The eternal 1-secure set, strategically protects graphical structures against attacks by placing sentinels within dominating sets. This study adapts this concept to real-world scenarios, like emergency response systems, by addressing challenges such as roadblocks and traffic congestion. We introduce the secure set and the eternal 1-secure set for fuzzy graphs based on edge membership levels J. Our analysis examines the relationship between the security number of a fuzzy graph G at level J and the domination number of its spanning subgraph at level J, demonstrating the potential of the eternal 1-secure set to enhance security measures in dynamic environments.

We present single-stage optimization of islands in finite-β stellarator equilibria. Stellarator optimization is traditionally performed as a two-stage process; in the first stage, an optimal equilibrium is calculated that balances a set of competing constraints, and in the second stage, a set of coils is found that supports the said equilibrium. Stage one is generally performed using a representation for the equilibrium that assumes nestedness of flux surfaces, even though this is not warranted and occasionally undesired. The second stage optimization of coils is never perfect, and the mismatch leads to worse performing equilibria and further deteriorates if additional constraints, such as force minimization, coil torsion, or port access, are included. The higher fidelity of single-stage optimization is especially important for the optimization of islands as these are incredibly sensitive to changes in the field. In this paper, we demonstrate an optimization scheme capable of optimizing islands in finite β stellarator equilibria directly from coils. We furthermore develop and demonstrate a method to reduce the dimensionality of the single-stage optimization problem to that of the first stage in the two-stage approach.

This article examines the appeal of Serbian nationalist ideology among the contemporary far right. We argue that the discursive othering of Bosnian Muslims as “Turks” as well as the Serbian grand narrative presenting the Bosnian War as a civilizational struggle between Christian Europe and Islam are uniquely resonant with the popular anti-Muslim and xenophobic discourses that are mobilizing right-wing extremists across the globe. Through an analysis of Serbian and far-right discourses, we demonstrate how the patterns of representation that were used to incite and justify the violence committed against Bosnian Muslims in the 1990s are being exported to remote corners of the world via the internet, where they merge with extraneous Islamophobic and racist ideologies to inspire a new generation of extremism, hatred, and violence.

The roadmap is organized into several thematic sections, outlining current computing challenges, discussing the neuromorphic computing approach, analyzing mature and currently utilized technologies, providing an overview of emerging technologies, addressing material challenges, exploring novel computing concepts, and finally examining the maturity level of emerging technologies while determining the next essential steps for their advancement.

Improved molecular strong-field approximation theory is used to calculate the ionisation probability for the high-order above-threshold ionisation process induced by a few-cycle pulse with two carrier frequencies and one envelope. The asymmetry in the photoelectron momentum distribution is due to the ultrashort nature of the driving pulse and due to the relative orientation of the molecule with respect to the laser field. We introduce the generalised asymmetry parameter, which can be used to quantitatively measure the asymmetry between the photoelectron spectra along arbitrarily many selected directions. We investigate the difference between the asymmetry parameters calculated for atomic and molecular targets and show that the contributions to the asymmetry strongly depend on the type of the employed driving pulse. For the driving pulse with components that are linearly polarised with mutually orthogonal polarisations, we find that the main source of the asymmetry, especially in the high-energy part of the spectrum, is the ultrashort nature of the pulse. The relative orientation of the molecule with respect to the laser pulse only affects the low- and medium-energy parts of the spectrum. On the other hand, for the driving pulse with circularly polarised counterrotating components, the asymmetry introduced by molecular orientation is more pronounced. We also analyse the influence of the characteristics of molecular orbitals on the asymmetries using the examples of N2 and O2 molecules.

