Abstract This paper explores the influence of macroeconomic indicators, namely GDP growth, the Consumer Price Index and the unemployment rate on the quality of loan repayments by households in the banking market of the Federation of Bosnia and Herzegovina. Potential influence is observed over a period of fourteen years at the level of nonperforming household loans using regression analysis. The authors aim to determine whether macroeconomic forces actually influence loan repayment, and if so how and what can be done by banks to utilize this information in order to reduce future credit losses, and by the government to maintain the stability of the banking sector.

Aim: The study deals with the effects of new system of rehabilitation by using individual dynamic programs through computer technology in the education and rehabilitation of persons with hearing impairments. The sample includes adolescents of both gender distribution with the hearing impairment, average intellectual abilities, between 15 and18 years of calendar age, attending the secondary vocational training school (N=49). Results: The results point to a significant statistical difference between the achievements of the examinees who underwent the classical educational rehabilitation treatment and those whose education was based on individual dynamic programs through computer technology, in favor of the latter. Conclusion: The study deals up with new social, cultural and science perspectives viewed throw the implementation of assistive technology in education and rehabilitation of deaf people.

Introduction: Renin-angiotenzin system (RAS) is frequently activated in patients with chronic liver disease. Angiotenzin - II (AT-II), produced by angiotenzin converting enzyme (ACE), has many physiological effects, including an important role in liver fibrogenesis. Combined antiviral therapy with PEG-IFN and ribavirin besides its antiviral effect also leads to a reduction in liver parenchyma fibrosis. Aim of the study: Determining the value of ACE in serum of patients with chronic hepatitis C before and after combined antiviral therapy, as well as the value of ACE activities in sera of the control group. Materials and methods: We studied 50 patients treated at Gastroenterohepatology Department, in the time-period of four years. Value of ACE in serum was determined by Olympus AU 400 device, with application of kit “Infinity TN ACE Liquid Stable Reagent”. HCV RNA levels in sera were measured by real time PCR. HCV RNA test was performed with modular analysis of AMPLICOR and COBAS AMPLICOR HCV MONITOR test v2.0, which has proved infection and was used for quantification of the viruses and monitoring of the patients’ response to therapy. Liver histology was evaluated in accordance with the level of necroinflammation activity and stage of fibrosis. Results: Serum activities of ACE in chronic hepatitis C patients is statistically higher than the values in the control group (p=0.02). Antiviral therapy in chronic hepatitis C patients statistically decreases serum activities of ACE (p= 0.02) and indirectly affects fibrogenesis of the liver parenchyma. Correlation between ACE and ALT activity after the therapy was proved (0.3934). Conclusion: Our findings suggest that the activity of ACE in serum is a good indirect parameter of the liver damage, and could be used as an indirect prognostic factor of the level of liver parenchyma damage. Serum activity of ACE can be used as a parameter for non-invasive assessment of intensity of liver damage.

Introduction: Faculty of Medicine, University of Sarajevo has officially started working on 22.11.1944, and is the oldest faculty in the medical field in Bosnia and Herzegovina. At the same time there are two systems of organization of the teaching process, the old system and the Bologna system. Aim: To analyze the implementation of the Bologna system, and making an overview of its justification. Material and methods: Answers from questionnaires from total of 459 students were analyzed (197 who had studied under the old system and 262 who studied under the Bologna system), so total of four generations of the Bologna system. They filled out a questionnaire in which they evaluated the teaching process. Student’s opinion about quality of medical education was measured by modified Lickert scale. Results: Students of old system are older than students of the Bologna process, whose average age is increasing from generation to generation, given the growing number of students who repeat a year. All students of old system repeated an academic year once or several times (p <0.05). Analysis of average grades showed statistically significant difference (p <0.05), where students in the Bologna system had higher averages than students who were studying under the old system. The presence of large number of female students, in both systems is significant (p <0.05). Out of 33 questions about satisfaction of class, 15 were answered with better average grade from students of the Bologna system. A slight improvement in the Bologna system is in terms of the evaluation of the quality of the educational process (teachers, methods, effects). The only significant progress has been proven in terms of rating the degree of computerization of the educational process–general records on enrolled students (old system vs Bologna system–3,44 vs 3,63), record of attendance (3,47 vs 3,73), obtaining certificates (3,08 vs 3,84), method of registration of exam (2,98 vs 3,71), method of practical exam (3,06 vs 3,36) and theoretical methods of taking exam (3,01 vs 3,14). Average grades where no average grade, on any issue, does not reach grade 4 of Likert Scale, talks about real problems of education in medical field. Conclusion: In a relatively large sample (four generations of students) true benefit and progress of the Bologna system has not been proven, in comparison to the old system. Bologna system has eased the students in the administrative sense by introduction of computerization of faculties, but the old problems and old questions about the organization’s process and delivery have not been eliminated.

