Objective: During the COVID-19 pandemic, fear, anxiety, and depression have become global concerns among the wider public. This study aimed to examine the occurrence of fear, anxiety and depressive symptoms associated with COVID-19, to assess influencing factors that lead to the development of these mental health conditions and to examine any changes in the mental health patterns of the society since the initial study a year ago in Sarajevo, Bosnia and Herzegovina. Method : An anonymous online survey based on Fear of COVID-19 Scale (FCV-19S), General Anxiety Disorder-7 (GAD-7) and Patients Health Questionnaires (PHQs) was conducted in the general population of Sarajevo in Bosnia and Herzegovina. Results: From 1096 subjects, 81.3% were females, 33.8% had a high school degree, 56.4% were married, 53.4% were engaged in intellectual labor, 42.3% experienced fear, 72.9% had anxiety symptoms and 70.3% had depressive symptoms during the COVID-19 pandemic and their mean age was 35.84 ± 10.86. Half (50.1%) of the subjects were COVID-19 positive and 63.8% had COVID-19 symptoms when responding to the questionnaire. Experiencing COVID-19 related fear (OR = 1.972) and having moderate to severe depressive symptoms (OR = 9.514) were associated with the development of mild to severe anxiety symptoms during the COVID-19 pandemic, which were in turn associated with the development of moderate to severe depressive symptoms (OR = 10.203) and COVID-19 related fear (OR = 2.140), respectively, thus creating a potential circulus vicious. COVID-19 positive subjects (OR = 1.454) were also more likely to develop mild to severe anxiety symptoms during the COVID-19 pandemic. Conclusion: In conclusion, the prevalence of fear, anxiety symptoms and depressive symptoms rose dramatically since the beginning of the COVID-19 pandemic in Bosnia and Herzegovina. They were interconnected and were significantly associated with age, gender, marital status and COVID-19 status. Therefore, an urgent mental health intervention is needed for the prevention of mental health problems.

This paper analyzes the most important trends in the manifestation of terrorism inspired by radical Islamic discourse since its appearance in the Middle East and North Africa in the 1980s until the present day. Considering the very specific historical context of this region, an insight into it was unavoidable, in an attempt to identify the key factors that favored the emergence of this type of terrorism, as well as its gradual affirmation in regional and international frameworks. The trends in the manifestation of terrorism inspired by radical Islamic discourse are viewed in this paper through two main time periods. The first covers the period from 1980. to 2000, when this type of terrorism began to appear in the countries of the MENA region, with gradual regional affirmation and expressed ambitions to extend the radius of activity of the newly formed radical Islamist organization to the international level. The second period commenced after the brutal terrorist attacks on American targets on September 11, 2001 and the declaration of war on terrorism, which, based on the indicators presented in this paper, inaugurated the era of progressive and extremely worrying rise of terrorism inspired by radical Islamic discourse, especially from the moment the entry of the Islamic State of Iraq and the Levant (ISIL) onto the international stage in mid-June 2014.

When migrating to Industry 4.0, organizations face the need to adapt to a new context characterized by high levels of uncertainty and complexity. The main driving force in this process are the meta-competencies that ensure high competitiveness and innovativeness. However, their content, classification levels, intersections, and development potential under the influence of digitalization are insufficiently covered by the literature. This article attempts to fill this gap by analyzing the impact of new technologies on meta-competences. It presents a conceptual model based on the assumption that the degree of digitalization enhances the effects of the interaction between the top-level meta-competencies - Foresight, strategic flexibility, and ambidextrousness. Additional factors, the inclusion of which in the model will allow for a better study of the nature of the relationship under consideration, are proposed.

Rare b hadron decays are considered excellent probes of new semileptonic four-fermion interactions of microscopic origin. However, the same interactions also correct the high-mass Drell-Yan tails. In this work, we revisit the first statement in the context of this complementarity and chart the space of short-distance new physics that could show up in rare b decays. We analyze the latest b → qℓ ^+ ℓ ^ − measurements, where q = d or s and ℓ = e or μ , including the most recent LHCb R K ∗ $$ {R}_{K^{\left(\ast \right)}} $$ update, together with the latest charged and neutral current high-mass Drell-Yan data, pp → ℓν and pp → ℓ ^+ ℓ ^ − . We implement a sophisticated interpretation pipeline within the flavio framework, allowing us to investigate the multidimensional SMEFT parameter space thoroughly and efficiently. To showcase the new functionalities of flavio, we construct several explicit models featuring either a Z ′ or a leptoquark, which can explain the tension in b → sμ ^+ μ ^ − angular distributions and branching fractions while predicting lepton flavor universality (LFU) ratios to be SM-like, R K ∗ ≈ R K ∗ SM $$ {R}_{K^{\left(\ast \right)}}\approx {R}_{K^{\left(\ast \right)}}^{\textrm{SM}} $$ , as indicated by the recent data. Those models are then confronted against the global likelihood, including the high-mass Drell-Yan, either finding tensions or compatibility.

