Background: Information and communication technologies (ICT) are widely used in a health care as a result of pharmaceutical informatics and technology developments. There is a huge potential for pharmaceutical practice of technologies utilization in a different practice settings especial community pharmacy and patient counseling. Objective: To evaluate Bosnia and Herzegovina (BH) pharmacists` knowledge and attitudes towards informational and communication technologies and extend of its utilization. Methods: Online survey conducted among pharmacists from different practice settings. Results: Pharmacists in BH are familiar and well known regarding importance of informational technologies. 93% are using special pharmaceutical information systems, and majority use technologies and software for prescription processing (47%), calculations (24%) communication (22%) and 9% for Internet search. 90% of pharmacists have profiles on social media mainly Facebook, followed by Instagram and LinekdIn mainly used for networking and communication with peers but less with patients. They have positive attitude regarding potential benefits of using social media for communication with patients and treatment outcomes improvement. Conclusion: Pharmacists in Bosnia and Herzegovina have satisfactory level of information and communication technologies understanding and knowledge. It is of high importance that education of future pharmacist in this field is in line with nature of pharmaceutical informatics in light of its clinical application rather than technical so future pharmacists can contribute to improvements in social media medicines-related information, learn from consumers’ online activities, and design new ways of delivering care to communities and individuals.

Introduction: Diabetes as lifelong chronic disease requires pharmacological treatment using plastic pens and needles. Proper disposal of used pens and needles have impact not just on health but environment as well. In 2020 there will be 3.2 million pens used and disposed in Bosnia and Herzegovina resulting in over 600 tons of this waste. Worldwide problem is related to proper disposal of used insulin pens and sharps. Aim: To investigate and evaluate what are the attitudes, knowledge and practices on insulin pens and needles disposal among diabetes patients in Bosnia and Herzegovina. Methods: The research was conducted in five cities in Bosnia and Herzegovina in period December 2019–January 2020 using questionnaire consisted of 28 questions distributed among patients with diabetes through their local patient associations. Results: Total 250 diabetes patients participated. 40.4% inject medicines for 2 times per day and 37.6% for three and more times a day. Patients have not been instructed on proper disposal of used pens or needles in 67.6% and 66% respectively. The most appropriate place to dispose used pens is pharmacies and 90% of respondents would participate in program of collecting used pens if one exists. 75.6% of respondents consider improper disposal of pens and needles as healthcare problem, 18.8% see this as ecological problem and for 4% of them this is not a problem at all. Conclusion: Current practice of disposing used insulin pens and sharps is improper. Patients are aware of health and environmental risk. There is a huge opportunity for pharmacists and other healthcare provides to provide better information and counseling diabetes patients on this topic.

Abstract. Experimental demonstration of a quantum random number generator based on one single-photon avalanche diode (SPAD) detector, a T  /    (  T  −  t  )   pulse-shaped laser, and an field-programmable gate array (FPGA) acquisition module is presented. An integrated laser driver drives an external laser diode at 670 nm wavelength, whereas the SPAD with a photon detection probability of 18.5% is integrated together with an active quenching-resetting circuit. The SPAD detector generates counts for the interarrival time (IAT) measurement system implemented in an FPGA, where the change of the IATs between consecutive pulses is used to derive a random bit stream. It is shown how the application of a pulse-shaped laser driver can increase the performance of the system as compared to the continuous-wave operation of the laser diode to achieve the maximum generation rate of 5 Mbps while using a single SPAD. The generated numbers pass all randomness tests of the National Institute of Standards and Technology (NIST), Dieharder, and ENT test (pseudorandom number sequence test) suits.

Gender inequalities are reflected in differential vulnerability, and exposure to the hazards posed by climate change and addressing them is key to increase the adaptive capacities of societies. We provide trajectories of the Gender Inequality Index (GII) alongside the Shared-Socioeconomic Pathways (SSPs), a scenario framework widely used in climate science. Here we find that rapid improvements in gender inequality are possible under a sustainable development scenario already in the near-term. The share of girls growing up in countries with the highest gender inequality could be reduced to about 24% in 2030 compared to about 70% today. Largely overcoming gender inequality as assessed in the GII would be within reach by mid-century. Under less optimistic scenarios, gender inequality may persist throughout the 21st century. Our results highlight the importance of incorporating gender in scenarios assessing future climate impacts and underscore the relevance of addressing gender inequalities in policies aiming to foster climate resilient development. Gender inequality increases vulnerability to climate change impacts and reduces societies’ adaptive capacity. Here the authors show how gender inequality may evolve in the future in five scenarios of socioeconomic development and highlight the importance of incorporating gender inequality in climate change research and policy.

Lipid multilayer gratings are promising optical biosensor elements that are capable of transducing analyte binding events into changes in an optical signal. Unlike solid state transducers, reagents related to molecular recognition and signal amplification can be incorporated into the lipid grating ink volume prior to fabrication. Here we describe a strategy for functionalizing lipid multilayer gratings with a DNA aptamer for the protein thrombin that allows label-free analyte detection. A double cholesterol-tagged, double-stranded DNA linker was used to attach the aptamer to the lipid gratings. This approach was found to be sufficient for binding fluorescently labeled thrombin to lipid multilayers with micrometer-scale thickness. In order to achieve label-free detection with the sub-100 nm-thick lipid multilayer grating lines, the binding affinity was improved by varying the lipid composition. A colorimetric image analysis of the light diffracted from the gratings using a color camera was then used to identify the grating nanostructures that lead to an optimal signal. Lipid composition and multilayer thickness were found to be critical parameters for the signal transduction from the aptamer functionalized lipid multilayer gratings.

