: Antitumor activity of two newly and sixteen previously synthesized 9-arylsubstituted 2,6,7 -trihydroxyxanthene-3-ones on diffuse large B-cell lymphoma cells were analyzed in this study. Xanth ene derivatives are characterized with numerous therapeutic applications, including anticancer, antioxidant, anti-inflammatory and other activities. In silico molecular docking analysis suggests significant binding affinities of certain compounds toward Akt and NF-κB proteins as two major players of cell proliferation and differentiation. Results of WST - 8 assay indicate mild or no activity of xanthene compounds on cell viability of HBL - 1 and DHL - 4 cell lines belonging to ABC and GCB DLBCL subtypes, respectively. Western blotting showed stimulatory activity of certain compounds, with increased expression of Akt in HBL - 1 and DHL - 4 cells. Our results provide an insight into activation of compensatory Akt mechanism in DLBCL models that could be an important step for further approaches in application of dual inhibitors for cancer treatment to achieve greater therapeutic effectiveness and drug resistance escape.

: Artificial Intelligence techniques are widely used for medical purposes nowadays. One of the crucial applications is cancer detection. Due to the sensitivity of such applications, medical workers and patients interacting with the system must get a reliable, transparent, and explainable output. Therefore, this paper examines the interpretability and explainability of the Logistic Regression Model (LRM) for breast cancer detection. We analyze the accuracy and transparency of the LRM model. Additionally, we propose an NLP-based interface with a model interpretability summary and a contrastive explanation for users. Together with textual explanations, we provide a visual aid for medical practitioners to understand the decision-making process better.

Right ventricular myxoma are primary rare benign cardiac tumors with each new case contributing to the new evidence in a management and treatment of the disease. We present an 80 year-old male patient with symptoms of fatigue on exertion and previous history of essential hypertension. Right ventricular myxoma was diagnosed on echocardiography and it was confirmed by futher diagnostic procedures. The most serious complication is arrhythmia and sudden cardiac death. A patient was referred for the urgent cardiosurgical intervention and successful extirpation of tumor was performed.

This paper primarily analyzes the classification of international organizations according to different criteria to see the specificity of the EU as a sui generis international organization. The authors specifically examine the legal order of the EU and the process of achieving full membership. They are interested in the EU accession process, particularly for countries in the Western Balkans like Bosnia and Herzegovina, which is covered by the Stabilization and Association Agreement. Candidate countries have access to various EU funds, which the authors analyze as pre-accession assistance. The study assesses Bosnia and Herzegovina’s status in European integration and delves into the use of IPA funds in the country, including its withdrawal, scope, and limitations. The authors emphasize the importance of IPA funds for Bosnia and Herzegovina.