Wealth and tradition of using thermo mineral waters in Bosnia and Herzegovina is the main potential for development of health tourism. The primary significance in spa centers is providing health services and the organization of tourist activities. Today in Bosnia and Herzegovina 15 spas as health institutions have been registered. History of use of thermo-mineral springs dates back to the ancient Greeks and Romans, who recognized the healing properties of geothermal resources. The topic of this paper is to present the perspective of the development of the tourism sector through the development of health tourism through spa treatment. There are registered 15 spas as health institutions which have 3,455 beds and generate around 200,000 overnight stays, which accounts for 23% of overall overnight stays in Bosnia and Herzegovina. It is therefore important to look at the current offer of spa treatments in Bosnia and Herzegovina and to make recommendations on how to improve this branch of health.

Investment decision making always bears a certain amount of risk and uncertainty. Therefore, we can say that the investment decision is the most difficult decision which a company owner or a manager has to make. During the process of investment decision making, every decision maker has to face the problems of choosing the right among several possible alternatives. The goal is to choose the alternative which is most likely to realise the company's development and investment goals. The decision maker may approach this problem in several different ways. Investment decision making is among the final steps of preparatory operations of an investment process. Before making this decision, it is necessary to follow certain procedures in order to successfully conduct the required investment studies. After the investment decision has been made, we can initiate the realisation process of a given investment. This paper uses 20 different investment projects which were analysed through 5 methods of investment efficiency evaluation that are mostly used in countries covered by the research. Additionally, a research which focuses on the ways in which companies from Bosnia and Herzegovina, Croatia, Serbia and Montenegro approach the investment decision making process was conducted.

Recently research shows that horseradish peroxidase, HRP, when combined with other compounds, is highly reactive toward different human tumour cells and that better understanding of catalytic mechanism and inhibition HPR could lead to a new targeted cancer therapy. Thus, the inhibition of HRP activity by dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was investigated for possible explanation of previously observed antitumour activities of this promising drug. HRP activity was studied under steady-state kinetic conditions by a spectrophotometric method. In the absence of the inhibitor values of = 0.47 mM and = 0.34 mM min−1, respectively, were determined. The hydrogen peroxide H2O2 kinetic measurements show a competitive inhibition with the inhibition constant = 2.56 mM. The activation energy values were found to be very similar for both reactions; in the absence of inhibitor activation energy was 17.7 kJ mol−1 and in the presence of inhibitor activation energy was 16.3 kJ mol−1. The values of Arrhenius constants were found to be different; = 4.635 s−1 was measured in the absence of inhibitor while in the presence of inhibitor Arrhenius constant was 1.745 s−1 showing that K2[B3O3F4OH] initiates conformational change in the structure of the HRP and subsequently reduces its activity.

This paper describes an R package LeArEst that can be used for estimating object dimensions from a noisy image. The package is based on a simple parametric model for data that are drawn from uniform distribution contaminated by an additive error. Our package is able to estimate the length of the object of interest on a given straight line that intersects it, as well as to estimate the object area when it is elliptically shaped. The input data may be a numerical vector or an image in JPEG format. In this paper, background statistical models and methods for the package are summarized, and the algorithms and key functions implemented are described. Also, examples that demonstrate its usage are provided. Availability: LeArEst is available on CRAN.