We present a detailed computational study of the UV/Vis spectra of four relevant flavonoids in aqueous solution, namely luteolin, kaempferol, quercetin, and myricetin. The absorption spectra are simulated by exploiting a fully polarizable quantum mechanical (QM)/molecular mechanics (MM) model, based on the fluctuating charge (FQ) force field. Such a model is coupled with configurational sampling obtained by performing classical molecular dynamics (MD) simulations. The calculated QM/FQ spectra are compared with the experiments. We show that an accurate reproduction of the UV/Vis spectra of the selected flavonoids can be obtained by appropriately taking into account the role of configurational sampling, polarization, and hydrogen bonding interactions.

Abstract Analysis of representative tools for SQL query processing on Hadoop (SQL-on-Hadoop systems), such as Hive, Impala, Presto, Shark, show that they are not still sufficiently efficient for complex analytical queries and interactive query processing. Existing SQL-on-Hadoop systems have many benefits from the application of modern query processing techniques that have been studied extensively for many years in the database community. It is expected that with the application of advanced techniques, the performance of SQL-on-Hadoop systems can be improved. The main idea of this paper is to give a review of big data concepts and technologies, and summarize big data optimization techniques that can be used for improving performance when processing big data.

Este estudo objetiva discutir a proposta do Programa de Residencia Pedagogica (PRP), relacionado a Politica Nacional de Formacao de Professores, apresentada pelo MEC em 18 de outubro de 2017. A proposta de Residencia Pedagogica foi apresentada no governo de Michel Temer no ano de 2017, teve seu rumo incerto apos uma breve descontinuidade em 2019 e foi retomada com o lancamento de um novo edital no ano de 2020. Destacamos que o atual contexto politico e educacional do Brasil demanda discussoes aprofundadas que busquem problematizar as concepcoes presentes nos projetos de formacao docente em disputa. Intentamos no desenvolvimento desta pesquisa, analisar a proposta do Programa de Residencia Pedagogica, bem como seus possiveis efeitos para a formacao de professores no Brasil. O estudo se organiza em 4 secoes, buscando uma retomada historica da constituicao da formacao docente no pais para a investigacao acerca das concepcoes de formacao docente presentes no PRP. A presente investigacao esta fundamentada na perspectiva metodologica da pesquisa qualitativa, a partir da analise documental e da analise de conteudo. Com este estudo, foi possivel perceber que o PRP vem ao encontro de premissas tecnicistas do fazer docente e demonstra em sua essencia uma visao pragmatica da formacao de professores, entretanto, a autonomia universitaria permitiu algumas iniciativas contra hegemonicas para a organizacao do projeto. PALAVRAS-CHAVE: Formacao de professores; residencia pedagogica; politicas educacionais. Doi: 10.21703/rexe.20201941caporal17

Abstract In spring 2020 both teachers and learners experienced the interruption of education as it had been established for over 150 years and seemed to be unchangeable. The paper focuses on students’ perspectives on how they perceive the changes in learning due to the pandemic educational emergency response based on the results of a survey of students in four countries: Bosnia and Herzegovina, North Macedonia, Poland and Turkey. We aim at discussing the data collected at the end of the 2019-2020 Spring semester. The research focuses on the accessibility of the tools for learning, modes of instruction, as well as interaction patterns. In addition, we present students’ opinions on the difficulties they experienced, the learning strategies they adopted and what aspects of online learning should remain as a regular educational practice after the pandemic period.

Abstract The paper examines the application of computer assisted language learning (CALL) in English language classes in Bosnia and Herzegovina. The research was designed as an empirical examination of the attitudes of teachers and students on the successful application of computer assisted language learning in English language classrooms in Bosnia and Herzegovina. Lack of motivation is one the problems that most teachers are faced with. There are many causes of poor motivation, but one of them is certainly the unattractiveness and dullness of traditional methods, teaching materials and resources. However, many authors with educational experience point out that the use of information technology can positively influence students’ motivation and encourage them to work actively. While adults, as digital immigrants, might not use modern information technology excessively, children and teens are true digital natives, who have grown up with the latest technologies and use them with great pleasure in all aspects of their lives adapting them to their needs (Prensky, 2001). The results obtained in this research are an indicator of the current attitude of teachers and students towards these issues, but they also highlight some important necessary reforms in the field of teacher education.

Aim To compare different pooling methods in an attempt to improve the COVID-19 PCR diagnostic capacities. Method We developed a novel information-dependent pooling protocol (indept), based on transmission of less informative sequential pools on to the next pooling cycle to maximize savings. We then compared it to the halving, generalized halving, splitting and hypercube protocols in a simulation study, across variety of scenarios. Results All five methods yielded various amount of test savings, which mostly depended on the virus prevalence in the population. In situations of low prevalence (up to 5%), indept had the best performance, requiring on average 20% of tests needed for singular testing across scenarios that were analyzed. Nevertheless, this comes at the expense of speed, with the worst-case scenario of indept protocol requiring up to twice the time needed to test the same number of samples in comparison to the hypercube protocol. In order to offset this, we developed a faster version of the protocol (indeptSp), which minimizes the number of terminal pools and manages to retain savings compared to other protocols, despite marginally longer processing times. Conclusion The increasing demand for more testing globally can benefit from application of pooling, especially in resource-restrained situations of the low- and middle-income countries or situations of high testing demand. Singular testing in situations of low prevalence should be systematically discouraged.