Introduction: Dilatation of the left atrium and left ventricular diastolic dysfunction (DDLV) according to recent studies has significance in the occurrence of postoperative atrial fibrillation (AF), stroke and death. Authors of some studies found no relationship between these parameters and atrial fibrillation. Objective: this study is to determine the time of occurrence and duration of atrial fibrillation in patients after surgical revascularization (CABG) due to the presence of left ventricular diastolic dysfunction and left atrium dilatation and identify the most significant predictors of incident AF. Methods: Prospective study included 116 patients undergoing surgical myocardial revascularization followed from admission to discharge. The study was conducted at the Special Hospital “Heart Center BH” Tuzla for a period of one year (March 2011/2012 g.). For all patients was performed preoperative ultrasound examination, especially parameters of diastolic function of the left ventricle and left atrium volume index (LAVi), as the best parameter sized left atrium, and the postoperative occurrence of certain AF and day occurrence, duration in hours, the number of attacks. To assess whether an event occurred or not was used logistic regression, and the effect of time on the event of interest is analyzed by Cox ‘s regression hazard parallel. Results: 75.9 % of patients had DDLV, and 91.4 % were hypertensives, 12.9 % from the previous stroke (ICV) and 42.2 % diabetics (DM), 14 % with COPD. The average age of patients was 61.41 ± 4.69 years. In both groups was 32.8 % women and 67.2 % men. LAVi preoperative values were significantly higher as DDLV greater degree. In patients with DDLV and higher values LAVi risk of AF is higher, the greater the length of AF and significantly higher number of attacks FA. Early occurrence of atrial fibrillation and its longer duration in function with increasing LAVi a marked increase in the value LAVi have the greatest hazard for the early appearance of atrial fibrillation. As a result of analysis of the most significant predictors of AF are DDLV and LAVi. Conclusion: Postoperative atrial fibrillation occurs earlier and lasts longer in patients with DDLV and elevated left atrial volume index especially LAV > 36ml/m2. LAVi has the best explanation of the function of hazard occurrence of atrial fibrillation after CABG.

Introduction. The protective ileostomy is a procedure that is now increasingly used after the creation of low colorectal anastomosis, and after resection of rectal cancer. The protective ileostomy is a procedure that, to a lesser extent, affects the prevention of anastomotic colorectal dehiscence, but it has a much greater signifi cance in reducing the severity of complications occurring after colorectal anastomosis dehiscence. However, the creation itself, as well as the closure of loop ileostomy are accompanied with certain complications. Aim of the study. The aim of this study was to determine the frequency and severity of complications of ileostomy and justifi cation for its creation, within the test sample of 42 patients. Patients and Methods. The study was designed as a retrospective-prospective study. 