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Gastric necrosis with perforation is a rare and potentially life-threatening condition in childhood beyond the neonatal period. We report a case of gastric necrosis and perforation of a portion of the great curvature due to a massive gastric dilatation caused by pathological aerophagia in a 13-years-old, mentally impaired adolescent girl. Despite the successful surgical treatment, the patient's condition rapidly deteriorated post-operatively and she died due to the multisystem organ failure and multiple infections. In addition, we surveyed the literature on this rare condition and assessed the preventive actions to reduce this life-treating condition.

Stanislava Talić, I. Odak, Anita Martinović Bevanda, Nikolina Crnjac, M. Paštar

The chemical composition of essential oils isolated from immortelle (Helicrysum italicum subsp. italicum) collected in Herzegovina during five different periods, was investigated by GC/MS analysis. The main compounds were a-pinene (15.7 %) and γ-curcumene (12.8 %), followed by 4,6,9-trimethyldec-8-en-3,5-dione (8.7 %), neryl acetate (6.9 %), limonene (6.4 %) and β-selinene (5.3 %). In total, 69 components were identified whose share changed over the vegetative cycle. Antioxidant activity of methanolic extracts of immortelle were determined according to DPPH (IC50 = 23–34 μg/mL) and FRAP (29 μg/mL is equivalent to 1.1‒2.2 mM Fe2+) methods. Acetylcholinesterase inhibitory potential, investigated by modified Ellman’s assay and determined as IC50 values, were 340–440 μg/mL for methanol extracts and 135 μg/mL for essential oil. Metanolic extracts showed strong antioxidant activity and potential to inhibit AChE. Essential oil possesses complex chemical composition, inhibition activity of AChE and weak antioxidant capacity.

S. Pantelić, Anđela Đošić

The aim of this research was to determine the connection between the level of physical activity and body composition among school-age children. The sample of participants included 479 students, 250 boys and 229 girls, school-age children, with an average age of 12,5±1,08. Their level of physical activity was evaluated using the FELS PAQ questionnaire, while their body composition was evaluated using the BIA method. To determine a connection between the group of predictor variables and the criterion variables, a canonical correlation analysis was used. The obtained results indicated that there is a positive correlation between the level of physical activity and the parameters of body composition, both for the sample of school-age boys (p= .002), and the sample of girls (p= .048). It could be concluded that the participants who were physically more active scored lower values for Body Fat and BMI, that is, higher values for Muscle Mass and Lean Body Mass.

Radica S Živković Zarić, A. Pejčić, S. Janković, M. Kostić, Miloš N. Milosavljević, M. Milosavljevic, V. Opančina

Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. K. kristinae is a pathogen microorganism that could cause invasive infections of various tissues in patients of any age. Majority of the patients had K. kristinae isolated from blood. It was also found in peritoneal fluid, pus, sputum, synovial fluid, bile, fluid from abdominal abscess, throat swab, urine catheter tip and mid-stream urine. Antibiotic treatment was almost universally effective, with only one death reported. Susceptibility was highest to vancomycin, linezolid, rifampicin, teicoplanin, tigecycline, cefotaxime, ampicillin/sulbactam, minocycline and meropenem. Initial treatment of Kocuria kristinae infections should involve parenteral vancomycin in combination with some other antibiotic to which it is susceptible.

