BACKGROUND: Measles is a highly contagious infectious disease caused by morbillivirus which usually affects young children. Once thought to have been eradicated, measles continues to be the leading cause of morbidity and mortality in the world. AIM: The purpose of this research is to analyze the risk factors and clinical characteristics of children hospitalized at the Pediatric Clinic under the diagnosis of measles during the epidemic in Sarajevo Canton 2019. METHOD: We applied a retrospective analysis of medical histories of 23 patients who were hospitalized under the diagnosis of measles at the Pediatric Clinic of the Clinical Center in Sarajevo from January to June 2019. We divided patients into two groups: Infants and children over one year of age. We diagnosed measles clinically, or through the serum IgM ELISA test for measles virus. RESULTS: A total of 23 patients, aged 1 month to 14 years, were hospitalized at the Pediatric Clinic, accounting for 3.5% of the total number of the diseased children. The largest numbers of hospitalized patients were infants 9 (39.1%). Comorbidities were present in 9 (39.1%) subjects, and the most common complication was bronchopneumonia, present in as many as half of the infants. There were four patients who needed mechanical ventilation (17.39%); three of whom were infants; and two lethal outcomes (8.69%), both in infancy. CONCLUSION: Responsible behavior of parents, health professionals, and society as a whole can prevent the far-reaching consequences of non-vaccination. Infants are critically endangered, as the most sensitive part of population, especially if the collective immunity is impaired.

Four 4-hydroxycoumarin derivatives were synthesized and the structure was confirmed by NMR spectroscopy and Mass spectrometry. Tested compounds have shown significant antimicrobial activity against Bacillus subtilis subsp. spizizenii, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis, and the effect of more halogens on the benzene nucleus, as well as the combination of halogen and alkyl groups, on the antimicrobial activity, was investigated. According to the docking study, these compounds can operate simultaneously on two enzymes, amylase and gyrase (1BAG and 1KZN), which are known to play an important role in bacterial life. Obtained docking study parameters for tested compounds showed an association with the in vitro results of the antimicrobial activity of these compounds. In silico tests of molecular properties of the tested compounds showed that the compounds met Lipinski's rule of five. In this paper, the ADME parameters of tested compounds were also calculated: Caco2 (in vitro Caco2 cell permeability), HIA (human intestinal absorption), MDCK (in vitro Mandin Darby Canine Kidney (MDCK) cell permeability), TPSA (topological polar surface area), etc.

Background. Monitoring the abilities of typically developed children is very important.Methods. This study aimed to determine the levels and differences in motor coordination of the upper extremities between first and third-grade primary school children using the subtest of the Bruininks-Oseretsky Test (BOT-2). The sample included 79 healthy subjects of both sexes, chronological age ranging from seven to nine years, body height 134.51 ± 8.43 cm (Mean ± SD), bodyweight 33.01 ± 8.65 kg (Mean ± SD). The Mann–Whitney U test determined differences between groups, for the benefit of the group of third-grade subjects in all upper extremity coordination variables.Results. The results showed that differences in age and biological growth and development in young children in some variables of upper-limb coordination influenced medium size (2ULC, 6ULC, 7ULC), but in most of the variables examined they had great influence (1ULC. 3ULC, 4ULC, 5ULC, TULC) according to Cohen’s criterion.Conclusion. It can be concluded that well-organized and expertly guided physical activities, as well as regular testing of children when it comes to developing coordination, can influence early detection of movement difficulties and eliminate problems in acquiring new coordination skills, and thus create an appropriate base for engaging in sports activities while growing up. Keywords: motor development, coordination, physical education.

The Web of Things (WoT) is a technology concept that allows the integration of the Internet of Things (IoT) with the World Wide Web (WWW). It will vastly affect our lives in the near future given that it offers new services and applications via the well-known web window. In todays’ world where one can hardly imagine everyday life without access to various online services and applications via a plethora of devices, one can notice that technology has a huge impact on our day-to-day quality of living. That is why a user’s Quality of Experience (QoE) towards used technology in general plays a crucial role in their Quality of Life (QoL). Furthermore, security perception in terms of technology is the feature that vastly affects QoE and, consequently, QoL, as the number of security and privacy threats, risks, and vulnerabilities in cyber space, i.e., the technology environment that we increasingly use, is constantly rising. In order to reach the ultimate goals—the adoption of WoT technology and improvement of our QoL—we must know how this important aspect of security is so far addressed and analyzed. Therefore, this paper gives a comprehensive and structured analysis of the existing literature in this field through a proposed framework and provides an overview of research opportunities that should be addressed and elaborated in future investigations.

