Background Ikigai (meaning or purpose in life) is a concept understood by most older adults in Japan. The term has also garnered international attention, with recent academic attempts to map it to concepts in the Western well-being literature. In addition, efforts to use social and home robots to increase well-being have grown; however, they have mostly focused on hedonic well-being (eg, increasing happiness and decreasing loneliness) rather than eudaimonic well-being (eg, fostering meaning or purpose in life). Objective First, we explored how Japanese older adults experience ikigai and relate these to concepts in the Western well-being literature. Second, we investigated how a home robot meant to promote ikigai is perceived by older adults. Methods We used a mixed methods research design—including 20 interviews with older adults, a survey of 50 older adults, and 10 interviews with family caregivers. For interviews, we asked questions about older adults’ sources of ikigai, happiness, and social support, along with their perception of the robot (QT). For surveys, a number of well-being scales were used, including 2 ikigai scales—ikigai-9 and K-1—and 6 Patient-Reported Outcomes Measurement Information System scales, measuring meaning and purpose, positive affect, satisfaction with participation in social roles, satisfaction with participation in discretionary social activities, companionship, and emotional support. Questions related to the perception and desired adoption of the robot and older adults’ health status were also included. Results Our results suggest that health is older adults’ most common source of ikigai. Additionally, although self-rated health correlated moderately with ikigai and other well-being measures, reported physical limitation did not. As opposed to social roles (work and family), we found that ikigai is more strongly related to satisfaction with discretionary social activities (leisure, hobbies, and friends) for older adults. Moreover, we found that older adults’ sources of ikigai included the eudaimonic aspects of vitality, positive relations with others, contribution, accomplishment, purpose, and personal growth, with the first 3 being most common, and the hedonic aspects of positive affect, life satisfaction, and lack of negative affect, with the first 2 being most common. However, the concept of ikigai was most related to eudaimonic well-being, specifically meaning in life, along the dimension of significance. Finally, we found that Japanese older adults have high expectations of a home robot for well-being, mentioning that it should support them in a multitude of ways before they would likely adopt it. However, we report that those with the highest levels of meaning, and satisfaction with their leisure life and friendships, may be most likely to adopt it. Conclusions We outline several ways to improve the robot to increase its acceptance, such as improving its voice, adding functional features, and designing it to support multiple aspects of well-being.

Modular quantum processor architectures are envisioned as a promising solution for the scalability of quantum computing systems beyond the Noisy Intermediate Scale Quantum (NISQ) era. Based upon interconnecting tens to hundreds of quantum processors (i.e cores) via quantum coherent and classical links, this approach unravels the pressing limitations of densely qubit-packed monolithic processors, mainly by mitigating the requirements of qubit control and enhancing qubit isolation. Therefore, this new architectural design enables executing large-scale algorithms in a distributed manner. In order to assess the performance and optimize such architectures, it is crucial to analyze the quantum state transfers occurring via inter-core communication networks, referred to as inter-core qubit traffic. This would provide insights to improve the software and hardware stack for multi-core quantum computers. To this aim, we present a characterization of the spatio-temporal inter-core qubit traffic for different large-scale quantum algorithms. The programs are compiled on an all-to-all connected multi-core architecture that applies the teleportation protocol for inter-core state transfer and supports up to around 1000 qubits. We characterize the qubit traffic based on multiple performance metrics to assess the computational process and the communication overhead. Based on the showcased results, we conclude on the parallelization and scalability of presented algorithms, qualitatively evaluate the resource requirements as we scale circuit sizes, and lay the foundations of application-oriented benchmarking of large-scale multi-core architectures.

Uncontrolled acetylene release during production processes, transportation, or storage can lead to explosions and detonations endangering safety of people and material assets. This paper investigates the impact of accidental release of acetylene gas in surrounding areas. The ALOHA software has been used in this paper to modelling of acetylene release. The modelling was performed for an accidental release of 2,000 kg acetylene from direct source for one minute. F or a typical average atmospheric condition in location, this accidental acetylene release would cause a red zone of 197 m (15,000 ppm) and yellow zone of 483 m (2,500 ppm) to downwind from the source. Inadequate storage can lead to accidental situations and negative impact on people and the environment.

