Malignant salivary gland tumors form 11% of all head and neck tumors. Salivary duct carcinoma (SDC) of the parotid gland is an uncommon and highly aggressive tumor accounting for 2% of all salivary gland malignancies. The fourth edition of the WHO Classification of Head and Neck Tumors reported global annual incidence of 0.4–2.6/100,000 people. Standard treatment for SDC is wide surgical resection along with lymph node dissection followed by adjuvant radiation therapy. The role of adjuvant chemotherapy is not known. Here, we present a case of an SDC of the parotid gland in a 55-year-old female. She presented with a painless swelling behind her right ear. Surgery was performed, and total right parotidectomy was done along with selective neck dissection (levels II, III, VA). The pathology report concluded that it was a G3 (poorly differentiated) SDC (micropapillary variant) with lymphovascular and perineural invasion. The clinical stage of the disease was T4aN2bM0. Adjuvant therapy consisted of concurrent radiation (TD 66 Gy) and chemotherapy with weekly paclitaxel (45 mg/m2), carboplatin (AUC 1.5), and trastuzumab (2 mg/kg; THC) for 6 weeks followed by 4 cycles of THC every 3 weeks. Adjuvant trastuzumab was continued for a total of 1 year. She is still without the evidence of the disease 7 years later. The consensus regarding the use of adjuvant chemotherapy does not exist. Based on all the data that have been presented before, the conclusion is that we need new treatment modalities to improve the outome of this aggressive disease.

In automated planning, the need for explanations arises when there is a mismatch between a proposed plan and the user’s expectation. We frame Explainable AI Planning as an iterative plan exploration process, in which the user asks a succession of contrastive questions that lead to the generation and solution of hypothetical planning problems that are restrictions of the original problem. The object of the exploration is for the user to understand the constraints that govern the original plan and, ultimately, to arrive at a satisfactory plan. We present the results of a user study that demonstrates that when users ask questions about plans, those questions are usually contrastive, i.e. “why A rather than B?”. We use the data from this study to construct a taxonomy of user questions that often arise during plan exploration. Our approach to iterative plan exploration is a process of successive model restriction. Each contrastive user question imposes a set of constraints on the planning problem, leading to the construction of a new hypothetical planning problem as a restriction of the original. Solving this restricted problem results in a plan that can be compared with the original plan, admitting a contrastive explanation. We formally define model-based compilations in PDDL2.1 for each type of constraint derived from a contrastive user question in the taxonomy, and empirically evaluate the compilations in terms of computational complexity. The compilations were implemented as part of an explanation framework supporting iterative model restriction. We demonstrate its benefits in a second user study.

Magnesium based materials are considered promising biodegradable metals for orthopedic bone implant applications as they exhibit similar density and elastic modulus to that of bone, biodegradability, and excellent osteogenic properties. The use of Mg based biomaterials eliminates the limitations of currently used implant materials such as stress shielding and the need for the second surgery. Recently, the development of Mg-based implants has attracted significant attention. Additive manufacturing is one of the effective techniques to develop Mg based implants. Additive manufacturing which could be named 3D printing is a transformative and rapid method of producing industrial parts with in the acceptable dimensional range. Therefore, recent investigations have tried to apply this method for the development of Mg-based implants. This state-of-the-art review focuses on the additive manufacturing of Mg biodegradable materials and their in-vitro corrosion and degradation, and mechanical properties. The future directions to develop Mg biodegradable materials are reported through summarization of current achievements.

Implementation of the "bulk liquid membrane" (BLM) system was investigated in terms of its efficiency for selective removal of heavy metal ions from natural resources and industrial wastewater. In this paper, the removal of lead (II) ions through a liquid membrane system and factors that influence the process were examined. The research was performed using the homemade transport cell. Two organic solvents were used as liquid membranes: 1,2-dichloroethane and chloroform. Metal ion concentration in aqueous phases was monitored by flame atomic absorption spectrophotometry, after 4 hours of experiment. Macrocyclic ether (dicyclohexano-18-crown-6) was used as ligand for Pb (II) ions. The effects of nonionic surfactants (Triton X-100, Triton X-45 and Triton X-405) added in the receiving phase of BLM system were investigated. The results showed significant increase in transport rate compared to systems without surfactants. Considering the surfactant structure, transport rate of Pb (II) ions followed the order: TX-100 >TX-45>TX-405. Presence of TX-100 increased transport of Pb (II) ions up to 78% through chloroform and 58% through 1,2-dichloroethane.  

