BACKGROUND Posterior communicating (Pcom) aneurysms in the modern era have tended toward increased complexity and technical difficulties. The pretemporal approach is a valuable extension to the pterional approach for basilar apex aneurysms, but its advantages for Pcom aneurysms have not been previously elucidated. OBJECTIVE To quantify characteristics of the pretemporal approach to the Pcom. METHODS We dissected 6 cadaveric heads (12 sides) with a pretemporal transclinoidal approach and measured the following variables: (1) exposed length of internal carotid artery (ICA) proximal to the Pcom artery; (2) exposed circumference of ICA at the origin of Pcom; (3) deep working area between the optic nerve and tentorium/oculomotor nerve; (4) superficial working area; (5) exposure depth; and (6) the frontotemporal (superior posterolateral) and (7) orbito-sphenoidal (inferior anterolateral) angles of exposure. RESULTS Compared with pterional craniotomy, the pretemporal transclinoidal approach increased the exposed length of the proximal ICA from 3.3 to 11.7 mm (P = .0001) and its circumference from 5.1 to 7.8 mm (P = .0003), allowing a 210° view of the ICA (vs 137.9°). The deep and superficial working areas also significantly widened from 53.7 to 92.4 mm2 (P = .0048) and 252.8 to 418.2 mm2 (P = .0001), respectively; the depth of the exposure was equivalent. The frontotemporal and spheno-Sylvian angles increased by 17° (P = .0006) and 10° (P = .0037), respectively. CONCLUSION The pretemporal approach can be useful for complex Pcom aneurysms by providing easier proximal control, wider working space, improved aneurysm visualization, and more versatile clipping angles. Enhanced exposure results in a potentially higher rate of complete aneurysm obliteration and complication avoidance.

The work here proposed aims at presenting the legal perspectives provided in the law of administrative improbity (Law. 8,429 / 92), especially with regard to the applicability of the necessary review in cases of impropriety handed down in actions of such nature.  It is important to remember that the necessary review has no legal provision in Law 8,429 / 92. However, there is discussion in the doctrinal and jurisprudential scope regarding the application of the institute in actions of administrative improbity with an unfounded sentence. At first, the paper seeks to present some aspects of the Administrative Improbity Law. Therefore, in brief lines, it will explain about the purpose of the necessary review and, finally, it will demonstrate the disagreements about the application or not of the actions resulting from administrative improbity.

We studied the feasibility of increasing the possible number of BCI commands that can be produced through our EEG-fTCD BCI by solving the 3-class problems of both the MI and flickering MR/WG paradigms.

The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phase II randomized controlled trial. Secondary trial endpoints included comparison of the incidence and severity of neurotoxicity, hypothesized to be lower in the veliparib arm, and tolerability of the addition of veliparib to CE. Physician‐rated and patient‐reported neurotoxicity was also compared.

ABSTRACT Introduction Eczema, allergic rhinitis, and asthma are traditionally considered atopic (or allergic) diseases. They are complex, multifactorial, and are caused by a variety of different mechanisms, which result in multiple heterogeneous clinical phenotypes. Atopic march is usually interpreted as the sequential development of symptoms from eczema in infancy, to asthma, and then allergic rhinitis. Areas covered: The authors reviewed the evidence on the multimorbidity of eczema, asthma, and rhinitis, and the implication of results of data-driven analyses on the concept framework of atopic march. A literature search was conducted in the PubMed and Web of Science for peer-reviewed articles published until July 2020. Application of Bayesian machine learning framework to rich phenotypic data from birth cohorts demonstrated that the postulated linear progression of symptoms (atopic march) does not capture the heterogeneity of allergic phenotypes. Expert opinion: Eczema, wheeze, and rhinitis co-exist more often than would be expected by chance, but their relationship can be best understood in a multimorbidity framework, rather than through atopic march sequence. The observation of their co-occurrence does not imply any specific relationship between them, and certainly not a progressive or causal one. It is unlikely that a sngle mechanism such as allergic sensitization underpins different multimorbidity manifestations.

Widely used additive manufacturing technique for plastic materials is Fused Deposition Modelling (FDM). The FDM technology has gained interest in industry for a wide range of applications, especially today when large number of different materials on the market are available. There are many different manufacturers for the same FDM material where the difference in price goes up to 50%. This experimental study investigates possible difference in strength of the 3D printed PLA material of five different manufacturers. All specimens are 3D printed on Ultimaker S5 printer with the same printing parameters, and they are all the same colour.

This paper defines project success factors and aspects that are significant for successful project performance and outcomes, in the context of Information Technology (IT) projects. The list of total 38 factors is obtained through the qualitative content analysis of data collected via survey of 108 IT professionals, through one open-ended question. Detected factors are grouped into five categories: project team, project customer, project planning, project execution and project control. The results extend and support findings of the former quantitative study and the resulting project success model. They emphasize the significance of project team and project control activities for successful project outcomes.

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Car jack is the basic equipment of every car. To replace the tires or to repair a specific defect on the car it is necessary to have a car jack. A modern way of creating the complex mechanical structures is described in this paper, which allows for rapid change of parameters and therefore of the whole design, i.e. the parameterized car jack model was developed. Also, the goal of this research is to carry out kinematic analysis of a car jack design. Parametric model is developed in such a way that all parameters of design are in correlations to one main parameter. The angle of thread spindle is chosen for main parameter. Usually, main parameter should be chosen as one of the parameters from power input elements. Car jack has a human hand power which is applied on car jack handle and because of that, the angle of rotation of thread spindle is the best for main parameter.

In this paper five neural network models were developed using NARX-SP neural network type in order to predict air pollutants concentrations (SO2, PM10, NO2, O3 and CO ) for the 72nd hour ahead for Sarajevo. Hourly values of air pollutants concentrations and meteorological parameters (air temperature, pressure and humidity, wind speed and direction) for Sarajevo were used. Optimal model was selected based on the values of R2, MSE and the complexity of models. Optimal neural network model can predict air pollutants concentrations for the 72nd hour ahead with high accuracy, as well as for all hours up to 72nd hour.