The most common type of renal cell carcinoma (RCC) is clear cell renal cell carcinoma (ccRCC), which has a high metastatic potential. Even though the International Metastatic RCC Database Consortium risk model is conventionally utilized for selection and stratification of patients with metastatic RCC (mRCC), there remains an unmet demand for novel prognostic and predictive markers. The goal of this study was to analyze the expression of Vascular endothelial growth factor (VEGF), Cluster of Differentiation 31 (CD31) to determine microvessel density, and Angiopoietin-1 (Ang-1) in primary kidney tumors, as well as their predictive and prognostic value in patients with metastatic ccRCC (mccRCC) who were treated with first-line sunitinib. The study included 35 mccRCC patients who were treated with first-line sunitinib in period between 2009 and 2019. Immunofluorescence was used to examine biomarker expression in tissue specimens of the primary tumor and surrounding normal kidney tissue. Median disease-free survival (DFS) was longer in patients with negative and low tumor VEGF score than in patients with medium tumor VEGF score (p ═ 0.02). Those with low tumor CD31 expression had a longer median DFS than patients with high tumor CD31 expression (p ═ 0.019). There was no correlation between Ang-1 expression and DFS. The expression of biomarkers in normal kidney tissue was significantly lower than in tumor tissue (p < 0.001). In conclusion, higher VEGF scores and greater CD31 expression were associated with longer DFS, but neither of these biomarkers correlated with progression-free survival or overall survival.

Filamentary resistance switching, or ReRAM, devices based on oxides suffer from device-do-device and cycle-to-cycle variability of electrical characteristics (electroforming voltages, set and reset voltages, resistance levels and cycling endurance). These are largely materials issues related to the microstructure of the switching oxide. Here we outline strategies to engineer the electrical performance of silicon oxide ReRAM by controlling the oxide microstructure at the nanometre scale through approaches including engineered interfaces and ion implantation. We demonstrate control over the distribution of switching voltages, electroforming voltages, and stable multilevel resistance states.

—For a continuous-input-continuous-output arbitrarily distributed quantum channel carrying classical information, the channel capacity can be computed in terms of the distribution of the channel envelope, received signal strength over a quantum propagation field and the noise spectral density. If the channel en-velope is considered to be unity with unit received signal strength, the factor controlling the capacity is the noise . Quantum channel carrying classical information will suffer from the combination of classical and quantum noise. Assuming additive Gaussian-distributed classical noise and Poisson-distributed quantum noise, we formulate a hybrid noise model by deriving a joint Gaussian-Poisson distribution in this letter. For the transmitted signal, we consider the mean of signal sample space instead of considering a particular distribution and study how the maximum mutual in- formation varies over such mean value. Capacity is estimated by maximizing the mutual information over unity channel envelope.

By delivering end-to-end latencies down to 5ms, data rates of up to 20Gbps, and ultra-high reliability of 99.999%, 5G is extending the capabilities of numerous industry verticals, including the Transport & Logistics (T&L). As the T&L industry has a pivotal role in modern production and distribution systems, it is expected to leverage 5G technology to significantly increase efficiency and safety in the T&L operations, through automating and optimizing processes and resource usage. However, to be able to truly benefit from 5G, the design, the development, as well as the management, of T&L services need to specify and include 5G connectivity requirements, and the features that are tailored to the specific T&L use cases. To this end, in this paper we introduce the concept of Network Applications (NetApps), as the fundamental building blocks of T&L services in 5G, which simplify the composition of complex services, abstracting the underlying complexity and bridging the knowledge gap between the vertical stakeholders, the network experts, and the application/service providers, while specifying service-level information (vertical specific) and 5G requirements (5G slices and 5G Core services). In this paper, we exemplify the concept of NetApps leveraging one of the VITAL-5G use cases, which provides faster and safer operations of vessels in the port of Galati, the largest port on the Danube River.

The COVID-19 pandemic has accelerated the process of digital transformation of higher education institutions. In a very short period, teachers and students abruptly switched to digital environments, which they had not used until then. As online teaching is very different from traditional teaching, teachers and students are faced with numerous new challenges. Online teaching requires a specific environment that primarily implies the availability of adequate technology as well as the skills that both teachers and students should have. Some higher education institutions have completely switched to online mode, while others have practiced a combined (online and offline) mode. The aim of this paper is, based on a questionnaire developed by Bernard et al. (2007), to examine the level of online skills, readiness for online learning and learning initiatives, attitudes about online learning, as well as the desire for online interaction with teachers and colleagues by the surveyed students.

As a consequence of the progress of the modern mobile medicine, wearable technologies, especially ECG wearables tend to become indispensable part of peoples' lives. As applications and devices for tracking cardiac electrical activity are rapidly entering the market, it is important to compare individual ECG wearable devices. This review takes a systematic approach on the analysis of wearable ECG devices. It provides a detailed introduction on the updated methods, to create a comparison between individual features of devices, and to evaluate techniques for fall risk assessment, diagnosis, and prevention. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) instructions were used as a report standard. In an effort to collect the appropriate data, various databases were queried together with specific subject-oriented keywords. This was combined with different inclusion and exclusion criteria to find the relevant data. To further improve the data gathering and reduce bias, a Zotero tool was used. The results of this paper show the comparison of the different devices and their features. All findings can be observed in the table and in words. As information for the QardioCore are scarce, all six authors consolidated on the VitalCore being the most accurate ECG wearable device, as its sensitivity and specificity are the highest. Recent advances in wearable ECG devices allow for more trouble free out of clinic fall risk assessment, detection and prevention. As people tend to prefer the comfort of their home over doctors, such progress will assure the everyday emerging of new wearables.