42 patients, with created protective ileostomy that occurred after low colorectal anastomosis, were included in the study. The average age was 64.38 years with a standard deviation of 9.63 years. The youngest patient was 36 years old and the oldest patient was 77 years old. The representation of patients by gender was 29 (69%) male patients and 13 (31%) female patients. During the study, functions and complications associated with the created loop ileostomy, as well as the need for surgical treatment and the period until the sinking of ileostomy were monitored in patients. Results. Out of the total number of observed patient complications of ileostomy occurred in 8 of them (19%), and in 34 (81%) patients there were no complications. Out of the total number of complications, only in cases of 2 (4.8%) patients , there was the need for surgical treatment. In 1(2.4%) patient, ileostomy remained permanently. Conclusion. This study showed that the loop ileostomy after the creation of low colorectal anastomosis is accompanied with fewer complications. The resulting complications are successfully disposed by conservative treatment, and only rarely require surgical re-intervention. Keyword: loop ileostomy, rectal cancer, complications of loop ileostomy (Scr Med 2016:47:11-15) ! " # $ # % & ' ( ' ! ' & ! ) ! * ! + , . * * ! / 0 " 1 * ! * . 2 3 4 5 5 ! 6 5 1 4 # $ 0 12 Scripta Medica Vol. 47 • No 1 • April 2016. • www.scriptamedica.com Introduction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` > = 9 B C F ? @ A B > = A C D < M < L B 8 > < ? ; C @ > ? < 9 H < = C F > M < = C F > < = 9 D C < A < > D H ? > ; > < = C F > @ 8 9 ; D A > < S A = 8 A @ 9 C < = C F G M > ; 9 ; 9 @ > = A N 9 @ G ; > ; 9 > D H C B B L ; A D a ^ B > < 9 < Q b 7 C H > G M = 8 9 ; 9 > ; 9 C ? ? C < A D P N A 9 S < C D = 8 9 ; C @ 9 C E @ C C ? A @ 9 C < = C K F G = C ? ; C = 9 B = @ C S B C @ C ; 9 B = > @ > D > < = C F C < A < K = 8 9 C B B L ; ; 9 D B 9 C E H 9 8 A < B 9 D B 9 = C > ; 9 H L B = A C D A D H 9 > = 8 A D ? > = A 9 D = < S 8 C 8 > N 9 > @ K ; 9 > H G < L 9 ; 9 H H 9 8 A < B 9 D B 9 Q c Y C F ? @ A B > = A C D < C E A @ 9 C < = C F G F > G C B B L ; A D C N 9 ; d ] ^ C E ? > = A 9 D = < Q e f D C ; H 9 ; = C C I = > A D P C C H ; 9 K < L @ = < A D = 8 9 = ; 9 > = F 9 D = C E B C F ? @ A B > = A C D < M 9 > B 8 ? > = A 9 D = ; 9 O L A ; 9 < > D A D H A N A H L > @ = ; 9 > = F 9 D = M < ? 9 B A > @ B > ; 9 M ? 9 ; < A < = 9 D B 9 > D H = 9 > F S C ; J I 9 = S 9 9 D H C B = C ; < > D H D L ; < 9 < Qe Aim of the study 7 8 9 > A F C E = 8 9 < = L H G S > < = C H 9 = 9 ; F A D 9 = 8 9 E L D B = A C D C E ? ; C K = 9 B = A D P A @ 9 C < = C F G M = 8 9 C B B L ; ; 9 D B 9 C E B C F ? @ A B > = A C D < C E A @ 9 C < K = C F G S A = 8 A D = 8 9 C I < 9 ; N 9 H < = L H G > D H E ; C F = 8 9 : ; < = ? C < = C ? 9 ; K > = A N 9 H > G L D = A @ A = < B @ C < L ; 9 Q g L ; = 8 9 ; F C ; 9 M = 8 9 > A F C E = 8 9 < = L H G S > < = C H 9 = 9 ; F A D 9 = 8 9 D 9 9 H E C ; < L ; P A B > @ = ; 9 > = F 9 D = C E B C F ? @ A K B > = A C D < > D H = C H 9 = 9 ; F A D 9 = 8 9 U L < = A : B > = A C D E C ; B ; 9 > = A D P > @ C C ? A @ 9 C < = C F G Q Patients and Methods 7 8 9 < = L H G S > < H 9 < A P D 9 H > < > ; 9 = ; C < ? 