Millimeter wave (mmWave) systems need beam management to establish and maintain reliable links. This complex and time-consuming process seriously affects communication efficiency. Benefiting from data-driven technology in deep learning, the beam can be predicted from the waveform without coordination between transceivers. By passively listening enough waveforms that are transmitted from the base station (BS) to other receivers, the BS can predict which beam is suitable for transmitting in the downlink. However, training such a waveform learning neural network usually requires a large number of labeled training samples. This is a huge challenge, because it is difficult for the receiver to get the precise signal parameters from the transmitter in advance in the non-cooperative mmWave system. As a result, the limited samples may cause overfitting and seriously restrict the performance. Although the data augmentation technology can improve the performance under limited samples, existing data augmentation methods are mostly based on strong prior knowledge which cannot further exploit the potential characteristics of data in the real environment. This paper proposes a mixed regularization training method for training the beam prediction neural network under limited training samples. Specifically, data augmentation is implemented in the data pre-processing procedure with prior knowledge and then the signal splicing strategy is proposed in the training procedure. In order to mine the time correlation characteristics of signals, the cyclic time shift (CTS) based data augmentation method is proposed in the data augmentation step. The simulation results show that our proposed deep regularized waveform learning method needs less training samples under the same performance. Moreover, the proposed method can achieve best performance compared with existing data augmentation methods.

As technology is the driver of the economy, it is necessary to follow emerging technological trends and to create appropriate conditions for its adoption and implementation as a human-centred technology. In this regard, rules and standards for the Internet of Things (IoT) and Artificial Intelligence (AI) should be established to best use the benefits of technology and to prevent or minimize the consequences of technology misuse. The fifth industrial revolution (Industry 5.0) has already begun, although Industry 4.0 is still developing. Consequently, the original attention has shifted from IoT to AI, with the IoT debate now being a prerequisite for the AI debate. As AI is transforming our lives, a growing number of countries have considered or already adopted national AI strategies. However, in many developing countries, national AI strategies and initiatives for establishing AI and IoT regulation and legislation frameworks yet need to be discussed. The subject of this article is the research of existing initiatives related to establishing the IoT and AI regulatory and legislative framework in the EU and its applicability in developing countries.

Player performance in an intense sport such as basketball is known to be related to attributes such as speed, agility, and power. This study presents a comparative analysis of associations between anthropometric assessment and physical performance in different age groups of elite youth basketball players, while simultaneously identifying the predictors for speed and agility in these players. U14 (n = 44), U15 (n = 45), and U16 (n = 51) players were tested for anthropometry, lower-body power, speed, and agility. U16 players were found to be taller, heavier, more muscular than U14 and U15 players. In addition, the U16 group showed better performance in all performance tests. Age had a significant positive correlation with countermovement (CMJ) and drop jump (DJ) performance in U14 players, and a significant negative correlation with 15m and 20m sprint times in the U15 group. CMJ and DJ emerged as the most significant predictors for sprint and agility variables, respectively. Body fat percentage was found to be a significant predictor for the speed and agility tests in all age groups, but a negative lower-body power predictor. Therefore, besides all sport-specific and fitness tests, it is essential to place emphasis on the percentage of body fat when designing players’ individualized training programs, and during team selection.

