Uvod: Mišićno-koštani poremećaji uzrokovani radom (engl. Work-Related Musculoskeletal Disorders – WRMSDs) najčešća su oboljenja povezana s radom, a opisuju širok dijapazon degenerativnih i upalnih stanja. WRMSDs pogađaju milione radnika na području cijele Evrope i svijeta, a sami poslodavci zbog njihovih posljedica troše milijarde eura. Zdravstvo kao poseban sektor ima jednu od najvećih prevalenci radom uzrokovanih mišićno-koštanih poremećaja (MKP) u svijetu daleko ispred građevinarstva, rudarstva i proizvodnje. Ispitanici i metode: U istraživanje bilo je uključeno 177 zdravstvenih profesionalca oba spola koji su svojim radom aktivno uključeni u pružanje zdravstvenih usluga, kategorizirani prema životnoj dobi i vrsti radnih zadataka koje obavljaju u različitim položajima tijela u okviru svojih stručnih službi. Instrumenti koji su se koristili u istraživanju su standardizirani holandski upitnik za MKP (Dutch Musculoskeletal Discomfort Questionnaire – DMQ), standardizirani upitnik za procjenu indeksa radne sposobnosti (Work Ability Index – WAI) i ergonomski interventni program. Istraživanje je trajalo od januara 2021. do oktobra 2021. godine. Rezultati: Najveća učestalost MKP povezanih s radom kod zdravstvenih profesionalaca prije i poslije provođenja ergonomskog interventnog programa bila je u području vrata (83,1% prije, 64,9% poslije), u regiji gornjeg dijela leđa (71,8% prije, 56,5% poslije) te u regiji donjeg dijela leđa (68,4% prije, 55,9% poslije). Prosječna vrijednost indeksa radne sposobnosti prije uvođenja ergonomskog interventnog programa iznosila je 35,44±8,59, dok se poslije provedenog ergonomskog interventnog programa statistički signifikantno povećala i iznosila je 38,40±7,30. Zaključak: Ergonomski interventni program je utjecao na smanjenje učestalosti MKP uzrokovanih radom, i povećanje radne sposobnost zdravstvenih profesionalaca.

Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction. Current therapeutics for CVDs mainly target disease symptoms. The most common CVDs are coronary artery disease, acute myocardial infarction, atrial fibrillation, chronic heart failure, arterial hypertension, and valvular heart disease. In their treatment, conventional therapies and pharmacological therapies are used. However, the use of herbal medicines in the therapy of these diseases has also been reported in the literature, resulting in a need for critical evaluation of advances related to their use. Therefore, we carried out a narrative review of pharmacological and herbal therapeutic effects reported for these diseases. Data for this comprehensive review were obtained from electronic databases such as MedLine, PubMed, Web of Science, Scopus, and Google Scholar. Conventional therapy requires an individual approach to the patients, as when patients do not respond well, this often causes allergic effects or various other unwanted effects. Nowadays, medicinal plants as therapeutics are frequently used in different parts of the world. Preclinical/clinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common CVDs. The natural products analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in CVDs pharmacotherapy, and some of them have already been approved by the FDA. There are insufficient clinical studies to compare the effectiveness of natural products compared to approved therapeutics for the treatment of CVDs. Further long-term studies are needed to accelerate the potential of using natural products for these diseases. Despite this undoubted beneficence on CVDs, there are no strong breakthroughs supporting the implementation of natural products in clinical practice. Nevertheless, they are promising agents in the supplementation and co-therapy of CVDs.

