This study investigates early‐age carbonate mineralization in cementitious systems using in situ Raman microspectroscopy. In the presence of dissolved CO2, clinker phases undergo accelerated dissolution, decomposing to form various calcium carbonate polymorphs and a transient amorphous silica gel network. Once the available CO2 is consumed, clinker hydration resumes, leading to delayed calcium–silicate–hydrate (C–S–H) and portlandite (Ca(OH)2) formation. The precipitation of portlandite through the pore network triggers a localized pozzolanic reaction at the silica gel–portlandite interface, yielding a distinct calcium–silicate–hydrate (C–S–H*). This templated mechanism produces a homogeneous and highly polymerized binder, leading to improved 24‐h compressive strength compared to reference samples. Correlation function analysis confirms that the evolution of silica gel, portlandite, and C–S–H follows a three‐stage sequence—mineralization, transition, and stabilization—quantitatively demonstrating a strong spatial anticorrelation between silica gel dissolution and portlandite precipitation. These findings establish a new chemomechanical framework for CO2 mineralization in cement, highlighting transient silica gel as a critical intermediate for engineering sustainable, high‐performance concrete.

Abstract This paper presents two offline, on-premise NLP proof-of-concept assistants built on a shared architecture for internal knowledge access in the Central Bank of Bosnia and Herzegovina: (i) a semantic document search tool for internal Word/PDF repositories and (ii) an HR chatbot that applies retrieval-augmented generation (RAG) over indexed HR policies and procedures. Rather than proposing a novel NLP method, the paper contributes by documenting a reusable offline architecture for institutional AI assistants in a security-constrained central banking environment and by providing pilot evidence on how established semantic retrieval and RAG techniques can be adapted to strict requirements of confidentiality, data sovereignty, and governance. The semantic search assistant combines exact phrase matching with embedding-based retrieval and hybrid re-ranking, while the HR chatbot generates source-grounded answers using locally hosted language models under explicit governance constraints, including B/H/S-only output, strict fallback behaviour, and transparent display of retrieved passages. Pilot results indicate that hybrid retrieval offers the most reliable performance across representative internal queries, while the HR chatbot demonstrates the feasibility of document-grounded employee support under offline institutional constraints. The findings provide preliminary evidence that offline NLP assistants can improve access to internal institutional knowledge while remaining compatible with the security and operational risk requirements typical of central banking environments.

Covering: January 2005 to July 2025The interplay between Responsible Research and Innovation, the Nagoya and Cartagena Protocols and other legislative frameworks, ethical practices, and intellectual property protection plays a pivotal role in shaping the field of natural products R&D&I, and the bioeconomy. Together, these elements establish a holistic framework for the sustainable and equitable utilization of natural resources, while promoting innovation and supporting economic growth.

This systematic review analyzed treatment strategies and outcomes for spinal low-grade gliomas, based on data from 63 studies encompassing 954 patients. Surgery was the primary treatment, with gross total or subtotal resection associated with improved survival. Subtotal resection followed by radiotherapy prolonged progression-free survival. Fractionated radiotherapy (45-50 Gy) showed disease stabilization and neurologic improvement, with some studies reporting a 5 year progression-free survival of 93% and an overall survival of 100%. Chemotherapy was mainly used in recurrent cases. Prognosis varied by histology; pilocytic astrocytomas showed excellent survival, while infiltrative gliomas were linked to poorer long-term outcomes.

Hydatidiform mole, the most common form of gestational trophoblastic disease, presents as complete or partial form. Complete hydatidiform mole (CHM) usually presents with prominent histological criteria, whereas partial hydatidiform mole (PHM) shows a wide spectrum of presentations depending on gestational age. Molecular markers enhance the understanding of the variation and heterogeneous presentation of molar pregnancies, as well as their biological potential and behavior. This retrospective study included 50 CHM and 50 PHM specimens, terminated in first trimester via suction curettage. A second histopathological review of slides stained with hematoxylin and eosin was conducted, as well as a selection of representative tissue slides for p53 immunostaining. This study aimed to determine the precise correlation between specific morphological criteria and the patterns of p53 immunoexpression. Semi-quantitative analysis of samples for both pathological criteria and p53 immunostaining was performed. p53 positivity was defined as follow: the percentage of positive cells/nuclei: + (10-40%); ++ (40-70%); +++ (>70%); and staining intensity was scored as: 1 – weak, 2 – moderate, and 3 – strong intensity. P53 expression was estimated on at least 200 nuclei of cytotrophoblasts per slide. Significant difference in p53 expression exist between CHM and PHM in staining intensity. CHM shows significant correlation of p53 positivity with hydrops, central cisterns and atypia. In PHM trophoblast pseudoinclusions demonstrate strong significant correlation with p53 positivity. The irregular pseudoinclusions demonstrate lower expression compared with round or oval, being consistent with benign behavior of PHM. Prominent morphological criteria strongly correlate with p53 immunoexpression for both CHM and PHM.

