Two main types of cardiac amyloidosis (CA) exist, as a result of either aberrant plasma cell production of misfolded monoclonal light chains, known as immunoglobulin light chain amyloidosis (AL), or production of disintegrated and misfolded transthyretin (TTR) proteins by the liver, also called transthyretin amyloidosis (ATTR). Non-invasive diagnostics (cardiac uptake on diphosphonate scintigraphy, Perugini score 2 or 3) have gained prominence in modern cardiology in correlation with the negative findings of free light chains in serum and the results of negative immunofixation in serum and urine. Additionally, criteria related to echocardiography or cardiac magnetic resonance are necessary for establishing a diagnosis. A total of 3.063 99mTc-MDP bone scintigrams were analyzed between August 2018 and March 2023, of which Perugini score 1 was validated in 13 patients, Perugini score 2 in 10 patients and Perugini score 3 in 1 patient. From our experience, we could observe that cardiac uptake can be verified in daily clinical practice and that is meaningful for monitoring patients with ATTR-cardiomyopathy (ATTR-CM). Although the sample size is not large, the importance of the study lies in the fact that it involves patients whose findings have been incidentally verified. If patients are selected according to clinical characteristics, the number of positive findings may potentially increase. Our study aimes to raise awareness among physicians of various specialties about the significance of the diagnostic algorithm for infiltrative cardiomyopathies. This is to ensure early diagnosis of this problem and initiation of treatment in the earliest stages when the therapeutic effect is most optimal. Such an approach would yield benefits for both patients and the entire healthcare system. A meticulous diagnostic and therapeutic approach is therefore fundamental for improving clinical outcomes in patients with ATTR-CM, including careful attention to specific TTR genetic variants and long-term follow-up.

Background: Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. Although there has been a noticeable increase in incidence over the last decades, the exact incidence is difficult to establish, because data and cancer registries are heterogeneous among countries. Objective: The study aimed to analyze the recent clinical trends of basal cell carcinoma by reviewing a six-year single institution’s experience. Methods: A total number of 582 patients with histologically diagnosed BCC were included in the study. All relevant data were collected from medical records and patients, using short questionnaire. Results: BCC was slightly more common among the male population with female to male ratio of 1:1.24. At the time of diagnosis, male patients were statistically significantly older (70.47±11.9 years) compared to female patients (67.64±12.22 years) (p=0.005). The most common types of BCC were nodular (51.64%) and superficial (25.95%), affecting most commonly the head and neck region (71.2%). Relative risk (RR) for development of BCC is 2.79 times higher in sun-exposed skin areas (p<0.001). Conclusion: Sun exposure remains one of the most important risk factors for the development of BCC, with episodes of sunburns, occupational and recreational risks noted among the majority of patients. Although non-fatal disease, due to morbidity and high frequency, prevention and early diagnosis are important to prevent further increase in the incidence of BCC among the population.

In this study, pyrophyllite was used for the first time in the composition of protective refractory coatings together with supplementary waste resources. The proposed refractory coatings are applicable for metallic and non-metallic structures, with the option of using them to protect machinery components in the chemical industry, metallurgy, and mining. Given that pyrophyllite has a low hardness, the goal was to improve the coating's resistance to cavitation erosion by adding 20 wt.% of hard refractory materials, i.e., crushed and micronized waste bricks based on mullite and corundum, respectively. Previous studies have demonstrated that protective coatings using a pyrophyllite filler have refractory qualities but insufficient resistance to cavitation erosion. As a result, the composition of refractory coatings, the preparation techniques, and the coating manufacturing process were altered. This study presents a simple method for combining conventional coatings made of refractory fillers (primary resource: pyrophyllite) with waste materials (mullite brick and corundum brick) used as reinforcement in protective refractory coatings for metal and non-metal structural elements that are highly resistant to cavitation erosion.