Abstract Cancer of the cervix has a progressive character and is one of the most significant public health problems in many countries. Our research aimed to translate EORTC QLQ CX 24 (European Organization for Research and Treatment of Cancer; Quality of life questionnaire-cervical cancer 24) from English to Serbian, to create essential cultural adaptations and to analyze psychometric properties of the translation in a model of female inpatients with cancer of the cervix. The QLQ CX 24 was translated and adapted according to internationally established guidelines, and then tested on a sample of 100 Serbian females with cancer of the cervix. The testing was repeated three times on the same patients. We calculated the internal consistency (Cronbach’s alpha), criterion validity, convergent validity, and discriminative validity of the QLQ CX 24. We used factor analysis to discover the original construct. The Serbian translation of QLQ CX 24 showed good internal consistency, showed satisfactory reliability, and temporal stability. In the first, when was rated by the investigators Cronbach’s alpha was 0.607, and one month later when the questionnaire also was rated by investigators Cronbach’s alpha was 0.696. When the scale was rated by females themselves Cronbach’s alpha was 0.802. Divergent as well as convergent validity tests had good results. The factorial analysis exposed six domains. The Serbian translation of QLQ CX 24 is a trustworthy and appropriate specific instrument for measuring the quality of life in females with cervical cancer.

Increased number of children with autism spectrum disorder (ASD) has also heightened interest in finding and providing appropriate interventions. Early intervention is implemented at the moment when deviations are noticed, without waiting for an official diagnosis. Parents are crucial participants in interventions carried out with children; therefore, this research considers interventions focused on training parents to work with children with ASD up to the age of six. For the purposes of this paper, we searched the following journals: Autism, Focus on Autism and Other Developmental Disabilities, and Research in Autism. The search was limited to editions from 2012 to 2022, and the following keywords were considered: parent training, early intervention, autism. References were searched manually. The initial search yielded a total of 992 articles. Twenty-four studies related to children up to six years old and involving parent training in early intervention were included in the analysis. Using a tool for assessing quantitative studies, the selected studies were evaluated, with each component assessed based on the information contained in the study as good, moderate, or weak. The overall rating for the paper can be strong, moderate, or weak. This paper highlights the importance of support to enhance parental competencies.

In the past ten years, there has been significant growth in tourism worldwide, including in Bosnia and Herzegovina. The tourism sector is facing a series of challenges and limitations in the general business environment due to the COVID-19 pandemic, as is the entire global economy. The current pandemic has slowed down the growth of world tourism and thus led to the poorer performance of private tourism subjects and an increase in unemployment in the sector. This study aims to analyse the habits of the inhabitants of Bosnia and Herzegovina and the changes in behaviour caused by the COVID-19 pandemic. The two main questions entertained are: whether socio-demographic variables influenced the intention to travel during the COVID-19 pandemic, and whether tourist travel habits influenced the intention to travel during the COVID-19 pandemic. The study uses a quantitative research approach that included data collection through an online survey. The questionnaire link was distributed electronically, via Facebook (social network), and e-mail. The population included in this research are the inhabitants of Bosnia and Herzegovina. The convenience sample included 265 respondents and the research was conducted for one and a half months (from March 2, 2022 to May 17, 2022). The results of the research show that socio-demographic factors influenced the intention to travel during the COVID-19 pandemic and that respondents who own a car would travel more in 2022 than respondents who do not own a car; that respondents aged 31-50 would travel more in 2022 than the older respondents, that respondents who are employed would travel more in 2022 than pensioners, that respondents living in a household of 1-2 members would travel more in 2022 than respondents living in a household of 5 or more members, that respondents with postgraduate studies would travel more in 2022 than respondents with elementary studies only and that respondents with a monthly income of over 2,500 BAM would travel more in 2022 than respondents with monthly income between 500 to 1,500 BAM. The results also show that those respondents who travelled frequently before the COVID-19 pandemic would travel less in 2022 in the context of the current situation of the COVID-19 pandemic.