Countermovement jump (CMJ) performance is widely used to assess explosive lower-limb function in football players. Although knee isokinetic strength is frequently measured in elite sport environments, the extent to which it relates to CMJ performance remains unclear, particularly when CMJ is performed with free arm movement. Therefore, the aim of this study was to examine the relationship between knee isokinetic muscle strength characteristics and CMJ performance in elite male football players. Twenty-four elite male football players (age 23.83 ± 5.98 years) participated in this cross-sectional study. CMJ height was assessed using an optical measurement system (Optojump Next). Concentric knee extensor and flexor peak torque was measured using an isokinetic dynamometer at angular velocities of 60°/s and 180°/s and expressed as peak torque/body weight% (PT/BW,%). Pearson correlation and linear regression analyses were used to examine associations between isokinetic strength variables and CMJ performance. Bilateral differences, hamstring-to-quadriceps (H/Q) ratios, and inter-limb asymmetries were also analyzed. Significant positive correlations were observed between CMJ height and knee extensor peak torque expressed as PT/BW (%) at both angular velocities. Stronger relationships were found at 180°/s (r = 0.558–0.642, p ≤ 0.005) compared with 60°/s (r = 0.483–0.500, p < 0.05). Regression analyses showed that knee extensor strength at 180°/s explained up to 41.2% of the variance in CMJ height. Hamstring strength demonstrated weaker and less consistent associations with CMJ performance, while H/Q ratios and inter-limb asymmetries were not significantly related to jump height. Quadriceps isokinetic strength expressed as PT/BW (%) was significantly associated with CMJ performance in elite male football players, with stronger relationships observed at higher angular velocity. These findings suggest that knee extensor strength assessed at higher angular velocity is meaningfully associated with explosive lower-limb performance and may provide useful complementary information within routine neuromuscular monitoring in professional football.

Lavandula angustifolia essential oil (LEO) was obtained by hydrodistillation of air-dried flowers collected in the Mostar region (Bosnia and Herzegovina). Its chemical composition was analyzed by gas chromatography-mass spectrometry, revealing a camphor content of 16.96%, substantially higher than the maximum value specified in the European Pharmacopoeia. Antimicrobial activity was evaluated using quantitative suspension tests according to EN 1276 and EN 1650 under simulated “dirty” conditions with organic load (bovine albumin, 3 g/L) and a 5 min contact time. High-concentration LEO (80% w/v) exhibited strong bactericidal activity against Escherichia coli ATCC 10536 and Staphylococcus aureus ATCC 6538, and yeasticidal activity against Candida albicans ATCC 10231 (>5 log10 CFU/mL reduction for bacteria, >4 log10 CFU/mL reduction for yeast), but was ineffective against Pseudomonas aeruginosa ATCC 15442 and Enterococcus hirae ATCC 10541. Lower concentrations (1.0% and 0.1% w/v) showed no bactericidal and yeasticidal activity, highlighting LEO’s efficacy limits. Antioxidant activity, assessed by DPPH radical scavenging, was dose- and time-dependent. Molecular docking provided insight into the interaction of major constituents with selected microbial and antioxidant-related targets. These findings highlight both the potential and limitations of LEO as a renewable bio-based resource for sustainable disinfectant formulations while emphasizing the importance of chemical composition and regulatory compliance.

Background/Objectives: Elevated lipoprotein(a) [Lp(a)] is an independent causal risk factor for atherosclerotic cardiovascular disease and may contribute to increased coronary complexity and adverse outcomes after acute myocardial infarction (AMI). Data regarding its prognostic significance in Southeastern Europe remains limited. This study aimed to evaluate the association between elevated Lp(a) levels, coronary artery disease severity, and major adverse cardiovascular events (MACE) at 1 and 6 months after AMI. Methods: This prospective study included 150 consecutive patients with STEMI and NSTEMI enrolled between December 2024 and August 2025. MACE was defined as a composite of overall cardiac death, recurrent myocardial infarction, cerebrovascular insult, heart failure with reduced ejection fraction occurrence, and new revascularization, either PCI or CABG. Results: Patients with elevated Lp(a) had significantly greater coronary disease burden, reflected by higher mean SYNTAX scores (17.3 ± 7.0 vs. 13.8 ± 7.0; p = 0.011) and a greater proportion of intermediate- and high-risk SYNTAX classifications (p = 0.016). Although the number of diseased vessels did not differ significantly, three-vessel disease was more frequent in the elevated Lp(a) group. At 1-month follow-up, overall MACE incidence was numerically higher but not statistically significant between groups. At 6 months, heart failure with reduced ejection fraction was significantly increased in patients with elevated Lp(a) (27.7% vs. 12.2%; p = 0.027). Binary logistic regression demonstrated that elevated Lp(a) independently predicted 6-month MACE (OR 2.768, p = 0.011, 95% CI 1.262–6.072), but not 1-month outcomes. Conclusions: Elevated Lp(a) is associated with increased coronary artery disease severity and higher mid-term MACE risk after AMI.

