Introduction: Dentists and generally dental personnel work under the risk of being infected by patients suffering from COVID-19, who are unaware that they are infected.  The reason lies in the fact that during dental procedures, aerosol is formed with droplets that may contain the virus. Thus, it is extremely important that dental personnel complies with adequate protective measures and equipment during clinical work. The aim of this investigation was to evaluate the knowledge of COVID-19 and determine the amount of stress with dental personnel of the Faculty of Dentistry in Sarajevo, Bosnia and Herzegovina.  Methods: Health care personnel of the Faculty of Dentistry with Clinics of the University in Sarajevo have been included in the research: teaching staff, clinical doctors, dental nurses and dental technicians. The research was conducted in April 2020. It was conducted by an anonymous survey that participants filled-in. Out of 157 distributed questionnaires in paper form, 134 participants responded. The questionnaire was divided into 3 parts: 1) personal data 2) knowledge of infection COVID-19 (diagnostic methods, transmission pathways, prevention measures); 3) the amount of stress (feelings and thoughts) during epidemic COVID-19 with personnel. Results: The largest number of participants (61.97%) consider that COVID-19 may be transmitted from infected to a healthy person by inhalation of droplets generated through coughing of an infected person and by direct contact with aerosol dispersed from the mouth of the infected patient during dental treatment. The largest number of participants, 80 of them (59.7%) consider that the method of nucleic acid test is used in diagnosing COVID-19.  COVID – 19 had a significantly larger influence on females; they showed higher extent of concern for the claim „I hardly fall asleep because of thinking about it“, „I try not to talk on this topic“ and „In my mind appear pictures in relation to this.“ (p<0.05) Conclusion: Knowledge of COVID-19 and measures of protection of health care personnel at the Faculty of dentistry with Clinics in Sarajevo is satisfactory. The largest fear of participants was fear of unconsciously transmitting the infection on people close to them and that members of their families become infected with COVID-19.

PurposeForests are negatively affected from rapid world population increase and industrialization that create intense pressures on natural resources and the possibility of an achieving circular economy. Forests can be considered as essential resources for providing sustainable society and meeting the requirements of future generations and circular economy. Therefore sustainable production tools as part of circular economy can be handled as one of the basic indicators for achieving circular economy. Accordingly the main purpose of this study is developing a novel rough – fuzzy multi-criteria decision-making model (MCDM) for evaluation sustainable production for forestry firms in Eastern Black Sea Region.Design/methodology/approachFor determining 18 criteria weights a novel Rough PIPRECIA (PIvot Pairwise RElative Criteria Importance Assessment) method is developed. Eight decision-makers (DMs) participated in the research, and to obtain group rough decision matrix, rough Dombi weighted geometric averaging (RNDWGA) operator has been applied. For evaluation forestry firms fuzzy MARCOS (Measurement of alternatives and ranking according to COmpromise solution) method was utilized.FindingsAfter application developed model the fourth alternative was found as the best. Sensitivity analysis and comparison were made to present the applicability of this method.Originality/valueDevelopment of novel integrated Rough PIPRECIA-Fuzzy MARCOS model with emphasis on developing new Rough PIPRECIA method.

Aim: To determine the impact of the COVID-19 pandemic on the overall practice of the histopathological and cytological laboratory at the University Hospital Centre Rijeka, and on the diagnosis of the most common cancers. Methods: The numbers of histopathological and cytological reports, newly diagnosed cancers of breast, lung, colon, endometrium, and prostate, molecular tests for EGFR mutations and HPV were extracted. Two periods, from March 1 to September 30 in 2019 and 2020 were analysed and compared, as the periods before and during the COVID-19 pandemic. Results: The total number of reports was statistically significantly lower during the COVID-19 pandemic in 2020, compared to the same period in 2019 (p&lt;0.000), histopathology by 24%, non-gynecological cytology by 20%, gynecological cytology by 13%, and Pap tests by 11%. During COVID-19 compared to the same period in 2019 the number of newly diagnosed malignant tumors was significantly reduced for colon cancers (–25%, p &lt;0.0001). The decrease in the new cases of breast (–3%) and prostate cancer (–4%) was less pronounced while the increase was recorded for lung (+ 2%) and endometrial cancer (+ 53%). The number of HPV tests dropped significantly during the COVID-19 pandemic, by 40% (p &lt;0.0001). Conclusions: This study confirmed the expected significant reduction in workload during the first wave of the COVID-19 pandemic in 2020, from 11% to 40%, although the number of patients with newly diagnosed cancers, except for colon, did not fall significantly. It would be important to form a joint national registry that would collect diagnostic and also therapeutic procedures, especially for oncology patients, in order to gain a more objective insight into the problems of the health system during pandemics. These data can be used to consider measures and strategies for the most adequate care, not only for COVID-19 but also for all other patients. © 2021 Hrvatski Lijecnicki Zbor. All rights reserved.

