Due to demographic change, more elderly people have the need to preserve and support mobility by car despite age-related functional limitations. Since accidents by the elderly are primarily caused by age related limitations, and not by careless or irresponsible behavior, it may be beneficial to detect driving impairing conditions. The presented review gives an overview of technologies to detect driving impairing conditions like drowsiness and stress or excessive demand. A comparison of the approaches to detect these conditions suggests that a combination of approaches is the most feasible method. However, there are still few systems that focus on the elderly. PMID: 22874374 [PubMed–in process] Stud health Technol inform. 2012;174:3-7. Efmi iNiTiATiVES fOr iNTEr-rEgiONAL COOPErATiON: ThE TrEhrT PrOJECT. Mihalas G, detmer d, li YC, Haux r, Blobel B. EFMi–European Federation for Medical informatics. mihalas@gmail.

Scientific publishing is the ultimate product of scientist work. Number of publications and their quoting are measures of scientist success while unpublished researches are invisible to the scientific community, and as such nonexistent. Researchers in their work rely on their predecessors, while the extent of use of one scientist work, as a source for the work of other authors is the verification of its contributions to the growth of human knowledge. If the author has published an article in a scientific journal it cannot publish the article in any other journal h with a few minor adjustments or without quoting parts of the first article, which are used in another article. Copyright infringement occurs when the author of a new article with or without the mentioning the author used substantial portions of previously published articles, including tables and figures. Scientific institutions and universities should,in accordance with the principles of Good Scientific Practice (GSP) and Good Laboratory Practices (GLP) have a center for monitoring,security, promotion and development of quality research. Establish rules and compliance to rules of good scientific practice are the obligations of each research institutions,universities and every individual-researchers,regardless of which area of science is investigated. In this way, internal quality control ensures that a research institution such as a university, assume responsibility for creating an environment that promotes standards of excellence, intellectual honesty and legality. Although the truth should be the aim of scientific research, it is not guiding fact for all scientists. The best way to reach the truth in its study and to avoid the methodological and ethical mistakes is to consistently apply scientific methods and ethical standards in research. Although variously defined plagiarism is basically intended to deceive the reader’s own scientific contribution. There is no general regulation of control of scientific research and intellectual honesty of researchers which would be absolutely applicable in all situations and in all research institutions. A special form of plagiarism is self-plagiarism. Scientists need to take into consideration this form of plagiarism, though for now there is an attitude as much as their own words can be used without the word about plagiarism. If the authors cite their own research facilities already stated then they should be put in quote sand cite the source in which it was published. Science should not be exempt from disclosure and sanctioning plagiarism. In the fight against intellectual dishonesty on ethics education in science has a significant place. A general understanding of ethics in scientific research work in all its stages had to be acquired during the undergraduate course and continue to intensify. It is also important ethical aspect of the publishing industry,especially in small and developing economies,because the issuer has an educational role in the development of the scientific community that aspires to relish so. In this paper author describe his experiences in discovering of plagiarism as Editor-in-Chief of three indexed medical journals with presentations of several examples of plagiarism recorded in countries in Southeastern Europe.

UDK 630*31/*32:621.936.6(497.6 Vareš)           621.936.6:621.892(497.6 Vareš) Chainsaw is the main tool for work, considering the terrain and soil in our country, in the process of the harvesting, and there is a big chance it will be the main tool in the future too. The goal of the research is to determine fuel and lubricant consumption of the chainsaw Husqvarna 372 XP, during the harvesting and making forest wood assortments, on the area of the Public enterprise forest, Vareš, section 37. During the research, 50 trees of the fir and spruce have been felled. Range of the diameter was from 8 to 76 cm, and the volume of the assortments was 86.16 m3. Volumetric method is applied in the measurement of fuel and lubricants, with precise determination of how much fuel it was in the thanks. Analysis showed that there is a strong correlation between consumption of the fuel and lubricant (L/m3) in relation to the size of the breast height diameter. Average fuel consumption in the process of logging and preparation was 0.104 L/m3, while the average consumption of lubricant was 0.023 L/m3. It is necessary to continue to pay great attention to the rationalization of consumption on fuel and lubricants, as well as reducing their harmful effects on humans and environment (introduction and usage of biodegradable fuels and lubricants).