9 B = A N 9 K ? ; C < ? 9 B = A N 9 < = L H G Q h d ? > = A 9 D = < S A = 8 @ C S B C @ C ; 9 B = > @ > D > < = C F C < A < > E K = 9 ; S 8 A B 8 = 8 9 B ; 9 > = A C D C E ? ; C = 9 B = A N 9 A @ 9 C < = C F G C B B L ; ; 9 H S 9 ; 9 A D B @ L H 9 H A D = 8 9 < = L H G Q i @ @ ? > = A 9 D = < S 9 ; 9 < A F A @ > ; A D > P 9 > D H < 9 Z Q j > = > E C ; = 8 9 < = L H G < L B 8 > < P 9 D H 9 ; M > P 9 M C ? K 9 ; > = A D P ; 9 < L @ = < M > D H B C F ? @ A B > = A C D < S 9 ; 9 L < 9 H E ; C F = 8 9 F 9 H A B > @ ; 9 B C ; H < M C ? 9 ; > = A C D > @ ? ; C = C B C @ < > D H B @ A D A B > @ 9 Z > F K A D > = A C D C E = 8 9 ? > = A 9 D = < = ; 9 > = 9 H > = = 8 9 Y @ A D A B C E k 9 D 9 ; > @ > D H i I H C F A D > @ l L ; P 9 ; G C E = 8 9 Y @ A D A B > @ Y 9 D = 9 ; A D m > D U > ` L J > Q l L ; P A B > @ = 9 B 8 D A O L 9 C E ? > = A 9 D = < A D B @ L H 9 H = 8 9 L < > P 9 C E @ C S ; 9 B K = > @ ; 9 < 9 B = A C D = 9 B 8 D A O L 9 S A = 8 < 8 > ; ? 9 Z B A < A C D I G = 8 9 ; F C B > L = 9 ; > D H ` A P > < L ; 9 M L D H 9 ; H A ; 9 B = N A < L > @ B C D = ; C @ C L = < A H 9 = 8 9 N A < B 9 ; > @ E > < B A > = 8 > = B C N 9 ; 9 H = 8 9 ; 9 B = L F > D H F 9 < C ; 9 B = L F Q n 9 < 9 B = A C D C E = 8 9 @ C S 9 ; F 9 < 9 D = 9 ; A B N 9 < < 9 @ < S > < B C D H L B = 9 H A D 8 A P 8 @ A P > = A C D Q i = = 8 9 < > F 9 = A F 9 M > D > H 9 O L > = 9 8 9 F C < = > < A < S > < ? 9 ; E C ; F 9 H S A = 8 = 8 9 L < > P 9 C E @ A P > = L ; 9 < > D H < @ C S K ; 9 < C ; ? = A C D < L = L ; 9 F > K = 9 ; A > @ > D H ` A P > < L ; 9 Q 7 C = > @ F 9 < C ; 9 B = > @ 9 Z B A < A C D S > < ? 9 ; E C ; F 9 H A D ? > = A 9 D = < S A = 8 ; 9 B = > @ = L F C ; < > = = 8 9 H A < = > D B 9 C E \ o B F E ; C F = 8 9 > D C > B L = 9 @ A D 9 Q f D F C < = B > < 9 < M = 8 9 ; 9 < 9 B = A C D S > < ? 9 ; E C ; F 9 H S A = 8 @ A D K 9 > ; 7 i < = > ? @ 9 ; Q f D > < F > @ @ D L F I 9 ; C E ? > = A 9 D = < M ; 9 < 9 B = A C D C E = 8 9 ; 9 B = L F S > < ? 9 ; E C ; F 9 H S A = 8 > < = > ? @ 9 ; E C ; @ C S > D = 9 K ; A C ; ; 9 < 9 B = A C D p B C D = C L ; q Q 7 8 9 > D > < = C F C < A < S > < B ; 9 > = 9 H L < K A D P = 8 9 F 9 B 8 > D A B > @ B A ; B L @ > ; < = > ? @ A D P H 9 N A B 9 < p < = > ? @ 9 ; < q Q i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g C ; F C < = C E = 8 9 B C @ C > D > @ > D > < = C F C < A < M > D > < = C F C < A < ? ; C = 9 B = A C D S A = 8 = 8 9 B ; 9 > = A C D C E ? ; C = 9 B = A N 9 A @ 9 C < = C F G S > < ? 9 ; E C ; F 9 H Q l = > D H > ; H < L ; P A B > @ = 9 B 8 D A O L 9 < S 9 ; 9 > ? ? @ A 9 H A D = 8 9 B ; 9 > K = A C D C E @ C C ? A @ 9 C < = C F G Q f D = 8 9 @ C S 9 ; ; A P 8 = O L > H ; > D = C E = 8 9 > I H C F 9 D M C D = 8 9 @ A D 9 = 8 > = B C D D 9 B = 9 H = 8 9 E ; C D = L ? ? 9 ; I 9 @ @ G I L = = C D > D H ? 9 @ N A B I L @ P 9 ? ; C = 9 B = A N 9 A @ 9 C < = C F G S > < B ; 9 > = 9 H Q ] B F @ C D P A @ 9 L F S A D H < S > < ? 9 ; E C ; F 9 H = 8 ; C L P 8 > D C ? 9 D A D P > = > I C L = \ ] B F C E m > L 8 A D W < N > @ N 9 Q p r A B = L ; 9 \ Q q 7 8 9 D = 8 9 ; 9 > ; 9 H P 9 < C E = 8 9 N > P A D > ; 9 B = L < > D H ?

