Using a strong-field-approximation theory, we investigate the high-order above-threshold ionization of diatomic molecules exposed to the monochromatic and bichromatic elliptically polarized fields. We devote particular attention to the difference between the photoelectron momentum distributions obtained with fields with opposite helicity. This difference is quantified using the elliptic-dichroism parameter, which represents the normalized difference between the differential ionization rates calculated with driving fields with opposite helicity. We find that this parameter strongly depends on the molecular orientation with respect to the laser field. In addition, this dependence is different for molecules with different types of highest-occupied molecular orbital. In other words, we show that the molecular structure is imprinted onto the elliptic-dichroism parameter for both monochromatic and bichromatic driving fields. This is explained by analyzing the interferences between various partial contributions to the differential ionization rate. In this way, elliptic dichroism also serves as a tool to analyze the electron dynamics. Finally, for heteronuclear diatomic molecules, we show that the elliptic dichroism is different from zero even for the direct electrons, i.e., the electrons that after liberation go directly to the detector. In this case, the dependence on the molecular orientation is far more pronounced for a bichromatic driving field.

Introduction After 2000, there are more obese than underweight people in the world. We face a rapid increase in average global warming of 1.5°C, reported as a syndemic problem of three interconnected epidemics: obesity, global warming, and undernutrition. We aimed to analyze the impact and association between global warming and obesity in children and differences by gender across Europe after 2000. Methods We searched PubMed, MEDLINE, Google Scholar, ScienceDirect, and Embase databases. The considered population were children aged 6–14. Only cross-sectional studies that defined obesity by the IOTF cutoffs and the subjects’ place of residence, used to determine precise climate zones, were included. We assessed the prevalence of obesity and overweight using a random-effects and the Mantel–Haenszel fixed-effect method when heterogeneity was greater/lower than 50%. We did a subgroup analysis for prevalence across gender, obesity, and overweight, two decades, regions, countries, and the Köppen–Geiger climate zones. Random effects of the meta-regression were used to study the global warming impact and differences in trends across European countries by gender for both conditions separately. Results We identified 114 studies that included 985,971 children from 39 European countries. A significant difference between genders was in favor of obese girls 4.78 (95% CI: 3.85–5.93) versus boys 5.76% (95% CI: 5.11–6.48, p = 0.03), respectively, but not for overweight children. Most of the obese girls were in South Europe 7.51% (95% CI: 6.61–8.51) versus East Europe 2.86% (95% CI: 23–3.12), versus boys in South Europe 8.66% (95% CI: 7.68–9.74) and North Europe 3.49% (95% CI: 2.90–4.19), respectively. The “cold” Köppen–Geiger climate zone, with lowest temperatures, has the largest trend rise between two decades of 2.8% and 1.53% for obese girls and boys, and 5.31% and 1.81% for overweight girls and boys, respectively, followed by the smallest number of obese girls 3.28% (95% CI: 2.17–4.92) and boys 3.58% (95% CI: 2.39–5.33), versus the zone with the highest temperatures “hot” for girls 7.02% (95% CI: 6.30–7.82) and for boys 8.23% (95% CI: 7.55–8.96), respectively. The meta-regression proved global warming has a significant impact on the distribution of obesity and overweight across climate zones, R2 = 0.52 and R2 = 0.22. No significant gender differences, or significant interaction, was noted. Conclusion Our meta-analysis provides a comprehensive overview of the association between and impact of global warming on obesity. This impact increases obesity among children in Europe throughout all climate zones, and emphasizes an urgent call for further preventive methods in schools, since obesity differences continue their trend of disappearing into the future. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021282127, identifier: CRD42021282127.

We propose an economical model to address the mass hierarchies of quarks and charged leptons. The light generations of the left-handed fermions form doublets under an SU(2)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \textrm{SU}(2) $$\end{document} flavor symmetry, which is gauged. The generational hierarchies emerge from three independent rank-one contributions to the Yukawa matrices: one is a renormalizable contribution, the second is suppressed by a mass ratio, and the last by an additional loop factor. The model is renormalizable, features only a handful of new fields, and is remarkably simple compared to typical completions of gauged flavor symmetries or Froggatt–Nielsen. The model has a rich phenomenology, and we highlight promising signatures, especially in the context of K and B meson physics. This includes an interpretation of the latest B+→K+νν¯\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$B^+ \rightarrow K^+ \nu \bar{\nu }$$\end{document} measurement from Belle II.

