The research on wheat accessions was carried out in order to evaluate their grain characteristics. Experiment was set in the agro-ecological conditions of Banja Luka in two experimental years (2015/16 and 2016/17). Ten obsolete wheat cultivars (Brkulja, Licanka, Partizanka, Vuka, Talijanka, Siđanka, Orasanka, Loznicanka, Dokucajevskaja and Nemcitaevskaja) and two landraces (Podrasnica and Previja) were used. Following grain characteristics were evaluated: grain length (mm), grain width (mm), grain thickness (mm), grain volume (mm³), grain surface area (mm²), thousand grain weight (g) and grain protein content (%). Significant interactions were found for most of these traits. The relationship between traits was established by correlation analysis. In this study genotypes Brkulja and Siđanka showed promising for most of the grain characteristics, while Vuka and Partizanka obtained the highest grain protein content.

Dental health and mental health are strongly associated. Neglecting either of them can negatively influence on the other and induce many health and communication problems. Association between oral/dental health, self-esteem, quality of life and holistic health has been recognized for a long time. There has been increasing interest in dental health among patients with major mental disorders as well as in mental states and problems among patients with orodental disorders. Despite of huge progress in the field of dentistry psychiatric patients have had poor oral/dental health. Patients with major mental disorders have quite number of the risk factors for oral disease and consequently poorer dental health, but oral/dental problems and diseases are commonly overlooked or neglected. Bad or inappropriate dental care is related to the patients' amotivation, ignorance, fears, low economic status, stigmas and negative attitudes by the medical professionals. It is important to stress that dental diseases in psychiatric patients deserve the same attention as other comorbid somatic diseases. In this review we accentuate the need for more collaboration in order to bridge the professional gap between dentistry and psychiatry.

The aim of this study was to determine the effects of programmed kinesiological treatment on transformation of postural spinal status in the sagittal plane kyphosis and fl at feet pes planus, in IV to VI grade pupils (second triad of nine-year elementary school). The study was conducted on a 290 pupil sample. Eight (8) variables were applied in the study to evaluate postural spine status kyphosis and fl at feet pes planus. The research had a longitudinal character. The use of contingent tables shows the frequencies and the corresponding percentages increase the deformity of the spine kyphosis and fl at feet pes planus. The results of the study indicate the statistical signifi cance of the percentage of deformity of the kyphosis and fl at feet pes planus. Changes in the arch of the feet and spine are mainly in the fi rst stage of deformation, which also enabled the correction of the condition with the application of programmed kinesiological treatment. Therefore, in the global assessment of the quality and justifi cation of the use of programmed kinesiological treatment for one school year, we must state that it contributed to the improvement of the deformity of the kyphosis and the fl at feet of the research sample of pupils.

This paper demonstrates and provides additional findings and instructions to produce new cold-recycled layers of pavement structures spatially and temporally sustainable. At the same time, recycled pavement structures have been enhanced with optimum amounts of new stone materials and binders made of cement and foamed bitumen. The subject of the research is based on the examination of recycled asphalt from surface and bituminous base courses of pavement structures for use on higher-type roads. The aim of the research is to model the process of producing recycled asphalt by cold recycling to optimize the process of influential parameters. In addition, one of the primary goals of the research is to demonstrate a sustainable way of producing new cold-recycled layers of pavement structures. The obtained results indicated the inevitability of the use of recycled material from pavement structures with the possibility of applying secondary and tertiary crushing of recycled mass, which depends on the type of layer for which the recycled material would be used. The research resulted in an optimum mixture variant of the stabilization layer of pavement structure that consists mainly of recycled material from a worn pavement structure improved with a relatively small amount of new aggregate with the addition of minimal stabilizers made of cement and foamed bitumen. The results showed that the optimum mixture variant of the stabilization layer is spatially and temporally stable. Additionally, the presented optimum variant of the stabilization layer enables sustainable development of road networks with minimum consumption of new natural resources.