Objective: To summarize the existing knowledge about adrenal gland abscesses, including etiology, clinical presentation, common laboratory and imaging findings, management and overall morbidity and mortality. Design: Systematic literature review. Methods: We performed a search in the PubMed database using search terms: ‘abscess and adrenal glands’, ‘adrenalitis’, ‘infection and adrenal gland’, ‘adrenal abscess’, ‘adrenal infection’ and ‘infectious adrenalitis’. Articles from 2017 to 2022 were included. We found total of 116 articles, and after applying exclusion criteria, data from 73 articles was included in the final statistical analysis. Results: Of 84 patients included in this review, 68 were male (81%), with a mean age of 55 years (range: 29 to 85 years). Weight loss was the most frequent symptom reported in 58.3% patients, followed by fever in 49%. Mean duration of symptoms was 4.5 months. The most common laboratory findings were low cortisol (51.9%), elevated ACTH (43.2%), hyponatremia (88.2%) and anemia (83.3%). Adrenal cultures were positive in 86.4% cases, with Histoplasma capsulatum (37.3%) being the leading causative agent. Blood cultures were positive in 30% of patients. The majority of the adrenal infections occurred through secondary dissemination from other infectious foci and abscesses were more commonly bilateral (70%). A total of 46.4% of patients developed long-term adrenal insufficiency requiring treatment. Abscess drainage was performed in 7 patients (8.3%) and adrenalectomy was performed in 18 (21.4%) patients. The survival rate was 92.9%. Multivariate analysis showed that the only independent risk factor for mortality was thrombocytopenia (p = 0.048). Conclusion: Our review shows that adrenal abscesses are usually caused by fungal pathogens, and among these, Histoplasma capsulatum is the most common. The adrenal glands are usually involved in a bilateral fashion and become infected through dissemination from other primary sources of infection. Long-term adrenal insufficiency develops in 46% of patients, which is more common than what is observed in non-infectious etiology of adrenal gland disorders. Mortality is about 7%, and the presence of thrombocytopenia is associated with worse prognosis. Further prospective studies are needed to better characterize optimal testing and treatment duration in patients with this relatively rare but challenging disorder.

Unlike other adverse drug reactions, visceral organ involvement is a prominent feature of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and correlates with mortality. The aim of this study was to systematically review cases published in PubMed-indexed, peer-reviewed journals in which patients had renal injury during the episode of DRESS syndrome (DS). We found 71 cases, of which 67 were adults and 56% were males. Female sex was associated with higher mortality. Chronic kidney disease (CKD) was present in 14% of patients who developed acute kidney injury (AKI) during DS. In 21% of cases, the kidneys were the only visceral organ involved, while 54% of patients had both liver and kidney involvement. Eosinophilia was absent in 24% of patients. The most common classes of medication associated with renal injury in DS were antibiotics in 34%, xanthine oxidase inhibitors in 15%, and anticonvulsants in 11%. Among antibiotics, vancomycin was the most common culprit in 68% of patients. AKI was the most common renal manifestation reported in 96% of cases, while isolated proteinuria or hematuria was present in only 4% of cases. In cases with AKI, 88% had isolated increase in creatinine and decrease in glomerular filtration (GFR), 27% had AKI concomitantly with proteinuria, 18% had oliguria, and 13% had concomitant AKI with hematuria. Anuria was the rarest manifestation, occurring in only 4% of patients with DS. Temporary renal replacement therapy was needed in 30% of cases, and all but one patient fully recovered renal function. Mortality of DS in this cohort was 13%, which is higher than previously reported. Medication class, latency period, or pre-existing CKD were not found to be associated with higher mortality. More research, particularly prospective studies, is needed to better recognize the risks associated with renal injury in patients with DS. The development of disease-specific biomarkers would also be useful so DS with renal involvement can be easier distinguished from other eosinophilic diseases that might affect the kidney.

The goal of our research is improvement of mathematics curriculum and popularization of mathematics among students of economics in developing countries. We analyze and compare curricula of pure mathematics courses that are taught to university students of faculties of economics in Japan and in Bosnia and Herzegovina. Data set contains math syllabuses in 2021/22 school year from six public universities in Bosnia and Herzegovina and seven from Japan. The text corpus was pre-processed and then the Term Frequency – Inverse Document Frequency algorithm, and Sentence Transformed Multi QA model were applied to build word vectors, find the similarity among Japanese and Bosnia and Herzegovina mathematics syllabuses using cosine similarity approach, and to find the key competences of these two countries mathematics syllabuses using the word cloud. Our results show the following similarity between the curricula: 60.7 percent using TF-IDF and 80.3 percent using Multi QA model. The key competences in the Japanese mathematics course are narrow and focused, in contrast to Bosnia and Herzegovina’s.

The complexity of orchestrating Beyond 5G services, such as vehicular, demands novel approaches to remove limitations of existing techniques, as these might cause a large delay in orchestration operations, and thus, negatively impact the service performance. For instance, the human-in-the-loop approach is slow and prone to errors, and closed loop control using rule-based algorithms is difficult to design, as an abundant number of parameters need to be configured. Applying Artificial Intelligence (Al)/Machine Learning (ML), in combination with Network Function Virtualization (NFV) and Software Defined Networking (SDN), seems a promising solution for enabling automation and intelligence that will optimize orchestration operations. In this article, we study the challenges in current ETSI NFV orchestration solutions for B5G C-V2X edge services; propose an Al/ML-based closed-loop orchestration framework; propose how and which Al/ML techniques can alleviate the identified challenges and what are the implications resulting from applying certain Al/ML techniques; and discuss A//ML-based system enablers for B5G C-V2X services.