Introduction. Colorectal metastatic liver tumors are the most common secondary liver tumors. During life, the liver metastases will develop either as synchronous or metachronous carcinomas in half of the total number of patients. At the time of the diagnosis, in approximately 25% of patients with colorectal cancer diagnosis, the presence of secondary deposits in the liver was observed, and additional 25% of patients were to develop metastases within fi ve years. Aim of the study. The objective was to demonstrate that anatomic resections of the liver present the method of choice in surgical treatment of colorectal liver metastases, when compared to metastasectomy. Patients and methods. The study included 70 patients, divided into two groups. Among the patients from the fi rst group, metastasectomy, which was consisted of the removal of metastases and the surrounding liver parenchyma no more than 1cm with the usage of Kelly-clysis technique or Ligasure device, was performed. In patients from the second group, anatomic resection of the liver was performed upon which metastases were removed and the associated anatomical segment or section, that is, half of the liver depending on the number and localization of metastases. Results. The average overall survival values for the fi rst group was 36 months with a standard deviation of 4.8 months. The average overall survival in patients from the second group was 36 months with a standard deviation of 2.6 months. The average value of disease-free survival in the fi rst group was 18 months with a standard deviation of 2.22 months. In the second group, the average disease-free survival was 22 months with a standard deviation of 0.74 months. Conclusion. Overall survival in both types of operation was identical, and the average overall survival was 36 months. Disease-free interval in the anatomical resection was 22 months, while it was 18 months in metastasectomy. From all the above mentioned, it can be concluded that surgery is a fundamental and irreplaceable method in the treatment of liver metastases of colorectal cancer. Key words: liver, metastasis, metastasectomy, anatomical resection (Scr Med 2016:47:7-10) & ' ( ) * + , * . / . 0 1 2 3 2 , 2 1 , 4 , * 5 , + * 6 7 8 ) 5 * 5 , 9 : ; + + 5 ; + < = > ? @ A A , B A ; @ 7 ) . 5 < / 9 + : 8 Scripta Medica Vol. 47 • No 1 • April 2016. • www.scriptamedica.com Introduction C D E D F G H I J E H J K H G F L M I N G O D M I H D O O D K P J M I F D L K I G M I L K J E O J E L P K J K I I Q O D F I N J I L M J E M D I N G O D M I H D O O D K E L R G F I Q S O D F O G I J M I J M G M T U V I I N G I L O G D W I N G X L J P K D M L M Y L K J Z Z F D [ L S O J I G E \ ] ^ _ D W Z J I L G K I M ` L I N H D E D F G H I J E H J K H G F X L J P K D M L M Y I N G Z F G M G K H G D W M G H D K X J F \ X G Z D M L I M L K I N G E L R G F ` J M D a M G F S R G X Y J K X J X X L I L D K J E ] ^ _ D W Z J I L G K I M ` G F G I D X G R G E D Z O G S I J M I J M G M ` L I N L K b R G \ G J F M T c d N G b F M I E L R G F F G M G H I L D K W D F H D S E D F G H I J E E L R G F O G I J M I J M G M ` J M Z G F W D F O G X a \ C J I G E E L K e f g h T i L I N I N G L O Z F D R G O G K I D W M Q F P L H J E I G H N K L j Q G M Y L K I F D X Q H I L S D K D W K G ` H \ I D M I J I L H M J K X F G X Q H I L D K D