Background: Periodontal complications are one of the common side effects associated with orthodontic therapy. Objective: This study aimed to evaluate the periodontal changes in patients before, during, and after the therapy with a fixed orthodontic appliance. Methods: Out of 38 healthy adolescents with permanent dentition who were indicated for fixed orthodontic therapy were included in this study. Patients were selected from Class I, treated by non-extraction methods, by using conventional orthodontic braces. After their examination and treatment by an orthodontist, the patients were referred to the periodontist before the placement of a fixed orthodontic appliance. The patients underwent the application of a periodontal anamnestic-diagnostic protocol, and the clinical-radiological evaluation. After a fixed orthodontic appliance was placed, the respondents were referred to the periodontist for regular mandatory check-ups, initially, after three months, and later on-after 6 months, after 1 year and after 2 years until the end of orthodontic therapy. Results: An increase in the mean value of the Plaque Index and Sulcus Bleeding Index was found at each check-up after the placement of a fixed orthodontic appliance. There is a statistically significant difference in the presence of gingival hyperplasia found by monitoring the changes after three and six months, and after one and two years following the start of orthodontic therapy. Conclusion: The assessment of periodontal changes in patients before, during and after the completion of fixed orthodontic therapy revealed that there is a strong need for mutual and close cooperation between orthodontist and periodontist during orthodontic therapy.

Due to the lack of channel reciprocity in frequency division duplexity (FDD) massive multiple-input multiple-output (MIMO) systems, it is impossible to infer the downlink channel state information (CSI) directly from its reciprocal uplink CSI. Hence, the estimated downlink CSI needs to be continuously fed back to the base station (BS) from the user equipment (UE), consuming valuable bandwidth resources. This is exacerbated, in massive MIMO, with the increase of the antennas at the BS. This paper propose a fully convolutional neural network (FullyConv) to compress and decompress the downlink CSI. FullyConv will improve the reconstruction accuracy of downlink CSI and reduce the training parameters and computational resources. Besides, we add a quantization module in the encoder and a dequantization module in the decoder of the FullyConv to simulate a real feedback scenario. Experimental results demonstrate that the proposed FullyConv is better than the baseline on reconstruction performance and reduction of the storage and computational overhead. Furthermore, the FullyConv added quantization and dequantization modules is robust to quantization error in real feedback scenarios.

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Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field, by publishing contributions of the biomedical experts from worlwide and spreading of Biomedical informatics knowledge and experiences in scientific and academic community. Acta Informatica Medica journal has been founded in the year 1993 as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). In the year 2019 Acta Informatica Medica has been accepted as official journal of the European Federation for Medical Informatics (www.efmi.org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 30 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. The journal follows the Guidelines and recommendations of ICJME, COPE, EASE, WAME, etc. as well as the recommendations of the “Sarajevo Declaration on Integrity and Visibility of Scholarly Journals”, accepted by 17 Editors of biomedical journals at “SWEP 2018” Conference held in Sarajevo and printed in the countries in South-Eastern Europe. SCImago rank for 2021 announced the bibliometric list of the journals deposited in SCOPUS indexed database. On the list are 16 journals which are published in Bosnia and Herzegovina, and between them are 7 within biomedical sciences. Three highest are Bosnian Journal of Basic Medical Sciences - H-Index is 29, Medical Archives - H-Index is 26 and Acta Informatica Medica - H-Index is 24, etc. Acta Informatica Medical journal has Impact Score, Overall Ranking, h-index, SJR, Rating, Publisher updated on May 27, 2022: Impact Score - 1.87; h-Index - 24; Rank -12749 and SJR - 0.372.

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The goal of this research is to evaluate the effects of applied kinesiological activities of different extensions on the transformation of basal-motor abilities of boys. The sample of respondents is represented by boys, students of VII, VIII and IX grades of primary school. „21. March "Matuzići - Doboj South. The total sample consists of a set of 76 respondents classified into three distinct groups. Based on the boys' statements about their participation in everyday physical activities, groups with the numbering were defined through non-athletes: non-athletes-1, recreational athletes-2 and athletes-3. To assess the basic motor skills of the respondents, the variables according to the Eurofit battery test program were used, as follows: Flamingo balance, endurance in the joint, lying-sitting, running 10 × 5m (back and forth), hand tapping, hand dynamometry, flexibility-mobility at the hip joint, jumping away from the spot and running 20m back and forth with progressive acceleration. The results of univariate covariance analysis showed high significance in endurance assessment tests (SHATL 20 and SHATL 10 × 5), followed by static arm strength (MSSIZG), and hand strength (MSSDIN) and torso flexibility (MFLPRK) and balance (MRFLAM). Statistically significant differences in effects did not occur with the three variables, namely hand tapping ( MBFTAR), long jump (MESSDM) or squat-sitting (MRSLSJ). Keywords: Boys, basic motor skills, kinesiological activities, extensibility

