The main goal of paper is to rank the criteria that are important for the selection of the most favourable supplier of the agricultural company by applying a multicriteria decision-making model. Subject of the paper is the procurement of mineral fertilizer for sowing certain field crops. As a method of work, the author uses DEMATEL (The Decision making Trial and Evaluation Laboratory) method of multicriteria decision making. In order to bring the research as close as possible to human thinking, the fuzzy logic of multicriteria decision-making was applied in the paper. Method is an expert assessment and ranking by experts in the field. In addition to the group of economic and technical criteria, the paper also uses criteria related to sustainable development such as environmental management system, green product, pollution and waste control, recycling and eco-product design. Results of the research show that the criteria that are from the economic group are still assessed as the most important for the decision maker. Importance of the research would be in pointing out the increase in the importance of criteria, especially those from the sustainability group according to their importance in the coming period, and the possibility of applying modern decision-making methods.

This is the issue of third volume of EFMI Inside - the official magazine of the European Federation for Medical Informatics (EFMI), founded in Lyon, France in August 2019, during “MEDINFO 2019” Conference and EFMI Council meeting. In this issue readers can find important information about events organized during 2022 by EFMI Working Groups and national Medical informatics associations, including the most influential Conference - 32nd MIE 2022 Conference held in Nice, France in May 2022, and EFMI STC held in Cardiff in September 22. This EFMI Inside issue contains important facts about other EFMI activities which needed to be recorded for people who couln’t be active participants at the evenings organized by EFMI and members of EFMI associatins.. Very important part of the issue is official report of the EFMI Council Secretary, Professor Alfred Winter about EFMI Council meetings during years 2020, 2021 and 2022 with included all important facts about EFMI activities during past, especialy during the mandate of Alfred Winter as Secretary from 2014 until 2022. It was the first time that all important facts about EFMI were completed at the one place and we decided to published it as some kind of historical bachground of EFMI for people who will continue managing EFMI Council and EFMI Board activities in the future.In this issue we also involved information about new elected Honorry Fellows during last three years and also obituaries about members who passed away, but their names need to be mentioned regarding its important contributions in the development of Medical informatics globaly and in its national organizatios, Some of chairs of Working Groups contributed with their reports in the past year who were actively involved in the development of Medical informatics in their countries, but also worldwide.

After the migration of Serbs in 1690 and 1735, the exploitation of mines in the area of present-day Serbia ceased, and after a standstill of nearly 200 years, the mining and metallurgical activities in Serbia were activated in the second quarter of the 20th century. The first concessions were bought by England in 1926, then the mines in Stari Trg (1927), Kišnica (1927), Ajvalija (1930), Novo Brdo (1933) were activated, and the Flotation (1930) and Smelter with Lead Refinery began to operate (1939) in Zvečan. In Kosovska Mitrovica, the chemical industry began operating in 1961, the Zinc Metallurgy and Lead Battery Factory in 1967, and all production facilities were expanded and modernized several times. The most intensive production and investment period of the "Trepča" Combine was in the period 1965-1985, when "Trepča" was a well-known producer of lead, zinc, silver, gold, cadmium, bismuth and products made of these metals. After 1990, the production declined for several reasons and, in 1999, the international army stopped production in "Trepča". In the past twenty years, the production has not been completely renewed nor the status of the "Trepča" Combine has not been regulated.

Allelopathy determines the dynamics of germination, development and growth of plant species in the environment. Therefore, in this study, the allelopathic effect of an aqueous extract isolated from walnut (Juglans regia L.) leaves (concentrated extract, 1:2, 1:4 and 1:8) on the germination percentage, mean germination value and germination rate of wheat (Triticum aestivum L.) and peas was monitored (Pisum sativum L.). Both tested species were sensitive to juglone, but the percentage of germination was significantly lower in wheat (by 80%) compared to peas, so it can be said that this species is more sensitive. The length of roots and shoots of both tested species decreased in proportion to the increase in the concentration of the extract. Monitoring of this biological phenomenon could help to understand the changes in the environment caused by allelochemicals.