W I N G F G M G H I L D K O J F S P L K I D E G M M I N J K e H O Y I N G J Z Z E L H J I L D K D W L K I G F R G K I L D K J E F J S X L D E D P \ Y Z D F I J E R G K D Q M G O a D E L k J I L D K Y J E E D ` G X I N G I F J K M W G F D W Z J I L G K I M W F D O I N G P F D Q Z ` L I N Q K F G M G H I J a E G I Q O D F M I D P F D Q Z ` L I N F G M G H I J a E G D K G M T d N G J L O D W I F G J I O G K I L M M Q F S P L H J E F G O D R J E D W J E E O G I J M I J M I J I L H I Q O D F M L K I N G E L R G F Y a G S H J Q M G I N G G [ Z G F L G K H G L K X L H J I G M I D I N G b R G S \ G J F M Q F R L R J E D W ] ^ S l h _ D W I N G D Z G F J I G X Z J I L G K I M T c m h _ D W H D K M G F R J I L R G E \ I F G J I G X Z J I L G K I M ` L I N O G I J M I J M G M X D K D I M Q F R L R G J \ G J F T n o G I J M I J M G H I D O L G M Z F G M G K I I N G P F D Q Z D W K D K J K J I D O L H F G S M G H I L D K M Q F P G F L G M ` N G F G I N G L K I G F M G H I L D K D W I N G N G Z J I L H Z J F G K H N \ O J ` L I N L K h T ^ S e H O D W I N G O G I J M I J M G M L M Z G F W D F S O G X ` L I N I N G Q M J P G D W p G E E \ S H F \ M L M D F q L P J M Q F G I G H N K L j Q G T V K J I D O L H J E E L R G F F G M G H I L D K M J F G a J M G X D K I N G Z F L K H L Z E G M D W M G P O G K I J E J K X M G H I D F J K J I D O \ D W I N G E L R G F T d N G G [ I G K I D W J K J I D O L H J E M Q F P G F \ L K H E Q X G M M G P O G K I G H D O L G M Y a L M G P O G K S I G H I D O L G M Y M G H I L D K G H I D O L G M J K X N G O L N G Z J I G H I D O L G M T Aim of the study d D G M I J a E L M N ` N G I N G F J K J I D O L H F G M G H I L D K D W I N G E L R G F L M I N G O G I N D X D W H N D L H G L K M Q F P L H J E I F G J I O G K I D W H D E D F G H I J E E L R G F O G I J M I J M G M Y ` N G K H D O Z J F G X I D O G I J M I J M G H I D O \ Y J M ` G E E J M I D O D K L I D F I N G X L M I J K H G L K X L M G J M G S W F G G I L O G J K X D R G F J E E M Q F R L R J E T Patients and methods d N G F G M G J F H N N J X I N G H N J F J H I G F D W J F G I F D M Z G H I L R G S Z F D M Z G S H I L R G M I Q X \ T d N G M Q F R G \ ` J M H D K X Q H I G X L K I N G r K L R G F M L I \ C E L K L H J E C G K I G F D W s J K t J q Q u J T d N G M I Q X \ H D R G F G X I N G Z G S F L D X W F D O v J K Q J F \ ] h h m I D v J K Q J F \ ] h e g T d N G M I Q X \ ` J M H D K X Q H I G X D K m h Z J I L G K I M Y X L R L X G X L K I D I ` D P F D Q Z M w P F D Q Z V J K X s x T C F L I G F L J W D F L K H E Q M L D K L K I N G M I Q X \ ` G F G F G M Z D S K X G K I M ` N D ` G F G I G H N K L H J E E \ J a E G I D a G I J u G K H J F G D W a \ M Q F P L H J E O G I N D X D W O G I J M I J M G H I D O L G M J K X a \ O G I N D X D W J K J I D O L H J E F G M G H I L D K M T o G I J M I J I L H X L M G J M G ` J M E D H J E L k G X D K E \ L K I N G E L R G F T d N G b F M I P F D Q Z D W F G M Z D K X G K I M y z { ^ w P F D Q Z V x Q K S X G F ` G K I M Q F P L H J E O G I J M I J M G H I D O L G M D W I N G I Q O D F J K X I N G M G H D K X P F D Q Z y z { ^ w P F D Q Z s x Q K X G F ` G K I J K J I D O L H J E F G M G H I L D K D W I N G I Q O D F T | K I N G P F D Q Z V Z J I L G K I M Y O G I J M I J M G H I D O \ Y ` N L H N ` J M H D K S M L M I G X D W F G O D R L K P O G I