Modern access controls employ biometrics as a means of authentication to a great extent. For example, biometrics is used as an authentication mechanism implemented on commercial devices such as smartphones and laptops. This paper presents a fingerprint biometric cryptosystem based on the fuzzy commitment scheme and convolutional neural networks. One of its main contributions is a novel approach to automatic discretization of fingerprint texture descriptors, entirely based on a convolutional neural network, and designed to generate fixed-length templates. By converting templates into the binary domain, we developed the biometric cryptosystem that can be used in key-release systems or as a template protection mechanism in fingerprint matching biometric systems. The problem of biometric data variability is marginalized by applying the secure block-level Bose–Chaudhuri–Hocquenghem error correction codes, resistant to statistical-based attacks. The evaluation shows significant performance gains when compared to other texture-based fingerprint matching and biometric cryptosystems.

ABSTRACT Sustainable development demands no depletion of energy resources that have lower environmental impact, that are available at reasonable costs and that do not have negative social impacts. Because of the multi-dimensionality of this sustainable goal multi – criteria methods have become popular in sustainable decision-making processes. In this paper, we have developed a model for decision makers to rank small hydropower projects according to multiple criteria. The proposed model ranks projects based on technical, economic, social, and environmental criteria. The model is supported by two multi-criteria decision analysis methods: PROMETHEE (to rank projects) and Analytic Hierarchy Process (to determine the weights of main criteria). It is observed that the most important criteria are found to be the investment safety, legal obstacles and the amount of flow and the flow pattern. The proposed model is successfully tested on the example of 24 small hydropower plants. Highest ranked projects are those were criterion “annual production” was the highest and with the lowest scores in environmental aspect criteria. The presented model can give objective standpoint to decision makers, energy policies designers and energy planners.

Abstract Objective To provide relevant insight into the current degree of usage of the research potential of students of biomedical sciences in Bosnia and Herzegovina. Method The chosen data collection method was online surveying via Google search engine. The target group were students of biomedical sciences in Bosnia and Herzegovina. The surveying was conducted in July 2019, and responses were subjected to descriptive statistics. Results Although the majority of participants claimed that they were familiar with the seminar and scientific papers writing methodology and that the related course is available in their faculty’s curriculum, the quality of such courses may be questioned as the majority of study participants self-reported that they do not possess or did not posses necessary knowledge for writing and publishing a scientific paper. Also, the majority of respondents reported that they have never participated in any scientific research, which questions the involvement of students in scientific research in our country as well. More than half of respondents were actively reading scientific papers, but a third of them did not have that habit. Two-thirds of students reported that they have never attended any scientific event where they could learn more about the scientific research methods. Inadequate awareness of the importance of research, lack of students’ interest in making a research, and lack of knowledge were characterized as main obstacles in conducting scientific research according to survey responses. Conclusion Information obtained through research indicate that the student potential in scientific research in Bosnia and Herzegovina has not been used in its maximal capacity, requiring several steps to be taken towards its improvement.

Efficient work of grids with the maximum potential utilization, together with supply and modern consumer satisfaction, as well as unpredictability of distributed energy sources, represents the challenge of successful load management. This paper proposes the load management framework and analyses state-of-the-art research activities from the area of load management in smart grids. It addresses three steps in load management framework: modelling and prediction, measurement and monitoring, and optimization and control. The original contribution of this meta-analysis and state-of-the-art review is a multi-factor approach to the process of load management with the identification of key influence factors from groups: system, context and user.

