We surveyed 27 anesthesiology residents to determine their basic understanding of biostatistics. We wanted to see how well they could interpret statistical presentation in biomedical literature and assess research outcomes. The questionnaire included three sections: demographics of the participants, their knowledge of statistics (21 questions) and their attitude and self reported confi dence about biostatistics. Recognition of a meta-analysis was the highest scoring question (85% gave the correct answer), and recognition of a case-control study scored the lowest (22%). There was no effect of gender, the year of study, the number of years elapsed since graduation at the medical school, or country in which the participants had attended medical school (US or foreign schools). The only factor that increased the number of correct answers signifi cantly was an additional course in biostatistics that two participants had attended after graduation. Sixty six percent indicated they did not understand all of the statistics they encountered in journal articles, but all of the participants felt it was important to be able to understand the literature. We conclude that most residents in this study lack the knowledge in biostatistics needed to interpret results in medical publications. Most participants in this survey expressed the desire to improve their knowledge on this subject, even though it would require taking special courses in basic epidemiology, and statistics for the non-statistician during their residency training.

Karol Visinko e autrice del instrumentario didattico in questo manuale che rapresenta un programma formativo che offre la possibilita di conoscere meglio la citta di Fiume, di viverla meglio, di sentirla e di custodirla dimostrando tanto amore per tutto quello che la rende particolare, diversa e unica. Il manuale La mia Fiume puo risvelgliare la curiosita per tante ricerce del passato e dell´ oggi fiumano nelle scuole elementari di Fiume.

U radu je predstavljena zamjena dijela sustava turbinske regulacije proizvodnih jedinica A i B HE Cakovec. U uvodu su navedeni bitni razlozi za zamjenu dijela sustava turbinske regulacije. Nakon toga predstavljeni su podsustavi sustava turbinske regulacije: turbinski regulator, upravljanje nizvodnim zatvaracima, mjerenja razina vode i elektrohidraulicki dio sustava turbinske regulacije. Također je predstavljeno mjerenje razina vode s hardverskom strukturom posebno prilagođenom za ova kontinuirana mjerenja. Posebna pozornost posvecena je dodatnoj funkciji turbinskog regulatora za nadzor kvarova u sustavima pozicioniranja privodnog i radnog kola. Dodatno su opisana HIL ispitivanja (Hardware in the Loop testing) sustava turbinske regulacije koja su provedena prilikom tvornickih ispitivanja i navedene njihove prednosti. Opisan je registrator prijelaznih pojava i događaja. Na kraju je dan osvrt na primopredajna ispitivanja, te redoslijed projektiranja i izvođenja radova na HE Cakovec.

Proton NMR spectroscopy and cyclic voltammetry have been applied to study the stability of three gold(III) complexes with L-histidine-containing peptides, [Au(Gly-L-His-N,N’,N’’)Cl]NO3.1.25H2O (Au1), [Au(L-Ala-L-His-N,N’,N’’)Cl]NO3.2.5H2O (Au2) and [Au(Gly-Gly-L-His-N,N’,N’’,N’’’)]Cl.H2O (Au3) under physiologically relevant conditions. It was found that tridentate coordination of Gly-L-His and L-Ala-L-His dipeptides, as well as tetradentate coordination of Gly-Gly-L-His tripeptide in Au1, Au2 and Au3 complexes, respectively, stabilized +3 oxidation state of gold and prevented its reduction to Au(I) and Au(0). No release of the coordinated peptides from Au(III) was observed under these experimental conditions. Considering remarkable stability of Au1, Au2 and Au3 complexes, their cytotoxic activity was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay toward five human tumor cell lines, MCF-7 (human breast adenocarcinoma), HT-29 (human colon adenocarcinoma), HeLa (human cervix carcinoma), HL-60 (human promyelocytic leukemia), Raji (human Burkitt’s lymphoma) and one human normal cell line MRC-5 (human fetal lung fibroblasts). While the cytotoxic activity of Au1, Au2 and Au3 against investigated human malignant cell lines was strongly cell line dependent, none of these complexes was cytotoxic against normal MRC-5 cell line. This study can contribute to the future development of gold(III)-peptide complexes as potential antitumor agents.