We report a study of resistive switching in a silicon-based memristor/resistive RAM (RRAM) device in which the active layer is silicon-rich silica. The resistive switching phenomenon is an intrinsic property of the silicon-rich oxide layer and does not depend on the diffusion of metallic ions to form conductive paths. Both unipolar and bipolar programming is demonstrated. Switching exhibits the pinched hysteresis I/V loop characteristic of RRAM/memristive systems, and on/off resistance ratios of 104:1 or higher can be easily achieved. Scanning Tunnelling Microscopy suggests that switchable conductive pathways are 10nm in diameter or smaller. © 2012 Materials Research Society.

MOTIVATION The high throughput sequencing (HTS) platforms generate unprecedented amounts of data that introduce challenges for the computational infrastructure. Data management, storage and analysis have become major logistical obstacles for those adopting the new platforms. The requirement for large investment for this purpose almost signalled the end of the Sequence Read Archive hosted at the National Center for Biotechnology Information (NCBI), which holds most of the sequence data generated world wide. Currently, most HTS data are compressed through general purpose algorithms such as gzip. These algorithms are not designed for compressing data generated by the HTS platforms; for example, they do not take advantage of the specific nature of genomic sequence data, that is, limited alphabet size and high similarity among reads. Fast and efficient compression algorithms designed specifically for HTS data should be able to address some of the issues in data management, storage and communication. Such algorithms would also help with analysis provided they offer additional capabilities such as random access to any read and indexing for efficient sequence similarity search. Here we present SCALCE, a 'boosting' scheme based on Locally Consistent Parsing technique, which reorganizes the reads in a way that results in a higher compression speed and compression rate, independent of the compression algorithm in use and without using a reference genome. RESULTS Our tests indicate that SCALCE can improve the compression rate achieved through gzip by a factor of 4.19-when the goal is to compress the reads alone. In fact, on SCALCE reordered reads, gzip running time can improve by a factor of 15.06 on a standard PC with a single core and 6 GB memory. Interestingly even the running time of SCALCE + gzip improves that of gzip alone by a factor of 2.09. When compared with the recently published BEETL, which aims to sort the (inverted) reads in lexicographic order for improving bzip2, SCALCE + gzip provides up to 2.01 times better compression while improving the running time by a factor of 5.17. SCALCE also provides the option to compress the quality scores as well as the read names, in addition to the reads themselves. This is achieved by compressing the quality scores through order-3 Arithmetic Coding (AC) and the read names through gzip through the reordering SCALCE provides on the reads. This way, in comparison with gzip compression of the unordered FASTQ files (including reads, read names and quality scores), SCALCE (together with gzip and arithmetic encoding) can provide up to 3.34 improvement in the compression rate and 1.26 improvement in running time. AVAILABILITY Our algorithm, SCALCE (Sequence Compression Algorithm using Locally Consistent Encoding), is implemented in C++ with both gzip and bzip2 compression options. It also supports multithreading when gzip option is selected, and the pigz binary is available. It is available at http://scalce.sourceforge.net. CONTACT fhach@cs.sfu.ca or cenk@cs.sfu.ca SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.

