The prospective study, lasted from January 2010 to January 2015, covered the respondents treated for breast carcinoma. The respondents were divided into 2 groups. First group, group A (59 respondents), included the respondents where the tumour was found in diameter to 2 cm and were operated by breast-sparing surgery. Second group, group B (88 respondents), was consisted of respondents where the tumour was discovered in diameter over 2 cm and which breast amputated as part of a radical cancer surgery by Madden technique. The aim of this study is to analyse the effects of surgical treatment of breast carcinoma with different diameter and influence of tumour diameter on treatment outcome. The parameters for comparison of results were the number of relapses, the time elapsed from surgery to recurrence and treatment outcome. There were no significant differences between the two groups regarding the motives for attending breast examination. The incidence of carcinoma in the left or right breast also showed no statistical difference. It was found that the most common breast cancer is in women age between 50 and 70. It has been shown that breast carcinoma with diameter over 2 cm was significantly more frequent in women age of 71 to 80. Recurrent disease was registered in 3 cases in respondents from group A. Recurrence in group B was not registered. Lethal outcome was observed in group B in 4 cases, and in group A in 1 case, which proved to be statistically different.

The prospective study, which ran from January 2011 to January 2015, included the respondents who were treated from various non-tumor breast changes and breast tumors. The respondents were divided into 2 groups. First one, group A (280 respondents), consisted of the respondents who are residing in the rural area. Second one, group B (343 respondents), consisted of the respondents who have residence in urban area. The aim is to analyze the attitude to non-tumor diseases and breast tumors by women of rural and urban environment. The observed parameters are the reasons for coming to the breast examination: palpable formation in the breast, regular examination, breast pain, breast swelling and other changes. Parameters to compare the results were time intervals from the detection of palpable formations to examination. There was no statistically significant difference in inflammatory diseases of the breast, except in the case of breast abscess formation which is more common in the group A. A statistically significant difference among the groups was not found in the incidence of benign and / or malignant tumors of the breast, neither. It turned out that immediately after tumor detection by palpation, 4 patients in group A went to examination the next day. Patients in group B went 3 times more often to examination after a few days of the initial palpation of the tumor than patients in group A. There are much more women in group A who after only one year from the moment of palpable formation came to examination. The number of women, who have come to examination after a few months and / or years, is almost identical. Patients in group A have less responsible attitude towards non-tumor diseases and breast tumors, so it is possible for this group to be in higher degree of risk of late diagnosis of malignant tumors.

The prospective study, which ran from January 2010 to January 2015, included the respondents treated for breast carcinoma. The respondents were divided into 3 groups. The first, the A group (63 respopndents), consists of women with (not) completed elementary school. The second, group B (60 resppondents), consists of women who have secondary education, while the third, group C (33 respondents) make women with college or university degrees. The aim is to analyze the impact of the level of education on early diagnosis of breast carcinoma in women. The observed parameters are the age of respondents and the primary risk factors. Parameters for the comparison of the results were: the attitude of the respondents to breast tumors, history of the breast self-examination, breast ultrasound examinations, data on mammography, as well as information on the diameter of the tumor at the moment of the discovery. There was no statistical difference in attitude of respondents about breast tumors when it comes to fear and / or phobia of breast carcinoma. It is almost identical to the number of respondents who have no opinion on breast tumors. Concerning the attitude of respondents that there is no risk of breast carcinoma, if nobody in the family previously had breast carcinoma, then in terms of the attitude that they do not want "their breasts to be explored", as well as the attitude that "any breast examination does not help much", a statistical difference between the studied groups was found. It was found that breast self-examination is performed by most of the respondents, but that patients in group C do it more often. It has been shown that ultrasound and mammography are more often performed by patients in group C and this characteristic makes a significant statistical difference. In Group C, the tumor was detected in diameter to 2 cm which proved statistically different. One of the reasons for early detection of tumors (diameter to 2 cm) in group C may be better enlightenment or a higher level of education of this group.

INTRODUCTION High prevalence of metabolic syndrome (MetS) in children and adolescents is a great concern of the modern society. OBJECTIVE bjective: Our aim was to determine the influence of previously investigated, but also and potentially novel risk factors for the development of metabolic syndrome in children and adolescents. METHODS Observational case-control clinical study was conducted involving children and adolescents with obesity/metabolic syndrome, treated on inpatient basis from January 2008 to January 2012 at the Pediatric Clinic of the Clinical Centre Kragujevac, Kragujevac, Serbia. The group of"cases"(n=28) included patients aged 10-16 years with the diagnosis of metabolic syndrome according to the International Diabetes Federation (IDF) criteria, while the control group included twice as many obese patients (n=56) matched to the compared group. RESULTS Presence of maternal gestational diabates (ORadjusted: 39.426; 95% Cl: 1.822-853.271; p=0.019), and/or lack of breastfeeding in the first six months of life (ORadjusted: 0.079; 95% CI: 0.009-0.716; p=0.024) were significant predictors for developing MetS. Also, microalbuminuria is associated with MetS in obese children and adolescants (ORadjusted: 1.686; 95% Cl: 1.188-2.393; p=0.003) CONCLUSION: Presence of maternal gestational diabetes and/or lack of infant breastfeeding are considered as relevant factors that may contribute to the increased risk of developing MetS syndrome, while microalbuminuria is frequently associated with MetS in obese children and adolescents.

1 Department of Pharmacology, Th e Faculty of Medical Sciences, University of Kragujevac, Serbia 2 Department of Economics, Center for Children and Childhood Studies, Rutgers University, the State University of New Jersey, U.S.A. 3 Department of Epidemiology & Community Health, School of Health Sciences & Practice, New York Medical College, U.S.A. 4 Clinic for Neurology and Psychiatry for Children and Youth, Clinical Center of Serbia, Belgrade, Serbia 5 Psychiatric Clinic, University Clinical Center Kragujevac, Serbia 6 Centre for Clinical Pharmacology, Medical Faculty, Military Medical Academy University of Defence, Belgrade Serbia 7 Faculty of Medical Sciences University of Kragujevac, Serbia 8 Primary Care Facility Svilajnac, Serbia