The dynamic properties of the actin cytoskeleton in smooth muscle cells play an important role in a number of cardiovascular disease states. The state of actin does not only mediate mechanical stability and contractile function but can also regulate gene expression via myocardin related transcription factors (MRTFs). These transcriptional co-activators regulate genes encoding contractile and cytoskeletal proteins in smooth muscle. Regulation of small non-coding microRNAs (miRNAs) by actin polymerization may mediate some of these effects. MiRNAs are short non-coding RNAs that modulate gene expression by post-transcriptional regulation of target messenger RNA. In this study we aimed to determine a profile of miRNAs that were 1) regulated by actin/MRTF-A, 2) associated with the contractile smooth muscle phenotype and 3) enriched in muscle cells. This analysis was performed using cardiovascular disease-focused miRNA arrays in both mouse and human cells. The potential clinical importance of actin polymerization in aortic aneurysm was evaluated using biopsies from mildly dilated human thoracic aorta in patients with stenotic tricuspid or bicuspid aortic valve. By integrating information from multiple qPCR based miRNA arrays we identified a group of five miRNAs (miR-1, miR-22, miR-143, miR-145 and miR-378a) that were sensitive to actin polymerization and MRTF-A overexpression in both mouse and human vascular smooth muscle. With the exception of miR-22, these miRNAs were also relatively enriched in striated and/or smooth muscle containing tissues. Actin polymerization was found to be dramatically reduced in the aorta from patients with mild aortic dilations. This was associated with a decrease in actin/MRTF-regulated miRNAs. In conclusion, the transcriptional co-activator MRTF-A and actin polymerization regulated a subset of miRNAs in vascular smooth muscle. Identification of novel miRNAs regulated by actin/MRTF-A may provide further insight into the mechanisms underlying vascular disease states, such as aortic aneurysm, as well as novel ideas regarding therapeutic strategies. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.

Introduction: Research indicates that women victims of domestic violence show significant cognitive changes, emotional numbing, and avoidance of interpersonal relationships. Aim: The aim of this research was to analyze emotional profile of women victims of domestic violence, and to determine the relationship between dimensions of emotions and frequency of women exposure to domestic violence. Methods: The research was conducted on the sample of 169 women, 111 were victims of domestic violence and 58 were women who did not experience domestic violence. Plutchik’s Emotions Profile Index (EPI) was used for measuring of the emotion profile, and the Modified Inventory of Domestic Violence for measuring experiences of different types of violence. Basic socio-demographic data were also collected. Results: Significant differences between women victims of domestic violence and women who did not experience domestic violence were found in a few dimensions of emotional profile. Women victims of domestic violence had higher results in the dimensions of deprivation/depression and aggression/destruction, while women who did not experience domestic violence had higher results in dimensions of reproduction and incorporation. Aggression was in significant negative correlation with reproduction, incorporation and self protection, whereas it was significant positive correlation with deprivation and opposition. There were significant and positive correlation between the dimensions of aggression and deprivation and frequency of all three forms of domestic violence and age of women. Conclusion: According to results obtained in this research, it can be concluded that women victims of domestic violence have significantly more intensive negative emotional dimensions in comparison to women who were not abused. Women victims of domestic violence with higher frequency of abuse describe themselves as more sad, apathetic, lonely, angry, quarrelsome and less sociable. Prominence of negative emotions, deprivation and aggression, can be factor of risk for mental health disorders and for re-victimisation of women victims of domestic violence.