The rapid expansion of telecommuting has intensified employees’ reliance on digital technologies, increasing the risk of techno-invasion that blurs boundaries between work and personal life. The research seeks to offer an understanding of how telecommuters cope with and reduce the problems brought by techno-invasion. In this quantitative-based research, the theories and hypotheses were rigorously designed based on a literature review, which encompassed some detected knowledge gaps, on the framework of the Job Demands-Resources Theory and Contextual Performance Model. A survey-based data collection method was employed in this study to obtain responses from 153 telecommuters based in Kuala Lumpur. The data were analysed using the SPSS and SMART-PLS4 package. Results indicated no significant relationship between techno invasion and telecommuters’ performance. Furthermore, emotional intelligence did not show a significant moderate effect on the relationship between techno invasion and work exhaustion. These results suggest practical steps for leaders to address work fatigue and burnout caused by technological intrusion by fostering a supportive work culture. This study contributes to the technostress literature by integrating the Job Demands-Resources (JD-R) framework with Contextual Performance Theory and empirically testing a moderated mediation model among Malaysian telecommuters.

Background and Objectives: Diazepam, a GABAA receptor agonist with sympatholytic properties, is sometimes co-administered with antiarrhythmic agents in the emergency management of atrial fibrillation (AF), yet evidence supporting this practice is remarkably limited. Given the established role of sympathetic activation in the initiation and maintenance of AF, we investigated whether adjunctive diazepam influences treatment outcomes. Materials and Methods: This single-centre retrospective cohort study included 72 hemodynamically stable patients presenting with AF to the emergency department of University Hospital Centre Split, Croatia. Patients were stratified by treatment strategy into a rhythm control group (n = 33, receiving any Class IC/III antiarrhythmic) and a rate control only group (n = 39, beta-blockers and/or digoxin). Diazepam was administered orally at the physician’s discretion (median dose 5 mg). Primary outcomes were rhythm conversion and achievement of a heart rate < 110 bpm. Secondary outcomes included changes in heart rate, blood pressure, and time to therapeutic goal. Results: Diazepam was administered to 32 patients (44.4%). In the rate control stratum, spontaneous rhythm conversion was significantly higher with diazepam (40.0% vs. 9.5%; OR 6.33, 95% CI 1.06–37.78, p = 0.046), corresponding to a model-predicted increase in conversion probability from 8% to 33%. This effect was absent in the rhythm control group (64.3% vs. 64.7%; OR 0.98, p = 1.000). Diazepam increased the odds of achieving HR < 110 bpm by 3.46-fold (95% CrI 0.63–23.1, posterior probability of benefit 92%) in the rate control group. Diazepam-treated patients in the rate control group had longer median time to therapeutic goal (4.2 vs. 2.8 h, p = 0.005). In the rhythm control group, diazepam was associated with reduced variability in diastolic blood pressure response (p = 0.006). Conclusions: Adjunctive diazepam was associated with a significantly higher rate of spontaneous rhythm conversion in AF patients receiving rate control therapy only, consistent with sympatholysis removing a key factor sustaining the arrhythmia. This effect was not observed when Class IC/III antiarrhythmics were co-administered, suggesting that diazepam’s benefit is context-dependent. These hypothesis-generating findings warrant prospective validation, with attention to thromboembolic risk in patients who convert unexpectedly.

Limited understanding of the biological processes that govern metastatic dissemination hinders its prevention and treatment1. Here, using 501 longitudinally collected primary and metastatic tumour samples from 24 patients with non-small cell lung cancer (NSCLC) enrolled in the TRACERx lung study and PEACE autopsy programme, we infer tumour evolution from diagnosis to death. With DNA-sequencing data encompassing 70% of the metastases that were radiologically detected before death and paired multi-region sampled primary tumours, we show that the genomes of metastases diverge markedly from those of their ancestral primary tumour, with additional driver alterations and genome doubling events occurring after metastatic dissemination. In 62.5% of patients, multiple primary tumour subclones disseminated, each founding a distinct metastasis. These metastases served as sources of onward spread: more than half of the metastases sampled were seeded by other metastases. The duration that metastases existed in situ influenced their likelihood of seeding further metastases. Most metastatic migrations started and ended in the same anatomical cavity. The few subclones that exited the thorax to seed metastases disseminated widely and were enriched for somatic copy-number alterations, suggesting that chromosomal instability may facilitate extrathoracic spread. This spatial and temporal evolutionary analysis sheds light on the extent of metastatic diversity and seeding in advanced NSCLC—which tends to be underestimated in single metastasis biopsies—and identifies genomic and clinical mediators of metastatic progression. DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