Uvod Dehidracija može ugroziti sportsku izvedbu i povećati rizik od teške tjelesne povrede. Negativni efekti dehidratacije na performanse se uočavaju već pri <2% (Barr, 1999). Naime, manjak tečnosti koji se javlja tokom jedne vježbe može potencijalno kompromitovati sljedeću sesiju vježbanja, ukoliko ne dođe do adekvatne zamjene tečnosti. Dakle, zamjena te čnosti poslije vježbanja često se može smatrati hidratacijom prije sljedećeg treninga (Shirreff s, Armstrong, & Cheuvront, 2004). Ipak, sportisti samoinicijativno ne piju dovoljnu količinu vode za sprječavanje dehidracije tokom fi zičke aktivnosti (Casa, Armstrong, Hillman, Montain, Reiff , Rich, Roberts, & Stone, 2000; Maughan i sar., 2010). Maughan & Shirreff s (2010), navode da neki sportisti piju previše tečnosti, dok neki mogu razviti i hiponatremiju zbog prevelikog unosa tečnosti. S druge strane, slobodnim mikropauzama koje se tokom treninga planiraju u cilju nadoknađivanja tečnosti gubi se na intenzitetu treninga, a ukoliko je cilj treninga sticanje motoričkog znanja onda dolazi do narušavanja organizacije i kontinuiteta rada (Gobson i sar., 2012). Pogotovo je to slučaj prilikom rada u parovima, kada jedan od partnera nadoknađuje tečnost, dok drugi stoji i čeka ga. Interesantno bi bilo ispitati da li nadoknađivanje tečnosti tokom treninga predstavlja samo naviku sportiste, ili zato zaista postoji objektivna potreba nastala kao rezultat gubitka tečnosti znojenjem i naprezanjem tokom treninga. Sam osječaj žeđi je individualnog karaktera, te bi stoga bilo potrebno provjeriti opravdanost slobodnog načina rehidriranja. Poznato je i da vrhunski judo takmičari hipohidracijom smanjuju težinu prije takmičenja, što takođe negativno utiče na organizam sportiste i dovodi do smanjenja funkcije te negativnih učinaka na zdravlje (Jung & Malliaropoulos, 2014). Gubitak tečnosti rezultira osjećajem letargije i gubitkom motivacije za nastavak vježbanja, pridonoseći razvoju umora (Watson, 2008). Kratkoročne promjene u hidrataciji mogu se procijeniti na temelju promjene mase tijela (Maughan & Shirreff s, 2010). Rezultati ove studije bi trebali potvrditi dehidraciju organizma u slučaju nekonzumiranja tečnosti tokom judo treninga, te ukazati na opravdanost organizovane rehidratacije u slučaju sportista 11-12 godina starosti. Abstract

Today nanotechnology has become a top research field in the world. The present review covers classification and different applications of nanomaterials including catalysis, water treatment, sensors, energy storage and nanomedicine, as well as their positive and negative impacts on the environment. Increased attention needs to be directed towards the new nanomaterials because the development of knowledge of these nanoparticles is still in its infancy. Nanoparticles are ultra-small particles with exceptional properties, but some nanoparticles and nanomaterials also exhibit harmful properties. This is the reason why we must continue to study them and their potentially damaging effects.

Slobodan Simovic, J. Komić, Bojan Guzina, Z. Pajić, Milenko Vojvodić

The research papers investigating the game-related parameters and phenomena of women's basketball matches are relatively smaller in size and number than the similar ones treating the same issues in men’s basketball - there has been some changes in that respect in recent years though. This paper’s sample of entity consisted of 40 games and thirteen variables of standard efficiency recorded at FIBA EuroBasket Women 2017 . The research had two basic models of regressions formed, i.e. the absolute and the relative one, each of which had total numbers scored as the dependent variable, and was performed by means of regression and correlation analysis - stepwise regression, as a gradual method of fitting regression models in order to define predictive variables. The obtained regression models and partial correlation indicate that the winning or losing performance was heavily influenced by both field goal efficiency and defensive rebounding, all of which has been corroborated in many other similar pieces of research. Also, the variables as turnovers and personal fouls were extracted as significant in terms of differentiation between the winning and losing team. When we take a closer look and see the observed parameters from the point of view of either First or Final rounds of the competition - since these rounds were played in different formats - it is noticeable that it is becoming more and more evident, of course besides the shot efficiency, the efficiency of free throws and the quality of defense.