Introduction: the effects of malignant tumors of oral cavity may be reflected through mental, physical, social and emotional well-being and quality of life of patients. Those suffering from malignancies show a large degree of psychological problems (fear, anxiety, depression, panic disorders, phobias) both at the time of diagnosis and during the treatment. Aim: to determine a level of depression in patients with oral cavity cancer and to link quality of life and level of depression of patients with oral cavity cancer. Patients and methods: The study was conducted at the Clinic of Maxillofacial Surgery of the Clinical Center University of Sarajevo (CCUS) in the period from July to late October 2015, through a survey of patients with verified oral cavity cancer, questionnaire related to socio-demographic characteristics of the patients, the University of Washington Quality of Life Questionnaire (UW-QOL), and the Beck Depression Inventory (BDI). Results: Majority of patients from our study, specifically 50 (56%) of them, did not suffer from depression, 8 (9%) respondents suffered from mild depression, 14 (16%) respondents had moderate depression, whereas 17 (19%) of them had severe depression. Conclusion: quality of life and level of depression of patients with oral cavity cancer are in negative and almost linear correlation. The worse the evaluation results of one’s physical or socio-emotional health, the higher degree of depression.

– Competência Clínica. RESUMO Nas últimas duas décadas, ocorreram mudanças curriculares nos cursos de Medicina com o objetivo de formar profissionais humanizados e capazes de atender às demandas atuais. No contexto desse novo modelo, ressalta-se a importância do ensino de comunicação da má notícia na graduação, habilitando acadêmicos a atuar de maneira empática e eficiente. O conteúdo carregado de emoção reforça a necessidade de o médico se preparar adequadamente para saber lidar com as reações dos pacientes e com os próprios sentimentos. Este artigo é um estudo transversal que avaliou, por meio de checklist, a habilidade de comunicação da má notícia apresentada por acadêmicos de Medicina do ciclo pré-clínico em prova prática no modelo Objective Structured Clinical Examination (Osce). Foram avaliados 119 alunos do quarto semestre do curso de Medicina da Universidade de Fortaleza, dos quais 67% obtiveram desempenho global superior ou igual a 90%. A maior dificuldade observada foi em realizar um “anúncio breve” do problema ao transmitir a má notícia, com 35,3% de erro. Em contrapartida, os estudantes foram eficazes em não “dourar a pílula” ao comunicarem o diagnóstico, quesito que obteve índice absoluto de acertos. Além disso, foi analisada a capacidade dos alunos em identificar a influência dos sintomas na vida do paciente, por meio dos estágios do luto de Kübler-Ross e da escala de desempenho clínico Eastern Cooperative Oncology Group (Ecog), obtendo uma porcentagem de acertos de 84,1%. Embora o desempenho global tenha sido avaliado como excelente, estudantes de Medicina do ciclo pré-clínico mostram-se hesitantes em suas primeiras consultas e no primeiro contato com os pacientes, em especial naqueles de forte conteúdo emocional, fato que ficou evidente ao se identificarem as principais falhas cometidas pelos discentes durante a prova prática de comunicação da má notícia. Dessa forma, com o intuito de aprimorar essa habilidade tão importante para a prática médica, reforça-se o uso de nossas experiências de ensino-aprendizagem, como pacientes atores, treinamento entre os pares, abordagem de protocolos padronizados e reflexões acerca da importância dessas estratégias no ensino da má notícia.

UDK: 582.711.71:547.56 Phenolic content and antioxidant activity of Rosa canina fruit extracts obtained with five different extraction systems were investigated. Extractions were done with water, and aqueous 50% methanol, 50% ethanol, 80% methanol and 80% ethanol. Antioxidant activity was investigated with DPPH, ABTS and FRAP methods using Trolox as a standard. The highest level of phenols (78.83 mg GAE/g), phenolic acids (11.21 mg CAE/g), and proanthocyanidins (29.12 mg CE/g) were found for 50% methanol extract. The highest flavonoid content (1.163 mg RE/g and 0.675 mg QE/g) was determined for 50% ethanol extracts and antocyanin content (0.139 mg CGE/g) for 80% methanol extract. The lowest level of phenols (35.89 mg GAE/g), phenolic acids (4.55 mg CAE/g) and proanthocyanidins (11.93 mg CE/g) had 80% ethanol extract. Flavonoid content (0.341 mg RE/g and 0.214 mg QE/g) was the lowest in water extract and anthocyanidin content (11.93 mg CE/g) in 50% ethanol extract. Antioxidant activity for DPPH was in a range 255.62-407.82 µmol TE/g, for ABTS 312.06-616.10 µmol TE/g and for FRAP 349.33-690.37 µmol TE/g with lowest values for 80% ethanol extract and highest values for 50% methanol extract. Phenols and proanthocyanidins showed high positive correlation with antioxidant activity for DPPH (r2 =0.927-0.9621), ABTS (r2 =0.980-0.9935) and FRAP (r2 =0.9352-0.9633). No correlation was observed for flavonoid and anthocyanidin content with antioxidant activity.

