchange resin was applied. The metals concentrations during the rainy day were in the order Ca > Mg > Na > Fe > Cu > Zn > Pb > Mn with mean values of 343, 6.03, 1.94, 0.18, 0.20, 0.03, 0.02, 0.01 mg dm−3, respectively, and during stable weather conditions: Ca > Mg > Na > Cu > Fe > Mn > Zn with mean values of 288, 7.62, 2.38, 0.11, 0.10, 0.01, 0.01 mg dm−3, respectively. Cd, Cr, and Ni concentrations were below limit of detection in both cases. Obtained values were compared with World Health Organization (WHO) regulations. The results showed that the Trstionica River in the investigated part of the stream meets most of the parameters required by the regulations. The correlation between analysed parameters was assessed, as well. Based on the calculated water quality index values, the water of Trstionica River falls into the category of excellent water.

Cervical cancer is the fourth most common malignancy in women worldwide and a leading cause of cancer-related mortality in developing countries. Important etiological factors in this cancer are high-risk human papillomaviruses (HPV), as roughly 96% of cervical cancer cases are positive for these oncoviruses. On the other hand, it has been recently pointed out that E6/E7 oncoproteins of high-risk HPV can upregulate the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis. Likewise, several recent reports showed that checkpoint blockades targeting PD-1/PD-L1 pathways have achieved efficient clinical responses via suppressing cancer progression and improving survival in several types of human cancers including metastatic cervical cancer. In this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway and its interaction with high-risk HPV and their oncoproteins, which could have an important impact on the management of HPV-associated cancers including cervical.

© The Author(s) 2020. Published by ARDA. Abstract Background: The subject of this research is the creation of an optimal school bench design with the aim of determining the most favorable posture of students while sitting, taking into account the relevant ergonometric and biomechanical characteristics of the human body. For the proposed model of the school bench which allows adjusting the different slopes of its surface, the corresponding computer model of the student and the table was first created, and then biomechanical and RULA analysis was performed in order to determine the maximum load in the lumbar part. Next, for each test subject of given weight, it was necessary to determine the amount of maximum load in lumbar zone L3/L4 for different slope angles and to determine the critical angles at which the maximum permissible load of 3400 N is reached.

Recent studies have been showed important role of elevated iron levels in pathogenesis of Type 2 Diabetes mellitus (T2D) and insulin resistance. The aim of this study was to determine serum of free iron concentration in T2D patients and find out associations with lipid profile. The study included 51 participants (27 healthy control and 24 no treated diabetes patients), with ages from 45 to 65 45-65 ages and both gender. As expected, concentrations of serum iron were elevated in diabetic patients compare to healthy subjects while statistical significant difference were shown between iron levels in control group and group with good control of glycaemia (p<0.05). In addition, there was a significant positive correlation between free iron concentration and LDL cholesterol levels and negative significant correlation between iron concentrations with HDL cholesterol in diabetics (p<0.05). These findings suggest that increase serum of free iron concentrations may have an important role and influence in development of disease, especially in lipid metabolism and profile as well in risk of further complications of diabetes.

From the point of welding procedure evaluation, it is important to analyse welds for their impact toughness and transition temperature for three main zones: weld metal, heat-affected zone and base metal. This paper covers butt welds of two QT steel grades, 690 and 890, with thicknesses of 30 mm and 20 mm, respectively. They are interesting regarding yield strength and characteristic weld zones. Basic details of GMAW process used in experiment are provided, with temperatures for impact toughness tests of weld zones varied from +20 °C down to -60 °C. Based on acquired experimental results of impact toughness, fitting curves were developed by use of Oldfield model, i.e. hyperbolic tangent function. Acquired transition temperatures (TT) from fitting curves show mostly allowable values for all three weld zones. As expected, lower strength grade 690 possess higher impact toughness, in comparison to higher strength grade 890. The standardized criteria of minimal absorbed energy of 30 J (KV) and 50% of shear fracture (SF) show different transition temperatures (TT-30J and TT-50%SF), while general dependence of impact toughness to shear fracture (KV vs. SF) shows a reasonable trend. Finally, used GMAW procedures may be considered as acceptable, since for both steel grades (690 and 890) all three weld zones show better TT-30J values than minimal required by standard (TT-30J=-40 °C) for QT structural steels.

This paper presents a low-cost, single sensor autonomous mobile robot. The proposed system is able to map an indoor environment, while at the same time localizing itself within it, and solving the SLAM (Simultaneous Localization and Mapping) problem using data gathered from the sensor. It is able to navigate the environment, choosing safe paths for exploration based on the data acquired by mapping and localization. The system is based on commercially available, in-expensive hardware, while the software is developed with open-source ROS (Robot Operating System) packages. The ability for autonomous navigation of the proposed system has been verified through real-world experiments. The system offers a simple to build platform, which can easily be extended.

We clarify open issues in relating low- and high-energy observables, at next-to-leading order accuracy, in models with a massive leptoquark embedded in a flavor nonuniversal SU(4)×SU(3)×SU(2)×U(1) gauge group. Extending previous work on this subject, we present a complete analysis of the O(αs) corrections to the matching conditions of semileptonic operators at the high scale. These corrections are not negligible, but they do not exceed the 10% level and are subleading compared to the O(α4) corrections proportional to the leading leptoquark coupling, which is expected to be much larger than the QCD coupling in the parameter space region of phenomenological interest. We further analyze the impact of radial modes, both at O(α4) and at O(αs) accuracies, highlighting their role in the renormalization of the theory.

Although the Internet has become the essence of communication, from an advertiser’s perspective digital advertising remains underexplored. This paper examines the effects of digital media buying efforts on advertisers in Bosnia and Herzegovina, while looking into the methodology of digital media usage behind the actual effects. A combination of secondary research analysis and qualitative research techniques was used. The empirical part is based on in-depth interviews with advertisers and representatives from the digital advertising industry.Perceptions and knowledge of digital advertising are the key drivers for a successful implementation of digital media buying, and advertisers in Bosnia and Herzegovina are aware of its most distinctive qualities. The success of the media buying campaigns relies on brand objectives and choosing the means suited for fulfilling the given goals, which in turn leads to the findings that the focus of companies’ strategies is directed towards the cost-efficient medium usage, rather than solely performance-oriented ones. Measurement of the effects and return on the investment depends on the success of setting up a goal and isolating digital from other marketing efforts.