The goal of the present study was to assess the family quality of life (FQOL) in families with children with developmental disabilities in Bosnia and Herzegovina. We examined the FQOL in relation to parents’ demographic variables (gender, age, employment status), children’s gender and age, type of children’s disability (mild and moderate intellectual disability, autism spectrum disorder) and parent’s depression, anxiety, and stress levels. The sample consisted of 270 parents of children with disabilities; 90 parents of children with autism spectrum disorder, 90 parents of children with mild intellectual disability, and 90 parents of children with moderate intellectual disability. We also included a control group of 90 parents of typically developing children. The results of this study showed that parents of children with autism spectrum disorder and parents of children with moderate intellectual disability had statistically significantly lower FQOL than parents of children with mild intellectual disability and parents of typically developing children. Child’s gender had a significant effect on FQOL. Also, depression, anxiety and stress levels significantly affected FQOL, while the parents’ gender, age, and employment status did not have a significant effect. Implications of these findings are discussed and some measures on supporting parents are proposed.

Drones can be used for many assistance roles in complex communication scenarios and play as the aerial relays to support terrestrial communications. Although a great deal of emphasis has been placed on the drone-assisted networks, existing work focuses on routing protocols without fully exploiting the drones superiority and flexibility. To fill this gap, this paper proposes a collaborative communication scheme for multiple drones to assist the urban vehicular ad-hoc networks (VANETs). In this scheme, drones are distributed regarding the predicted terrestrial traffic condition in order to efficiently alleviate the inevitable problems of conventional VANETs, such as building obstacle, isolated vehicles, and uneven traffic loading. To effectively coordinate multiple drones, this issue is modeled as a multimodal optimization problem to improve the global performance on a certain space. To this end, a succinct swarm-based optimization algorithm, namely Multimodal Nomad Algorithm (MNA) is presented. This algorithm is inspired by the migratory behavior of the nomadic tribes on Mongolia grassland. Based on the floating car data of Chengdu China, extensive experiments are conducted to examine the performance of the MNA-optimized drone-assisted VANET. The results demonstrate that our scheme outperforms its counterparts in terms of hop number, packet delivery ratio, and throughput.

Low temperature deposition of high-quality epitaxial GaN is crucial for its integration inelectronic applications. Chemical vapor deposition at approximately 800 °C using SiC with anAlN buffer layer or nitridized sapphire as substrates is used to facilitate the GaN growth. Here,we present a low temperature atomic layer deposition (ALD) process usingtris(dimethylamido)gallium(III) with NH3 plasma. The ALD process shows self-limitingbehaviour between 130-250 °C with a growth rate of 1.4 Å/cycle. The GaN films produced werecrystalline on Si(100) at all deposition temperatures with a near stochiometric Ga/N ratio withlow carbon and oxygen impurities. When GaN was deposited on 4H-SiC, the films grewepitaxially without the need for an AlN buffer layer, which has never been reported before. The bandgap of the GaN films was measured to be ~3.42 eV and the fermi level showed that the GaN was unintentionally n-type doped. This study shows the potential of ALD for GaN-basedelectronic devices.