The CIAO Study (“C omplicated Intra-A bdominal infection O bservational” Study) is a multicenter investigation performed in 68 medical institutions throughout Europe over the course of a 6-month observational period (January-June 2012).Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study.2,152 patients with a mean age of 53.8 years (range: 4–98 years) were enrolled in the study. 46.3% of the patients were women and 53.7% were men. Intraperitoneal specimens were collected from 62.2% of the enrolled patients, and from these samples, a variety of microorganisms were collectively identified.The overall mortality rate was 7.5% (163/2.152).According to multivariate analysis of the compiled data, several criteria were found to be independent variables predictive of patient mortality, including patient age, the presence of an intestinal non-appendicular source of infection (colonic non-diverticular perforation, complicated diverticulitis, small bowel perforation), a delayed initial intervention (a delay exceeding 24 hours), sepsis and septic shock in the immediate post-operative period, and ICU admission.Given the sweeping geographical distribution of the participating medical centers, the CIAO Study gives an accurate description of the epidemiological, clinical, microbiological, and treatment profiles of complicated intra-abdominal infections (IAIs) throughout Europe.

BackgroundLung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenocarcinoma phenotype can be determined immunohistochemically using TTF-1 and Napsin A. Expression of oncofetal protein IMP3 in human cancer is associated with poor differentiation and aggressive behaviour. In the present study expression of IMP3 was correlated with expression of TTF-1 and Napsin A, histological subtype and clinical stage of lung adenocarcinoma. We were interested whether distant metastases are associated with IMP3 overexpression, regardless of the histologic subtype of adenocarcinoma.MethodsIn retrospective study, consecutive series of 105 patients with advanced lung adenocarcinoma diagnosed from 2006 to 2009 in Clinical Hospital Center Split, Croatia, were analysed. Clinical data were collected from the Pulmology Department and time of death from the Mortality Registry. Paraffin blocks of bronchoscopic biopsies were collected from the Institute of Pathology and 15 cases excluded from the analysis due to insufficient material. Expression of IMP3, Napsin A and TTF-1 were analysed by indirect enzyme immunohistochemistry. Statistical analysis was performed and P values less than 0.05 considered significant.ResultsOf 90 patients, 71 (78%) were males and 19 (22%) females. Median age for males was 61.5 years (min-max 43–83) and for females 61 years (min-max 44–86). Pleural effusion was found in 15 (16.6%) and distant metastases in 45 (50%) cases. According to histological subtypes, there were 34 acinar, 2 lepidic, 2 papillary and 52 solid subtypes. IMP3 overexpression was found in 63 cases (70%) and was correlated with solid subtype (P = 0.002) and negative/weak Napsin A expression (P = 0.004). Strong Napsin A expression correlated with TTF-1 expression (P = 0.003) and lower histological grades (P = 0.031). Patients with IMP3 overexpression more often had distant metastases than patients with negative IMP3, 55.5% versus 33.3% (P = 0.033). Non solid subtypes with IMP3 overexpression developed distant metastasis more common than non solid subtypes with negative IMP3, 72% versus 35% (P = 0.028).ConclusionsExpression of IMP3 correlates with solid subtype and with distant metastases regardless of histological subtype of lung adenocarcinoma.Virtual slideshttp://www.diagnosticpathology.diagnomx.eu/vs/1966211581795258ZusammenfassungHintergrundDas Lungenkarzinom kommt meistens als nicht resektabler Tumor vor und die Diagnose kann nur in kleinen Biopsaten oder zytologisch gestellt werden. In der Gruppe der nicht kleinzelligen Lungenkarzinome kann der nicht anders spezifizierte Adenokarzinom Phänotyp mit Hilfe der Antikörper TTF-1 und Napsin A diagnostiziert werden. Die Expression des onkoföetalen Proteins IMP3 ist bei humanen Karzinomen mit agressivem Verhalten und metastatischem Potential verbunden. In dieser Studie korreliert die Expression von IMP3 mit TTF-1, Napsin A, histologischem Typ und klinischem Staging des Lungenkarzinoms. Wir waren daran interessiert, ob Fernmetastasen mit IMP3 Überexpression assoziiert sind, unabhängig von der histologischen Subtyp von Adenokarzinom.MethodeIn der retrospektiven Studie wurden die von 2006 bis 2009 im Klinischem Krankenhaus Split, Kroatien diagnostizerte Adenokarzinome der Lunge von 105 Patienten analysiert. Die klinischen Daten stammten aus der Abteilung für Pulmologie und im Falle des Todes vom Todesregister. Die Paraffinblöcke der primären Lungenbiopsate dieser Patienten wurden im Institut für Pathologie mit der indirekter Enzym - Immunohistochemie mittels Kombination der Antikörper gegen IMP3, Napsin A und TTF1 untersucht. 15 Fälle aus der Analyse aufgrund unzureichender Material ausgeschlossen. Es wurde eine statistische Untersuchung durchgeführt und Werte weniger als 0.05 P wurden als statistisch signifikant bezeichnet.ErgebnisseVon 90 Patienten mit Lungencarcinom waren 71 (78%) mänlich, durchschnittliches Alter war für Männer 61.5 Jahre (min-max 43–83) und 61 Jahre für Frauen (min-max 44–86). Pleurale Effusionen fand man in 15 Fällen (16.6%) und Fernmetastasen in 45 (50%) Fällen. Histologische Sybtypen waren: 2 lepidic Karzinome, 34 azinäre Karzinome, 2 papilläre und 52 solide Karzinome. IMP3 war exprimiert in 63 Fälle (70%). Positive IMP3 Expression war mit solidem Typ (P = 0.002) und negativer Napsin A Expression (P = 0.004) assoziert. Napsin A Expression war mit niedrigem Gradus (P = 0.031) und positiver TTF-1 Expression (P = 0.003) assoziert. Patienten mit IMP3 Überexpression öfter hatten Fernmetastasen als Patienten mit negativen IMP3, 55.5% versus 33.3% (P = 0.033). Non solide Subtyp mit IMP3 Überexpression entwickelten Fernmetastasen Meer häufiger als nicht festem Subtyp mit negativen IMP3, 72% versus 35% (P = 0.028).SchlussworteDie Expression von IMP3 ist mit negaativer Expression von Napsin A, solidem Subtyp und Metastasen verbunden und hat praktische predictive Werte in der pathologischen Diagnose des Adenokarzinoms der Lunge. Die Expression von IMP3 korreliert mit soliden Subtyp und mit Fernmetastasen unabhängig von histologische Subtyp Lungenadenokarzinom.