For quite a while, it has been evident that homogeneous network architectures, based on cells with a uniform radiation pattern, cannot fulfill the ever increasing demand of mobile users for capacity and service quality while still preserving spectrum and energy. However, only with the introduction of the Fourth Generation mobile communication networks to deal with the surging data traffic of multimedia applications, have smaller cells been widely used to break down service zone areas of macro base stations into multiple tiers, thus improving network performance, reducing traffic congestion, and enabling better management of spectrum and energy consumption in a macro network. In this paper, we present an analytical model for assessing the efficiency of bandwidth and energy usage, as well as of network deployment, taking into account overall network investment and maintenance costs. This paves the way to the improved planning of network coverage, and its capacity and reliability, thus preserving its spectrum and energy, as well as the environment. The analysis considers the downlink of an arbitrary heterogeneous cellular network by using tools of stochastic geometry that adopt the distribution of base stations in the form of a Poisson Point Process. The proposed analytical model is verified by the according software simulations using the ns-3 network simulator. The obtained results closely match the theoretically predicted values and boundaries, clearly indicating that, in all three analyzed aspects: spectral, energy, and deploymental, the efficiency of small-cell networks was higher with respect to traditional large-cell networks and increased even further for heterogeneous (two-tier in our tests) networks.

PURPOSE The aim of this retrospective study was to evaluate and compare diagnostic accuracy and complication rates of percutaneous computed tomography (CT)-guided biopsies of pulmonary lesions 10-35 mm, 35-50 mm, and >50 mm, using the coaxial biopsy technique. METHODS Over a 4-year period, 235 lung biopsies were performed using the coaxial biopsy technique with 18G semi-automated true-cut needle. There were 163 (69.4%) male and 72 (30.6%) female patients, with a mean age of 64.01±9.18 years (18-85 years). The mean lesion size was 59.6±29.3 mm. The lesions were stratified into three groups according to size: lesions <35 mm (n=42, 17.9%), lesions 35-50 mm (n=53, 22.5%), and lesions >50 mm (n=140, 59.6%). Diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for all biopsies, and for each group separately, as well as the incidence of complications. RESULTS The overall diagnostic accuracy was 95.4%, with 95.52% sensitivity, 100% specificity, 100% PPV, and 47.37% NPV. For lesions <35 mm, diagnostic accuracy, sensitivity, and PPV were 100%. The lowest diagnostic accuracy was 93.9% in lesions >50 mm, with 93.65% sensitivity, 100% specificity, 100% PPV, and 42.86% NPV. An adequate sample was obtained in 219 core biopsies (93.2%), while 16 biopsies (6.8%) were nondiagnostic due to necrosis (4.25%) and insufficient biopsy material (2.55%). The most frequent complication was minor pneumothorax, which was seen at a rate of 19.1%; pneumothorax requiring chest tube placement occurred in 3 patients (1.3%). CONCLUSION Diagnostic accuracy decreased with increasing lesion size. On the other hand, complication rates were higher in smaller lesions, more distanced from the pleura.

Objectives Previous research using non-invasive (magnetoencephalography, MEG) and invasive (electrocorticography, ECoG) neural recordings has demonstrated the progressive and hierarchical representation and processing of complex multi-talker auditory scenes in the auditory cortex. Early responses (<85 ms) in primary-like areas appear to represent the individual talkers with almost equal fidelity and are independent of attention in normal-hearing (NH) listeners. However, late responses (>85 ms) in higher-order non-primary areas selectively represent the attended talker with significantly higher fidelity than unattended talkers in NH and hearing–impaired (HI) listeners. Motivated by these findings, the objective of this study was to investigate the effect of a noise reduction scheme (NR) in a commercial hearing aid (HA) on the representation of complex multi-talker auditory scenes in distinct hierarchical stages of the auditory cortex by using high-density electroencephalography (EEG). Design We addressed this issue by investigating early (<85 ms) and late (>85 ms) EEG responses recorded in 34 HI subjects fitted with HAs. The HA noise reduction (NR) was either on or off while the participants listened to a complex auditory scene. Participants were instructed to attend to one of two simultaneous talkers in the foreground while multi-talker babble noise played in the background (+3 dB SNR). After each trial, a two-choice question about the content of the attended speech was presented. Results Using a stimulus reconstruction approach, our results suggest that the attention-related enhancement of neural representations of target and masker talkers located in the foreground, as well as suppression of the background noise in distinct hierarchical stages is significantly affected by the NR scheme. We found that the NR scheme contributed to the enhancement of the foreground and of the entire acoustic scene in the early responses, and that this enhancement was driven by better representation of the target speech. We found that the target talker in HI listeners was selectively represented in late responses. We found that use of the NR scheme resulted in enhanced representations of the target and masker speech in the foreground and a suppressed representation of the noise in the background in late responses. We found a significant effect of EEG time window on the strengths of the cortical representation of the target and masker. Conclusion Together, our analyses of the early and late responses obtained from HI listeners support the existing view of hierarchical processing in the auditory cortex. Our findings demonstrate the benefits of a NR scheme on the representation of complex multi-talker auditory scenes in different areas of the auditory cortex in HI listeners.