Introduction: Clance Impostor Phenomenon Scale (CIPS) is the most common and psychometrically sound instrument used to measure the impostor phenomenon. The aim of this study was to translate and make a cultural adaptation of the CIPS from English into Croatian. Materials and Methods: The translation process included two independent forward translations, combination of the forward translations into one single translation, back-translation, back-translation review, pre-piloting and drafting of the final translation after several revisions and minor adjustments by a professional reviewer. Results: We noticed no semantic differences when comparing the original and the back-translated versions of the CIPS. Thus, the final translation was only slightly changed in comparison with the first version. Conclusions: The version of the CIPS which was translated and culturally adapted into Croatian represents a reliable translation ready to be used in Croatia and Bosnia and Herzegovina.

The application of machine learning (ML) techniques could facilitate the identification of predictive biomarkers of somatostatin analog (SSA) efficacy in patients with neuroendocrine tumors (NETs). We collected data from 74 patients with a pancreatic or gastrointestinal NET who received SSA as first-line therapy. We developed three classification models to predict whether the patient would experience a progressive disease (PD) after 12 or 18 months based on clinic-pathological factors at the baseline. The dataset included 70 samples and 15 features. We initially developed three classification models with accuracy ranging from 55% to 70%. We then compared ten different ML algorithms. In all but one case, the performance of the Multinomial Naïve Bayes algorithm (80%) was the highest. The support vector machine classifier (SVC) had a higher performance for the recall metric of the progression-free outcome (97% vs. 94%). Overall, for the first time, we documented that the factors that mainly influenced progression-free survival (PFS) included age, the number of metastatic sites and the primary site. In addition, the following factors were also isolated as important: adverse events G3–G4, sex, Ki67, metastatic site (liver), functioning NET, the primary site and the stage. In patients with advanced NETs, ML provides a predictive model that could potentially be used to differentiate prognostic groups and to identify patients for whom SSA therapy as a single agent may not be sufficient to achieve a long-lasting PFS.

Introduction: Type 2 diabetes mellitus is a chronic disease that is causing enormous economic and social costs. It is characterized by many microvascular and macrovascular complications, such as heart attack, stroke, retinopathy, nephropathy, neuropathy, etc. Such complications can cause severe limitations and decrease the quality of life. The objective of this study was to assess the effect of type 2 diabetes mellitus on the quality of life using the EQ-5D-5L questionnaire, taking into account cardiovascular complications (heart attack, hospitalization due to angina pectoris, stroke, hospitalization due to heart insufficiency, transient ischemic attack, coronary revascularisation), complications of diabetes (microalbuminuria, renal failure, retinopathy, and neuropathy), and demographic characteristics (age, gender, body mass index, height, and weight).Materials and Methods: This cross-sectional study included 484 participants with type 2 diabetes mellitus. Quality of life was estimated by the EuroQol instrument EQ-5D-5L and visual analogue scale (VAS). The following complications related to type 2 diabetes were taken into account: heart attack, hospitalization due to angina pectoris, stroke, hospitalization due to heart insufficiency, transient ischemic attack, coronary revascularization, microalbuminuria, renal insufficiency, retinopathy, and neuropathy.Results: The mean value of the EQ index was 0.895, with the value of -0.59 as the lowest, and 1.0 as the highest quality of life of the study patients. Multivariate linear regression model showed that heart attack, hospitalization due to unstable angina pectoris, retinopathy, and neuropathy significantly decreased the quality of life of the study participants (p<0.05). Spearman's correlation showed that there was a significant correlation between age, height, duration of type 2 diabetes, body mass index, and the EQ index (p<0.001).Conclusion: The results suggest that type 2 diabetes complications, such as heart attack, neuropathy, retinopathy, and hospitalization due to unstable angina pectoris significantly decrease the quality of life of type 2 diabetes mellitus patients (T2DM).

