Abstract Rationale: Circumcision like any other surgical procedure is not devoid of complications. Serious complications are rare and include iatrogenic hypospadias, glans ischemia/necrosis, and glans amputation, all of which require an emergent treatment. Patient concerns: We report here a case of 6 months-old-boy with a superficial glans ischemia following circumcision. Diagnosis: Physical examination revealed a severely cyanotic glans with the moderate edema of the dorsal penile skin. Plasma levels of D-dimer were 8.57 mg/L. Urine passage was unremarkable while color Doppler ultrasonography revealed a normal blood flow. Interventions: The patient was successfully treated with subcutaneous injection of enoxaparin (low-molecular-weight heparin) and topical 2.5% dihydrotestosterone. Outcomes: The appearance of the glans penis on the 5th day was close to normal while the control levels of D-dimer dropped to the reference range. The patient was discharged from the hospital on the 6th day. At 6-month follow-up, the appearance of the glans penis was normal. Lessons: Acute glans penis ischemia following circumcision is a rare complication. Its successful treatment with enoxaparin and topical dihydrotestosterone has not been previously reported in the literature.

SEIS, the seismometer of the InSight mission, which landed on Mars on 26 November 2018, is monitoring the seismic activity of the planet. The goal of the Mars Structure Service (MSS) is to provide, as a mission product, the first average 1‐D velocity model of Mars from the recorded InSight data. Prior to the mission, methodologies have been developed and tested to allow the location of the seismic events and estimation of the radial structure, using surface waves and body waves arrival times, and receiver functions. The paper describes these validation tests and compares the performance of the different algorithms to constrain the velocity model below the InSight station and estimate the 1‐D average model over the great circle path between source and receiver. These tests were performed in the frame of a blind test, during which synthetic data were inverted. In order to propagate the data uncertainties on the output model distribution, Bayesian inversion techniques are mainly used. The limitations and strengths of the methods are assessed. The results show the potential of the MSS approach to retrieve the structure of the crust and underlying mantle. However, at this time, large quakes with clear surface waves have not yet been recorded by SEIS, which makes the estimation of the 1‐D average seismic velocity model challenging. Additional locatable events, especially at large epicentral distances, and development of new techniques to fully investigate the data, will ultimately provide more constraints on the crust and mantle of Mars.

Metal chelators can be potentially employed in the treatment of various diseases, ranging from metal overload to neoplastic conditions. Some xanthene derivatives were previously reported to complex metals. Thus, in a search for a novel iron or copper chelator, a series of 9-(substituted phenyl)-2,6,7-trihydroxy-xanthene-3-ones was tested using a competitive spectrophotometric approach. The most promising compound was evaluated in biological models (breast adenocarcinoma cell lines and erythrocytes). In general, substitution of the benzene ring in position 9 had a relatively low effect on the chelation. Only the trifluoromethyl substitution resulted in stronger chelation, probably via a positive effect on solvation. All compounds chelated iron, but their copper-chelating effect was only minimal, since it was no longer observed under highly competitive conditions. Interestingly, all compounds reduced both iron and copper. Additional experiments showed that the trifluoromethyl derivative protected erythrocytes and even cancer cells against excess copper. In summary, the tested compounds are iron chelators, which are also capable of reducing iron/copper, but the copper-reducing effect is not associated with increased copper toxicity.

Single-cell sequencing (SCS) data have great potential in reconstructing the evolutionary history of tumors. Rapid advances in SCS technology in the past decade were followed by the design of various computational methods for inferring trees of tumor evolution. Some of the earliest methods were based on the direct search in the space of trees with the goal of finding the maximum likelihood tree. However, it can be shown that instead of searching directly in the tree space, we can perform a search in the space of binary matrices and obtain maximum likelihood tree directly from the maximum likelihood matrix. The potential of the latter tree search strategy has recently been recognized by different research groups and several related methods were published in the past 2 years. Here we provide a review of the theoretical background of these methods and a detailed discussion, which are largely missing in the available publications, of the correlation between the two tree search strategies. We also discuss each of the existing methods based on the search in the space of binary matrices and summarize the best-known single-cell DNA sequencing data sets, which can be used in the future for assessing performance on real data of newly developed methods.

The aim of study was to examine the effect of the boar ejaculate collection frequency on the parameters of its quality. The research covered a three-year period, and four most common boar breeds in our area. A total of 1705 ejaculates were taken from Yorkshire boars, 1693 ejaculates from Landrace boars, 1106 ejaculates from Pietrain boars and 669 ejaculates from Duroc boars. Within each breed, groups were formed according to the frequency of ejaculate taking (once, twice, three, four, five, or six times a month). Evaluation of ejaculate quality was performed in a reprocentre laboratory, according to their quality standards. Quality parameters that have been determined were the volume of ejaculate, sperm concentration, progressive sperm motility, live sperm count, the number of doses per ejaculate and the overall assessment of ejaculate. Results of this study show that the volume and progressive motility increase with the increase of frequency in ejaculate taking, while the sperm concentration drops, except for the Pietrain boars. The best results were observed in ejaculates collected 5-6 times during the month. The highest mean volume of ejaculate was found in the Landrace boars (292.22 ml), in ejaculate taking frequency of five times per month. The highest average progressive sperm motility was 92% in the Yorkshire boars, on collection frequency of six times a month, while the highest concentration of spermatozoa was found in the Duroc boars in collection frequency of one taking per month (447.32 mil/ml). The results of this study indicate that the frequency of ejaculate taking affects the boar semen quality parameters.

Quasi-asymptotic behavior of functions as a method has its application in observing many physical phenomena which are expressed by differential equations. The aim of the asymptotic method is to allow one to present the solution of a problem depending on the large (or small) parameter. One application of asymptotic methods in describing physical phenomena is the quasi-asymptotic approximation. The aim of this paper is to look at the quasi-asymptotic properties of multidimensional distributions by extracted variable. Distribution T(x0,x) from S'(Ṝ+1×Rn) has the property of the separability of variables, if it can be represented in form T(x0,x)=∑φi(x0)ψi (x) where distributions, φi(x0) from S'(Ṝ1) and ψi from S(Rn), x0 from Ṝ1+ and x is element Rn different values of do not depend on each other. Distribution T(x0,x) the element S'(Ṝ+1×Rn) is homogeneous and of order α at variable x0 is element Ṝ1+ and x=x1,x2,…,xn from Rn if for k>0 it applies that T(kx0,kx)=kα T(x0,x). The method of separating variables is one of the most widespread methods for solving linear differential equations in mathematical physics. In this paper, the results by V. S Vladimirov are used to present the proof of the basic theorems, regarding the quasi-asymptotic behavior of multidimensional distributions by a singular variable, with the application of quasi-asymptotics to the solution of differential equations.