When solving real problems, and to make a quality decision, it is necessary to consider a great number of often complex parameters. For these reasons, the development of decision-making process modeling has seen significant growth in recent years, and multi-criteria optimization models have stood out among them as useful for solving complex and conflicting phenomena. Multi-criteria optimization models make it easier for decision-makers to find the optimal solution in situations where there are many different criteria, which can often conflict with each other. The choice of the appropriate method of exploitation of mineral deposits follows the consideration of the problem and the approach to further development, which is primarily the determination of the criteria that influence the choice of the optimal alternative.

Physical inactivity, unhealthy diet, fast-paced lifestyle, as well as genetic predispositions lead to the appearance of diabetes mellitus, and with it many other complications, of which diabetic foot syndrome is very common. In order to avoid complications with the diabetic foot, one of the forms of prevention is wearing specially designed footwear that protects and reduces the pressure on the foot and thus the risk of ulcers. Insoles also play a big role in preventing complications. The paper will present a conceptual solution of a model of footwear for patients with diabetes mellitus and a prototype of an insole made of knitwear, which was previously printed with medical clay, honey and extracts of the plants Rosmarinus officinalis and Zingiber officinale. Samples of knitwear that were printed with a paste containing Rosmarinus officinalis extract showed exceptional antimicrobial activity against Staphylococcus aureus bacteria. Replaceable insoles for footwear are intended for the prevention of complications from Diabetes mellitus.

Background: The organizational climate is defined as the perception of events within the work environment (relationships, values, actions) among organization members that are psychologically meaningful. It also includes the influence of the surroundings on employee motivation and behavior. This concept is studied within the field of industrial and organizational psychology, particularly focusing on healthcare institutions. Objective: The study aims to explain the concept, definition, and history of organizational climate, with a specific focus on healthcare institutions. It also aims to examine the factors influencing the work environment and the extent to which they can improve it. Methods: The research utilizes both quantitative and qualitative methods. The quantitative approach is presented through a non-standardized survey method. Qualitative research was conducted using case studies of healthcare institutions in Sarajevo Canton. The integration of these methods allowed for a comprehensive examination of the organizational climate. Results: The survey provided detailed insights into the organizational climate within healthcare institutions in Sarajevo Canton. It identified key factors that influence the work environment and highlighted areas for potential improvement. Discussion: The findings underscore the importance of strategic management of human resources and potential in creating a positive organizational climate. The study suggests that improving organizational climate is a long-term, multi-layered process involving doctors, managers, and all organizational members working towards common goals. Further research is needed to explore specific interventions that can enhance organizational climate in healthcare settings. Conclusion: This underscores the need for healthcare institutions to focus on fostering a supportive organizational climate and nurturing positive interpersonal interactions to enhance overall job satisfaction among employees.

We investigate a discrete counterpart of planar dynamical system of nonlinear differential equations induced by kinetic differential equations for a two-species chemical reaction. Chemical reactions exhibit a wide range of dynamical behavior. We show how the theoretical analysis provides insight into the potential behavior of chemical reaction systems, determining the areas of parametric space which indicate scenarios for local stability, then for one type of bifurcation co-dimension one and one type of bifurcation co-dimension two. Precisely, we prove the existence of period-doubling bifurcation and 1:2 resonance bifurcation also, by using the center manifold theorem and the technique of normal forms. All mathematical investigations are illustrated with numerical examples, bifurcation diagrams, Lyapunov exponents and phase portraits.

In this study, the selection of suppliers within an alternative food supply network for fruits and vegetables, specifically Box Schemes, was conducted using multi-criteria decision-making methods. The Entropy-MABAC method was used as the multi-criteria decision-making approach, and the research focused on five suppliers from the city of Novi Sad. Eleven socioeconomic criteria were chosen for the research to identify the most favourable supplier. The results indicate that the criterion "product character," i.e., whether the final agricultural product is organic or conventional, was rated the highest, and the first supplier was selected as the most favourable. These results provide a solid foundation for future research, which should focus on further examining the impact of supply methods on end consumers of agricultural products within the alternative food network and developing new methods to aid in selecting the most favourable supplier.