OBJECTIVE: The aim of this study is view, statistical and comparative processing of new cases of female breast cancer with pathohistological verification in the territory of the municipality of Cacak and the Republic of Serbia in 2010. Also, comparative analysis of detected breast malignancies (symptomatic and asymptomatic) was done with results of required screening and no screening in female population of 40-64 years old in the municipality of Cacak. METHOD: In the municipality of Cacak, in the general type hospital in 2010. in accordance with personnel, equipment and possibilities, the advantage of screening in the appropriate population was considered. If screening would be implemented according to the acceptable norms and with satisfactory response, that would significantly reduce the rate of disease and also mortality rate. RESULTS: 3760 women were examined with the breast problem and breast cancer was detected and confirmed with pathohistological test at 69 of them. The most common are ductal and lobular breast cancer (which partly agrees with the pathohistological verification in the territory of Serbia). 3500 woman passed through Radiological service, of which 3100 is in the age population of 40-64 year subjected to screening). In the municipality of Cacak there are about 40000 women in this age group. If we accept the rate of the disease in 2010th, the percentage of disease without screening would have been 2%. It was shown that the rate of the disease was significantly reduced when screening was performed. CONCLUSION: The comparative analysis supports the feasibility of possible breast cancer screening in general type hospitals in accordance with the personnel and equipment capabilities, and if the response of the population covered by screening would be in as large numbers as possible-it would be chieved what is the purpose and ultimate goal of cancer screening-reducing mortality by 22% to 50%.