In this study, changes in Class III peroxidase (POX) and polyphenol oxidase (PPO) activity in Phragmites australis (Cav.) Trin. Ex Steud. Utricularia vulgaris L. and Salvinia natans (L.) from the Bardača wetland during one vegetation season (June-October) were monitored. The highest activities of soluble and ionic cell wall bound peroxidases (solPOX and ionPOX, respectively) were measured for Phragmites communis (leaf > root > rhizome), followed by Utricularia vulgaris (whole plant), then Salvinia natans (whole plant). The results showed that during the vegetation period (August-September) the activity of solPOX, ionPOX and PPO in Phragmites communis increased, but the activity decreased drastically in October. For Salvinia natans and Utricularia vulgaris, a different seasonal distribution was obtained in the PPO activity, i.e. with a maximum activity during July and a minimum one during September. Different seasonal trends in enzyme activities are probably the result of abiotic stress caused by changing physic-chemical environmental conditions and different adaptive capacities of the studied species to habitat conditions. Correlations between physicochemical environmental parameters and enzyme activities indicate the possibility of using POX and PPO activities as an important bioindicatos of environmental status.

The European Union permitted 6 antimicrobial agents that can be used in laying hens. These are colistin, tyrosine, neomycin, oxytetracycline, chlortetracycline, and erythromycin. Antimicrobial drugs are used today primarily for the prevention and treatment of diseases in poultry and often (not in the EU) to stimulate growth. Because these drugs are often used irrationally, there are good chances that their residues will be found not only in poultry meat but also in the eggs within a certain period after the termination of treatment. In addition to the administration of authorised VMPs, the residues in eggs can be the result of erroneously applied medicated food, the contamination of the food with some antimicrobial drug in the mixing unit, as well as ?extra-label? use of drugs in poultry. The antimicrobial agents are distributed in the body and deposited in the eggs, mainly in the yolk where they persist longer than in the albumen. Drugs that are poorly absorbed from the gastrointestinal tract (aminoglycosides, aminocyclitols, polymyxins) cannot be detected in the eggs, while the residues of some antimicrobial drugs can be detected for up to two months (chloramphenicol) after the last treatment. The rational use of drugs in veterinary medicine has manifold significance. When using drugs only when they are really necessary (indicated), in the right dose and route of administration, the potential damage can be reduced and efficiency increased, while the risk of microorganism resistance development would be significantly decreased. All of this becomes more important when these drugs are used in food animals.

pH represents the concentration of free H+ in pine needles extracts (PNE) and is therefore an important initial parameter in quality control. Electrical conductivity and pH of samples of fresh and stored for 20 days of PNE with black cumin oil and olive oil had values of 0.00 due to the encapsulation of water molecules, pH and electrical conduction was not possible. The pH of the other samples was in a weakly acidic environment because the pH of natural pine needles is 3.8. Electrical conductivity values in all samples except pine needle extract and honey increased during storage. By monitoring the parameters of pH and electrical conductivity in the quality control of PNE, it gives us a significant insight into the physical state of the phases and the way of storage.

Introduction. Hepatitis A virus is the most common cause of acute viral hepatitis, and in people over 25 years of age the disease may have different degrees of severity. Even though hepatitis A virus infection was long believed to be transmitted strictly by fecal-oral route, now this virus is classified among sexually transmitted diseases. Homosexual population, especially those positive for human immunodeficiency virus, is at the greatest risk of hepatitis A virus infection. Case 1. A twenty-six-year-old male homosexual was admitted with clinical and laboratory findings of acute hepatitis. The patient tested positive for enzyme-linked immunosorbent assay immunoglobulin M antibodies to hepatitis A virus and human immunodeficiency virus antibodies, and later on human immunodeficiency virus infection was confirmed by polymerase chain reaction test. After the discharge, the antiretroviral therapy was initiated. Case 2. A twenty-seven-year-old male homosexual was transferred to our clinic from the Regional Hospital, where he was hospitalized due to acute hepatitis A virus infection, after a positive serological test for anti-human immunodeficiency virus antibodies. Human immunodeficiency virus infection was confirmed by polymerase chain reaction test, and upon discharge, antiretroviral therapy was initiated. Conclusion. In order to take the most effective preventive measures, it is very important to identify individuals and groups at high risk of coinfection with human immunodeficiency virus and hepatitis A virus. Timely vaccination against hepatitis A virus among people living with human immunodeficiency virus is recommended and therefore it is necessary to design effective strategies for education of groups at risk.