Introduction. At the end of 2019 and the year before, there was a significant spread of measles in the World Health Organization (WHO) European Region.Gap statement. Among the countries that reported, a measles outbreak was Bosnia and Herzegovina (BiH).Aim. To describe the measles outbreak in BiH (an entity of the Federation of BiH, FBiH) in 2019.Methodology. Confirmatory IgM serology, measles nucleic acid detection by real-time RT-PCR and virus genotyping were done in the WHO-accredited laboratory for measles and rubella at the Clinical Center of the University of Sarajevo, Unit for Clinical Microbiology. Genotype was determined in all measles-RNA-positive cases by sequence analysis of the 450 nt fragment coding the C-terminal of measles virus nucleoprotein (N).Results. From 1 January to 31 December 2019, 1332 measles cases were reported, with the peak observed in April 2019 (413/1332, 31.01 %). Sarajevo Canton had the highest incidence, number of cases and percentage (206.4; 868/1332; 65.17 %) of measles cases. Around four-fifths of infected persons were unvaccinated (1086/1332, 81.53 %), while 4.58 % of the patients (61/1332) were immunized with one dose of measles-containing vaccine. The highest proportion of cases was found in children 0-6 years of age (738/1332, 55.41 %). Measles IgM positivity was determined in 75.88 % (346/456), while virus RNA was detected in 82.46 % (47/57) of the swab samples. All measles virus sequences belonged to genotype B3. SNP (position 216: C=>T) was detected in 1 of the 40 sequences obtained during this outbreak.Conclusion. Due to suboptimal immunization coverage, BiH belongs to countries at a high risk for measles outbreaks. Post-COVID-19 (coronavirus disease 2019) pandemic, targeted and tailored strategies are required to ensure routine vaccination demand and acceptance and broad partner and stakeholder group participation.

Background. Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and schizophrenia (SCZ) are highly heritable and linked to disruptions in foetal (neuro)development. While epigenetic processes are considered an important underlying pathway between genetic susceptibility and neurodevelopmental conditions, it is unclear (i) whether genetic susceptibility to these conditions is associated with epigenetic patterns, specifically DNA methylation (DNAm), already at birth; (ii) to what extent DNAm patterns are unique or shared across conditions, and (iii) whether these neonatal DNAm patterns can be leveraged to enhance genetic prediction of (neuro)developmental outcomes. Methods. We conducted epigenome-wide meta-analyses of genetic susceptibility to ASD, ADHD, and schizophrenia, quantified using polygenic scores (PGSs) on cord blood DNAm, using four population-based cohorts (npooled=5,802), all North European. Heterogeneity statistics were used to estimate DNAm pattern overlap between PGSs. Subsequently, DNAm-based measures of PGSs were built in a target sample, and used as predictors to test incremental variance explained over PGS in 130 (neuro)developmental outcomes spanning birth to 14 years. Outcomes. Probe-level analyses showed SCZ-PGS associated with neonatal DNAm at 246 loci (p<9x10-8), predominantly in the major histocompatibility complex. Functional characterization of SCZ-PGS loci confirmed strong genetic effects, significant blood-brain concordance and enrichment for immune-related pathways. 8 loci were identified for ASD-PGS (mapping to FDFT1 and MFHAS1), and none for ADHD-PGS. Regional analyses indicated a large number of differentially methylated regions for all PGSs (SCZ-PGS: 157, ASD-PGS: 130, ADHD-PGS: 166). DNAm signals are largely unique for individual PGSs. Finally, a DNAm-based measure of genetic susceptibility at birth nominally increased explained variance for several child cognitive and motor outcomes above PGS, but not after multiple testing correction. Interpretation. Genetic susceptibility for neurodevelopmental conditions, particularly schizophrenia, is detectable in cord blood DNAm at birth in a population-based sample, with largely distinct DNAm patterns between PGSs. These findings support the early-origins perspective on schizophrenia. Funding. HorizonEurope; European Research Council Keywords. Population-based; Genetic susceptibility; DNA methylation; Epigenetics; Neurodevelopmental conditions; Generation R Study; PREDO; ALSPAC; MoBa

In diffusion research, journalistic coverage is acknowledged as a significant factor in spreading awareness and fostering knowledge about innovation, potentially accelerating or impeding the adoption process. With regards to AI-related innovations, this dynamic has largely been studied within the context of Western developed countries. There is far less understanding of how this process unfolds in the news ecosystem of post-communist countries, particularly those with lower democratic standards and weaker economic development, such as Bosnia and Herzegovina. With the intention of gaining preliminary insights, this study investigated how the journalistic organizations in Bosnia and Herzegovina covered the emergence and societal adoption of ChatGPT, a novel form of generative AI, during the initial six-month period following its widespread availability. The content analysis of relevant news messages (N=542) published by 40 legacy and digital- only news outlets was used to explore the key characteristics of journalistic coverage, the attention given to the issue over time and the media depictions of this innovative AI technology. Results indicate that a small group of news outlets, predominantly legacy news organizations, provided significantly more content on ChatGPT than others, particularly public broadcasting services. Findings highlight a tendency among news outlets to focus on either the risks or benefits of ChatGPT and similar AI-based products and amplify sources associated with the business sector and high-tech industry, overrepresented by male voices.

