Technoeconomic, environmental and safety criteria generally affect the management of metallic and non-metallic mining operations. The first basic question that needs to be addressed when planning ore mining is which methods are adequate and what is the optimal mining technology? Due to the complex geologic framework of ore deposits, geological exploration has rendered synonymous the inherent uncertainties, vagueness, and inaccuracies. As a result, subjective evaluation by engineers and expert experience have become increasingly important. Given that the natural language used by miners and geologists is most suited for relaying knowledge and expressing opinions, the paper tests a fuzzy optimization methodology that uses linguistic variables. Consequently, extent analysis is applied to fuzzy AHP by means of triangular fuzzy numbers to arrive at a decision about the optimal mining technology. The entire procedure constitutes an integrated mine management system, which will contribute to sustainable production in the future. A case study to which the model was applied is presented in the paper.

The review and analysis of a timeline work and stoppage/failure of transportational complex on separation in SC coal mine „Gračanica“ LLC Gornji Vakuf – Uskoplje has been given in this work. The work is based on collecting and analysing data. Collecting data lasted for one year and it is analysed and shown in this work. Rightfully determined the state of work and stoppage/failure, allows precautions and choice of strategy for the next period. Conclusions about which stoppage/failure affected the stoppage of transportational system and separation in full are derived from the research, and based on those conclusions, suggestions about activities which would minimize these stoppages on acceptable value are given. Key words: mine, coal, effective work, stoppage, failure, transportational complex, separation, belt conveyor, scraper.

Due to properties as flammability, explosiveness, suffocation (decreased oxygen content), toxicity (incomplete combustion), large lengths of gas pipelines, risk of leakage, etc., natural gas is media that requires special care during transport and use. There are many examples in the world where unprofessional and negligent use of gas led to unimaginable and tragic consequences with human casualties and huge material damages. This paper analyzes management of accidental situations at the Sarajevo Canton gas system. Problematic aspects of management will be presented through two case studies instead of presenting idealized models that integrate all structures responsible for dealing with such accidental situations. The methodological approach in this paper is presented through selection of accidents on gas network that had a significant impact and required a coordinated response from the competent services. The goal is to consider possibilities of improving technical measures by installing valves with remote control, which would raise safety to a higher level. With this step forward in technical terms, it would be possible to close the valve on gas system in the shortest period of time by controlling it from the dispatch center, which would stop the uncontrolled gas release. The paper will suggest locations where it would be optimal to install valves with remote control, in order to close the necessary section, and at the same time, the least number of consumers would have a gas supply interruption. Key words: gas system, accident, technical measures

Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment of neurodegenerative and metabolic diseases as well as cancer therapies. In the present study, we directly compared 3′-8″-biflavones (amentoflavone, bilobetin, ginkgetin, isoginkgetin, and sciadopitysin) and their monomeric subunits (apigenin, genkwanin, and acacetin) and evaluated their radical scavenging activity (with DPPH), antifungal activity against mycotoxigenic fungi (Alternaria alternata, Aspergillus flavus, Aspergillus ochraceus, Fusarium graminearum, and Fusarium verticillioides), and inhibitory activity on enzymes (acetylcholinesterase, tyrosinase, α-amylase, and α-glucosidase). All the tested compounds showed weak radical scavenging activity, while antifungal activity strongly depended on the tested concentration and fungal species. Biflavonoids, especially ginkgetin and isoginkgetin, proved to be potent acetylcholinesterase inhibitors, whereas monomeric flavonoids showed higher tyrosinase inhibitory activity than the tested 3′-8″-biflavones. Amentoflavone proved to be a potent α-amylase and α-glucosidase inhibitor, and in general, 3′-8″-biflavones showed a stronger inhibitory potential on these enzymes than their monomeric subunits. Thus, we can conclude that 3′-8″-dimerization enhanced acetylcholinesterase, α-amylase, and α-glucosidase activities, but the activity also depends on the number of hydroxyl and methoxy groups in the structure of the compound.

Simple Summary Our study centers on refining the diagnosis of small-cell lung cancer (SCLC), a unique subtype with distinct therapeutic implications compared to other lung cancers. Our primary goal is the identification of specific differentially expressed proteins in SCLC as opposed to healthy lung tissue. Additionally, we aim to discern the protein expression of SCLC from large cell neuroendocrine carcinoma (LCNEC), a closely related entity. This research has the potential to enhance our understanding of these intricate lung cancers, potentially transforming the landscape of detection and tailored treatment strategies. Abstract The accurate diagnosis of small-cell lung cancer (SCLC) is crucial, as treatment strategies differ from those of other lung cancers. This systematic review aims to identify proteins differentially expressed in SCLC compared to normal lung tissue, evaluating their potential utility in diagnosing and prognosing the disease. Additionally, the study identifies proteins differentially expressed between SCLC and large cell neuroendocrine carcinoma (LCNEC), aiming to discover biomarkers distinguishing between these two subtypes of neuroendocrine lung cancers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed/MEDLINE, Scopus, Embase, and Web of Science databases. Studies reporting proteomics information and confirming SCLC and/or LCNEC through histopathological and/or cytopathological examination were included, while review articles, non-original articles, and studies based on animal samples or cell lines were excluded. The initial search yielded 1705 articles, and after deduplication and screening, 16 articles were deemed eligible. These studies revealed 117 unique proteins significantly differentially expressed in SCLC compared to normal lung tissue, along with 37 unique proteins differentially expressed between SCLC and LCNEC. In conclusion, this review highlights the potential of proteomics technology in identifying novel biomarkers for diagnosing SCLC, predicting its prognosis, and distinguishing it from LCNEC.