To improve our understanding of the molecular mechanisms underlaying seed priming, RNA transcriptome analysis was performed using primed and non-primed seeds of Silene sendtneri. Seed priming was performed by submergence in 1% silicic acid for 24h at 4°C, followed by rinsing with sterilised water and desiccation to original moisture content. Silene sendtneri is a species with no sequenced genome and annotation of de novo assembly of transcriptome was done against several species. Gene ontology (GO) analysis indicated that genes related to heavy metal transporters and heat shock proteins are differentially expressed after priming with silicic acid. Within these gene categories, genes such as heavy metal-associated isoprenylated plant protein 26-like (log2fold -8.79) were downregulated, while others such as heavy metal ATPase 5 (log2fold 6.46), heat shock factor protein HSF30-like isoform X1 (log2fold 5.98) were upregulated.

Abstract Background Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has one of the lowest 5-year cancer survivals. Fifty risk-associated variants within 34 glioma genetic risk regions have been found by genome-wide association studies (GWAS) with a sex difference reported for 8q24.21 region. We conducted an Australian GWAS by glioma subtype and sex. Methods We analyzed genome-wide data from the Australian Genomics and Clinical Outcomes of Glioma (AGOG) consortium for 7 573 692 single nucleotide polymorphisms (SNPs) for 560 glioma cases and 2237 controls of European ancestry. Cases were classified as glioblastoma, non-glioblastoma, astrocytoma or oligodendroglioma. Logistic regression analysis was used to assess the associations of SNPs with glioma risk by subtype and by sex. Results We replicated the previously reported glioma risk associations in the regions of 2q33.3 C2orf80, 2q37.3 D2HGDH, 5p15.33 TERT, 7p11.2 EGFR, 8q24.21 CCDC26, 9p21.3 CDKN2BAS, 11q21 MAML2, 11q23.3 PHLDB1, 15q24.2 ETFA, 16p13.3 RHBDF1, 16p13.3 LMF1, 17p13.1 TP53, 20q13.33 RTEL, and 20q13.33 GMEB2 (P < .05). We also replicated the previously reported sex difference at 8q24.21 CCDC26 (P = .0024) with the association being nominally significant for both sexes (P < .05). Conclusions Our study supports a stronger female risk association for the region 8q24.21 CCDC26 and highlights the importance of analyzing glioma GWAS by sex. A better understanding of sex differences could provide biological insight into the cause of glioma with implications for prevention, risk prediction and treatment.

Introduction: In Australia and New Zealand, liver allocation is needs based (based on model for end-stage liver disease score). An alternative allocation system is a transplant benefit-based model. Transplant benefit is quantified by complex waitlist and transplant survival prediction models. Research Questions: To validate the UK transplant benefit score in an Australia and New Zealand population. Design: This study analyzed data on listings and transplants for chronic liver disease between 2009 and 2018, using the Australia and New Zealand Liver and Intestinal Transplant Registry. Excluded were variant syndromes, hepatocellular cancer, urgent listings, pediatric, living donor, and multi-organ listings and transplants. UK transplant benefit waitlist and transplant benefit score were calculated for listings and transplants, respectively. Outcomes were time to waitlist death and time to transplant failure. Calibration and discrimination were assessed with Kaplan–Meier analysis and C-statistics. Results: There were differences in the UK and Australia and New Zealand listing, transplant, and donor populations including older recipient age, higher recipient and donor body mass index, and higher incidence of hepatitis C in the Australia and New Zealand population. Waitlist scores were calculated for 2241 patients and transplant scores were calculated for 1755 patients. The waitlist model C-statistic at 5 years was 0.70 and the transplant model C-statistic was 0.56, with poor calibration of both models. Conclusion: The UK transplant benefit score model performed poorly, suggesting that UK benefit-based allocation would not improve overall outcomes in Australia and New Zealand. Generalizability of survival prediction models was limited by differences in transplant populations and practices.