Self-rated health is associated with health behaviour and socio-demographic and socio-economic conditions on the way that health risks and poor socio-economic status determine poor self-rated health. The aim of the study was to determine self-rated health among students, perceive health behaviour risk and association with socio-demographic and socio-economic characteristics of students. Methods: Study is conducted as a cross-sectional study among students of health sciences in autumn semester 2022. Year. Specially designed questionnaire was constructed based on international guidelines. Anonymously filling out an on line formed questionnaire by voluntary singing on university web site. Results: More than three quarter of students perceived their health as a good and no one perceived health as a poor. Most students perceived their health as good (83,2%), mainly students with a technical background and those who are living in good socio-economic conditions (89,0%) (p0,05). The most frequent health risks among students are lack of physical activity (44,5%) and less than six hours for sleep and rest (43,8%). More than a third of students perceived fear, nervousness and tension (34,3%), a lack of time for friendship and family (33,6%) and irregular diet (31,4%). Every seventh student perceived overweight and obesity. Students who are living in poor socio-economic conditions perceived more health risks as well as those who don’t have medical background and who are employed. More students in urban area perceived mental problems than those in rural areas. Conclusion: Students are mainly perceived their health as a good and have health risks which will be reduced through health promotion in university educational programmes.

Lifestyles develop throughout the life, but adolescence and early youth are important stages in acquiring healthy lifestyles habits. This is also vulnerable period for substance misuse, worsened diet habits and sedentary lifestyles linked to academic activities and responsible for developing non communicable diseases (NCD). Goal of the article is to analyse lifestyles habits and risk factors for developing NCD among students of health sciences. Study is conducted at the University Apeiron, Faculty of Health Sciences among students from first to fourth years of study. Specially designed questionnaire was prepared and distributed on line, anonymously and voluntary fulfilled by students. Every fifth student is smokers, 5,1% consume alcohol daily, more males (12,1%) than females (2,9%) (p0,05). Majority of males (42,2%) consumed alcohol drinks in one occasion during previous month, statistically more than females (21.2%) (p0,05). More than two third of students eat fruits and vegetables daily and one third have regular meals. Moderate physical active are 42,3% of students, and physical inactive are more females than males (p0,05). Risk factors for NCD have to be prevented with supportive policies in school environment and community. Students of health sciences should be a positive model of changing risk habits for NCD and saving future quality of life.

Medicinal plants play a major role in the development of human cultures. Medicinal plants are a rich source of phytochemical compounds, which have proven therapeutic efficacy throughout the ages. The therapeutic efficacy is attributed to those secondary biologically active compounds. Plants have provided the human being with all his needs of food, drink, and clothing. In addition they are an important source for the treatment of many diseases being the basis of the science of alternative medicine, In recent times, the area cultivated for these medicinal plants has increased, and scientific research has tended to study the effectiveness of these plants in treating many diseases. Most plants have an effective effect as an antioxidant, anti-hyperlipidemia, hypoglycemic, antihypertensive as well as for cardiovascular diseases and strokes. The study aims to provide important data on the extent to which some medicinal plants are used in the treatment of various diseases.

Wind Farm Podveležje is located on the plateau Podveležje, about 10 km east of the city of Mostar, in the center of the Herzegovina-Neretva Canton. The Wind Farm consists of 15 wind turbines, each with a power of 3.2 MW, making a total capacity of 48 MW. The geological structure of the surrounding area on the Podveležje plateau is very complex due to its intricate tectonic complex, ranging from layered to thinly layered Upper Cretaceous limestone with Turonian-aged radiolites as the bedrock. Cracks are often highly prominent, filled with rock weathering products, terra rosa and clay material. During geological and geotechnical investigations at foundation locations, caverns were identified in certain places. The program of additional works (destructive boreholes and TV logging) was carried out to delineate the cavern locations on WT-3, WT-4, WT-8, WT-12, WT-15, and WT-16 plateaus. The aim of the paper is to describe the cavern rehabilitation at locations of wind turbine foundation including substrate preparation, filling procedures, mixture composition, and performing destructive boreholes to verify rock mass compactness.

