The aim of this study is to investigate how various elements of digital content impact the behavioural engagement of the content’s users in the setting of Southeast Europe, which has recently experienced turbulence in its political and social interrelationships. Using the stimulus-organism-response (S-O-R) theory we develop a model that considers two types of stimuli: digital content tone (consisting of positive and negative valence) and digital content substance, as well as two types of behavioural responses: opens and clicks on the content. Research is conducted in six countries over a period of three years, investigating objective users’ behavioural indicators for a regional newsletter. The results show digital content tone impacts users’ response in terms of opens and that this effect differs across the region. Furthermore, we show that the digital content substance is significantly related to number of clicks on the newsletter content and that this effect is curvilinear for the number of news features and number of calls, while it is positive and linear for the stakeholder/keywords mentions. Theoretical and managerial implications of the study are elaborated and discussed.

The aim of this article is to determine the contamination influence on the parameters of gas flow through multihole orifice (MHO) meter. The numerical investigations of the contamination influence for the MHO flow meters have not been reported in the previous researches. The air flow was steady, 3-D, and turbulent. The finite volume method was used for the purpose of numerical analyses. The main considered physical properties of air were density and dynamic viscosity. The standard $k-\varepsilon $ turbulence model was used. MHO meter with two different $\beta $ parameters was observed. Also, the influence of contamination formed in front of the MHO meter with the same $\beta $ parameters was analyzed. In order to qualitatively analyze the influence of the contamination, the 15 different combinations of contamination parameters for seven different Reynolds numbers were analyzed. The pressure drop, singular pressure loss coefficient, and discharge coefficient were analyzed. The grid sensitivity study was performed on four systematically refined numerical grids for MHO meter without contamination and the results were compared with the experimental results found in the literature. Also, the grid refinement was done for MHO meter with contamination for two different values of Reynolds number. It was found that for the same values of contamination angle, regardless of the contamination parameters ratio, the results were unchanged. Also, it was found that the contamination has an influence on the change of pressure drop values, which directly affects the change of other parameters. Pressure drop and singular pressure loss coefficient of the orifice with contamination are smaller compared to the values for a pure orifice, whereby the measurement accuracy was reduced. Also, for cases of contamination, the discharge coefficient was increased, leading to a negative measurement error. It was found that the same trend occurs regardless of the Reynolds number. It was found that the MHO meter was less sensitive to the pressure drop changes due to the increase of contamination angle in regard to the single-hole orifice meters.

Heart failure is a leading cause of morbidity and mortality. Around 4% of patients with heart failure carry a pathogenic genetic aberration that causes cardiomyopathy and subsequently leads to heart failure. There are five types of primary genetic cardiomyopathies that can give rise to heart failure: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy, arrhythmogenic cardiomyopathy (ACM), restrictive cardiomyopathy (RCM), and left ventricular noncompaction (LVNC). If genetic cardiomyopathy is suspected, genomic/genetic testing is recommended because it provides the underlying cause for the diagnosis, prognostic parameters, and possibility to test family members at risk. Testing should be conducted as part of a multidisciplinary approach by a team of adult or paediatric cardiologists, geneticists, and genetic counsellors. Here we will discuss 1) different genomic testing approaches and the management of variants of uncertain significance, 2) management of patients with suspected genetic cardiomyopathy in a multidisciplinary team, and 3) the associations between genotypes and phenotypes of most commonly mutated genes such as MYH7, TNNT2, TPM1, MYBPC3, TTN, and others. In conclusion, genetic testing of patients with cardiomyopathies helps with proper diagnosis, prognosis, treatment, and identification of relatives at risk.