The aim of this study is to investigate the determinants of Germany's OFDI in the last 21 years on the set of top ten Germany’s OFDI destination (United States of America, United Kingdom, China, France, Poland, Mexico, India, Turkey, Spain and Russia (Russian Federation)) by using panel data analysis. The research revealed that Germany’s OFDI are driven by market seeking motives (FDI vertical), and also highlighting the importance of the stable political environment, attractive tax environment, more trade openness, and stable macroeconomic environment of the top ten Germany’s partners for attractiveness of the Germany’s OFDI. It indicates that openness of an economy is statistically significant in attracting FDI.

Objective: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. Methods: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months. Results: One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease duration, and disease subtypes (70% diffuse cutaneous) were similar between males and females. Active digital ulceration, very low body mass index, and tendon friction rubs were significantly more frequent in males. Physician global assessment of disease severity and digital ulcer activity was significantly higher in males. Composite pulmonary involvement was also more frequent in males, though not statistically significantly. After 12 months, they are the pattern of differences changed female patients had significantly more frequent pulmonary involvement. Conclusion: In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.

For a manifold $M$ and an integer $r>1$, the space of $r$-immersions of $M$ in $\mathbb {R}^n$ is defined to be the space of immersions of $M$ in $\mathbb {R}^n$ such that the preimage of every point in $\mathbb {R}^n$ contains fewer than $r$ points. We consider the space of $r$-immersions when $M$ is a disjoint union of $k$ $m$-dimensional discs, and prove that it is equivalent to the product of the $r$-configuration space of $k$ points in $\mathbb {R}^n$ and the $k^{\text {th}}$ power of the space of injective linear maps from $\mathbb {R}^m$ to $\mathbb {R}^n$. This result is needed in order to apply Michael Weiss's manifold calculus to the study of $r$-immersions. The analogous statement for spaces of embeddings is “well-known”, but a detailed proof is hard to find in the literature, and the existing proofs seem to use the isotopy extension theorem, if only as a matter of convenience. Isotopy extension does not hold for $r$-immersions, so we spell out the details of a proof that avoids using it, and applies to spaces of $r$-immersions.

Abstract Aim: The study aimed to evaluate the acute effect of ultrafiltration on the mechanical properties of the aorta using brachial-ankle pulse wave velocity (PWV) before and after hemodialysis (HD). Patients and Methods: This study included 80 patients who were on a long-term HD program. The input variables were anamnestic data, body composition monitor (BCM) parameters, and echocardiography findings. The assessment of hydration status was determined by BCM, whose work is based on the principle of multifrequency bioimpedance spectroscopy. Another diagnostic procedure was the use of an arteriograph apparatus to assess PWV and Augmentation Index (AIx). All measurements were performed before and after dialysis on the middle dialysis day of the week. Results: The participants were divided into two groups based on hydration status: the experimental group consisted of 40 overhydrated participants and the control group consisted of 40 normovolemic participants. Statistically, the following BCM parameters correlated significantly positively with PWV: total body fat (r = 0.222; P < 0.05), overhydration (r = 0.290; P < 0.001), and relative overhydration (r = 0.290; P < 0.001). From echocardiography findings, only left atrial diameter correlated statistically significantly positively with PWV (r = 0.359; P < 0.001). Comparison of the mean PWV values within the experimental group before and after HD showed a statistically significant decrease from 14.32 ± 2.34 m/s to 8.72 ± 1.52 m/s (Z = 3.254; P = 0.0001). Mean PWV values within the control group did not decrease significantly from 13.39 ± 1.32 m/s to 10.39 ± 1.18 m/s (Z = 0.524; P = 0.742). If we compare the mean values of PWV between groups, then before HD treatment, there was no statistically significant difference between groups with PWV values in the experimental group of 14.32 ± 2.34 m/s and the control group of 13.39 ± 1.32 m/s (Z = 0.762; P = 0.852). According to the results of univariate regression analysis before and after HD treatment, only overhydration showed an absolute effect on PWV before and after HD. Conclusion: Overhydration showed an effect on brachial-ankle PWV before and after HD, and brachial-ankle PWV should be followed in HD patients.