The objective of this research work was to explore the scope, structure and quality of production and use of domestic wheat in the RS. The subject of the research was to determine the production of wheat in the Republic of Srpska, the needs for seed wheat, determine the amount imported, and to identify measures to increase domestic production of seed wheat and to reduce imports. The analysis of commercial wheat production in the period 2006-2010 showed that the production took place in the average area of ​​44,017.6 ha, with an average yield of 3.28 t/ha and total production of 145,591 t. The highest level of wheat production was recorded in 2007 when it was 172,481 t, and a minimum production was in 2010 when it was 84,647 t. In the Republic of Srpska in 2010, the area under wheat amounted to 33,641 ha, which required about 8,410 tonnes of wheat seed, and only 4.27% of the quantities of seed wheat needed for the RS market were produced in the RS, the rest came from imports. According to the Indirect Taxation Administration data, the Republic of Srpska imported 125 t of wheat seed in 2009. The quantities of imported wheat vary considerably from year to year and are influenced by the weather in the sowing season and the prices on the market. Analysis of seed wheat in period 2006-2010 showed that the seed wheat occupied an average area of ​​128.8 ha, with the average yield of 4.06 t/ha and the total average production of 514.2 tonnes. The highest production was recorded in 2008 when it was 656.25 tonnes, and the lowest in 2010, 359.4 tonnes. Demand for wheat seed of the Republic of Srpska, based on five-year average, amounts to 13,205 tonnes, in which the domestic production share is 514 tonnes or 3.9%. The value of domestic wheat seed production in this period was BAM 393,616, and the value of missing quantities of seeds that are imported is BAM 9,824,152, based on the domestic price.