Abstract Dietary creatine has been recently put forward as a possible intervention strategy to reduce post‐COVID‐19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel‐group, randomized placebo‐controlled double‐blind trial, we analyzed the effects of 6‐month creatine supplementation (4 g of creatine monohydrate per day) on various patient‐ and clinician‐reported outcomes, and tissue creatine levels in 12 patients with post‐COVID‐19 fatigue syndrome. Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3‐month and 6‐month follow‐ups (p < .05). Two‐way analysis of variance with repeated measures revealed a significant difference (treatment vs. time interaction) between interventions in tissue creatine levels (p < .05), with the creatine group was superior to placebo to augment creatine levels at vastus medialis muscle, left frontal white matter, and right parietal white matter. Creatine supplementation induced a significant reduction in general fatigue after 3 months of intake compared to baseline values (p = .04), and significantly improved scores for several post‐COVID‐19 fatigue syndrome‐related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6‐month follow‐up (p < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post‐COVID‐19 fatigue syndrome; additional studies are warranted to confirm our findings in various post‐COVID‐19 cohorts.

Abdominal pain is highly prevalent in patients with inflammatory bowel disease (IBD) in remission, but the aetiology is incompletely understood.

Background Pharmacotherapy literacy (PTHL) is a specific ability to safely access, appraise and understand the available information concerning medication and to calculate and act accordingly. The concept of PTHL is mostly unknown for the majority of diabetes mellitus type 2 (DMT2) patients in Serbia. With diabetes being one of the major public health problems in Serbia with a prevalence of 9.1%, this two-study research aims at constructing performance-based instrument and estimating the prevalence of PTHL levels and identification of predictors of low PTHL scores in patients with DMT2. Methods Multistage study was performed to adapt the existing performance–based instrument (PTHL-SR) into specific questionnaire for DMT2 population (PTHL-DM instrument). PTHL levels were assessed through cross-sectional study categorising patients into groups of low, medium, and high PTHL levels. We considered 19 predictors for low PTHL scores, from sociodemographic characteristics, health behaviours and health characteristics, access to health-related information and empowerment-related indicators. Univariate and multivariate logistic regression analyses were used to determine independent predictors of low PTHL. Results The final 15-item PTHL-DM instrument proved to have satisfactory reliability (KR20 = 0.475) and internal reliability [ICC for the whole instrument was 0.97 with 95% confidence intervals (0.95–0.99)]. Positive correlation (rho = 0.69) between PTHL-DM score (15 questions) and the total PTHL-SR score (14 questions) was also observed. It was demonstrated that the majority of 350 patients had low PTHL (62%), and only 5% high PTHL level. Mean score on PTHL-DM was 7.8 ± 2.3. Probability of low PTHL increased among smokers, patients with low interest in health and those who estimated their health as bad. Patients who used pharmacists as sourse of information were less likely to be pharmacotherapy illiterate. Combined therapy with insulin and Oral Hypoglycemic Agents was associated with higher PTHL. Conclusions Our data indicate that specific PTHL-DM tool is objective, valid, and reliable. It was found that low level of PTHL prevailed among DMT2 patients. Medication literacy is influenced by age, residence, education, and family status. Patients with better health literacy also reported better health behaviours. Different patient empowerment programs and approaches aimed at raising PTHL would be essential to improve self-management and control of this widespread chronic disease in Serbia.

Origanum vulgare L. has been proven to be the strongest herbal antiseptic in the world, native to the Mediterranean region, but is widely naturalized elsewhere in the temperate Northern Hemisphere. This study aimed to estimate the phytotoxic effect of three different concentrations of oregano essential oil (O. vulgare) on three selected plant species namely, wheat, tomato and mint using biotest germination and effects on seedling growth, as well as its toxicological properties using Allium test. Our results revealed that oregano essential oil exhibits allelopathic effect on selected species. All three tested concentrations of oregano essential oil caused a significant inhibition of Allium cepa L. root growth, as well as a reduction in the mitotic index values in A. cepa meristem cells. O. vulgare essential oil demonstrated phytotoxic and antiproliferative effects. Further research is needed to confirm our results.