BACKGROUND The association between adverse pregnancy outcomes (APOs) and maternal apical periodontitis remains unclear as it has not been examined rigorously or reviewed systematically. OBJECTIVE To systematically review and critically evaluate the available evidence on the association of maternal apical periodontitis with several APOs. METHODS A literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science, Scopus, PubMed, and Cochrane Database of Systematic Reviews (CDSR), from inception to 25 February 2021, with no language restrictions. Observational studies including longitudinal clinical trials, cohort, case-control, and cross-sectional studies of prospective and retrospective design were included. Articles with duplicate or overlapping results, abstract-only papers, case reports, case series, animal studies and reviews were excluded. Two independent reviewers were involved in study selection, data extraction and appraising the included studies; disagreements were resolved by a third reviewer. The Newcastle-Ottawa Scale (NOS) and the adapted form of the NOS were used to assess the quality for case-control and cross-sectional studies, respectively. RESULTS Two case-control and one cross-sectional study were included in the current review. The included studies were published between 2015 and 2017, with a total of 1187 participating individuals with an approximate age range of 15 to 40 years. As the included studies reported different outcomes, the heterogeneity of data prevented the use of a meta-analysis. The overall quality of the evidence was "Fair" for two out of three included studies, while one study was categorised as "Good". DISCUSSION Two out of three included primary studies had a substantial number of methodological inconsistencies and flaws, and caution should be exercised in interpreting the results of this systematic review because several important covariates were not considered in the original investigations. CONCLUSION Based on a limited volume and "Fair" and "Good" quality of evidence, a positive association between maternal apical periodontitis and APOs was observed. However, more "Good" quality clinical studies are needed to confirm the results of the current review.

multilateral policy spaces. Let us not forget that on the twentieth anniversary of UNSCR 1325 last year, Russia proposed a draft resolution to the UNSC that, if passed, would have seriously diluted the hard-won advances of the past two decades. The resistance to the agenda, notably by antifeminist regional and transnational coalitions, is certainly one of the most serious threats that the WPS community is facing today. In the form of a conversation between Joy Onyesoh, Madeleine Rees, and Catia Cecilia Confortini – all affiliated with the Women’s International League for Peace and Freedom (WILPF) – the last chapter tackles the question of co-optation and how feminist advocacy has a role to play in confronting this challenge. To conclude, while this cutting-edge volume fulfills its promise, the “new directions” referred to in the title could have been more explicitly defined and discussed; its contributions could have been more clearly highlighted with the addition of a conclusion bringing together the insights of the 14 chapters. New Directions in Women, Peace and Security nonetheless offers a remarkable and accessible overview of the current theoretical debates in the field, as well as the future research avenues and policy challenges of the constantly evolving WPS agenda.

Tilapia fingerlings (0.5 ± 0.08g) were reared during the nursery phase in two different stocking densities (0.5 fish/m2 for control in a pond of 600m² and 75 fish/m2 for compensatory group in a cage of 4m²) for a period of 100 days. After this period, a 50-day trial study was performed with 43 juvelines of tilapia (Oreochromis niloticus) for each group (control 294 ± 24.43g and compensatory 99.33 ± 16.99g) stocked at the same density (0,28 fish/m2) in order to evaluate the compensatory growth in eathern ponds of 160m2 for each treatment. Throughout the experimental period the water quality was monitored and biometrics were performed to evaluate the zootechnical performance. The results revealed that the fishes of compensatory group presented higher specific growth rate compared to control, demonstrating a compensatory growth. At the end of the trial both treatments presented weight loss strongly influenced by temperature decrease. These results showed the compensatory growth of O. niloticus and the possibility to use this strategy (nursery in high density) contributing to ensure a successful production of O. niloticus in this region of the country.

