SCADA (Supervisory Control and Data Acquisition) systems are computer systems used for monitoring and controlling industrial processes such as power plants and power grid systems, water, gas and oil distribution systems, production systems for food, cars and other products. We propose a new approach for regulating and detecting malicious behaviour of network devices in SCADA systems. Our approach consists of building proles that describe normal communication between pairs of devices in the network. Each prole describes four aspects of network communication: device ngerprint, connectivity pattern, pseudo-protocol pattern and packet content. We validate our approach using network trac from two real-life SCADA installations.

In this study the adhesive joint fracture behaviour of a nano-toughened epoxy adhesive was investigated. Two experimental test methods were used; (i) the standard tapered double cantilever beam (TDCB) test to measure the mode I adhesive joint fracture energy, GIC, as a function of bond gap thickness and (ii) a circumferentially deep notched tensile test to determine the cohesive strength of the adhesive for a range of constraint levels. It was found that the fracture energy of the adhesive followed the well-known bond gap thickness dependency [1]. SEM analysis of the TDCB fracture surfaces revealed significant plastic void growth. Finally, numerical modelling of the experimental tests suggested that most of the fracture energy was dissipated via highly localised plasticity in the fracture process zone ahead of the crack tip.

In the present study, the mixed-mode fracture toughness of an adhesively bonded composite joint system was examined using a variety of linear elastic fracture mechanics (LEFM) based tests. These tests include the mode I double cantilever beam (DCB), mixed-mode asymmetrical DCB (ADCB) and mode II end load split (ELS) test. The joint system was also evaluated using the wide area lap shear (WALS) test that is often employed by the aerospace industry. While lap shear type tests are relatively simple to perform and post-process compared to their LEFM counterparts, the results can often be misleading and are greatly dependent on the overlap length, thickness of substrate and type of fillet. The experimental tests were also simulated using OpenFOAM, a finite volume based software package. Through this combined experimental-numerical approach, a greater understanding of the influence of the peel ply surface treatment and scrim cloth on the behaviour of the WALS test was achieved.

Configuration space integrals have in recent years been used for studying the cohomology of spaces of (string) knots and links in $\mathbb{R}^n$ for $n>3$ since they provide a map from a certain differential algebra of diagrams to the deRham complex of differential forms on the spaces of knots and links. We refine this construction so that it now applies to the space of homotopy string links -- the space of smooth maps of some number of copies of $\mathbb{R}$ in $\mathbb{R}^n$ with fixed behavior outside a compact set and such that the images of the copies of $\R$ are disjoint -- even for $n=3$. We further study the case $n=3$ in degree zero and show that our integrals represent a universal finite type invariant of the space of classical homotopy string links. As a consequence, we obtain configuration space integral expressions for Milnor invariants of string links.

Many authors have argued that we should make a clear conceptual distinction between mononational and multinational states. Yet the number of empirical examples they refer to is rather limited. France or Germany are usually seen as mononational, whereas Belgium, Canada, Spain and the UK are considered multinational. How should we classify other cases? Here we can distinguish between (at least) two approaches in the literature: statistical (i.e., whether significant national minorities live within a larger state and, especially, whether they claim self-government) and subjective (i.e., when citizens feel allegiance to sub-state national identities). Neither of them, however, helps us to resolve the problem. Is Italy multinational (because it contains a German-speaking minority)? Is Germany really mononational (in spite of the official recognition of the Danes and the Sorbs in some Lander)? On the other hand, is Switzerland the “most multinational country” (Kymlicka)? Let us assume that there is no definite answer to this dilemma and that it is all a matter of degree. There are probably few (if any) clearly mononational states and few (if any) clearly multinational states. Should we abandon this distinction in favour of other concepts like “plurinationalism” (Keating), “nations-within-nations” (Miller), “postnational state” (Abizadeh, Habermas), or “post-sovereign state” (MacCormick)? The article discusses these issues and, in conclusion, addresses the problem of stability and shared identity “plural” societies.

Background and Aims: In December 2009 the COnsortium to Perform Human Biomonitoring on a European Scale (COPHES) financed by FP7 EU, began work towards an EU HBM framework. This will be accompanied...

Genome-wide association studies have linked lung cancer risk with a region of chromosome 15q25.1 containing CHRNA3, CHRNA5 and CHRNB4 encoding α3, α5 and β4 subunits of nicotinic acetylcholine receptors (nAChR), respectively. One of the strongest associations was observed for a non-silent single-nucleotide polymorphism at codon 398 in CHRNA5. Here, we have used pharmacological (antagonists) or genetic (RNA interference) interventions to modulate the activity of CHRNA5 in non-transformed bronchial cells and in lung cancer cell lines. In both cell types, silencing CHRNA5 or inhibiting receptors containing nAChR α5 with α-conotoxin MII exerted a nicotine-like effect, with increased motility and invasiveness in vitro and increasing calcium influx. The effects on motility were enhanced by addition of nicotine but blocked by inhibiting CHRNA7, which encodes the homopentameric receptor α7 subunit. Silencing CHRNA5 also decreased the expression of cell adhesion molecules P120 and ZO-1 in lung cancer cells as well as the expression of DeltaNp63α in squamous cell carcinoma cell lines. These results demonstrate a role for CHRNA5 in modulating adhesion and motility in bronchial cells, as well as in regulating p63, a potential oncogene in squamous cell carcinoma.