The suitable characteristics of fly ash from thermal power plants make it a proper adsorbent for removing various pollutants from water and aqueous solutions. Valorization and utilization of fly ash can reduce the use of conventional adsorbents. The paper presents an overview of the possibility of using raw and modified fly ash to remove fluorides from water and aqueous solutions, as well as the influence of different process parameters (sorbent dose, contact time, pH value, temperature, etc.) on the value of adsorption capacity and adsorption efficiency of used sorbent. Fly ash can be used as an effective sorbent for the removal of fluoride, both in raw and modified form, with given optimal process parameters. Raw fly ash shows better adsorption properties when performing the experiment in a column, with a higher dose of sorbent and longer contact time, in an acidic environment (pH = 2-3), compared to batch experiments. Various authors have modified fly ash by treatment with certain chemical agents (HCl, Ca (OH)2…) or by synthesis of zeolite based on fly ash. Modification of fly ash improves its adsorption properties, so in slightly acidic conditions (pH = 6), for a relatively short contact time (10-30 min), in batch conditions, significant adsorption efficiency (~ 90%) can be achieved.

Background: The pandemic of the new corona virus has taken its toll on the mental health of entire humankind with special impact on vulnerable groups, such as drug users in substitution treatment. Objective: The aim of the study was to determine the impact of the COVID-19 pandemic on mental health in the population of opiate addicts who are on substitution therapy. Methods: The research was conducted in the Institute of Addiction Diseases of the ZE-DO canton on the population of patients addicted to opiates who are included in the substitution therapy program. The sample of 80 patients was randomly selected with respect to the inclusion criteria. An 8-parameter questionnaire with symptoms of anxiety and depressive disorder, ranked by intensity on the Likert scale from 0 to 4, was used as a measuring instrument. The change in these symptoms in the one-year period before the pandemic to the one-year period of the pandemic are compared. The results are analyzed in descriptive statistics using the SPSS program. The statistical significance was monitored by the χ2 test. Results: The results of this research show an apperent statistically significant increase in the symptoms of anxiety and depressive disorder, as well as an increase in drug abuse during the pandemic period compared to the period before it. Conclusion: Results imply the existence of a significant adverse effect of the COVID-19 pandemic on the mental health of treated opiate addicts. This research impose the need to affirm the prevention of further abuse of illegal substances, as well as the introduction of new customized programs through various psychosocial interventions and therapies carried out by psychiatrists and psychologists. Telemedicine presents itself as useful way of intervention and treatment.

Background: The VEPs provide an objective measure of brain function, analyzing integrity of visual processing. With patients affected with schizophrenia, the changes with the implementation of VEP are evident, such as symmetrical deceleration of the impulse (reduction of the amplitude) and the continuance of latency, which points to a degenerative illness, suggesting the presence of optical neuritis or hemianopsia conjoined with mentioned intracranial illness. Objective: The aim of the study was to determine the correlation of l P100 latency and P100 amplitude (µV) between patients with schizophrenia and patients with migraine headache. Visual evoked potentials (VEPs) were applied. Methods: The sample included 80 subjects: a) S group- 40 patients with schizophrenia (21 males; 19 females), b) H group-40 healthy subjects with migraine headache (10 males; 30 females). The study was conducted at the Department of Psychiatry, Neurology and Radiology, University Clinical Center Sarajevo. Results: Our research revealed positive correlations were registered in P100 latency in left view field of both eyes and in P100 amplitude in the region of right eye (p=0.01) in comparison with left eye region (p=0.05) in patients with schizophrenia. Conclusion: Results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing. Our study is useful to initiate new questions and recommendations for further studies, specifically on changes in the occipital lobe in the schizophrenic patient’s brain. Changes in the volume in the occipital lobe are quite evident and further studies are required to better understand how the progressive brain changes affect the structural, functional, and metabolic activities of the occipital lobe in schizophrenia.