Introduction: Components of the metabolic syndrome (MetSy) have gone through myriad of changes ever since the initial cluster was defined. The Seven Countries Study taught us the basics of classical risk factors for atherosclerotic artery disease and their influence on both cardiovascular and cerebrovascular morbidity and mortality. Material and Methods: In a 3-continent, 7-country (USA, Japan, Greece, the Netherlands, Finland, Italy, and former Yugoslavia then, now Croatia and Serbia) sample of 12,763 participants -- all healthy men over 40 at entry -- systematic, quinquennial checkups were conducted over 4 decades and MetSy was defined using the IDF definition. ResultS: A total of 9,09% of participants were identified to have MetSy, while the detailed description of risk factors' combination is shown in Table 1 and Figure 1, below. Conclusion: The leading combination was hypertension (HTA), diabetes (DM) and dyslipidemia (HLP), while hypertension was the hallmark risk factor irrelevant of presence or absence of MetSy. The results of this study call for a contemporary comprehensive research involving both sexes that could elucidate better real life risk factors' relationships in aforementioned countries.

A microgrid concept for the thermal and electrical energy supply of a Sport-Recreation Center Ajdinovići (S.R.C.A.) has been proposed in this paper. A self-contained and intelligent power distribution grid has been developed for this case, taking into account the location, locally available renewable energy sources and the very purpose of this center. Comparative analyses between independent power supply through the proposed hybrid power system and the supply over the transmission and distribution network were performed. Technical and economical optimization of an energy system with distributed power generation was done by applying HOMER and DIgSILENT PowerFactory professional software tools. As a result, hybrid power system is more cost-effective than the conventional supply by the power distribution network, microgrid meets the technical criteria based on the analysis of power flows and the stability of the network has been achieved. Establishment of energy independence for the existing S.R.C.A. besides economic factor will show several benefits regarding better use of locally available resources, reduction of CO2 emissions and energy efficiency increment as well as an employment opportunity to the local people, thus contributing to the sustainability of the region.

ABSTRACT Introduction: Zonisamide is a benzisoxazole with 3-methanesulfonamide side chain, chemically unrelated with other anticonvulsants, and approved as mono-therapy of newly diagnosed focal epilepsy with or without secondary generalization in adults or adjunctive therapy in the treatment of partial seizures, with or without secondary generalization, in adults, adolescents, and children aged 6 years and above. Areas covered: Pharmacokinetics, clinical efficacy, and the adverse effects of zonisamide are discussed in the article. The discussion is based on data from published preclinical studies, clinical trials, observational studies, systematic reviews, and approved summary of product characteristics. Expert opinion: Zonisamide is an anticonvulsant with multiple mechanisms of action on neuronal tissue, which achieves seizure freedom in more than 80% of patients with newly-onset focal epilepsy and in 6.2 to 18.1% of patients with focal onset seizures inadequately controlled by first-line anticonvulsants. Within the recommended dose range, it follows linear kinetic of elimination; it is metabolized in the liver by two cytochrome isoforms, so pharmacokinetic interactions are rare and with little clinical significance. Up to 10% of patients taking zonisamide will have problems with weight loss and more than 10% with irritability, confusion or depression, and long-lasting therapy may cause renal calculi in 1.2% of patients.

Exhaled breath analysis has become a promising monitoring tool for various ailments by identifying volatile organic compounds (VOCs) as indicative biomarkers excreted in the human body. Throughout the process of sampling, measuring, and data processing, non-biological variations are introduced in the data leading to batch effects. Algorithmic approaches have been developed to cope with within-study batch effects. Batch differences, however, may occur among different studies too, and up-to-date, ways to correct for cross-study batch effects are lacking; ultimately, cross-study comparisons to verify the uniqueness of found VOC profiles for a specific disease may be challenging. This study applies within-study batch-effect-correction approaches to correct for cross-study batch effects; suggestions are made that may help prevent the introduction of cross-study variations. Three batch-effect-correction algorithms were investigated: zero-centering, combat, and the analysis of covariance framework. The breath samples were collected from inflammatory bowel disease (n=213), chronic liver disease (n=189), and irritable bowel syndrome (n=261) patients at different periods, and they were analysed via gas chromatography-mass spectrometry. Multivariate statistics were used to visualise and verify the results. The visualisation of the data before any batch-effect-correction technique was applied showed a clear distinction due to probable batch effects among the datasets of the three cohorts. The visualisation of the three datasets after implementing all three correction techniques showed that the batch effects were still present in the data. Predictions made using partial least squares discriminant analysis and random forest confirmed this observation. The within-study batch-effect-correction approaches fail to correct for cross-study batch effects present in the data. The present study proposes a framework for systematically standardising future breathomics data by using internal standards or quality control samples at regular analysis intervals. Further knowledge regarding the nature of the unsolicited variations among cross-study batches must be obtained to move the field further.

