Background:Delayed-release dimethyl fumarate (DMF), indicated for the treatment of patients with relapsing-remitting multiple sclerosis (MS), is a disease-modifying therapy with potential immunomodulatory and neuroprotective effects. In clinical trials, DMF was associated with reduced white blood cell and absolute lymphocyte counts. Current US prescribing information recommends obtaining a complete blood count, including absolute lymphocyte count (ALC), before initiating and during DMF treatment. Methods:We conducted an integrated analysis of phase 2b/3/long-term extension studies of DMF in MS (N = 2,470) to characterize ALC profiles. Results:Mean ALCs decreased by 30% during the first year and then plateaued, remaining above the lower limit of normal (LLN). Among patients treated ≥6 months (N = 2,099), 2.2% experienced ALCs <500 mm3 persisting ≥6 months. ALCs remained ≥LLN in 84% and 76% of patients during the first 6 and 12 months, respectively; of these, 0.1% and 0%, respectively, developed ALCs <500 mm3 persisting ≥6 months at any time. Evidence of ALC improvement following DMF discontinuation was observed. DMF efficacy was not substantially different in patients with and without lymphopenia. Conclusion:Lymphocyte monitoring provides effective means for early identification of patients at risk for developing severe, prolonged lymphopenia.

Aim: The aim of this study was to analyze frequency of restless legs syndrome (RLS) in patients with hypertension and diabetes mellitus. Patients and Methods: It was analyzed 120 subjects (from Health Center Živinice/Family Medicine Department) through a survey conducted in the period from March to June 2015, of which 30 (8 men/22 women). Subjects were 30 patients with longtime hypertension (HT)(18 men/12 women), 30 patients with diabetes mellitus (DM) type I or II (9 men/21 women), 30 patients with long standing DM type I or II and HT (12 men /18 women), and 30 control subjects (12 men/18 women). RLS were evaluated by questionnaire - International RLS Study Group Criteria. The average age of patients in the group with HT was 58.70 ± 9.07, in the group with DM 48.43 ± 15.37, and in the group of patients with HT and DM 63.90 ± 7.49 years. In the control group mean age was 52.76 ± 14.83 years. Statistical data were analyzed in Excel and SSPS statistical program. Results: RLS was identified in 10 (30%) of those with HT; 7 (21%) in patients with DM, and 10 (30%) in patients with HT+DM. In the control group RLS was verified in 4 (12%) patients. Comparing the results, it was observed significant difference between the HT and the control group (p=0.0012) and HT+ DM and control group (p=0.0012). The frequency of RLS between DM and the control group was not significantly significant (p=0.107). Conclusion: RLS is frequent in patients with hypertension (30%), hypertension+ diabetes mellitus (30%), and patients with DM (21%).

Contemporary forms of business in tourism impose new trends conditioned by an ever-increasing number of tourists travelling in the world today. It is an undeniable fact that tourists are increasingly demanding and that it is not a simple task to satisfy all their needs and expectations. Tourist satisfaction is an important strategic weapon on which success of a tourist destination is dependent. Customer satisfaction often results in prolonged stay in a tourist place, which is certainly dependent on a fair relationship between the service user and provider, but also on the way in which that service has been delivered. Meeting the expected level of satisfaction should be a common attitude, as the emotional reaction of the visitor is based on the difference between the expected and the delivered service. A basic indicator of customer satisfaction in tourism are revisits of a tourist destination. Guests visit many destinations several times during their lifetimes, which clearly indicates that satisfaction with time spent at a certain place leads to the intention of revisiting. On the other hand, an increasingly large share of family business in tourism, especially the accommodation sector, can be directly related to the tendency of achieving tourist satisfaction through an experience based on a direct contact with service providers. Successful hosts have already realized that their guests must not be perceived merely as numbers, but need to strive towards creating a personal relationship that would generate satisfaction. The practice of renting out accommodation in private homes and households has been present in Montenegro for decades. Moreover, that form of accommodation is numerically superior to all other kinds. The goal of this paper is to explore the satisfaction of customers with services offered on tourist destinations and to establish in what way it affects the successfulness of family business based on private accommodation facilities. Research described in this paper was conducted in the coastal town of Sutomore (Bar municipality) in the Republic of Montenegro, which has been recording a significant growth of tourist visits in the recent years. The paper demonstrates the results of survey research created according to the qualitest model, conducted on a sample of 160 tourists accommodated in private accommodation premises. The results obtained will serve to propose measures for improvement the tourism offer.

Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complexes. About ninety percent of patients with lupus are women between the ages of 20 and 40. The disease may affect only one organ system, and it also can be a multisystem and affect the skin, joints, kidneys, lungs, nervous system, and serous membrane. In the case report is presented a 38 year old patient with severe systemic lupus erythematosus, which adequately reacted to the treatment of mycophenolate mofetil. Keywords: Systemic lupus erythematosus, the effect of therapy, mycophenolate mofetil. (Scr Med 2016:47:74-75) ( ) * + , . , / 0 1 0 2 3 4 5 4 . 4 3 . 6 . , 7 . , 8 9 : ; + 7 , 7 < = . 0 = > ? @ A B B . C B < A : + 0 1 / / / Introduction D E F G H I J K L M N M F H O E G P H I Q G R F M F S D T U V J F Q W J F H Q F H R X M Y Z [ Y R \ Y H G J R L R ] E J Y \ P J K P G J F F M H F Q Y W K H L L F Q O H W Q I Q ] H W ^ E N Q G P R ] H Y J K Q M G R Q Y G J ^ R W J H F Q Y W J I I M Y H K R I N L H _ H F ` a b J Y H G E N H O K H Y G R X L M N M F N Q G J H Y G F Q O H \ R I H Y c M F M Q L L E J Y G P H O H N O R W M K G J d H F G Q ] H R X L J X H c ^ M G K P J L W O H Y c H L W H O L E Q Y W I H Y K Q Y Q L F R ^ H K R I H J Y X H K G H W ` e D T U J F I Q Y J X H F G H W ^ E F M ^ Z f H K G J d H Q Y W K L J Y J K Q L F J ] Y F M F M Q L L E R Y G P H F [ J Y c f R J Y G F Q Y W J Y G H O Y Q L R O ] Q Y F ` g R R W [ Y R \ L H W ] H R X G P H N Q G J H Y G Q Y W G P H Q K G J d J G J H F R X P J F h P H O F J L L Y H F F Q Y W W J F H Q F H K R M O F H Q O H W H K J Z F J d H X Q K G R O F J Y G P H K P R J K H R X N P Q O I Q K R G P H O Q N E i F Q L J K E L Q G H F c b D j k l F c Q Y G J I Q L Q O J Q L F c K R O G J K R F G H O R J W F c J I I M Y R F M N N O H F Z F J d H Q ] H Y G F Q Y W I R Y R K L R Y Q L Q Y G J ^ R W J H F ` m Case report k Y n Q O K P o p p q c r s Z E H Q O Z R L W N Q G J H Y G \ Q F Q W I J G G H W G R G P H l H N Q O G I H Y G R X O P H M I Q G R L R ] E ^ H K Q M F H R X N R R O ] H Y H O Q L K R Y W J G J R Y c \ H Q [ Y H F F Q Y W N Q J Y J Y G P H f R J Y G F Q Y W I M F K L H F ` t H O I H W J K Q L P J F G R O E F P R \ H W G P Q G F P H P Q W ^ H H Y G O H Q G H W M Y W H O Q W J Q ] Y R F J F R X F H O R Y H ] Q G J d H O P H M I Q G R J W Q O G P O J G J F F J Y K H j M ] M F G o p p u Q Y W G P H G O H Q G I H Y G J Y d R L d H W L R \ Z W R F H K R O G J K R F G H O R J W F Q Y W P E W O R _ E K P L R O R v M J Y H ` w P H N Q G J H Y G W J W Y R G K P H K [ J Y X R O O H ] M L Q O K R Y G O R L F X R O Q L R Y ] H O N H O J R W R X G J I H ` w P H R ^ f H K G J d H x Y W J Y ] F F P R \ H W N Q L H F [ J Y Q Y W d J F J ^ L H I M K R M F I H I ^ O Q Y H F c \ J G P ^ M G G H O y E O Q F P R Y G P H X Q K H c N J G Z G J Y ] H W H I Q R X G P H L R \ H O L H ] Q Y W X R R G W R O F M I c Q F \ H L L Q F F E Y R d J G J F J Y G Q L R K O M O Q L f R J Y G F ` T Q ^ R O Q G R O E x Y W J Y ] F F P R \ H W F H d H O H Q Y H I J Q \ J G P G P H d Q L M H F R X H O E G P O R K E G H F p ` z { _ { p { o h L Q Y W P H I R ] L R ^ J Y z ` s ] h W L c J Y K O H Q F H W L H d H L F R X N O R G H J Y J Y G P H M O J Y H z ` s ] h o z P c W H K O H Q F H W K O H Q G J Y J Y H K L H Q O Q Y K H R X z q I L h I J Y c M O J Y Q O E N O R G H J Y N R F J G J d H S | | | V c O H W M K H W d Q L M H R X K R I N L H I H Y G K R I N R Y H Y G F c Q N R F J G J d H j b j G H F G c Q N R F J G J d H Q Y G J Z W F l b j } o p p k ~ h I L c Q Y G J Z F F l b j N R F J Z G J d H } o p p k ~ h I L ` l M O J Y ] P R F N J G Q L J  Q G J R Y c G P H N Q G J H Y G \ Q F G O H Q G H W \ J G P I H G P E L N O H W Y J F R L R Y H J Y Q W R F H R X { I ] h [ ] h W Q E c Q Y G J ^ J R G J K F Q Y W G O Q Y F X M F J R Y R X N Q K [ H W O H W ^ L R R W K H L L F ` n E K R N P H Y R L Q G H I R X H G J L J Y Q W R F H R X o p p p I ] W Q J L E \ Q F ] J d H Y R Y G P H F H d H Y G P W Q E R X P R F N J G Q L J  Q G J R Y ` l M H G R G P H L R \ d Q L M H R X O H W ^ L R R W K H L L F Q G G P H ^ H ] J Y Y J Y ] R X G O H Q G I H Y G c N M L F H G P H O Q N E \ J G P K E K L R N P R F N P Q I J W H \ Q F Y R G M F H W ` j W Z W J G J R Y Q L \ R O F H Y J Y ] R X G P H W J F H Q F H S L R \ d Q L M H J Y G P H O H W ^ L R R W K H L L F V R K K M O O H W R Y G P H G \ H Y G J H G P W Q E R X G O H Q G I H Y G ` j X G H O H F G Q ^ L J F P H W W H G H O J R O Q G J R Y J Y G P H P H I Q G R N R J H G J K F E F Z G H I c \ H W H K J W H W G R Q W I J Y J F G H O I H G P E L N O H W Y J F R L R Y H N M L F H G P H O Q N E X R O G P O H H W Q E F c Q G Q W Q J L E W R F H R X { p p p I ] N Q O H Y Z G H O Q L ` j X G H O G P H Q ^ R d H I H Y G J R Y H W c F G Q ^ J L J G E J Y O H W ^ L R R W Z L J Y H \ Q F Q K K R I N L J F P H W ` j X G H O G P H P R F N J G Q L G O H Q G I H Y G c P J ] P N O R G H J Y F d Q L M H F J Y M O J Y H r ` z ] h o z P Q Y W O H W M K H W K O H Z Q G J Y J Y H K L H Q O Q Y K H r { I L h I J Y O H I Q J Y H W ` w P H N Q G J H Y G \ Q F W J F K P Q O ] H W \ J G P O H K R I I H Y W Q G J R Y F Q ^ R M G G P H O Q N E \ J G P K R O G J K R F G H O R J W F c I E K R N P H Y R L Q G H I R X H G J L c P E W O R _ E K P L R O R Z v M J Y H c R F G H R N R O R G J K N O R G H K G J R Y Q Y W Q Y G J N L Q G H L H G G P H O Q N E ` w P H N Q G J H Y G P Q W K R I H X R O O H ] M L Q O K P H K [ M N F Q Y W Q G G P H L Q F G K R Y G O R L c J Y D H N G H I ^ H O o p { € c G P H d Q L M H R X N O R G H J Y J Y M O J Y H Q Y W K O H Q G J Y J Y H K L H Q O Q Y K H c Q F \ H L L Q F R G P H O L Q ^ R O Q G R O E N Q Z O Q I H G H O F \ H O H \ J G P J Y Y R O I Q L d Q L M H F ` Discussion w P H K Q F H R X N O H F H Y G H W N Q G J H Y G J F W J F K M F F H W J Y G H O I F R X W J Q ] Y R F J F F E F G H I J K L M N M F H O E G P H I Q G R F M F J Y Q K K R O W Q Y K H \ J G P G P H K O J G H O J Q X R O G P H W J Q ] Y R F J F Q Y W H _ G O H I H L E X Q d R O Q Z ^ L H O H F N R Y F H Q X G H O I H G P E L N O H W Y J F R L R Y H N M L F H G P H O Q N E Q Y W K R Y G J Y M R M F G P H O Q N E \ J G P