UDK: 582.916.16:547.56             547.56:543.42 Total contents of phenols, flavonoids, phenolic acids and proanthocyanidins have been determined in methanolic extracts of Fraxinus ornus L. and Fraxinus pennsylvanica Marsch. leaves and branches bark.  DPPH and FRAP assay were used in the determination of antioxidant capacity. F. ornus leaves had higher contents of flavonoids (13.08 mg RE g-1 DW) and proanthocyanidins (7.29 mg LCE g-1 DW) while the bark had higher contents of phenols (56.47 mg GAE g-1 DW), phenolic acids (14.32 mg CAE g-1 DW) and coumarins (94.81 mg CE g-1 DW). F. pennsylvanica leaves were richer in contents of phenols (25.73 mg GQE g-1 DW), flavonoids (2.87 mg CE g-1 DW and 5.13 mg RE g-1 DW), phenolic acids (14.60 mg CAE g-1 DW) and coumarins (20.01 mg CE g-1 DW) while the bark had more proanthocyanidins (6.88 mg CE g-1 DW). F. ornus leaves had lower contents of phenolic acids (11.09 mg CAE g-1 DW) than F. pennsylvanica leaves. Also, F. pennsylvanica bark had higher contents of flavonoids (1.25 mg RE g-1 DW) and proanthocyanidins (6.88 mg CE g-1 DW) than F. ornus bark. Antioxidant capacity for both species was higher for the leaves than the bark. Generally, F. ornus had better antioxidant capacity than F. pennsylvanica. Very high correlations were found between antioxidant capacity and phenols (r2= 0.9361-0.9805), flavonoids (r2= 0.9358-0.9876) and coumarins (r2= 0.9661-0.9938) in leaves. In bark, correlations were found for phenols (r2= 0.9744-0.9796) and coumarins (r2= 0.9757-0.9911).

Abstract Pojskic, H, Sisic, N, Separovic, V, and Sekulic, D. Association between conditioning capacities and shooting performance in professional basketball players: an analysis of stationary and dynamic shooting skills. J Strength Cond Res 32(7): 1981–1992, 2018—Little is known about the influence of conditioning capacities on shooting performance in basketball. The aim of this study was to examine the relationship between different conditioning capacities and shooting performance in professional basketball players. In this investigation, we examined 38 males (all perimeter players; height: 185.5 ± 6.73 cm; mass: 78.66 ± 10.35 kg). Conditioning capacities were evaluated by tests of muscular strength, aerobic endurance, jumping and throwing capacities, sprinting speed, preplanned agility, anaerobic endurance, and fatigue resistance. Shooting performance was evaluated using game statistics, as well as 6 tests of shooting performance performed in controlled settings: (a) 3 tests of static (i.e., nonfatigued) shooting performance (standardized execution of 1- [S1], 2- [S2] and 3-point shots [S3] in stationary conditions), and (b) 3 tests of dynamic (i.e., fatigued) shooting performance (standardized execution of 1- [D1], 2- (D2), and 3-point shots [D3] in dynamic conditions). All 3 dynamic shooting tests and the S1 test were significantly (p ⩽ 0.05) correlated with corresponding game statistics. Multiple regression indicated that conditioning capacities were significantly related to D1 (R2 = 0.36; p = 0.03), D2 (R2 = 0.44; p = 0.03), S3 (R2 = 0.41; p = 0.02), and D3 (R2 = 0.39; p = 0.03) tests. Players with a higher fatigue resistance achieved better results on the D1 test (&bgr; = −0.37, p = 0.03). Preplanned agility (&bgr; = −0.33, p = 0.04), countermovement jump (&bgr; = 0.42, p = 0.03), and fatigue resistance (&bgr; = −0.37, p = 0.02) were significant predictors of D2 performance. The countermovement jump (&bgr; = 0.39, p = 0.04), medicine ball toss (&bgr; = 0.34, p = 0.04), and anaerobic endurance (&bgr; = 0.46, p = 0.04) predicted the results of D3 performance. Jumping, throwing, and anaerobic endurance capacities were good determinants of the skill of dynamic shooting over a long distance. These findings emphasize the importance of explosive power and anaerobic capacity as determinants of shooting performance in high-level basketball players.