While examining biomedical signals, signal classification as well as measurements, quantifications and their assessment is very important for studying different diseases and disorders. Through this paper, we have focused on different signals and biomedical devices, whose purpose is to give high quality information about diseases and disorders in prenatal age. The main focus was on ultrasound techniques and the relationship between 2D, 3D and 4D ultrasound, on Doppler ultrasound, cardiotocography, KANET test, and in general, comparison of standardized and automated techniques. Purpose of this paper is to compare some of the available techniques used to assess the fetus in the womb, how they advance through time and whether they are being automated.

The primary focus of this paper review is to summarize the most important facts and findings regarding the use of Artificial Intelligence (AI) in the modeling, processing and analysis of biomedical data and to give an insight on the contributions of AI, Machine learning and Deep learning to the field of medicine. This study compiled and analyzed work published in the period between 1986 and 2021 related to the use of AI in medicine, its various applications and historical development, with a focus on papers published from 2015 until today, due to the accumulation and development of newer technologies. Out of a total of 117 papers reviewed, 52 were selected for a more detailed analysis and presented in a table summarizing the key points, advances, advantages and disadvantages of AI, its subfields and algorithms. The goal of this paper was to extract the most famous AI learning algorithms, past and current, and focus on the methods of modeling, processing and analysis by which these algorithms operate and perform tasks in order to help doctors and experts better understand the underlying mechanisms behind biological processes, and in some cases, even replace humans in data classification, identification, diagnosis and prediction of different conditions associated with diseases.

In this paper, a measurement campaign for off-body communications in an indoor environment is investigated for a set of on-body antennas. The channel impulse response was measured with the user approaching and departing from an off-body fixed antenna using two user dynamics, standing at fixed positions and walking. The processing of the measurement data allowed to evaluate system loss statistics. Different antenna configurations are classified in terms of mobility and visibility depending on the on-body antenna placement. A dependence on distance is found for the antennas with the lowest mobility (chest and head), while no significant dependence is found for the antennas with the highest mobility (arms and legs). Regarding the standard deviation of system loss, higher values are found in walking scenarios (above 1.0 dB) compared to the standing ones (below 0.6 dB) showing a clear dependence on mobility.

Education and society always lag behind technical state of the art achievements. General computer literacy needed decades to become the part of public acceptance after computers become available. Smart phones enters our life and becomes an extension of the human body yet we still do not know how to properly apply them in education. Artificial intelligence is an exciting technology that adapts educational experiences to different learning groups, teachers and tutors. Intelligent Management Systems (IMS) are not a novelty in education though. There have been many experiments, but they have all somehow stalled due to immature technology or misinterpretation. We can now see a new impetus for AI in education, and its impact will soon be very noticeable. In education, AI can: personalize learning, connect and create innovative learning content, perform tutoring in intelligent tutoring systems, is used to help pupils with special needs, help teachers assess, give students access to learning content, and translate educational content from different languages, removing language barriers. This article will explore the different possibilities of using AI in education and its use in education.

This paper presents an Artificial Nerual Network (ANN) for identification of postmenopausal women who are at high risk for developing osteopathy. While 800 patients took part in the study, 180 were used for network training. The following parameters were used: T-score (from −2,5 to −4), Age, Blood calcium level (<1,9 mmol/L), Blood vitamin D level (<20 ng/ml), Hip fracture, Spine fracture, Joint fracture, Glucocorticoids use, Smoking status, and BMI. The network has 10 input parameters and 1 output parameter. For the final architecture of expert system, a neural network with 20 neurons in hidden layer was chosen based on the training results. The signal from each neuron from hidden layer is directed to neuron in output layer, where this neuron processes the signal and gives desired output of the network. The sensitivity was 97,5%, specificity 70%, and accuracy 94,44%.

The virus SARS-Co V -2 that has caused a pandemic of COVID-19 in 2019 is still a major concern for health care systems. The reason for this is the fact that the outcome of the disease is difficult to predict, as deadly complications can occur in all people. Diagnosing COVID-19 relies on polymerase chain reaction (PCR) testing and antigen testing, both of which require special referral. The aim of this study was to develop artificial intelligence (AI) expert system which will facilitate COVID-19 diagnosis based on parameters that can be readily collected from blood specimens. The database contains 1000 samples, divided into 2 categories: (1) healthy and (2) sick subjects The following parameters were used: CRP, LDH, SE, AST, ALT, D-dimer and IL-6. The sensitivity of the developed system was 100%, specificity 98.33%, and accuracy 99.67%, on the basis of which we can conclude that the use of AI in the diagnosis of COVID19 has a significant potential.

Diagnosis of anemia is a time intensive and medically expensive procedure requiring a multitude of tests to establish a final diagnosis. Classification is an even more complex procedure that often takes years to complete thus delaying proper treatment and worsening the prognosis. This paper presents the application of machine learning, K-nearest neighbors (KNN), in order to diagnose and classify anemia. Monitoring parameters used as input for diagnosis were: age, sex, ferritin, transferrin, vitamin B12, erythrocyte count, iron, folic acid, hemoglobin, while the parameter relevant for classification was MCV. The results of the study indicate significant possibilities for the application of this system in the field of medical diagnostics.