This paper presents the development and experimental validation of an adaptive pneumatic gripper for collaborative robotic palletizing of packages with varying mass and surface characteristics. The main objective is to determine the optimal gripping-force and minimum operating pressure required to ensure stable and safe handling without slippage. A dynamic mathematical model was developed, incorporating the effects of package mass, friction coefficient, contact surface area, and inertial forces during manipulation. Numerical analysis was performed for different friction conditions (μ = 0.30-0.90) and contact configurations, enabling the determination of the minimum required gripping-forces and corresponding operating pressures. Experimental validation was conducted on a real industrial system with a collaborative robot. The results show a linear relationship between pressure and gripping-force, described by F = 22.152 p − 17.535, with a high correlation coefficient (R2 ≈ 0.998). The maximum experimentally obtained gripping-force was approximately 70-75 N at a pressure of around 4 bar. Quantitative deviations between numerical and experimental results (65-75 %) were observed and corrected by introducing a calibration factor (kcorr ≈ 0.30). The proposed model and experimental system enable reliable optimization of gripping-force and improve manipulation stability under real industrial conditions. The main contribution of this study lies in the integration of analytical modelling, numerical optimization, and industrial experimental validation for collaborative robotic palletizing systems

Left ventricular free-wall rupture (LVFWR) is a rare but often fatal complication of acute myocardial infarction (AMI). While typically requiring emergency surgical intervention, spontaneous healing is exceptionally uncommon. This case is noteworthy for the spontaneous resolution of a left ventricular rupture in a hemodynamically stable patient, successfully managed with multimodality imaging and selective surgical revascularization. A 66-year-old white European male with a history of hypertension and smoking presented with non-ST elevation myocardial infarction (NSTEMI) and was managed conservatively. Transthoracic echocardiography showed preserved left ventricular ejection fraction (55%) with lateral wall hypokinesia. The patient was discharged with a recommendation for coronary angiography. 1 month later, he was re-admitted for recurrent chest pain and dynamic electrocardiographic changes. Imaging revealed a rupture of the lateral left ventricular wall, confirmed by multidetector computed tomography (MDCT) and cardiac magnetic resonance (CMR), which showed a thrombus encased in fibrous tissue at the rupture site, along with minimal pericardial effusion. Despite the presence of a contained rupture, the patient remained hemodynamically stable. He underwent urgent coronary artery bypass grafting (CABG) using the left internal mammary artery (LIMA) to the left anterior descending artery. Intraoperatively, no rupture was evident apart from localized discoloration of the affected myocardium. The postoperative course was uneventful. 5 months later, follow-up CMR demonstrated regression of the thrombus and further fibrous remodeling, with restored myocardial integrity and an improved ejection fraction of 51%. Two years post-intervention, the patient remains asymptomatic with stable cardiac function. This case illustrates that not all LVFWRs result in catastrophic outcomes. In selected patients with subacute, contained ruptures, spontaneous healing is possible under close surveillance and guided by advanced imaging. Cardiac CT and CMR were pivotal in characterizing the rupture, confirming myocardial stability, and informing treatment strategy. While surgery remains the standard of care, conservative management may be considered in hemodynamically stable patients, provided careful monitoring and multidisciplinary evaluation are ensured. This case underscores the critical role of multimodality imaging in assessing mechanical complications of AMI and supports the potential for individualized therapeutic approaches.

We identify a novel next-to-leading order renormalization effect in the dimension-six SMEFT with direct phenomenological impact. The Higgs-Yukawa operator that modifies the top-Higgs coupling $\kappa_t$ induces a shift in the $ W $ mass at two-loop order through a large anomalous dimension, rendering electroweak precision observables a powerful indirect probe of $\kappa_t$. We show that this effect is essential for the consistent interpretation of data from future Tera-$Z$ and Giga-$W$ factories such as FCC-ee. The effect is realized in a simple renormalizable two-Higgs doublet model.

Restless legs syndrome (RLS) is frequently reported in peripheral neuropathies, but its prevalence and clinical correlates in Charcot–Marie–Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) remain poorly defined. We aimed to determine RLS prevalence in CMT1A and HNPP and to assess associations with disease severity, muscle strength, disability, and quality of life (QoL).