The Vehicle Routing Problem (VRP) is important in supply chain management as it optimizes goods and services delivery to customers, resulting in improved organizational productivity. This study introduces an innovative hybrid methodology integrating the Multi-Criteria Decision Making (MCDM) approach with Clarke and Wright’s savings algorithm to tackle the capacitated vehicle routing problem. In addition to the conventional aim of optimizing truck routes, this strategy considers customer satisfaction. The initial step involves clustering all customers through the utilization of Clarke and Wright’s savings algorithm, which efficiently organizes customers into groups based on their geographical closeness. Following this, the hybrid Best-Worst Method (BWM) and Ranking Alternatives For Similarity to Ideal Solution (RAFSI) method are utilized to allocate the best routes and establish customer prioritization. The major objective of this study is to reduce overall transportation expenses while ensuring compliance with vehicle capacity limitations, aiming to improve customer satisfaction. The proposed approach seeks to balance cost-efficiency and customer-centricity in vehicle routing by including customer prioritizing and Clarke and Wright’s savings algorithm. The effectiveness and practical application of the proposed methodology are demonstrated through a case in the food industry. The obtained results using the proposed methodology give a more precise platform for decision-making and highlight its relevance for enhancing supply chain performance and addressing the intricate challenges associated with the capacitated vehicle routing problem. The hybrid technique presented in this study provides a comprehensive framework for effectively tackling the intricate challenges associated with the capacitated vehicle routing problem.

Background/Aim: The placenta is an extraembryonic organ necessary for foetal development. Due to its availability and high content of stem cells and growth factors, placenta tissue has found its application in regenerative medicine. The aim of this paper was to determine whether the age of the pregnant woman or the gestational age affects the morphology of the term placenta and whether placentas of advanced maternal age are suitable for application in regenerative medicine. Methods: In this research 30 placentas of healthy pregnant women, aged from 18 to 42 years and from 36 up to 41 weeks of gestational age were used for analyses. Tissue samples were stained with standard haematoxylin and eosin staining and immunohistochemical staining with anti-CD34 antibody. The parameters of volume density of chorionic villi, intervillous spaces and fibrinoids, as well as the thickness of the placental barrier were determined. Results: The volume densities of chorionic villi and fibrinoids were higher in placentas of advanced maternal age, as well as in placentas of gestational age from 38 to 41 weeks of gestation, while the volume of intervillous spaces was lower in these groups. With increased maternal and gestation age, the placental membrane thickens. Conclusion: When sampling placentas for regenerative medicine purposes, only the placentas from pregnant women younger than 35 years of age and whose gestational age are not exceeding 38 weeks should be selected.

The agriculture sector in the Republic of Serbia holds significant economic and social importance due to its substantial contribution to domestic gross domestic product (GDP) and employment of a large number of people. Agricultural products play a crucial role in Serbia's export structure. Food is one of Serbia's major export products, with a trade surplus steadily increasing since 2005. Fruit cultivation, as part of the agricultural sector, is of great importance, with domestic producers effectively utilizing natural advantages for production, thus achieving recognition and competitiveness internationally. This study aims to analyze the trends in foreign trade parameters over a decade, focusing on one agricultural product, specifically apricots. The research employs a quantitative research method using standard descriptive statistical instruments. Results indicate that Serbia maintains a trade surplus in apricots, with significant fluctuations and varying growth and decline trends in analyzed trade parameters over the period.

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Background: Urgent surgical treatment of bleeding gastric and duodenal ulcer is indicated in cases where there is no treatment by an interventional gastroenterologist and radiologist readily available, or there is no satisfactory response to the applied interventional procedure. Objective: The aim of our study is to show that there is the still large number of patients with massive bleeding gastric or duodenal ulcers who had to undergo emergency surgery, in order to achieve hemostasis, provide survival analisys, and to present a methode of the surgical procedure which we perfomed. Methods: This study analysed 49 patients in the period of 5 years (2013-2018), who underwent emergency surgery due to bleeding ulcer. All patients had one or more gastroscopies in order to stop the bleeding, which were ineffective. Surgical treatments which are used in managing ulcer bleedings depended on the localization of the lesion and how severe the bleeding is. Indicated treatment is direct compression of a bleeding blood vessel (ulcer niche), truncal vagotomy, pyloroplasty, gastroduodenal artery ligature, ligature of the right gastroepiploic artery. Resection procedures were performed as well: antrectomy, proximal, subtotal and total gastrectomy. All surgical treatments aimed to preserve the patients of gastrointestinal tract where such an approach could be carried out. Results: There were total of 49 patients who underwent surgical treatment of bleeding ulcer of which 31 are male (63,27%) and 18 are female (36,73%). The survival was 38,78% (19 patients); mortality 61,22% (30 patients). The most common surgical treatment was direct suture of a bleeding vessel with a ligature of the gastroduodenal and right gastroepiploic artery. When we observe the results of resection procedures subtotal gastrectomy was most commonly used. Surgical procedure performed were bilateral vagotomy, ligature of gastroduodenal and right gastroepiploic artery if the ulcer is localized in the antral, pyloric or duodenal region and not penetrating showed that there is no need for gastrotomy/duodenotomy and direct suturing of the bleeding vessel significantly reduces operative procedure, and saves the patient from additional surgical trauma and allows the desired hemostasis. In 5-10% of patients with bleeding ulcers, emergency surgery is indicated due to massive bleeding and hemorrhagic shock and then surgery is the only chance of survival. The primary goal of any surgery for bleeding ulcer is to establish bleeding control. massive ulcer bleeding. All these patients did not have the opportunity to avoid surgery and stop the bleeding with the treatment of an interventional gastroenterologist and radiologist. Survival is 38.78%, mortality is still high 61.22% but it is encouraging that without the application of surgical treatment it would be 100% in this group of patients. Conclusion: Regardless of the risk posed by surgical treatment of a bleeding ulcer, it still brings the patient the only chance for life in cases when the interventional radiological and gastroenterological approach has failed or been disabled. Surgical treatment of bleeding ulcer in cases when the gastroenterological and radiological approach is insufficient or disabled - Single center experience.

The main objectives of this study were to 1) assess the following quantitative urban green space (UGS) indicators: share of UGS, total UGS per capita, and the public UGS per capita for Sarajevo and its corresponding municipalities; 2) propose the minimum area of UGS per capita and the minimum functional UGS area per capita; and 3) discuss the methodological approach used and its applicability and relevance for UGS quantity and quality assessment. UGSs were photo-interpreted based on or-thophotos and Google Satellite images and mapped manually. The total UGS area for Sarajevo is 58.5 km², with continuous green spaces present in hilly and mountainous areas of the city, whereas more built-up zones are present in flat areas. The total public UGS per capita is 28.0 m², or 9.8 m² if forest parks are excluded. The results can help in better understanding UGSs in Sarajevo and can serve as a reference for decisionmakers and policymakers.

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