Suchey-Brooks method based on morphological features of pubic symphysis is a common method of age evaluation of human skeletal remains. The aim of the study was the classification of the examined samples into a particular phase according to Suchey-Brooks method, comparing the estimated age according to Suchey-Brooks with living age of the identified persons. The study was conducted on 120 pairs of pubic bones symphysis of male who disappeared from the area of north-west Bosnia during previous war, who were exhumed and the process of their identification was previously finished. The youngest person was 19 years old and the oldest 86. The study was retrospective, made by comparing the morphological characteristics of pubic symphysis pairs of the examined sample with Suchey-Brooks standards. The statistical analysis of data obtained by the survey showed that the smallest deviations from the average were in phase II by Suchey-Brooks, while the maximum deviation was in phase IV. The standard deviation generally increases from phase to phase, which is to be expected. The span of age obtained for Bosnian population is smaller at all stages in relation to Suchey Brooks-standards, as well as standard deviation, except in phases IV and VI. There was a significant difference noticed in phase V in the estimation of age between the original method and Bosnian population. In general, Suchey-Brooks method leads to underestimation of age, but the underestimation or overestimation in relation to the actual age is possible at each stage, which indicates the individual biological variation.

The  aim of this study was to compare the sociodemographic and clinical features of odon­togenic infections between hospitalized and non-hospitalized  children and to show what were the risk factors in children that could predict the course of odontogenic infection and indicate the need for hospital treatment. The design of our study was of the case-control type. The two study groups consisted of 70 inpatients and 35 outpatients with odontogenic infections who were treated at Department of Pediatric Dentistry and Department of Maxillofacial Surgery at Clinical Center in Kragujevac, Serbia. Clinical and sociodemographic data were col­lected retrospectively from patients' hospital re­cords. The following characteristics were signifi-cantly associated  with hospital treatment of chil-dren with acute odontogenic infection: li­ving in a village (OR =7.26,[1.43-36.96]), multi-spatial infection (OR =0.04, [0.00-0.91]), and affec­tion of upper face (OR = 0.01, [0.00-0.86]). Tooth extraction was important intervention in the treatment regimen and reduced frequency of hospitalization (OR=0.07, [0.01-0.70]). The dif­ferences between hospitalized and non-hospitali­zed children were not significant in regard to: ethnicity, employment of parents,  anatomical region of infection, side of the facial infection, source of infection (posterior or anterior deci­duous or permanent teeth), and treatment (drai­nage and incision, oral or parenteral antibiotics). In children with acute odontogenic infection it is necessary to do tooth extraction in timely manner, especially if the source of infection is tooth from upper jaw and if it is multi-spatial in­fection.

Renata Dobrila-Dintinjana1, Dragan Trivanovic2, Marijan Dintinjana3, Jelena Vukelic4 and Nenad Vanis5 1Department of Radiation Oncology, Clinical Hospital Center Rijeka, University of Rijeka, School of Medicine, 2General Hospital Pula, Department of Internal Medicine, 3Clinic of General Medicine Dr Dintinjana, 4Department of Speech and Hearing Disorders Diagnostics and Rehabilitation, Clinical Hospital Center Rijeka, 5Division for Gastroenterology and Hepatology, Clinical Center University of Sarajevo, Faculty of Medicine, University of Sarajevo, 1,2,3,4Croatia 5Bosnia and Herzegovina

The need to find a prion disease neuroimaging biomarker is important with the development of therapeutic agents. Diffusion tensor imaging (DTI) is an MRI sequence that can visualise white matter changes in the brain. Voxel-based analysis of DTI and voxel based morphometry (VBM) was performed on 17 asymptomatic prion protein gene mutation carriers, 14 symptomatic inherited prion disease patients, seven sporadic CJD patients (sCJD) and 24 healthy controls. There were significant differences found in grey matter voxels between the symptomatic and the control patients in the cortex bilaterally. In addition there was reduced fractional anisotropy in the corpus callosum, frontal white matter, internal capsule, optic radiation and cerebellum; these regions did not overlap with areas of brain atrophy. In the asymptomatic patients there were directional changes seen in keeping with the symptomatic patients, but due to the small patient number no statistically significant differences were found with VBM and voxel based analysis of DTI. In sCJD grey matter changes were found in the thalamus on VBM but voxel based analysis of DTI demonstrated change in the corpus callosum, thalamus and cerebellar white matter. These data show that voxel based analysis of DTI can detect significant microstructural white matter changes in the absence of its loss. DTI may prove to be a useful biomarker in prion disease.