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis of SCLC is crucial since most patients present with advanced/metastatic disease, limiting the potential for curative treatment. While SCLC exhibits initial responsiveness to chemotherapy and radiotherapy, treatment resistance commonly emerges, leading to a five-year overall survival rate of up to 10%. New effective biomarkers, early detection, and advancements in therapeutic strategies are crucial for improving survival rates and reducing the impact of this devastating disease. This review aims to comprehensively summarize current knowledge on diagnostic options, well-known and emerging biomarkers, and SCLC treatment strategies and discuss future perspectives on this aggressive malignancy.

The aim of this paper is to highlight the importance of a multidimensional approach to the contextual assessment of learning abilities in students with cerebral palsy. The paper presents a case study of a nine-year-old student with multiple developmental disabilities (cerebral palsy and additional influencing difficulties) attending a regular primary school with an individual educational program (IEP). In order to determine the measures for individualizing the educational process for the student, the assessment of internal conditions and learning abilities was conducted individually within a daily rehabilitation center, while the environmental conditions were observed within the school setting. The evaluation of the assessment results emphasized the significance of conducting assessments in all relevant contexts, as it was the only way to obtain a comprehensive understanding of the student's level of functioning and the necessary measures for improving her learning and participation.Key words: multidimensional assessment, learning abilities, cerebral palsy

Helichrysum italicum (Roth) G. Don., immortelle, is a plant species used in ethnomedicine and the food industry as a spice added to food, beverages, and bakery products. It has been shown to possess various biological activities, such as antioxidant and antibacterial activity, making it useful as a natural preservative. We investigated the phytochemical profile and biological activity of H. italicum essential oils from wild-grown plant material collected from natural habitats in the Republic of Croatia and Bosnia and Herzegovina. Using high-resolution scanning electron microscopy (SEM), a visual investigation of plant organs (stem, leaf, and flower) was performed, confirming the presence of essential oil reservoirs on the surface of all examined plant organs. Essential oils were isolated by hydrodistillation in the Clevenger apparatus. The chemical composition of the essential oils was determined using the GC-MS analytical technique. Cytotoxic activity tests were performed in vitro on three cell lines: skin (fibroblast), lung, and breast cancer. Using statistical tools, the synergistic and selective effects of H. italicum essential oil on healthy and tumor cells were correlated to chemical composition and cytotoxic activity. The synergistic and antagonistic effects of H. italicum essential oil’s individual components were simulated by testing pure compounds and their mixture of cytotoxic activity on fibroblasts and breast cancer cells. The results confirm that essential oil’s biological activity is much greater than the sum of the effects of its components. The present data are novel contributions to the body of knowledge on the biological activity of this species used in the food industry.

The main goal of the paper is to examine comprehension of basic emotion and facial expression of children with hearing impairment. The research encompasses a sample of 66 respondents out of which 33 have non-damaged hearing and the remaining 33 respondents have hearing impairment. The age of respondents ranges, in chronological order, from 7 to 15 years. Recognition of emotions and facial expressions is being examined through 4 sets of tasks. The Emotion Recognition Test (ERT) is being used for evaluation, it has been adapted for the purpose of this paper and thereby adjusted for electronic usage via computer and internet. Through statistical processing of given data, following components have been calculated: minimal and maximum values, arithmetic mean, standard deviation, Wilcoxon Signed Ranks Test, Mann-Whitney U test, curvature test and flattening of distribution curve, t-test. Research results concluded that hearing impairment in children affects, with statistical significance, recognition and comprehension of facial expressions and emotions compared to their peers with no hearing impairment. The results were expected given the hearing condition and the consequences which hearing impairment creates. Children with hearing impairment possess poor vocabulary which affects comprehension of emotions. Statistically significant difference occurs among children with hearing impairments and recognition and comprehension of facial expression and emotions within situational context and isolated facial expressions.Key words: deaf children, comprehension of emotions, emotions of the deaf, facial expressions, hearing impairments.

