The election of Donald Trump to the presidency of the United States missed by a mere few weeks the 120th anniversary of the opening night of Alfred Jarry’s Ubu the King (10 December 1896). Numerous similarities between the 45th US president and the character that inaugu -rated the theatrical avantgarde didn’t go unnoticed. The poet Charles Simic wrote that the “story of his presidency and the cast of characters he has assembled in the White House would easily fit into Jarry’s play without a single word needing to be changed” (Simic 2017). British author Rosanna Hildyard had the same idea when she published her translation and adaptation of Jarry’s play under a tell-all title: Ubu Trump (2017). And early in 2018, Paula Vogel organized a “National UBU ROI Bake-Off” in which she invited playwrights to compose skits featuring key “ingredients” from Jarry’s play. So, on Presidents’ Day (19 February 2018) theatres across the country performed pieces that ranged from a farce about Trump and Anthony Scaramucci, who briefly and scandalously held the position of White House communications director, to a monologue by an actor playing Melania Trump, to Ubu’s funeral. More recently, in late February 2020, an advertisement from Verso Books for Hal Foster’s new book What Comes after Farce? landed in my inbox. The blurb is spot on:

This article proposes geometrically-based stochastic channel model with scatterers homogeneously distributed within <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-dimensional (<inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-D) hyperspherical-shaped scattering region for single-bounce propagation scenario, with arbitrary positions of base station (BS) and mobile station (MS). For such defined geometrically-based stochastic channel model, the angular and temporal statistics are determined by introducing the projective approach. Accordingly, azimuthal angle and time of arrival marginal PDFs are derived in closed form, while the elevation angle PDF can be delivered numerically in general, and in closed-form for specific environmental parameters. The fidelity of the analytically obtained results is evaluated by their comparison to the corresponding normalized histograms. Also, it is shown that the proposed <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-D model can be used to analyze some of the existing channel models like 2-D uniform disk and 3-D uniform (hemi)sphere models. Additionally, by introducing the mentioned projective approach, it is shown that the angular statistics of the proposed <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-D model are the same as the angular statistics of some nonuniform 2-D and 3-D models, which is an important property of the proposed model. Such observation enabled us, for the first time in the literature, to determinate angular statistics for geometrically-based stochastic channel models such as inverted parabolic scattering model, 2-D Gaussian model and 3-D Gaussian hemisphere model, for arbitrary positions of BS and MS. Such angular characteristics of proposed channel model are validated through several empirical datasets.

An amendment to this paper has been published and can be accessed via the original article.

AbstractDeveloping beneficial applications for sewage sludge is a key challenge in many countries, given the amount of sludge generated and the disposal or recycling options currently available. Se...

The original published article contained a mistake.

Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer’s disease (AD). Substantial progress has been made in identifying positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers for AD, but they have limited use as front-line, non-invasive diagnostic tools. Small extracellular vesicles (EVs) are released by all cell types and contain an enriched subset of their parental cell molecular composition, including lipids. EVs are released from the brain into the periphery, providing a potential source of tissue and disease specific lipid biomarkers. However, the EV lipidome of the central nervous system (CNS) is currently unknown and the potential of brain-derived EVs (BDEVs) to inform on lipid dyshomeostasis in AD remains unclear. The aim of this study was to reveal the lipid composition of BDEVs in human frontal cortex tissue, and to determine whether BDEVs in AD have altered lipid profiles compared to age-matched neurological controls (NC). Here, using semi-quantitative mass spectrometry, we describe the BDEV lipidome, covering 4 lipid categories, 17 lipid classes and 692 lipid molecules. Frontal cortex-derived BDEVs were enriched in glycerophosphoserine (PS) lipids, a characteristic of small EVs. Here we report that BDEVs are enriched in ether-containing PS lipids. A novel finding that further establishes ether lipids as a feature of EVs. While no significant changes were detected in the frontal cortex in AD, the lipid profile of the BDEVs from this tissue exhibited disease related differences. AD BDEVs had altered glycerophospholipid (GP) and sphingolipid (SP) levels, specifically increased plasmalogen glycerophosphoethanolamine (PE-P) and decreased polyunsaturated fatty acyl containing lipids (PUFAs), and altered amide-linked acyl chain content in sphingomyelin (SM) and ceramide (Cer) lipids relative to vesicles from neurological control subjects. The most prominent alteration being a two-fold decrease in lipid species containing docosahexaenoic acid (DHA). The in-depth lipidome analysis provided in this study highlights the advantage of EVs over more complex tissues for improved detection of dysregulated lipids that may serve as potential biomarkers in the periphery.

Abstract With an incidence of 350.000 new cases per year, cancer of the oral cavity ranks among the 10 most common solid organ cancers. Most of these cancers are squamous cell carcinomas. Five‐year survival is about 50%. It has been shown that clear resection margins (>5 mm healthy tissue surrounding the resected tumor) have a significant positive effect on locoregional control and survival. It is not uncommon that the resection margins of oral tumors are inadequate. However, when providing the surgeon with intraoperative feedback on the resection margin status, it is expected that obtaining adequate resection margins is improved. In this respect, it has been shown that specimen‐driven intraoperative assessment of resection margins is superior to defect‐driven intraoperative assessment of resection margins. In this concise report, it is described how a specimen‐driven approach can increase the rate of adequate resections of oral cavity squamous cell carcinoma as well as that it is discussed how intraoperative assessment can be further improved with regard to the surgical treatment of oral cavity squamous cell carcinoma.

High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein–Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the initiation and/or progression of this cancer. Accordingly, we herein explored the prevalence of high-risk HPVs and EBV in 80 HN cancer tissues from the Syrian population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We report that high-risk HPVs and EBV are present in 35/80 (43.7%) and 41/80 (51.2%) of our samples, respectively, and the most frequent HPV types are 33, 16, 18, 45, 52, 58, 35, 51, and 31, in this order. More significantly, our data reveal that 25/80 (31.2%) of cancer cases are positive for high-risk HPVs as well as EBV, and their co-presence is associated with high/intermediate-grade squamous cell carcinomas. These data confirm the co-presence of high-risk HPVs and EBV in HN cancers in the Syrian population of the Middle East and demonstrate that their co-incidence is linked to a more aggressive cancer phenotype. Thus, future studies are required to confirm these data and elucidate the exact role of high-risk and EBV cooperation in human HN carcinogenesis.