Introduction: Composite materials may be exposed to chemicals in food and beverages in the oral cavity, which can lead to changes in surface roughness. The aim of this in vitro study was to evaluate the surface roughness of two restorative materials after exposure to coffee and green tea followed by a dental bleaching procedure. Methods: For nanofilled composite and microhybrid composite, 15 samples each were fabricated. Five specimens from each composite were stored in instant coffee and green tea for 4 h a day. After 30 days of immersion, specimens received dental at-home bleaching, using 16% carbamide peroxide (CP), for 7 h a day. The control group was stored in deionized water for 30 days. Surface roughness was determined by profilometry 24 h after polymerization, after 30 days of immersion, and after bleaching. The data were analyzed using a t-test for paired samples and mixed analysis of variance, at a 0.05 significance level. Results: Neither beverages nor CP treatment significantly altered the surface roughness of the composites. There was no difference between the tested composite materials regarding roughness. Conclusion: Surface roughness of the microhybrid and nanohybrid composites was not modified by coffee, green tea, and subsequent whitening treatment.

For a manifold $M$ and an integer $r>1$, the space of $r$-immersions of $M$ in $\mathbb {R}^n$ is defined to be the space of immersions of $M$ in $\mathbb {R}^n$ such that the preimage of every point in $\mathbb {R}^n$ contains fewer than $r$ points. We consider the space of $r$-immersions when $M$ is a disjoint union of $k$ $m$-dimensional discs, and prove that it is equivalent to the product of the $r$-configuration space of $k$ points in $\mathbb {R}^n$ and the $k^{\text {th}}$ power of the space of injective linear maps from $\mathbb {R}^m$ to $\mathbb {R}^n$. This result is needed in order to apply Michael Weiss's manifold calculus to the study of $r$-immersions. The analogous statement for spaces of embeddings is “well-known”, but a detailed proof is hard to find in the literature, and the existing proofs seem to use the isotopy extension theorem, if only as a matter of convenience. Isotopy extension does not hold for $r$-immersions, so we spell out the details of a proof that avoids using it, and applies to spaces of $r$-immersions.

Introduction: Fetal central nervous system (CNS) anomalies are among the most severe and common anomalies, with an incidence of 1: 100 to 1: 500 in newborns. Depending on the type of anomaly, the diagnosis can only be made at specifi c periods of pregnancy. The prenatal ultrasound (US) is an eff ective primary imaging modality for depicting these anomalies, and magnetic resonance imaging (MRI) is a method that provides useful confi rmation and resolves any doubts regarding the diagnosis made on prenatal ultrasound. In situations where ultrasound examination is diffi cult, fetal MRI can provide superior information owing to its many advantages. The aim of this study was to determine the importance of prenatal MRI in making an accurate diagnosis and assessment of fetal CNS anomalies after neurosonographic doubt and in detecting additional anomalies that might have been overlooked on ultrasound, which infl uences clinical decision making and anomaly outcomes. Material and methods: For this research, which was designed as a systematic review of the primary scientifi c research literature, numerous articles were used, i.e.17 scientifi c research papers, published in relevant scientifi c research online databases such as PubMed, Medline, Google Scholar, and the same were published in English in the period from 2015 to 2021. Results: From the assessment of the quality of studies with a cohort design, most studies used in this systematic review are high-quality studies (11 in total) and a smaller number are medium-quality studies (6 in total). Out of 575 cases, MRI confi rmed the ultrasound diagnosis and agreed with it in 59.8% of cases, while in 20.2% of cases, it changed the diagnosis, i.e., in 16.5%, it rejected the ultrasound diagnosis. Additional anomalies detected only on MRI occurred in 236/1225 cases, which totals 19.3% of additional anomalies. Termination of pregnancy was reported in 82/317 cases, accounting for 25.9%, while in 176 cases, the pregnancy continued. A total of 11 cases of neonatal death were reported, and the number of stillbirths or deaths after birth was reported in 8 cases. Conclusion: MRI using T2W SSFSE sequences in 3 planes, T1W and DWI in the axial plane, is a complementary modality to prenatal ultrasound in making an accurate diagnosis and assessment of CNS anomalies and detecting associated anomalies previously overlooked on ultrasound. Keywords: fetal magnetic resonance imaging, fetal neurosonography, fetal central nervous system anomalies, prenatal diagnosis.