The main aim of this study was to determine the correlation of motor knowledge of acrobatic elements with successful performance of parallel turns in alpine skiing. An additional aim was to determine whether there is a difference between groups divided on the basis of knowledge of alpine skiing. The research was conducted on a sample of 27 students enrolled in the third year of study at the Faculty of Sport, by the chronological age of 21-23 years. The sample of variables consisted of 14 variables to assess knowledge of acrobatic elements and one variable to assess the performance of the ski element parallel turns. The results indicate a statistically significant correlation between some acrobatic elements (e.g. with roll forward r= .438) with performance of parallel turns at the level of significance (p<0.05). Students, who have acquired the technique of acrobatic elements on the higher level or on the level of stabilization and automation with minor mistakes, achieve better results when learning the element of skiing technique – parallel turns. Based on the analysis of results we can conclude that some elements of acrobatics and skiing can interconnect according to the requirements for the motor abilities required for successful performance of acrobatic elements and we can say that the learning of acrobatic elements on higher level have a positive influence on the learning of element of alpine ski technique.

Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most studies have been underpowered to detect associations of a realistic magnitude. We assessed 41 common non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence of association with breast cancer risk had been previously reported. Case-control data were combined from 38 studies of white European women (46 450 cases and 42 600 controls) and analyzed using unconditional logistic regression. Strong evidence of association was observed for three nsSNPs: ATXN7-K264R at 3p21 [rs1053338, per allele OR = 1.07, 95% confidence interval (CI) = 1.04–1.10, P = 2.9 × 10−6], AKAP9-M463I at 7q21 (rs6964587, OR = 1.05, 95% CI = 1.03–1.07, P = 1.7 × 10−6) and NEK10-L513S at 3p24 (rs10510592, OR = 1.10, 95% CI = 1.07–1.12, P = 5.1 × 10−17). The first two associations reached genome-wide statistical significance in a combined analysis of available data, including independent data from nine genome-wide association studies (GWASs): for ATXN7-K264R, OR = 1.07 (95% CI = 1.05–1.10, P = 1.0 × 10−8); for AKAP9-M463I, OR = 1.05 (95% CI = 1.04–1.07, P = 2.0 × 10−10). Further analysis of other common variants in these two regions suggested that intronic SNPs nearby are more strongly associated with disease risk. We have thus identified a novel susceptibility locus at 3p21, and confirmed previous suggestive evidence that rs6964587 at 7q21 is associated with risk. The third locus, rs10510592, is located in an established breast cancer susceptibility region; the association was substantially attenuated after adjustment for the known GWAS hit. Thus, each of the associated nsSNPs is likely to be a marker for another, non-coding, variant causally related to breast cancer risk. Further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.

We study implications of large lepton-quark-leptoquark couplings for direct leptoquark searches at Large Hadron Collider. We present all existing flavor constraints on the strength of these couplings assuming that leptoquarks under consideration interact exclusively with charged leptons and quarks of the same generation. We find that these leptoquarks can have sizeable couplings to the Standard Model fermions. This insures a self consistency of our study. We discuss the leptoquark production mechanisms at LHC and demonstrate the importance of inclusion of a t-channel pair production and, in particular, a single leptoquark production through a recast of an existing CMS search at LHC for the second generation leptoquark. Our recast yields the best direct limit on Yukawa coupling of the second generation leptoquark that couples to a muon and a strange quark to date.

ABSTRACT The performance of the new Bio-Rad Geenius HIV-1/2 confirmatory assay was compared with that of the Chiron RIBA HIV-1/HIV-2 strip immunoblot assay using 166 samples from HIV-1-, HIV-2-, or HIV-1/2-positive and HIV-negative individuals and two quality control panels. Our results indicate that the Geenius assay is a suitable alternative for confirmatory HIV testing.

Here we report on the preparation of two hydrogen atom free 3,3'-bi(1,2,4-oxadiazole) derivatives. 5,5'-Bis(fluorodinitromethyl)-3,3'-bi(1,2,4-oxadiazole) was synthesised by fluorination of diammonium 5,5'-bis(dinitromethanide)-3,3'-bi(1,2,4-oxadiazole). For our previously reported analogue 5,5'-bis(trinitromethyl)-3,3'-bi(1,2,4-oxadiazole), a new synthetic route starting from new 3,3'-bi(1,2,4-oxadiazolyl)-5,5'-diacetic acid was developed. In this course also hitherto unknown 5,5'-dimethyl-3,3'-bi(1,2,4-oxadiazole) was isolated. The compounds were characterised by multinuclear NMR spectroscopy, IR and Raman spectroscopy, elemental analysis as well as mass spectrometry. X-ray diffraction studies were performed and the crystal structures for the 5,5'-dimethyl and 5,5'-(fluorodinitromethyl) derivatives are reported. The energetic 5,5'-(fluorodinitromethyl) and 5,5'-(trinitromethyl) compounds do not contain any hydrogen atoms and show remarkable high densities. Furthermore, the thermal stabilities and sensitivities were determined by differential scanning calorimetry (DSC) and standardised impact and friction tests. The heats of formation were calculated by the atomisation method based on CBS-4M enthalpies. With these values and the room-temperature X-ray densities, several detonation and propulsion parameters, such as the detonation velocity and pressure as well as the specific impulse of mixtures with aluminium, were computed using the EXPLO5 code.

The first part of the paper reviews existing technologies for remote marine monitoring with emphasis on latest achievements in the area, including the main common properties and differences between data buoys, moorings, landers, drifters and floats. Novel design for modular smart event triggered marine monitoring platform is proposed in second part of the paper. Mechanical and electrical design of the proposed platform is provided, including early experimental results regarding power consumption. Event trigger mechanism, used for saving battery power consumption, is explained and minimum amount of platform power consumption is determined. Some ideas for future work are also provided.