Simple Summary Merkel cell carcinoma (MCC) is a rare and highly aggressive type of skin neuroendocrine cancer that frequently recurs and metastasizes within a relatively short period. Despite rapid growth and characteristic skin color, MCC often goes undiagnosed in its early stage. Therefore, therapy is often initiated at the advanced stage, and selecting appropriate therapeutic interventions is critical. The emergence of novel immunotherapeutic agents, such as immune checkpoint inhibitors (ICI), presents a promising treatment option for advanced MCC. Several biomarkers, such as PD-L1 expression, tumor mutational burden (TMB), and microsatellite instability (MSI), showed significant potential as predictive biomarkers for treatment with ICI. Despite their predictive value, each has demonstrated limited value in MCC over recent years. Abstract Merkel cell carcinoma (MCC) is primarily a disease of the elderly Caucasian, with most cases occurring in individuals over 50. Immune checkpoint inhibitors (ICI) treatment has shown promising results in MCC patients. Although ~34% of MCC patients are expected to exhibit at least one of the predictive biomarkers (PD-L1, high tumor mutational burden/TMB-H/, and microsatellite instability), their clinical significance in MCC is not fully understood. PD-L1 expression has been variably described in MCC, but its predictive value has not been established yet. Our literature survey indicates conflicting results regarding the predictive value of TMB in ICI therapy for MCC. Avelumab therapy has shown promising results in Merkel cell polyomavirus (MCPyV)-negative MCC patients with TMB-H, while pembrolizumab therapy has shown better response in patients with low TMB. A study evaluating neoadjuvant nivolumab therapy found no significant difference in treatment response between the tumor etiologies and TMB levels. In addition to ICI therapy, other treatments that induce apoptosis, such as milademetan, have demonstrated positive responses in MCPyV-positive MCC, with few somatic mutations and wild-type TP53. This review summarizes current knowledge and discusses emerging and potentially predictive biomarkers for MCC therapy with ICI.

Thanks to the climatic and geographical conditions, the area of the Northwestern part of Bosnia and Herzegovina has a long tradition of producing honey and other bee products. However, there is little or no literature data on the physico-chemical properties and biological activity of different types of honey and other bee products from Bosnia and Herzegovina. Five different types of honey were analyzed: monofloral honey (acacia, chestnut, linden), meadow honey and forest honey. Physico-chemical parameters, sensory analysis, color of honey, antioxidant activity, and content of total phenols were analyzed in five types off collected honey samples. The analyzes performed showed that chestnut honey contains the highest and acacia honey has the lowest content oftotal phenolic compounds. The forest honey showed the best antioxidant activity. The color of the honey was measured according to the CIELab system and the estimated L, a, bparameters show that all types of honey from this area can be characterized asdark types of honey (L50) with the presence of a yellow color. The obtained results show that the analyzed samples of five different types of honey are rich in polyphenolic components and represent a good source of antioxidants in the human diet.KEYWORDS:honey,physico-chemical parameters, color, antioxidant activity, total phenols

We provide observational evidence that suggests the presence of a molten silicate layer above the core of Mars, which is overlain by a partially molten layer, indicating that the core of Mars is smaller than previously thought. The detection of deep reflected S waves on Mars inferred a core size of 1,830 ± 40 km (ref. ^ 1 ), requiring light-element contents that are incompatible with experimental petrological constraints. This estimate assumes a compositionally homogeneous Martian mantle, at odds with recent measurements of anomalously slow propagating P waves diffracted along the core–mantle boundary^ 2 . An alternative hypothesis is that Mars’s mantle is heterogeneous as a consequence of an early magma ocean that solidified to form a basal layer enriched in iron and heat-producing elements. Such enrichment results in the formation of a molten silicate layer above the core, overlain by a partially molten layer^ 3 . Here we show that this structure is compatible with all geophysical data, notably (1) deep reflected and diffracted mantle seismic phases, (2) weak shear attenuation at seismic frequency and (3) Mars’s dissipative nature at Phobos tides. The core size in this scenario is 1,650 ± 20 km, implying a density of 6.5 g cm^−3, 5–8% larger than previous seismic estimates, and can be explained by fewer, and less abundant, alloying light elements than previously required, in amounts compatible with experimental and cosmochemical constraints. Finally, the layered mantle structure requires external sources to generate the magnetic signatures recorded in Mars’s crust.

Extracranial internal carotid artery aneurysms (EICAAs) can lead to serious medical conditions, such as stroke or compression over cranial nerves. In very few cases, there may be hemorrhagic complications due to the rupture. Although rare, they should be suspected cause in every patient with transitory ischemic attack or stroke, especially in the presence of pain, palpable mass or bruit in the neck.