Temperature-stable dissolving film eliminates cold-chain storage and successfully immunizes mice sublingually and buccally. A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an amorphous solid with a glass transition above room temperature and nitrogen-hydrogen bonding between virus and film components are critical determinants of stability. Administration of live influenza virus in the optimized film by the sublingual and buccal routes induced antibody-mediated immune responses as good as or better than those achieved by intramuscular injection. This work introduces the possibility of improving global access to a variety of medicines by offering a technology capable of reducing costs of production, distribution, and supply chain maintenance.

Introduction: Ramadan is the holy month of Muslims including fasting sometimes more than 20 hours. Even diabetes patients can be exempted from fasting it has been shown that almost 80% of diabetes type 2 patients intend and do fasting. To avoid acute complications during fasting, different recommendations on diabetes management are available. Considering the fact that there are more than 226 thousand diabetics in Bosnia and Herzegovina, it is important to provide structured support and healthcare service to those who are practicing fast during Ramadan. Aim: To evaluate knowledge, practice and attitudes of physicians treating diabetes (diabetologists and endocrinologists) in Bosnia and Herzegovina regarding management of diabetes in fasting patients during Ramadan. Methods: A 32 questions survey has been developed, validated and disseminated to the 27 specialists treating diabetes in Bosnia and Herzegovina through online form examining demographic characteristics, current practices and attitudes and knowledge on diabetes management during Ramadan. Results: All surveyed physicians deal with patients who are fasting during Ramadan. The majority of surveyed physicians 23 (85,2%) proactively initiate a discussion about planned fasting. More than 63,0% are following their experience and only 18,5% ADA/EASD guidelines on diabetes management during Ramadan. There are no significant differences between gender of the physicians, place of work and specialization when it comes to specific knowledge related to treatment guidelines, but some differences are observed. Conclusion: Although overall physicians` knowledge of diabetes management during Ramadan is satisfying there is opportunity in additional specialized education and measures introduction into the practice in order to improve treatment outcomes and standards of care.

Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2+) and triple-negative breast cancers. Therapies targeting HER2 receptors have significantly improved HER2+ breast cancer patient outcomes. However, several recent studies have pointed out the deficiency of existing treatment protocols in combatting disease relapse and improving response rates to treatment. Overriding the inherent actions of the immune system to detect and annihilate cancer via the immune checkpoint pathways is one of the important hallmarks of cancer. Thus, restoration of these pathways by various means of immunomodulation has shown beneficial effects in the management of various types of cancers, including breast. We herein review the recent progress in the management of HER2+ breast cancer via HER2-targeted therapies, and its association with the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) axis. In order to link research in the areas of medicine and mathematics and point out specific opportunities for providing efficient theoretical analysis related to HER2+ breast cancer management, we also review mathematical models pertaining to the dynamics of HER2+ breast cancer and immune checkpoint inhibitors.

Before even opening the book, Democracy by Decree: Prospects and Limits of Imposed Consociational Democracy in Bosnia and Herzegovina captures the reader’s attention with its intriguing and provocative title. But what author Adis Merdzanovic delivers in its pages is equally engaging. Merdzanovic illustrates how the consociational power-sharing arrangements in Bosnia and Herzegovina were imposed by the international community following the wars in the 1990s, rather than genuinely initiated from inside a country, and have, perhaps unsurprisingly, largely failed.