I E K R N P H Y R L Q G H I R X H G J L ` D E I N Z G R I F Q Y W F J ] Y F J Y R M O K Q F H Q O H I H H G J Y ] G P H K O J G H O J Q X R O W J Q ] Y R F J F ` w P H O H Q O H  R X G P H H L H d H Y K O J G H O J Q X R O G P H K L Q F Z F J x K Q G J R Y R X F E F G H I J K L M N M F H O E G P H I Q G R F M F J Y G P H N Q G J H Y G i I Q L Q O O Q F P c Q O G P O J G J F c [ J W Y H E W J F R O W H O F c P H I Q G R L R ] J K Q L W J F R O W H O F c N R F J G J d H Q Y G J Y M K L H Q O Q Y G J ^ R W E Q Y W Q N R F J G J d H Q Y G J Z W F l b j Q Y W Q Y G J Z F F l b j Q Y G J ^ R W E ` ‚ w P H K Q F H O H N R O G J F F P R \ Y W M H G R G P H J I N R O G Q Y K H R X H Q O L E W J Q ] Y R F J F R X F E F Z G H I J K L M N M F H O E G P H I Q G R F M F c Q Y W H Q O L E Q ] ] O H F F J d H G O H Q G Z I H Y G ` Conclusion l M H G R J Y Q ^ J L J G E G R N H O X R O I [ J W Y H E ^ J R N F E c K L J Y J K Q L Z L Q ^ R Z O Q G R O E Q F F H F F I H Y G J F d H O E J I N R O G Q Y G J Y J Y W J d J W M Q L G P H O Z Q N H M G J K Q N N O R Q K P G R G P H F H N Q G J H Y G F J Y R O W H O G R Q K P J H d H L R Y ] Z G H O I O H I J F F J R Y R X G P H W J F H Q F H ` w P J F K Q F H O H N R O G N O H F H Y G H W G P H N Q G J H Y G \ P R \ Q F G O H Q G H W N O R I N G L E \ J G P Q ] Z ] O H F F J d H G P H O Q N E N M L F H W R F H F R X I H G P E L N O H W Y J F R L R Y H Q Y W P J ] P W R F H F R X I E K R N P H Y R L Q G H I R X H G J L Q Y W \ P R Q K P J H d H W K R I N L H G H L Q ^ R O Q G R O E Q Y W K L J Y J K Q L O H I J F F J R Y R X G P H W J F H Q F H ` Reference { ` t Q O J F F R Y R d Q Y Q H L Q J Y G H O Y H I H W J K J Y H ` { € ` k  W Q Y f H ` U M ] H Y H ƒ O Q Q M Y d Q L W S H G Q L V Z ƒ H R ] O Q W i ƒ Q O W „ x Y … ƒ Q Y Z f Q T M [ Q i † R I Q Y R d o p p z ‡ Y f J ] Q o ` r { { i { q o o o ` D K P M O ˆ t ` ‰ \ H O d J H d R X K L J Y J K Q L I Q Y J X H F G Q G J R Y F R X G P H F E F G H I J K L M N M F H O J G H I Q G R W M F J Y Q W M L G F ` l R F G M N Y R Y Q \ \ \ ` M N G R W Q G H ` K R I ` r ` j M F G J Y t j c ƒ Q L R \ Š U i b Q G M O Q L P J F G R O E Q Y W G O H Q G Z I H Y G R X L M N M F Y H N P O J G J F ` D H I J Y b H N P O R L { q i o c { q q q ` ˆ n J W i q q € o o u  z ` U ] Y H O ‹ ` w P H M F H L Q ^ R O Q G R O E G H F G H F J Y G P H W J Q ] Y R F J F R X D U T ` Š Œ L J Y ˆ Q G P R L o p p p … € r i z o z Z r o `  Ž Ž  + 2 2 (  . ( ) * . ) 5 ‘ 2 , . , , ’ 7 2 “ ”  . 0 ’ . 7 . 8 = 8 • – * ( + , — , , 1 — — • – > * ( + • – > , 1 ’ , = ’ Odgovor na terapiju mikofenolat mofetilom kod pacijentice sa teškim oblikom sistemskog eritemskog lupusa SAŽETAK Sistemski eritemski lupus (SEL) je bolest nepoznate etiologije u kojoj su tkiva i ćelije oštećeni patogenim autoantitijelima i imunskim kompleksima. 90% oboljelih su žene, a starosna dob u kojoj najčešće oboljevaju je između 20. i 40. godine života. Bolest može zahvatiti samo jedan organski sistem, a može biti i višesistemska i zahvatiti kožu, zglobove, bubrege, pluća, nervni sistem i serozne membrane. U radu je prikazan slučaj 38-ogodišnje pacijentice sa teškim oblikom sistemskog eritemskog lupusa, koji je adekvatno odreagovao na terapiju mikofenolat mofetilom. Ključne riječi: Sistemski eritemski lupus, efekat terapije, mikofenolat mofetil 75 LJ. BOŽIĆ-MAJSTOROVIĆ, B. GAŠIĆ, D. JOVIĆ, M. VUKČEVIĆ, J. AĆIMOVIĆ