Women’s rights have increasingly become an international concern and various in-ternational conventions on women’s rights came into being in the last decades. Bosnia-Herzegovina has signed and ratified all important international conven-tions relating to women’s rights, whereas the numerous women's civil society organ-izations continue to advocate for the proper implementation of conventions while helping women to claim their rights guaranteed in these conventions and locally enacted laws on gender equality. This article, based on interviews conducted be-tween August 2020 and June 2021 with members of women's civil society organiza-tions in Bosnia-Herzegovina, takes a closer look at the process of norm diffusion. In particular, this article aims to contribute to the understanding of the processes of norm implementation and the related challenges from the perspective of women’s civil society organizations in the specific context of Bosnia-Herzegovina.

Background: The Brixia scoring system interpreted chest X-ray changes, serves as an indicator of the extent of changes in the lung parenchyma Objective: To indicate the effect of D-dimer and C-reactive protein (CRP) on Brixia score in patients with positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: The research had prospective, descriptive and analytical character, and included patients (n=104) with Coronavirus disease 2019 (COVID-19) diagnosis. Chest X-ray, as well as calculation of Brixia score was done on admission, in the first week of hospitalization, on discharge, and 10 days after discharge (the patient was considered a post-COVID patient. Maximum CRP and D-dimer values were taken into account, along with data about dependence of mechanical ventilation and oxygen therapy. Results: Initial Brixia score was significantly associated with the values of CRP (r = .23, p <.05). Higher level of CRP affected the higher result on the Brixia score after the initial X-ray. High CRP and D-dimer were significantly associated with oxygen use in patients, while high D-dimer was also statistically significantly associated with comorbidity. The mean value of Brixia score (during four time points) was significantly related to the values of CRP, D-dimer, the use of mechanical ventilation and oxygen therapy, but also with the existence of comorbidities. The largest statistically significant positive correlation of Brixia scora is with the values of D-dimer (r = .45, p <.000), but also with the values of CRP (r = .36, p <.000). Conclusion: Values of CRP have an impact on Brixia score. Investigation of clinical characteristics and outcomes of severe clinical presentation of COVID-19 along with CXR scoring system will contribute to early prediction, accurate diagnosis and treatment as well as to improve the prognosis of patients with severe illness.

Introduction: Neck pain (NP) may have a local mechanical (non-specific) origin caused by dysfunction of the joint, muscle, and ligament structures in the neck or by a discogenic etiology. Most people (50–60%) suffer from NP at some point in their lives. They are more common in highly developed countries and in urban areas. The aim of this study is to determine the prevalence of NP and its impact on daily living activities in the student population. Methods: The study included students of the University of Sarajevo - Faculty of Health Studies in the period from May 2021 to June 2021. The sample of respondents was formed by the method of random selection and included respondents of both sexes, aged 19–28 years. The study was conducted as a transversal cross-sectional study at a specific time point on the frequency of NP and the ability to perform activities of daily living in the student population. Results: Out of the total number of 255 respondents, 77 (30.2%) reported that they have NP while 178 (69.8%) respondents reported that they do not feel NP and it was found that there was no statistically significant difference between the age groups of the subjects with and without NP. The study concluded that a higher percentage of respondents with NP did not engage in leisure activities and that respondents with NP had lower mobility in daily life, sleep disturbance, and poorer ability to perform activities of daily living due to NP. Conclusion: The study conducted revealed that a significant percentage of the student population with NP has a lower ability to perform activities of daily living. Considering the above facts and the current transformation of the educational model, in which static postures dominate, it is necessary to design and implement programs for targeted physical activity and prevention of long-term inactivity that leads to painful musculoskeletal syndromes.