The research was carried out on a sample of 1000 (500 male and 500 female) students randomly selected from several faculties within the AAB College in Pristina, Kosovo. Respondents were treated in accordance with the Declaration of Helsinki. For the assessment of physical activity, the international questionnaire (InternationalPhysical Activity Questionnaire IPAQ). To assess the state of nutrition, morphological parameters were applied: body height, body weight and body mass index. Descriptive analysis, non-parametric technique of difference within the group as well as regression analysis were applied to process the results. The obtained results show that the average height of the student population is Mean = 174.74±8.6; body weight, mean= 70.88±12.7; body mass index, Mean = 23.1±3.3. The prevalence of overweight is 26.1%, while obesity is 2.8%. The results obtained are almost the same as the countries in the region. The survey for the assessment of physical activity indicates an insufficient involvement of students in physical activities that corresponds to the prevalence of overweight. When asked how much time you usually spend sitting during a working day, the prevalence of 2-7 hours is 84.6%. Regression analysis shows a correlation between inactivity during the day and body mass index. The data show a trend towards increasing obesity in the student population and this is an extremely powerful reason for: the Ministry of Youth, Culture and Sports, for the Ministry of Education, for Universities and Colleges, tocreate conditions for the highest possible participation of students in sports and recreational activities.

Abstract This study presents findings on the indicators of educational displacement as an early risk factor for radicalization in school settings in the U.S. We collected and analyzed data from 301 students living in 43 U.S. states to inform the creation of Reimagine Resilience, an innovative violence prevention training program for educators and educational staff developed at Teachers College, Columbia University, and to measure early indications of educational displacement as a risk factor for radicalization. The study shows that poor teacher-student relations and multiple experiences of biased speech and behavior are significant early predictors of the students’ educational displacement. Educational displacement, in this study, is measured as a lack of social belonging in schools.

Abstract Reimagine Resilience (2023), designed and established at Teachers College, Columbia University, is an innovative program that builds awareness and understanding among educators and educational personnel in the U.S. on the precursors and causes of educational displacement in students, supporting educators in promoting belonging, connectedness, and resilience to prevent educational displacement, extremism, and radicalization among students in their schools and classrooms. The study demonstrates the effectiveness of the Reimagine Resilience Program in producing attitudinal shifts in participating education personnel as they cultivate an awareness of their own biased speech and conduct. Further, this study spotlights the Program’s efficacy in identifying ways to actively prevent educational displacement as educators gain new knowledge of protective and risk factors for radicalization and targeted violence. This study underscores the importance of innovation in pedagogy, practice, assessment, and professional training for educators and educational staff to effectively engage educators in extremism and violence prevention.

Analyzing students’ academic performance is important for evaluating enrollment criteria which establish the standards required for pupils who finished secondary school to gain admission to a higher education institution. The aims of this research were to develop a machine learning prediction Decision Tree classifica-tion model and analyze the performance of engineering students based on their performances during second-ary school education. The performance of students was analyzed and measured as a binomial response whether students successfully finished the first and the second study years. The developed model examined general success, number of awards obtained at competitions, special awards, average grades in mathematics, physics, and one of the official state languages during secondary school as predictor variables. The number of courses transferred from the first into the second study year and students’ GPA obtained during the first study year were added as predictor variables in the analysis and development of a prediction model for the students’ performance during the second study year and their enrollment in the third study year. Developed machine learning prediction model showed that for the performance of enrolled students in the first study year general success of students during secondary school is the most important predictor variable, followed by mathematics and physics grades. However, for the performance of the students enrolled in the second study year the most important predictor variable was number of the courses transferred from the first into the second study year, followed by students’ GPA obtained during the first study year and general success. Machine learning Decision Tree classification modeling was shown to be an adequate tool for the prediction of the performance of engineering students during the first and second study years.

In the current study, we assessed the prevalence and molecular features of HER2-low phenotype in the apocrine carcinomas of the breast (ApoCa) and its relationship with tumor-infiltrating lymphocytes (TILs). A cohort of 64 well-characterized therapy-naïve ApoCa was used. The TIL distribution was assessed using the hematoxylin and eosin whole slide/scanned images following the international TILs working group recommendations. Next-generation sequencing (NGS) was performed in a subset of HER2-low ApoCa. All patients were women, with a mean age of 62 years. Forty-three carcinomas were pure apocrine carcinoma (PAC; ER−/AR+), and the remaining 21 were classified as apocrine-like carcinomas (ALCs; ER+/−, AR+/−). HER2/neu was positive (score 3+ by IHC and/or amplified by FISH) in 20/43 (47%) PAC and 4/21 (19%) ALC. The prevalence of HER2-low expression (scores 1+ or 2+ without HER2 amplification) in ApoCa was 39% without significant differences between PAC and ALC (P ═ 0.14); however, the HER2-low phenotype was more prevalent in triple-negative PAC than in ALC (P < 0.001). Levels of TILs were low (≤10%) in 74% of ApoCa (median: 5%, range 0%–50%). TIL levels were significantly higher in ALC than in PAC (P ═ 0.02). HER2 status had no impact on TIL distribution (P ═ 0.45). The genomic profile of HER2-low ApoCa was similar to other subtypes of ApoCa. ApoCa has predominantly low TIL, particularly PAC. The prevalence of the HER2-low phenotype in ApoCa is high, which should have therapeutic and clinical implications given the recently approved therapies with antibody–drug conjugates (ADCs) for HER2-low breast cancers.