Abstract Background Almost 50% of NSCLC patients who initially show a successful response to tyrosine kinase inhibitors targeted therapy (TKI therapy) eventually develop acquired EGFR T790M mutation. The T790M secondary mutation can cause resistance to the targeted therapy and disease relapse. Since this mutation can be present at very low frequencies in liquid biopsy samples, droplet digital PCR (ddPCR), due to its high sensitivity, has opened the possibility for minimally invasive monitoring of the disease during TKI targeted therapy. Materials and methods For this study, a total of 45 plasma samples from NSCLC patients with previously detected EGFR-activating mutations were analyzed. Extracted circulating free DNA was amplified and examined for the presence of T790M mutation using ddPCR technology. For the data analysis, QuantaSoft Software was used. Results Of 45 tested plasma samples, a total of 14 samples were identified as positive for the T790M mutation. The same samples eventually showed the presence of T790M mutation in FFPE. Droplet digital PCR showed its great advantage in high sensitivity detection of rare allele variants. Our ddPCR assay detected T790M mutant allele in frequencies from 0.1%. The average number of droplets generated by ddPCR was 9571. Conclusion Monitoring of the T790M mutation has an important role in the examination of the effects of the prescribed TKI therapy. Since monitoring of potential changes during TKI therapy requires repeated sampling, our results showed that ddPCR technology has made it possible to use liquid biopsy as an adequate minimally invasive alternative for single nucleotide polymorphisms (SNP) detection.

This paper investigates the application of Adaptive Fuzzy PID Control in the context of car control using a bilateral teleoperator. A bilateral teleoperator allows the operator to operate a remote car using his own controls and at the same time receive feedback on the car’s condition. The goal of the research is the analysis and comparison of different control methods, including PID controller, Adaptive Fuzzy PID controller, and the use of energy and wave variables of the bilateral teleoperator. The paper presents a car control model by means of a bilateral teleoperator, which was implemented in a simulation environment. Then performance comparisons of different control methods were made. The PID controller was used as the basic method, while the Adaptive Fuzzy PID controller was additionally included to achieve system adaptivity. Also, the use of energy and wave variables of the bilateral teleoperator was additionally investigated. The results of the comparison show that the use of bilateral teleoperator wave variables gave the best response of the control system. The analysis of signal waveforms and frequencies enabled more precise monitoring of the car’s condition and the detection of possible problems or instability in the system. This knowledge can be of great importance for improving the performance of car control by means of a bilateral teleoperator.

Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various diseases and it accounts for around 25 % of serious side-effects reported after drug administration. Furthermore, some groups of drugs such as nonsteroidal anti-inflammatory drugs, antibiotics, antiviral drugs, antifungal drugs, immunosuppressants, and chemotherapeutic drugs have the "preference" for damaging the kidney and are often referred to as the kidney's "silent killer". Clinically, the onset of acute kidney injury associated with drug administration is registered in approximately 20 % of patients and many of them develop chronic kidney disease vulnerability. However, current knowledge about the mechanisms underlying this dangerous phenomenon is still insufficient with many unknowns. Hence, the valuable use of these drugs in clinical practice is significantly limited. The main aim of this study is to draw attention to commonly prescribed nephrotoxic drugs by clinicians or drugs bought over the counter. In addition, the complex relationship between immunological, vascular and inflammatory events that promote kidney damage is discussed. The practical use of this knowledge could be implemented in the engineering of novel biomarkers for early detection of drug-associated kidney damage such as Kidney Injury Molecule (KIM-1), lipocalin associated with neutrophil gelatinase (NGAL) and various microRNAs. In addition, the utilization of artificial intelligence (AI) for the development of computer algorithms that could detect kidney damage at an early stage should be further explored. Therefore, this comprehensive review provides a new outlook on drug nephrotoxicity that opens the door for further clinical research of novel potential drugs or natural products for the prevention of drug-induced nephrotoxicity and accessible education.

Museum development is a side effect of tourism development since museums are significant components of cultural and tourist infrastructure, and tourism encourages infrastructure development in general. In Bosnia and Herzegovina, where tourism is a critical sector of the economy with a decades-long flow, the pattern of comparative development of tourism and museums has been recognized. The study provides a comparative review of the country's tourism and museum development, showcasing the multiple benefits of tourism and museums. Museums are one of the most important socio-cultural benefits of tourism because they preserve and present heritage, improve science, education, and cultural profiling, encourage employment and visitation, provide a better stay, generate income, and contribute to environmental urbanization and higher living standards. The identification of museums and museum resources revealed that, during the past three decades, approximately thirty museums of a predominantly thematic character have been established, particularly in the country's most visited destination (Sarajevo). Furthermore, an open-air museum (ethno-village) trend has begun. Museum visitation is increasing in tandem with tourist trips to the country, despite a lack of adequate monitoring (incomplete figures that are inconsistent with the situation in the field). Despite the fact that the global crisis disrupted tourism and museum development (COVID-19), both areas are key drivers of economic revitalization, as evidenced by new ideas and projects in this field. However, in addition to the benefits of increased museum activity, the study highlighted certain issues (e.g., lower engagement of professional staff and women etc.), which will encourage future research to provide more sustainable strategies for museum development.