Most of the papers that treat the composition of essential oils for this purpose use GC/MS or GC/MS and GC/FID techniques for the identification and/or quantification of individual compounds. Therewithal, papers usually treat the composition as semiquantitative (percentage composition as the area of the peak of a particular compound in relation to the total area of the peaks on the chromatogram, given as 100 %). At the same time, the quality of the results is not treated in metrological terms. A GC/MS method for the quantification of components present Helichrysum italicum hydro-distilled essential oil samples from Bosnia and Herzegovina with a similar composition was developed and optimized. The stability of the method setup and adequacy of sample storage and manipulation were assessed. Calibration method and assessment of measurement uncertainty were established for neryl acetate, one of the major compounds with known health benefits.

In clinical practice, there is a very common discrepancy between the clinical findings of patients with lumboischialgia and the radiological findings. This research aimed to determine the degree of correlation between the ODI index and the VAS scale with degenerative changes in the lumbar spine found using MRI. The study included 100 patients, who were referred for an MRI of the lumbar spine and who had a clear clinical picture of lumboischialgia. Patients underwent MRI. Degenerative changes in the lumbar spine and discs were analysed. Patients were asked to answer the questions in the questionnaire about the subjective feeling of pain and functional status, and ODI and VAS scores were calculated. There has been a statistically significant correlation found between the answers to the survey questions and the VAS score (p < 0.001). There was a significant correlation obtained between the level of degeneration and the disability index (p = 0.022), while the correlation with the VAS score has not been found to be significant (p = 0.325). This study has demonstrated a significant correlation between the VAS pain score and the ODI, as well as a significant correlation between the level of degeneration on MRI scans and the disability index; however, the correlation of MRI scan results with VAS score has not been found to be significant.

The identification of vulnerabilities is a continuous challenge in software projects. This is due to the evolution of methods that attackers employ as well as the constant updates to the software, which reveal additional issues. As a result, new and innovative approaches for the identification of vulnerable software are needed. In this paper, we present VULNERLIZER, which is a novel framework for cross-analysis between vulnerabilities and software libraries. It uses CVE and software library data together with clustering algorithms to generate links between vulnerabilities and libraries. In addition, the training of the model is conducted in order to reevaluate the generated associations. This is achieved by updating the assigned weights. Finally, the approach is then evaluated by making the predictions using the CVE data from the test set. The results show that the VULNERLIZER has a great potential in being able to predict future vulnerable libraries based on an initial input CVE entry or a software library. The trained model reaches a prediction accuracy of 75% or higher.

Joint safety and security analysis of cyber-physical systems is a necessary step to correctly capture inter-dependencies between these properties. Attack-Fault Trees represent a combination of dynamic Fault Trees and Attack Trees and can be used to model and model-check a holistic view on both safety and security. Manually creating a complete AFT for the whole system is, however, a daunting task. It needs to span multiple abstraction layers, e.g., abstract application architecture and data flow as well as system and library dependencies that are affected by various vulnerabilities. We present an AFT generation tool-chain that facilitates this task using partial Fault and Attack Trees that are either manually created or mined from vulnerability databases. We semi-automatically create two system models that provide the necessary information to automatically combine these partial Fault and Attack Trees into complete AFTs using graph transformation rules.

Background: Video-assisted thoracic surgery (VATS) for both minor and major thoracic procedures has become routine practice worldwide. In this study, we present our experience with multiportal and uniportal VATS (MVATS and UVATS) in Bosnia and Herzegovina (B&H). MVATS and UVATS procedures were performed in two B&H Clinical Centers: Tuzla and Sarajevo. The first MVATS procedure at Tuzla Clinical Center was conducted in 2004, and the first UVATS lobectomy was performed in 2019. At Sarajevo Clinical Center, the initial MVATS took place in 2005, and the first UVATS lobectomy was carried out in 2020. Methods: We retrospectively analyzed 401 VATS procedures with prospective data, collected between 06/2017 and 04/2023. The VATS technique was employed for wedge resections, partial resections, lobectomies, and other types of resections, including metastasectomy. Results: Out of the 401 patients, 242 (60.34%) were male, and 159 (39.66%) were female, with a mean age of 57.2±23 years. The procedures consisted of 231 UVATS and 170 MVATS. Lobectomy was performed in 61 (15.21%) cases, wedge resections in 216 (51.37%), partial resections in 85 (21.19%), and other types of resections in 39 (9.72%) patients. The median duration of the procedure was 210 minutes for lobectomy, and 77.5 minutes for wedge and other types of resections. Major complications, such as bronchopleural fistula in 22 (5.49%) cases, wound infections in 20 (4.99%), atelectasis in 19 (4.74%), lung infiltrations in 15 (3.74%), and bleeding in 15 (3.74%) patients, were observed. The overall mean hospital stay for all procedures was 6.45 days. Conclusion: Uniportal and multiportal VATS techniques are feasible and safe for various indications in thoracic surgery. VATS can be performed in middle-income countries such as Bosnia and Herzegovina with acceptable results, by thoracic surgeons experienced in general thoracic surgery