OP-145 and SAAP-148, two 24-mer antimicrobial peptides derived from human cathelicidin LL-37, exhibit killing efficacy against both Gram-positive and Gram-negative bacteria at comparable peptide concentrations. However, when it comes to the killing activity against Escherichia coli, the extent of membrane permeabilization does not align with the observed bactericidal activity. This is the case in living bacteria as well as in model membranes mimicking the E. coli cytoplasmic membrane (CM). In order to understand the killing activity of both peptides on a molecular basis, here we studied their mode of action, employing a combination of microbiological and biophysical techniques including differential scanning calorimetry (DSC), zeta potential measurements, and spectroscopic analyses. Various membrane dyes were utilized to monitor the impact of the peptides on bacterial and model membranes. Our findings unveiled distinct binding patterns of the peptides to the bacterial surface and differential permeabilization of the E. coli CM, depending on the smooth or rough/deep-rough lipopolysaccharide (LPS) phenotypes of E. coli strains. Interestingly, the antimicrobial activity and membrane depolarization were not significantly different in the different LPS phenotypes investigated, suggesting a general mechanism that is independent of LPS. Although the peptides exhibited limited permeabilization of E. coli membranes, DSC studies conducted on a mixture of synthetic phosphatidylglycerol/phosphatidylethanolamine/cardiolipin, which mimics the CM of Gram-negative bacteria, clearly demonstrated disruption of lipid chain packing. From these experiments, we conclude that depolarization of the CM and alterations in lipid packing plays a crucial role in the peptides’ bactericidal activity.

At the beginning of 2020, the Sarajevo-based publishing house El-Kalem, released a biography of Derviš M. Korkut, a Bosniak hero, to whom Yad Vashem posthumously awarded Righteous among the Nations on December 14, 1994. Winston Churchill's words, with which the author begins the biography—that the Balkans produce more history than they can handle—best describe the difficult times in which Korkut lived. For Korkut and his fellow Bosnians, these difficult times lasted from the beginning of the 20th century to its very end. The book is based on exhaustive archival research and reconstructs Korkut’s life very precisely, while the concise overview of the historical circumstances of the 20th century in the Balkans, and in Bosnia and Herzegovina, allows a better understanding of his actions. His defense of his Jewish neighbors began early when the Minister of Interior of the newly established Kingdom of Serbs, Croats, and Slovenes, Milorad Drašković, initiated a procedure for the disenfranchisement of Yugoslav Jews. Korkut took part in the campaign against Drašković’s policies, publicly condemned such a policy, and gave a speech in the town of Derventa, in favor of the Jews When, at the beginning of 1942, Nazi General Johann Hans Fortner came to the National Museum, demanding the handover of the Haggadah—a 15th-century Jewish manuscript brought to Bosnia and Herzegovina by Sephardic Jews who settled in Sarajevo, then part of the Ottoman Empire—Korkut managed to save the Haggadah, risking his own life in doing so (p. 40). Shortly after rescuing the Haggadah, a friend asked Korkut to help a Jewish girl, Donkica Papo (later Mira Baković), whose parents had already been sent to an Ustasha camp. After spending several months hiding in Korkut’s house, he managed to obtain forged documents for her and save her. In 1994, while Bosnia and Herzegovina was ravaged once again by the war, Mira Baković wrote to Yad Vashem, explaining how Derviš and his wife Servet Korkut had saved both her life and the Haggadah. Yad Vashem posthumously awarded him “Righteous Among the Nations” on December 14, 1994 at the Israeli Embassy in Paris (p. 63). This poignant, well-written biography shows not only a life of a truly remarkable man, but also how difficult times throughout the 20th century, reflected on the people in Bosnia and Herzegovina and how they tried to respond to them by preserving the unique Bosnian multi-ethnic, multi-confessional, and multicultural community. The story of Derviš M.Korkut’s life, marked by courage, perseverance, and resistance needs to be given the place in collective memory that it deserves, a task this book achieves. Written in English and thus available to a wider readership, it not only pays tribute to Derviš M. Korkut, but also sheds light on the Sarajevo he sought to preserve at the risk of his life.