Abstract Tourist boards, through their social activities, can make a tourist destination, tourist attractions and tourist products attractive, unique, and special. Through relevant scientific knowledge, using the tools and techniques of destination management as well as modern forms of communication, tourist boards can make the entire area of a tourist destination very interesting and desirable for tourist visits throughout the year by promoting the specificity, authenticity and originality of the tourist offer and tourist products. Keywords: tourist board; tourism promotion through sports and sports recreation competitions; tourism promotion through social networks, tourism

Abstract Voltage unbalance is common issue encountered in low voltage distribution networks, caused by uneven allocation of single-phase customers among phases. This paper analyses part of real low voltage distribution network in Bosnia and Herzegovina. The impact of single-phase customers and single-phase connected micro photovoltaic power plants (MPPP-s) were analysed. To reduce unbalance and improve voltage profiles, Phase Balance Optimization toolbox in DIgSILENT PowerFactory software was performed in six scenarios with different distribution of customers and different percentage of penetration of MPPS-s. The aim was to find method with least number of changes in customer and photovoltaic phase connection that fits within defined limits of voltage variations and voltage unbalance of European standard for power quality (EN 50160). Conclusion is that MPPP-s cause voltage increases in the network, as well as an increase in voltage unbalance, but these effects can be mitigated by proper distribution of customer loads and MPPS-s among phases.

This paper is about the parameter identification of an energy based hysteresis model from measurements by employing automatic differentiation and neural networks. We first introduce the energy based hysteresis model and the parameters which are to be identified. Then we show how the model can benefit from automatic differentiation. After that we incorporate a parametrization of the energy based hysteresis model via distribution functions and identify the parameters of the distribution function. Then, the hysteresis model is sampled and the generated datasets are used to train neural networks to predict the hysteresis parameters. The described methods are tested and verified on synthetic as well as measurement data.

The aim of this study was to investigate the mechanical behavior of beech and fir finger joints under laboratory conditions. The samples were manufactured using a 9 mm finger joint with glued surfaces, in accordance with the EN 14 080 standard. Polyurethane adhesive of class D3, commonly used for the production of exterior wooden structures in Bosnia and Herzegovina, was applied to the samples. The specimens were subjected to destructive four-point bending tests according to the BAS EN 408 standard, and the achieved bending strength was statistically evaluated and compared to the results of unglued samples.

Timber structures have been a popular choice for construction due to their natural and aesthetic appeal. However, with the increasing focus on sustainability and eco-friendliness, alternative building materials are gaining popularity. One such material that has gained attention is coconut wood. Coconut wood is a by-product of the coconut industry and has several unique properties that make it an excellent choice for timber structures. This paper reviews the properties and applications of coconut wood in timber structures and discusses its advantages, limitations, and challenges. We discussed the physical and chemical properties and durability of coconut wood. The average density of coconut palm wood ranges from 0.41-1.11g/cm3, while its moisture content ranges from 50% to 400%. Coconut wood has low shrinkage and swelling rates, reducing the risk of cracking or warping. The holocellulose content is about 67% while the lignin content is approximately 25%. Chemical and natural products, are effective in protecting coconut wood against decay and insect attack. Understanding such characteristics of coconut wood is critical for its optimal utilization in various industries. By employing appropriate preservation techniques and utilizing this versatile and sustainable resource, coconut wood can continue to provide significant benefits for communities and industries around the world.