Jinming Wen, Jian Weng, Yi Fang, H. Gačanin, Weiqi Luo

The lattice <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\boldsymbol{A})$</tex-math></inline-formula> of a full-column rank matrix <inline-formula><tex-math notation="LaTeX">$\boldsymbol{A}\in \mathbb {R}^{m\times n}$</tex-math></inline-formula> is defined as the set of all the integer linear combinations of the column vectors of <inline-formula><tex-math notation="LaTeX">$\boldsymbol{A}$</tex-math></inline-formula>. The successive minima <inline-formula><tex-math notation="LaTeX">$\lambda _i(\boldsymbol{A}),\,1\leq i\leq n,$</tex-math></inline-formula> of lattice <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\boldsymbol{A})$</tex-math></inline-formula> are important quantities since they have close relationships with the following problems: shortest vector problem, shortest independent vector problem, and successive minima problem. These problems arise from many practical applications, such as communications and cryptography. This paper first investigates some properties of <inline-formula><tex-math notation="LaTeX">$\lambda _i(\boldsymbol{A})$</tex-math></inline-formula>. Specifically, we develop lower and upper bounds on <inline-formula><tex-math notation="LaTeX">$\lambda _i(\boldsymbol{A})$</tex-math></inline-formula>, where <inline-formula><tex-math notation="LaTeX">$\boldsymbol{A}$</tex-math></inline-formula> are, respectively, the Cholesky factor of <inline-formula><tex-math notation="LaTeX">$\boldsymbol{G}_1+\boldsymbol{G}_2$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$(\boldsymbol{G}_1+\boldsymbol{G}_2)^{-1}$</tex-math></inline-formula> for two given symmetric positive definitive matrices <inline-formula><tex-math notation="LaTeX">$\boldsymbol{G}_1$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$\boldsymbol{G}_2$</tex-math></inline-formula>. The bounds are, respectively, expressed as the successive minima of <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\boldsymbol{A}_1)$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\boldsymbol{A}_2)$</tex-math></inline-formula>, and <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\hat{\boldsymbol{A}}_1)$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$\mathcal {L}(\hat{\boldsymbol{A}}_2)$</tex-math></inline-formula>, where <inline-formula><tex-math notation="LaTeX">$\boldsymbol{A}_1, \boldsymbol{A}_2, \hat{\boldsymbol{A}}_1$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$\hat{\boldsymbol{A}}_2$</tex-math></inline-formula> are, respectively, the Cholesky factors of <inline-formula><tex-math notation="LaTeX">$\boldsymbol{G}_1, \boldsymbol{G}_2, \boldsymbol{G}_1^{-1}$</tex-math></inline-formula>, and <inline-formula><tex-math notation="LaTeX">$\boldsymbol{G}_2^{-1}$</tex-math></inline-formula>. Then, we show how some properties of <inline-formula><tex-math notation="LaTeX">$\lambda _i(\boldsymbol{A})$</tex-math></inline-formula> are used to design a suboptimal integer-forcing strategy for cloud radio access network. Our approach provides much higher time efficiency while keeping the same achievable rate as the algorithm reported by Bakoury and Nazer (I. E. Bakoury and B. Nazer, “Integer-forcing architectures for uplink cloud radio access networks,” in <italic>Proc. 55th Annu. Allerton Conf. Commun. Control Comput.</italic>, Oct. 2007, pp. 67–75). Simulation tests are performed to illustrate our main results.

S. Pantelić, Slavljub Uzunović, Nenad Đorđević, D. Stosic, D. Nikolić, D. Piršl

This research was conducted with the purpose of determining to what extent and how the dance program affects  the pre-school children coordination. The sample comprised 65 children of pre-school age (the control group consisted of 31 children, experimental of 34 children), aged 6 years ± 6 months. The experimental group performed dance activities over a period of 8 weeks (2X35 minutes each week). The control group performed regular activities in the kindergarten. The level of coordination in children was determined applying BOT-2 test battery (the Bruininks-Oseretsky test of Motor Proficiency). By analyzing the obtained research results, it was found a statistically significant difference between the dance and the control group in three variables: Jumping Jacks (0.000), Jumping in place-same sides synchronized (0.012) and Tapping feet and fingers- opposite sides synchronized (0.011), respectively. Statistically significant differences between the groups indicate the positive effect of the applied dance program on the development of motor coordination in pre-school children using an experimental dance program for twelve weeks. Dance program influences the coordination of the pre-school age children. The results showed that children participating in the dance program achieved better results in investigated bilateral coordination in three variables, thus recommending its application in the regular preschool children curriculum.

Constance H. Li, S. Prokopec, Ren X. Sun, Fouad Yousif, N. Schmitz, Fatima Gurnit Peter J. Andrew V. Paul C. Peter J. David K Al-Shahrour Atwal Bailey Biankin Boutros Campbell , F. Al-Shahrour, Gurnit Atwal et al.

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

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