Introdução: A Doença de Osgood-Schlatter é uma condição ortopédica comum em adolescentes ativos, caracterizada por dor e inflamação na tuberosidade da tíbia, onde o tendão patelar se insere. Apresentação do Caso: Adolescente, 14 anos, comparece à clínica de ortopedia acompanhado pelo pai, com queixas de dor e inchaço no joelho direito.  Discussão: Essa doença ocorre durante os períodos de crescimento rápido, quando a tração repetida dos músculos quadríceps na tuberosidade da tíbia resulta em lesões e irritação. Neste artigo científico, apresentamos uma revisão abrangente sobre a Doença de Osgood-Schlatter, abordando sua epidemiologia, fisiopatologia, apresentação clínica, diagnóstico e opções de tratamento. O diagnóstico geralmente é feito com base nos sintomas e no exame físico, mas a radiografia pode ser útil para descartar outras patologias.O tratamento da Doença de Osgood-Schlatter é principalmente conservador, com ênfase na redução da atividade física, uso de gelo para alívio da dor e fisioterapia para fortalecer os músculos da coxa e melhorar a biomecânica do joelho. Conclusão: Foi observado a carência da literatura que aborda tal condição. Portanto, são necessários futuros estudos que tratem sobre  qual tratamento a ser utilizado.

Introdução: A doença de Meige é uma distonia segmentar que afeta os músculos da face, sendo caracterizada, por blefaroespasmos associados a deturpação da musculatura oromandibular. Apresentação do Caso: Paciente do sexo masculino, 46 anos, relata edema persistente em membros inferiores desde a adolescência, acompanhado por episódios frequentes de infecções cutâneas na área afetada. O paciente faz uso frequente de antibióticos e anti-inflamatórios, com melhora apenas temporária. Informa que cinco outros membros da família sofrem de edema crônico nos membros inferiores, mas com sintomas menos severos. Discussão: Podem ser usados para seu tratamento relaxantes musculares, benzodiazepínicos, aplicações de toxina botulínica e, se necessário, cirurgia para modulação cerebral. Todavia, ainda não há relatos de cura da doença, sendo o tratamento baseado em melhora dos sintomas. Conclusão: A doença de Meige provoca um sofrimento imensurável àqueles que vivem com ela. Conhecer seu tratamento é indispensável para dar um pouco mais de conforto à vida dessas pessoas.

The presence of pharmaceuticals in natural waters has been the subject of numerous studies in the last decade due to their potential negative effects on human health and the environment. Indeed, the intensive use of pharmaceuticals leads to their presence in municipal wastewater. Unfortunately, international and national regulations still do not require continuous monitoring of the presence of pharmaceuticals in natural waters and drinking water, so wastewater treatment plants do not focus on removing them from wastewater. Diclofenac, 2-[2-(2,6-dichloroanilino)phenyl]acetic acid (DCF), is a nonsteroidal compound used as an analgesic, anti-inflammatory, and antipyretic drug and is therefore commonly found in wastewater. Due to its properties, DCF remains biologically active in the aquatic environment and easily enters the food chain. Therefore, DCF should be removed from wastewater before it is discharged into water bodies. Adsorption is an efficient and simple method that can be used to remove DCF from water. In this study, the possibility of removing DCF by adsorption on activated carbon is investigated. Modified hazelnut shell (MHS), modified commercial activated carbon Cullar (MC) and unmodified commercial activated carbon Cullar (C) were batch tested as adsorbents. The tested adsorbents were characterised by FTIR, zeta potential and pH pzc , while the adsorbent efficiency was tested in the pH range from 2 to 10 and described by isothermal studies. Among the tested adsorbents, the maximum uptake of 48.7 mg g −1 was found when modified activated carbon Cullar was used, while both Freundlich and Langmuir isotherm models fitted well to the data. Modified activated carbon from hazelnut shells showed effective removal of DCF.