Introduction Clozapine is a drug that can cause several side effects. Among the less commonly described is a drug-induced lung disease. Due to its non-specific clinical presentation, it represents a diagnostic challenge. The diagnosis is made based on: 1. Association of exposure to the agent and development of symptoms, 2. Pulmonary infiltration, 3. Exclusion of other causes, 4. Withdrawal of symptoms when the agent is excluded from therapy. To date, there have been only a few descriptions of this condition. Objectives Case report of rare side effect of clozapine. Methods Case report Results Case report: male patient (37) with schizophrenia, was hospitalized after a brutal suicide attempt. The PCR test for COVID-19 that was routinely performed on admission was negative. After the introduction of clozapine into therapy, the patient became febrile. There was a drop in oxygen saturation, a Lung CT scan showed inflammatory changes („ground-glass opacities“), and COVID-19 pneumonia was suspected. Due to the worsening of the mental state, the dose of clozapine was increased. The physical condition further deteriorated: febrile, sO2 declining. After repeated PCR tests for COVID-19 (all negative), interstitial pneumonia caused by clozapine was suspected, and clozapine was excluded from therapy. The physical condition started to improve. Quetiapine was introduced, and occasional episodes of agitation were relieved with intramuscular diazepam. In the following days, the patient’s mental state improved and he was discharged. Conclusions Despite its superiority over other antipsychotics, clozapine was with good rationale ranked third in treatment guidelines for schizophrenia. Disclosure No significant relationships.

BACKGROUND Deep vein thrombosis (DVT) can be symptomatic or asymptomatic in patients with acute pulmonary embolism (PE). The prognostic value of the symptomatic DVT at the presentation regarding the prognosis of PE is unknown. METHODS Data were extracted from the REgional Pulmonary Embolism Registry (REPER) which enrolled 1604 hospitalized patients after multidetector computed tomography (MDCT) diagnosed symptomatic acute PE. According to the ESC risk model, patients were classified into four subgroups. Patients who had leg edema with or without pain, and patients with leg pain and DVT confirmed by compression ultrasound were considered to have symptomatic DVT. This study aims to compare all-cause hospital mortality between patients with symptomatic DVT and patients without symptoms or signs of DVT across the PE risk stratums. RESULTS All-cause mortality in patients with symptomatic DVT compared to those who had no signs or symptoms of DVT were 2/196 (1.0%) vs 11/316 (3.5%), p=0.145, 4/129 (3.1%) vs 17/228 (7.5%), p=0.106, 14/196 (7.1%) vs 54/290 (18.6%), p<0.001 and 16/55 (29.1%) vs 51/139 (36.7%), p=0.402 in patients with low, intermediate-low, intermediate-high and high-risk PE, respectively. In multivariate analysis symptomatic DVT was associated with decreased inhospital mortality only in patients with intermediate-high PE (OR 0.320, 95%CI 0.164-0.627; p=0.001). Intermediate-high risk PE patients with symptomatic DVT who were treated with thrombolysis had significantly lower hospital mortality than patients without signs or symptoms of DVT (2.2% vs. 11.4%, p=0.003). CONCLUSIONS Intermediate-high risk PE patients with symptomatic DVT at presentation may benefit from thrombolysis and have lower hospital all-cause mortality in such circumstances.

TPS612 Background: The ongoing, multi-center FLEX trial (NCT03053193) began in the United States in 2017, with the ultimate goal of 30,000 patients enrolled. The primary objective is to create a large-scale collaborative registry of early-stage breast cancer patients that links comprehensive clinical and full genome expression data to reveal new prognostic and/or predictive gene signatures. A key secondary objective of the trial is to enable investigator-initiated studies to explore early-stage breast cancer at a relatively low cost to the investigator. Methods: The prospective FLEX trial enrolls patients aged ≥ 18 years with histologically proven stage I-III breast cancer, with negative or 1-3 positive lymph nodes. Eligible patients have received MammaPrint, with or without BluePrint testing as standard of care, and consent to clinically annotated full transcriptome data collection. The FLEX base study protocol permits investigators to submit their own concept proposal, and upon review and approval by the Research and Scientific Review Committees, investigators interrogate clinical and genomic data from the FLEX database. The 10-year enrollment goal is a minimum of 30,000 patients. Since April 2017, 9,170 patients have been enrolled at over 109 sites in the United States. To date, 38 investigator-initiated substudies have been approved and are in progress, and 28 abstracts have been published in the US scientific congresses. To ensure inclusion of diverse populations, patients from local communities and 11 National Cancer Institute-designated Comprehensive Cancer Centers were included. Our diverse data set is helping meet the needs of historically under-represented patients with breast cancer. Of the self-reported ethnicities within the FLEX database, 65% are White or Caucasian, 8% Black or African American, 4% Latin American, and 2% Asian. There are 5 ongoing FLEX sub studies investigating racial disparities. The molecular profiling and differential gene expression analysis in early-stage breast cancer patients of African American, Asian, Hispanic ancestries helps to provide critical insights that correlate tumor biology with treatment outcomes. FLEX is expanding globally with sites anticipated in multiple European countries. The FLEX trial continues to expedite the discovery and development of novel genomic profiles, bringing precision oncology into the clinic to improve breast cancer management. Clinical trial information: NCT03053193.