This study was carried out in the Onigambari area of Oyo state to determine the choice of farmers to practice Ago-forestry in the area. The χ2 test result revealed that the educational level of the respondents correlated highly with the respondents major occupation (p<0.01). χ2 test shows that there was significant relationship (p<0.01) between the respondents’ level of education and awareness of agroforestry systems. This shows that farmers with a better educational background can accept agro forestry easily than those will lower education. Farmers’ awareness of Agroforestry systems, willingness to plant trees, purpose of planting trees and desired tree species were evaluated. It was observed that 74% of the respondents are not willing to practice agroforestry while 24% shows interest. 64% confirmed they are aware of the practice while 32% had never heard of such practice. The t-test result shows a significant difference with respect to the willingness of the respondents to practice agroforestry. Of those that areaware, 38% practice agroforestry for the purpose of fuel wood, 36% as source of income while only 2% practice for the purpose of wind breaking. Eucalyptus calmuldulensis, Magnifera indica, Gmelina aboreal are some of the tress used for this practice in the study area. Lack of seed and scarcity of land were identified as limiting factors that prevent farmers from practicing agroforestry. In summary it was observed that the respondent’s level of education correlated significantly to the level of education, also the level of education determines respondent’s willingness to practice  agroforestry. It is recommended that Seeds, Seedlings and land be made available to encourage the practice among farmers. Extension workers are encouraged to engage farmers more on the benefits of agroforestry. Keyword: Farmers, Agroforestry, Climate change, Land degradation, Natural Fallow

In offshore engineering design, nonlinear wave models are often used to propagate stochastic waves from an input boundary to the location of an offshore structure. Each wave realization is typically characterized by a high-dimensional input time-series, and a reliable determination of the extreme events is associated with substantial computational effort. As the sea depth decreases, extreme events become more difficult to evaluate. We here construct a low-dimensional characterization of the candidate input time series to circumvent the search for extreme wave events in a high-dimensional input probability space. Each wave input is represented by a unique low-dimensional set of parameters for which standard surrogate approximations, such as Gaussian processes, can estimate the short-term exceedance probability efficiently and accurately. We demonstrate the advantages of the new approach with a simple shallow-water wave model based on the Korteweg–de Vries equation for which we can provide an accurate reference solution based on the simple Monte Carlo method. We furthermore apply the method to a fully nonlinear wave model for wave propagation over a sloping seabed. The results demonstrate that the Gaussian process can learn accurately the tail of the heavy-tailed distribution of the maximum wave crest elevation based on only $$1.7\%$$ 1.7 % of the required Monte Carlo evaluations.

Significance Dysregulation of the alternative complement pathway due to impaired binding of complement factor H (CFH) to self-ligands or altered self-ligands (e.g. malondialdehyde [MDA]-modified molecules) involved in homeostasis can promote the development of complement-related diseases, such as age-related macular degeneration (AMD). We identified, in an unbiased GWAS approach, that common genetic variants within the CFH gene family (rs1061170 and the deletion of the complement factor H-related protein 1 and 3 genes [CFHR3 and CFHR1]) act as major modulators of CFH recruitment and its ability to regulate complement on MDA-epitopes. These findings demonstrate the importance of the genetic status within the CFH/CFHR3/CFHR1 locus in tissue homeostasis and provide a mechanistic explanation as to why deletion of CFHR3/CFHR1 is protective in AMD development. Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like protein 1 (FHL-1) to self-ligands or altered self-ligands (e.g., malondialdehyde [MDA]-modified molecules) involved in homeostasis, thereby causing impaired complement regulation. Considering the critical role of CFH in inhibiting alternative pathway activation on MDA-modified surfaces, we performed an unbiased genome-wide search for genetic variants that modify the ability of plasma CFH to bind MDA in 1,830 individuals and characterized the mechanistic basis and the functional consequences of this. In a cohort of healthy individuals, we identified rs1061170 in CFH and the deletion of CFHR3 and CFHR1 as dominant genetic variants that modify CFH/FHL-1 binding to MDA. We further demonstrated that FHR1 and FHR3 compete with CFH for binding to MDA-epitopes and that FHR1 displays the highest affinity toward MDA-epitopes compared to CFH and FHR3. Moreover, FHR1 bound to MDA-rich areas on necrotic cells and prevented CFH from mediating its cofactor activity on MDA-modified surfaces, resulting in enhanced complement activation. These findings provide a mechanistic explanation as to why the deletion of CFHR3 and CFHR1 is protective in AMD and highlight the importance of genetic variants within the CFH/CFHR3/CFHR1 locus in the recognition of altered-self in tissue homeostasis.