J M I J M G M J K X M Q F F D Q K X L K P E L R G F Z J S F G K H N \ O J K D O D F G I N J K e H O ` L I N I N G Q M J P G D W p G E L S H F \ M L M I G H N K L j Q G D F q L P J M Q F G X G R L H G Y ` J M Z G F W D F O G X T | K P F D Q Z s Z J I L G K I M Y J K J I D O L H F G M G H I L D K D W I N G E L R G F ` J M Z G F W D F O G X Q Z D K ` N L H N O G I J M I J M G M ` G F G F G O D R G X J K X I N G J M M D H L J I G X J K J I D O L H J E M G P O G K I D F M G H I L D K Y I N J I L M Y N J E W D W I N G E L R G F X G Z G K X L K P D K I N G K Q O a G F J K X E D H J E L k J I L D K D W O G I J M I J M G M T d N G W D E E D ` L K P M Q F P L H J E J Z Z F D J H N G M ` G F G Q M G X } O G X L J E Y v L K H L M L D K J K X o J u Q H N E J Z J F D I D O \ T V W I G F I N G D Z G K L K P Y ` G J H H G M M G X I D I N G O D a L E L k J I L D K D W I N G E L R G F Y W D E E D ` G X a \ L K S I F J D Z G F J I L R G Q E I F J M D K D P F J Z N \ w | ~ r  V x Y ` N L H N Z F D R L X G X I N G X G I G H I L D K D W I N G Z F G H L M G I Q O D F Z D M L I L D K T q L R G F F G M G H I L D K ` J M Z G F W D F O G X J I F G X Q H G X H G K I F J E R G K D Q M Z F G M M Q F G C €  w h S ^ H O ‚ ] h x Y ` L I N I N G Z J I L G K I L K d F G K X G S E G K a Q F P Z D M L I L D K T  J F G K H N \ O J I F J K M G H I L D K a G P J K ` L I N X L J I N G F O \ I J P D W F G M G H I L D K E L K G Y ` N L E G I N G M G H I L D K D W Z J S F G K H N \ O J ` J M Z G F W D F O G X a \ q L P J M Q F G D F p G E E \ S H F \ M L M I G S H N K L j Q G T s L E L D S R J M H Q E J F M I F Q H I Q F G M ` G F G I J u G K H J F G D W ` L I N H E L Z M J K X R J M H Q E J F M Q I Q F G M T Results d N G D Q I H D O G M D W I N G G [ J O L K G X M J O Z E G D W D R G F J E E M Q F R L S R J E a J M G X D K p J Z E J K S o G L G F H Q F R G M W D F Z J I L G K I M W F D O I N G P F D Q Z V ` N D Q K X G F ` G K I O G I J M I J I G H I D O L G M Y I N G O G X L J K D R G F J E E M Q F R L R J E ` J M { l O D K I N M ` L I N J M I J K X J F X X G R L J I L D K D W g T ƒ O D K I N M J K X J D K G S \ G J F Y I ` D S \ G J F J K X I N F G G S \ G J F M Q F R L R J E ` J M ƒ ^ T { _ Y l ƒ T { _ J K X ^ h _ T w C N J F I e T x d N G J R G F J P G D R G F J E E M Q F R L R J E L K P F D Q Z s Z J I L G K I M Y ` N D Q K S X G F ` G K I I N G J K J I D O L H J E M Q F P G F \ Y ` J M { l O D K I N M ` L I N J M I J K X J F X X G R L J I L D K D W ] T l O D K I N M J K X J D K G S Y I ` D S J K X I N F G G S \ G J F M Q F R L R J E ` J M ƒ f T { _ Y l m T ^ _ J K X ^ h _ T Chart 1. Medial overall survival V W I G F I N G M I J I L M I L H J E H D O Z J F L M D K M D W p J Z E J K S o G L G F H Q F R G M D W D R G F J E E M Q F R L R J E a \ o J K I G E S C D [ I G M I w ] z h T e l m „ Z z 9 V. ŠKRBIĆ, M. SIMATOVIĆ, J. ĐERI, G. JANJIĆ, S. MIHAJLOVIĆ h T l ƒ { x Y L I H J K a G H D K H E Q X G X I N J I I N G F G ` J M K D M I J I L M I L H J E E \ M L P K L b H J K I X L G F G K H G w Z … h T h ^ x a G I ` G G K I N G M I Q X \ P F D Q Z M V J K X s ` N G K L I H D O G M I D D R G F J E E M Q F R L R J E T d N G O G X L J K R J E Q G D W X L M G J M G S W F G G M Q F R L R J E L K I N G P F D Q Z V ` J M e ƒ O D K I N M ` L I N J M I J K X J F X X G R L J I L D K D W ] T ] ] O D K I N M Y J D K G S \ G J F