Este artigo discute a producao das culturas infantis a partir das experiencias de meninos e meninas, de 3 a 5 anos de idade, com a linguagem das historias em quadrinhos (HQs), tendo como foco as relacoes de genero. Reconhece as HQs como uma das producoes midiaticas que interfere nos modos de viver das criancas, muitas vezes reforcando estereotipos fundados nas diferencas sexuais. Assim, em uma interlocucao com a filosofia, sociologia, sociologia da infância, pedagogia da infância e arte, problematiza como as criancas se apropriam dos quadrinhos, o que deles reproduzem, inventam ou reinventam. Trata-se de um estudo de caso realizado em uma pre-escola municipal localizada na regiao do Grande ABC Paulista, que teve como procedimentos metodologicos: a observacao e registro de campo, os relatos orais das criancas, a analise dos documentos oficiais da Rede Municipal de Educacao e da pre-escola, entrevista com quadrinhista e a analise das HQs produzidas pelas criancas. Defende que meninos e meninas participam de maneira ativa na sociedade da qual fazem parte, portanto, nao so reproduzem a cultura do mundo adulto, mas ao se apropriarem coletiva e criativamente desta produzem as culturas infantis. Demonstra serem as HQs parte da cultura material da infância, que se constituem em suportes para aspectos simbolicos das culturas infantis, que as criancas compartilham entre si e com os adultos e as adultas, onde se observam padroes e valores identitarios sendo negociados; isso revela que elas nao so reproduzem estereotipos da cultura heteronormativa, mas transgridem as fronteiras de genero. Nesse sentido, aponta para o desafio de trazer as criancas para o debate acerca da relacao “infâncias, midia e genero”, na perspectiva de (re)conhecer como elas fruem, produzem e vao alem das imagens midiaticas. “Girls don´t draw cars… but there are girls who do it”: child cultures, gender and comics Abstract This article discusses child culture-oriented productions based on the experience of boys and girls aged 3-5 with the language found in comics, focusing on gender relations. The article views comics as one of the media products which can be related to child behavior, from the perspective of sexual differentiated stereotypes. It also examines an association with philosophy, sociology, sociology of childhood, early childhood pedagogy and art, in a sense which casts light on how children interact with comics.  It shows a case study conducted at kindergarten, in the Greater ABC region, which had methodological procedures: the field observation and recordings; the oral reports of children; analysis of the official documents of the Municipal Administration of Education and the documents of preschool; an interview with a comic artist, and analysis of comics produced by children.  