With recent clinical breakthroughs, immunotherapy has become the fourth pillar of cancer treatment. Particularly, immune cell-based therapies have been envisioned as a promising treatment option with curative potential for leukemia patients. Hence, an increasing number of preclinical and clinical studies focus on various approaches of immune cell-based therapy for treatment of acute leukemia (AL). However, the use of different immune cell lineages and subsets against different types of leukemia and patient disease statuses challenge the interpretation of the clinical applicability and outcome of immune cell-based therapies. This review aims to provide an overview on recent approaches using various immune cell-based therapies against acute B-, T-, and myeloid leukemias. Further, the apparent limitations observed and potential approaches to overcome these limitations are discussed.

Multi-criteria decision-making methods (MCDM) represent a very powerful tool for making decisions in different areas. Making a rational and reliable decision, while respecting different factors, is a challenging and difficult task; MCDM models have a great impact on achieving this goal. In this paper, a new MCDM technique is presented—ranking alternatives by defining relations between the ideal and anti-ideal alternative (RADERIA), which was tested for the evaluation of human resources (HR) in a transportation company. The RADERIA model has three key advantages that recommend it for future use: (1) the RADERIA model has a new approach for data normalization that enables defining the normalization interval according to the judgments of a decision-maker; (2) an adaptive model for data normalization of the RADERIA model allows tough conversion into various forms of decreasing functions (linear, quadratic equation, etc.); and (3) the resistance of the RADERIA model to the rank reversal problem. Furthermore, in many simulations, the RADERIA method has shown stability when processing a larger number of datasets. This was also confirmed by a case study with 36 alternatives, as considered in this paper. The results and verification of the proposed new method were acquired through a comprehensive verification of the complexity of the results. The complexity of the results was executed through (1) comparison with four other multi-criteria methods, (2) checking the resistance of the RADERIA model to the rank reversal problem, and (3) the analysis of the impact of changes in the measurement scale on the ranking results.

Introduction: Neural tube defects (NTDs) are multifactorial congenital anomalies of the central nervous system that results from failed neural tube closure between the 3rd and 4th weeks of embryonic development. Numerous clinical and experimental studies indicate that supplementation with folic acid before and during early pregnancy reduces the development of these anomalies. The present study examined the incidence and risk factors for NTDs and evaluated the effects of folic acid supplementation.Methods: This cross-sectional study included all children with NTDs who were hospitalized at the Pediatric Clinic, Clinical Centre University of Sarajevo during the period from January 01, 2008 to December 31, 2012. Data were collected retrospectively from the medical histories of hospitalized children. The study included children in pediatric clinics from four cantons (Sarajevo, Zenica–Doboj, Unsko–Sanski, and Central Bosnia) of the Federation of Bosnia and Herzegovina. The number of live births for the specified period in each of the four cantons was taken from a report by the Cantonal Ministry of Health.Results: Among the 69,096 live births recorded during the study period, 39 children had verified NTDs, with an overall incidence of 0.56:1,000 (or 5.6:10,000) in all four cantons. The most common NTDs were myelomeningocele with hydrocephalus (22/39, 56.4%), followed by isolated myelomeningocele (9/39, 23.1%), spina bifida occulta (7/39, 17.9%), and occipitocele (1/39, 2.6%). A total of 33.3% (13/39) of mothers took folic acid, but only one began supplementation prior to pregnancy, while 67.7% (26/39) of mothers did not take folic acid during pregnancy. NTDs were found more frequently in primiparas (53.8%), women with low education (basic school, 64.1%), and unemployed women (82.1%).Conclusion: It is important to make national recommendations for folic acid supplementation for women of reproductive age, but also change the public health policy that includes mandatory fortification of basic foods as this is the best measure for primary prevention of NTDs in the whole population regardless of employment and education status. Additional comprehensive studies are required to assess the incidence and risk factors throughout Bosnia and Herzegovina.