Introduction The aim of this article was to report the long-term results of increased ileocystoplasty in 58 patients with spinal cord injury (SCI) with an impact on overall renal function and quality of life. In a representative number of patients, where we followed individual subjects for more than 20 years, we wanted to determine their quality of life and preservation of renal function after surgery. Material and methods After unsuccessful conservative therapy of urinary incontinence, increased ileocystoplasty was performed. In addition to biochemical analysis, intravenous urography (IVU) was performed preoperatively (urography and/or ultrasound assessment of the upper urinary tract) and urodynamic tests were performed in all patients preoperatively. Results After a follow-up of patients within the group (>20 years), 2 patients reported being incontinent. The median elapsed time of action was 20 (13–24) years. Vesical capacity increased in all cases postoperatively when the median vesical capacity was 420.0 (387.5–460.0) ml (p <0.001). Long-term complications included use of bladder chambers, kidney stones and urosepsis. Creatinine clearance confirmed satisfactory renal function after the elapsed time period from surgery. Conclusions The results confirmed that augmentation ileocystoplasty had excellent long-term outcomes in the definitive therapy of refractory neurogenic detrusor overactivity in patients with SCI.

Psychological impairments can follow an anterior cruciate ligament (ACL) injury and can impact the rehabilitation process. Our aim was to investigate experiences of sports physical therapists (PTs) in addressing psychological impairments in patients after ACL injury. We conducted four focus group interviews with fourteen sports PTs. The PTs’ experiences of working with psychological impairments after ACL injury were summarized in four main categories: (1) “Calling for a guiding light”, where PTs stated that the most common method of acquiring knowledge on addressing psychological impairments was through discussions with colleagues, and, at the same time, PTs expressed an insufficient knowledge of how to address psychological impairments; (2) “Meeting the burden of psychological impairments” where PTs stated that psychological impairments are greater than physical; (3) “Trying to balance physical and psychological aspects” where patient education and assessments were reported to be important in order to understand psychological impairments during rehabilitation; and (4) “Goal setting: a helpful challenge” where sports PTs expressed a need for specific knowledge of the rehabilitation of psychological impairments following ACL injury. To help provide the current best practice, we encourage researchers to develop psychologically centered interventions for rehabilitation after an ACL injury, and PTs to stay up‐to‐date with the literature published on the subject, including to implement eventual interventions.

Background The dependency of rural economies on agricultural practices for survival has been in decline for a number of years, seriously threatening rural communities sustainability. It is now evident that attracting young people into agricultural professions is proving difficult. As a consequence, policy measures that aim to enhance the likelihood of rural employment for young people or rural NEETs have been introduced in countries with the aim of reducing at-at-risk-poverty rates and supporting the long term viability of rural economies. The aim of this rapid review is to summarise the published literature reporting on the effectiveness of initiatives, interventions and programmes that target rural NEETs.Methods The following databases will be searched: Web of Science, SCOPUS, EBSCOhost, ERIC and ProQuest. Internet searching through Google Scholar will also be carried out. The result of the search will be downloaded and saved to Mendeley. Informed by PRISMA guidelines, duplicates will be removed. The titles and abstracts of all remaining studies will be screened by at least two independent reviewers informed by the study inclusion and exclusion criteria. Where a decision to include or exclude cannot be reached by the two independent reviewers an additional reviewer will adjudicate. All results, screening process results will be documented in tabular form and communicated in a PRISMA flow diagram.Discussion This rapid review protocol will provide a time limited state-of-the-art evidence report, specific to the challenges experienced by rural NEETs, that will help those involved in policy development, policy response initiatives and proximal implementation. It is intended that additional opportunities for innovation and/or research may be communicated to relevant stakeholders. Hence, they will be able to create a useful framework for embedding rural youth in the context of so needed structural transformation of rural communities.Systematic Review Registration This protocol has been submitted to the International Prospective Register for Systematic Reviews - PROSPERO, published, and assigned the following reference number: CRD42021236794.