It supports that boys and girls actively take part in their societies. In fact, not only do they reproduce the adult world culture, but also produce child cultures. It demonstrates that comics are part and parcel of childhood as a symbolic resource to be shared among adults and children. It points out that identity patterns and values are in the spotlight, suggesting that gender boundaries are to be redrawn. In sum, the article prompts further reflections on childhood, the media and gender. Keywords : Childhood. Gender. Media. “Las ninas no dibujan coches… pero hay ninas que los dibujan”: culturas infantiles, relaciones de genero e historietas Resumen Este articulo discute la produccion de las culturas infantiles a partir de las experiencias de ninos y ninas de 3 a 5 anos de edad con el lenguaje de las historietas (comics), teniendo como foco las relaciones de genero. Reconoce las historietas como una de las producciones mediaticas que interfiere en la manera de vivir de los ninos, muchas veces reforzando estereotipos fundados en las diferencias sexuales. De esta manera, en una interlocucion con la filosofia, sociologia, sociologia de la infancia, pedagogia de la infancia y el arte, problematiza como los ninos, se apropian de las historietas, lo que de ellas reproducen, inventan o reinventan. Se trata de un estudio de caso realizado en un kindergarten municipal ubicado en la region del Grande ABC Paulista, que tenian los procedimientos metodologicos: la observacion y el campo de registro; los informes orales de los ninos; el analisis de los documentos oficiales de la Red de Educacion Municipal y preescolar; entrevista con el comic; y el analisis de los comics producidos por los ninos. Defiende que los ninos y ninas participan de manera activa en la sociedad de la cual hacen parte, por lo tanto no solo reproducen la cultura del mundo adulto, pero al apropiarse colectiva e individualmente de esta producen las culturas infantiles. Demuestra que las historietas son parte de la cultura material de la infancia, que se constituye en soportes para aspectos simbolicos de las culturas infantiles, que los ninos comparten entre si y con los adultos, donde se observan patrones y valores de identidad siendo negociados; eso revela que ellas no solo reproducen estereotipos de la cultura normativa heterosexual, pero infringen las fronteras de genero. En ese sentido, apunta para el desafio de traer los ninos para el debate acerca de la relacion “infancias, media y genero”, en la perspectiva de (re)conocer como ellas disfrutan, producen y van mas alla de las imagenes mediaticas. Palabras claves: Infancia. Relaciones de Genero. Media.

BACKGROUND Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. AIM To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. PATIENTS AND METHODS Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. RESULTS In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. CONCLUSIONS Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.