OBJECTIVES Infection is still the leading cause of morbidity and mortality among burn patients worldwide. Isolation and identification of pediatric burn wound bacterial colonizers can prevent infection and improve burn trauma treatment. In this study, we explored early microbial colonizers within the burn wounds and the susceptibility of those isolates to antibiotics among hospitalized pediatric patients with minor and moderate burns, clinically significant infections and outcomes. METHODS A retrospective analysis of pediatric patients admitted to the inpatient pediatric surgical ward and treated for minor and moderate burns from 2009 to 2018 was performed. RESULTS One hundred six patients met the inclusion criteria. The mean age was 3.6 ± three years (0.2-14.1 years). The most common type of burn was scald burns (82.1%). The mean TBSA of the hospitalized pediatric burn cases was 8.5% (IQR, 6-12%). Seventy-nine (74.5%) patients had positive wound cultures at admission, regardless of the hospital admission day. Fifty-eight (73.4%) had one bacterial growth (mono isolate), while 21 (26.6%) had mixed growth or poly isolates. Among patients with mixed growth or poly isolate, 16 had two bacteria, three had three bacteria, and one had four bacteria isolated, totaling 105 isolated microorganisms (14 different species, 70.5% Gram-positive bacteria and 29.5% Gram-negative bacteria). Twelve patients (11%) developed clinically significant infections (eleven got burn wound infection, and one had septicemia). All patients received prophylactic systemic antibiotics. Only 35.2% of the isolated bacteria from the wounds were sensitive to the prophylactic antibiotics, and only ∼17% in case of clinically significant infections. We found a statistically significant difference in the length of hospital stay between patients with initially colonized samples of burn wounds compared with patients with initial negative samples (p = 0.008). All patients in the cohort survived hospital discharge. CONCLUSION Despite common bacterial colonization of acute burn wounds, only ∼10% of the patients developed clinically significant infections, a minority of which were sensitive to prophylactic antibiotics. Our findings indicate the need to refine the antibiotic approach in pediatric patients with minor/moderate burns in our local setting.

INTRODUCTION Early diagnosis and treatment of primary vesicoureteral reflux (VUR) are essential for preserving renal function. OBJECTIVES The study explored whether preoperative cystoscopic grading of refluxing ureteric orifices (UO) correlated with their shape in an institution with non-performance of hydrodistention of the UO in the diagnosis and grading of VUR. We also assessed the relationship between the UO shape and VUR grade with the effectiveness of endoscopic correction of primary VUR in children. METHODS This retrospective study included consecutive patients ≤15 years treated for primary VUR. The reflux grade was based on the results of preoperative voiding cystourethrography as mild, moderate, or severe. RESULTS Fifty-one patients with 77 renal refluxing units (RRU) underwent endoscopic treatment with Deflux®. VUR was bilateral in 51 % of patients. VUR was mild in 13 %, moderate in 53 %, and severe in 34 % of cases. The patients with mild and moderate VUR had stadium-shaped UOs in 60 % and 54 % RRUs, respectively. Horseshoe-shaped UOs constituted 42 % of UOs in patients with severe VUR, followed by 31 % of golf-hole UOs. The reflux resolution rate after the first endoscopic injection was 84 %. The preoperative VUR grade correlated with UOs shape (p < 0.001). No significant correlation between UOs configuration and the outcome of endoscopic treatment was seen (p = 0.452). The preoperative VUR grade negatively correlated with a favorable endoscopic treatment (p = 0.043). DISCUSSION AND CONCLUSION Our data indicate ureteral orifice shapes are closely related to preoperative VUR grade. There was no correlation between the UO configuration and the success rate of endoscopic treatment of VUR, in contrast to the significant negative correlation between the VUR grade and the success rate of endoscopic treatment.