Mining of the thick coal layers that include roof caving operation can results in residual coal quantities in the gob as a potential threat causing occurence of spontaneous oxidation process, smoldering, and endogenous mine fire that can affect the safety and regular mine operations. Endogeneous fire occurences in Zenica coal mines are directly linked to complex natural conditions reflecting in complex geological conditions, great depth of mining, high methane content in coal seams, and tendency of coal to spontaneous oxidation process. The subject of the paper is the analysis of endogenous fire supression method applyed in conditions of complete coal thickness longwall mining in Raspotočje mine, that has been rehabilitiated upon the endogeneous fire and then reactivated. The following methods were used in fire fighting: passive fire fighting methods (sealing of the area affected by the fire), active method (injection of electrofilter ash) and ventilation methods. Furthermore additional data (position of gob area and sealing objects, air flow regulators, routes of possible air migration, suggested technical solutions, etc) were added in the linear and canonic schemes for the purpose of defining efficient solutions for fire fighting. Key words: endogenous fire, longwall mining, advancing mining, fire fighting.

Morus alba L. is a plant with a long history of dietary and medicinal uses. We hypothesized that M. alba possesses a significant biological potential. In that sense, we aimed to generate the chemical, antimicrobial, toxicological, and molecular profile of M. alba leaf and fruit extracts. Our results showed that extracts were rich in vitamin C, phenols, and flavonoids, with quercetin and pterostilbene concentrated in the leaf, while fisetin, hesperidin, resveratrol, and luteolin were detected in fruit. Extracts exhibited antimicrobial activity against all tested bacteria, including multidrug-resistant strains. The widest inhibition zones were in Staphylococcus aureus ATCC 33591. The values of the minimum inhibitory concentration ranged from 15.62 μg/ml in Enterococcus faecalis to 500 μg/ml in several bacteria. Minimum bactericidal concentration ranged from 31.25 μg/ml to 1000 μg/ml. Extracts impacted the biofilm formation in a concentration-dependent and species-specific manner. A significant difference in the frequency of nucleoplasmic bridges between the methanolic extract of fruit (0.5 μg/ml, 1 μg/ml, 2 μg/ml), as well as for the frequency of micronuclei between ethanolic extract of leaf (2 μg/ml) and the control group was observed. Molecular docking suggested that hesperidin possesses the highest binding affinity for multidrug efflux transporter AcrB and acyl-PBP2a from MRSA, as well as for the SARS-CoV-2 Mpro. This study, by complementing previous research in this field, gives new insights that could be of great value in obtaining a more comprehensive picture of the Morus alba L. bioactive potential, chemical composition, antimicrobial and toxicological features, as well as molecular profile.

Antibiotic-resistant bacteria are currently an important public health concern posing a serious threat due to their resistance to the current arsenal of antibiotics. Uropathogens Escherichia coli (UPEC), Proteus mirabilis, Klebsiella pneumoniae and Enterococcus faecalis, antibiotic-resistant gram-negative bacteria, cause serious cases of prolonged UTIs, increasing healthcare costs and potentially even leading to the death of an affected patient. This review discusses current knowledge about the increasing resistance to currently recommended antibiotics for UTI therapy, as well as novel therapeutic options. Traditional antibiotics are still a part of the therapy guidelines for UTIs, although they are often not effective and have serious side effects. Hence, novel drugs are being developed, such as combinations of β-lactam antibiotics with cephalosporins and carbapenems. Siderophoric cephalosporins, such as cefiderocol, have shown potential in the treatment of individuals with significant gram-negative bacterial infections, as well as aminoglycosides, fluoroquinolones and tetracyclines that are also undergoing clinical trials. The use of cranberry and probiotics is another potential curative and preventive method that has shown antimicrobial and anti-inflammatory effects. However, further studies are needed to assess the efficacy and safety of probiotics containing cranberry extract for UTI prevention and treatment. An emerging novel approach for UTI treatment is the use of immuno-prophylactic vaccines, as well as different nanotechnology solutions such as nanoparticles (Nanoparticles). Nanoparticles have the potential to be used as delivery systems for drugs to specific targets. Furthermore, nanotechnology could enable the development of nano antibiotics with improved features by the application of different Nanoparticles in their structure, such as gold and copper Nanoparticles. However, further high-quality research is required for the synthesis and testing of these novel molecules, such as safety evaluation and pharmacovigilance.