OBJECTIVE The aim of this study was the quantification of alveolar bone resorption as well as the number and percentage of teeth with dental caries. MATERIALS AND METHODS Four samples of jaws and single teeth were studied from four time periods, i.e. from the Krapina Neanderthals (KN) who reportedly lived over 130,000 years ago, and groups of humans from the 1(st), 10(th) and 20(th) centuries. Resorption of the alveolar bone of the jaws was quantified by the tooth-cervical-height (TCH) index. Diagnosis of dental caries was made by inspection and with a dental probe. TCH-index was calculated for a total of 1097 teeth from 135 jaws. Decay was calculated for a total of 3579 teeth. RESULTS Resorptive changes of the alveolar bone in KN and 1(st) century man were more pronounced on the vestibular surface than interdentally (p<0.05), while no significant difference could be confirmed for 10(th) and 20(th) century man (p=0.1). The number (percentage) of decayed teeth was 0 (0%, n=281 teeth) in KN, 15 (1.7%; n=860 teeth) in 1(st) century, 24 (3.4%; n=697 teeth) in 10(th) century, and 207 (11.9%, n=1741 teeth) in 20(th) century. CONCLUSION On the basis of our results it may be postulated that in contemporary man in relation to KN, the accumulation of plaque pathogens in the interdental space is substantially greater than on the vestibular side. These findings have practical, educational and preventive value for oral hygiene improvement, especially of the interdental space, which should help decrease the prevalence of periodontal disease and dental caries, and improve oral as well as general health.

Department of Family medicine has been formed in academic year 2002/2003, few years later after the foundation of the School of Medicine University of Mostar. The formal members of department are professor and assistants who lecture and lead seminars. In addition, physicians in rural practices contribute to teaching of family medicine. Clinical teaching of family medicine at Mostar School of Medicine is organized in the summer semester of sixth year of the study. It lasts six weeks and contains lectures, seminars and practices. Every student has right and obligation to evaluate educational process at the end of the course in a form of questionnaire and essay. Family medicine continuously receives high marks by students, especially practices. Evaluation of teaching by students is good way of giving feedback about teaching. We believe that student opinion can revise and improve teaching practice. Our good experience and good marks may prompt the changing our educational curriculum to include family medicine at each study year of medical program.

We have outlined novel graph theoretical model for computing π-electron currents in π-electron polycyclic conjugated hydrocarbons. We start with Kekule valence structures of a polycyclic conjugated hydrocarbon and their conjugated circuits. To each 4n+2 conjugated circuits we assign counter clockwise current i and to each 4n conjugated circuit we assign clockwise current i. By adding the contributions from all conjugated circuits in a single Kekule valence structure one obtains π-electron current pattern for the particular Kekule valence structure. By adding the conjugated circuit currents in all Kekule valence structure one obtains the pattern of π-electron currents for considered molecule. We report here π-electron current patters for coronene and 17 its isomers, which have been recently considered by Balaban et al., obtained by replacing one or more pairs of peripheral benzene rings with five and seven member rings. Our results are compared with their reported π-electron current density patters computed by ab initio molecular orbital (MO) computations and satisfactory parallelism is found between two so disparate approaches.

Introduction: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of the hormonally inactive cortisone to active cortisol, thus facilitating glucocorticoid receptor activation in target tissues. Increased expression of 11β-HSD1 in adipose tissue has been associated with obesity and insulin resistance. In this study, we investigated the association of two 11β-HSD1 gene (HSD11B1) polymorphisms with the metabolic syndrome (MetS) and its characteristics in the Bosnian population. Materials and methods: The study included 86 participants: 43 patients diagnosed with MetS and 43 healthy controls. Subjects were genotyped for two HSD11B1 gene polymorphisms: rs846910: G>A and rs45487298: insA, by the high resolution melting curve analysis. Genotype distribution and an influence of genotypes on clinical and biochemical parameters were assessed. Results: There was no significant difference in the mutated allele frequencies for the two HSD11B1 gene polymorphisms between MetS patients and controls. In MetS patients, no significant associations between disease-associated traits and rs45487298: insA were found. Regarding rs846910: G>A variant, heterozygous patients (G/A) had significantly lower systolic (P = 0.017) and diastolic blood pressure (P = 0.015), lower HOMA-IR index (P = 0.011) and higher LDL-cholesterol levels (P = 0.049), compared to the wild-type homozygotes. In the control group, rs45487298: insA polymorphism was associated with lower fasting plasma insulin levels (P = 0.041), lower homeostasis model assessment insulin resistance (HOMA-IR) index (P = 0.041) and lower diastolic blood pressure (P = 0.048). Significant differences between rs846910: G>A genotypes in controls were not detected. Haplotype analysis confirmed the association of rs45487298: insA with markers of insulin resistance in the control subjects. Conclusions: Our results indicate that a common rs45487298: insA polymorphism in HSD11B1 gene may have a protective effect against insulin resistance.