Introduction: This paper presents mobile application implementing a decision support system for acid-base disorder diagnosis and treatment recommendation. Material and methods: The application was developed using the official integrated development environment for the Android platform (to maximize availability and minimize investments in specialized hardware) called Android Studio. Results: The application identifies disorder, based on the blood gas analysis, evaluates whether the disorder has been compensated, and based on additional input related to electrolyte imbalance, provides recommendations for treatment. Conclusion: The application is a tool in the hands of the user, which provides assistance during acid-base disorders treatment. The application will assist the physician in clinical practice and is focused on the treatment in intensive care.

On July 5th passed away academician professor Jana Zvarova, one of pioneers and one of most influential Medical informatics scientist and expert in Europe and in the world. Professor Jana Zvarova was born in Prague, Czechoslovakia. After graduating in mathematics in 1965 at the Faculty of Mathematics and Physics, Charles University in Prague she has been working with several faculties of Charles University in Prague. She completed external doctoral studies under the supervision of Prof. Dr. Albert Perez, member of IFIP. He brought her attention to the field of Medical informatics and opened the contacts with founders of IMIA. Jana Zvárová founded the Medical informatics section of the Czech Society of biomedical engineering and Medical informatics in the year 1978. The same year, she received Ph.D. scientific degree at Charles University in Prague. She passed the habilitation at Charles University in 1991 and she was nominated by the president of the Czech Republic Vaclav Havel as Full Professor at Charles University in Prague in 1999. She reached the highest Czech scientific degree, Doctor of Sciences in 1999 at the Academy of Sciences of the Czech Republic.

The Arab cultural heritage was an era of invaluable preservation and development of numerous teachings, including biomedical sciences. The golden period of Arab medicine deserves special attention in the history of medicine and pharmacy, as it was the period of rapid translation of works from Greek and Persian cultures into Arabic. They preserved their culture, and science from decay, and then adopted them to continue building their science on theirs as a basis. After the fall of Arabian Caliphate, Arabian pharmacy, continued to persevere, and spread through Turkish Caliphate until its fall in the First World War. That way, Arabian pharmacy will be spread to new areas that had benefited from it, including the area of occupied Bosnia and Herzegovina. Because of the vast territorial scope of the Ottoman Empire, the focus of this paper is description of developing pharmacy in Bosnia and Herzegovina during the time of Ottoman reign.

145 EUGENE GARFIELD (1925–2017) Eugene Garfield (1925-2017) is an American scientist, one of the founders of bibliometrics and scientometrics (13). He received a PhD in Structural Linguistics from the University of Pennsylvania in 1961. Dr. Garfield was the founder of the Institute for Scientific Information (ISI), which was located in Philadelphia, Pennsylvania. He founded the ISI in 1960 and developed an indexing system for science literature, based on the analysis of citations used within a given work. Works earn an “impact factor,” a measure of citations to other science journals that serves as an indicator of their importance in the field. The more citations in reputable journals, the higher the impact factor. The ISI sold subscriptions to their publication the Science Citation Index, and over time grew to include the Social Sciences Citation Index (SSCI) and the Arts & Humanities Citation Index (A&HCI). These databases now form the foundation of the online research tool called the Web of Knowledge. He is responsible for many innovative bibliographic products, including Current