Po regionalnoj zemljopisnoj podjeli eksploatacijsko polje tehnicko-građevnog kamena "Crna Draga" se nalazi u Banovini, a prema teritorijalno-upravnom ustrojstvu u istocnom dijelu opcine Lasinje, koja administrativno pripada Karlovackoj županiji. Eksploatacijsko polje je smjesteno oko 20 km od Karlovca, 4, 3 km od Lasinja i 4, 2 km od mjesta Dugo Selo, neposredno uz zapadnu granicu Sisacko-moslovacke županije. Uže podrucje ležista tehnicko-građevnog kamena je brdovito, osnovni plato kamenoloma nalazi se na nadmorskoj visini od 129 metara. Na udaljenosti oko 500 m od eksploatacijskog polja tehnicko-građevnog kamena "Crna Draga" nalaze se prve kuce i građevine, a eksploatacijsko polje dobro je povezano mrežom sumskih cesta s bližom i daljom okolicom. Do ležista se može doci asfaltnom cestom Katlovac-Racica-Lasinja, i južnim odvojkom duljine oko 2 km prema mjestu Crna Draga, te sumskim putem od mjesta Britvici. Važno je napomenuti da uz eksploatacijsko polje tece i potok. Kamenolom je smjesten na nadmorskoj visini od približno 129 do 160 m n.m.

Aesculus flava (syn. A. octandra) is a species of buckeye native to eastern North America, from Pennsylvania, west to eastern Illinois, and south to the northernmost parts of Alabama and Georgia. Pollen dimorphism has been detected in anthers of some woody species. Uninuclear microspores isolated from closed flower buds in horse chestnut (R a d o j e v i c , 1989, 1991; C a l i c et al., 2003/4) and red chestnut (M a r i n k o v i c and R a d o j e v i c , 1992) showed differences in size, shape, staining intensity, fluorescence, viability, and embryogenic potential (R a d o j e v i c et al., 2000). Moreover, pollen orginating from 13 species of the genus Aesculus showed differences in size and shape, pore position, sculpturing of the colpal membrane, and sculpturing of the mesocolpia (P o z h i d a e v, 1995). The small yellow-green inflorescence of Aesculus flava is about 17 cm long and 7 cm wide. Composed of an upright panicle of many solitary flowers, it appears in mid-May, the inflorescence clearly rising above the expanded foliage. As in flowers of Aesculus hippocastanum, A. flava flowers located in the basal part of the panicle are female and fertile, while flowers in the middle are bisexual and those on the top are male (H e y w o o d , 1978).

Genetic variability within Serbian populations of the pottioid moss Hilpertia velenovskyi (Schiffn.) Zander was studied. Eight populations of this rare and endangered moss species were chosen for peroxidase isozyme analyses. From the data obtained, it can be inferred that four haplotypes are present among H. velenovskyi populations in Serbia, the Banat population being distinctive from all others.

AIMS Anderson-Fabry disease affects various organ systems due to glycosphingolipid accumulation. Enzyme replacement therapy (ERT) has been reported to decrease left ventricular wall thickening (LVWT) and to improve diastolic dysfunction. METHODS AND RESULTS This prospective study included 29 patients (patients; mean age 37 +/- 13 years) with genetically, enzymatically and/or biopsy-proven Anderson-Fabry disease and long-time ERT. Data on symptoms, cardiac medications and history of hypertension were collected and all patients had comprehensive echocardiographic examination prior to ERT and at follow-up. Disease was at an early stage with a total mean Mainz severity score index of only 18.6 +/- 13.0. Prior to ERT, 79% of patients reported acroparesthesia. The median creatinine level was 121 +/- 108 mcmol/L and LVWT was present in nine patients (31%). Binary appearance of the interventricular septum was found in 20% and posterobasal fibrosis in 83%. At median follow-up of 37 months, acroparesthesia decreased to 55% (P = 0.016). There was no change in creatinine levels. The incidence of LVWT was unchanged, only an increase in interventricular septal wall thickness from 11.7 +/- 0.4 to 12.5 +/- 0.5 was observed (P = 0.009). Left atrial size and the percentage of patients with binary appearance and posterobasal fibrosis were unchanged. There was a small improvement in diastolic function (29% decrease of E/Ea; P < 0.002). CONCLUSION Our Anderson-Fabry cohort had successful long-time ERT with impressive amelioration of subjective symptoms. Although there was not much improvement in cardiac changes apart from a slight improvement of diastolic function, at least, there was no progression of cardiac disease. For complete reversibility of cardiac changes in Anderson-Fabry disease, ERT might have to be started earlier in life and/or prescribed for a longer time.