Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their energy, it also provides a unique opportunity to explore energy trading and sharing amongst them. This paper investigates peer-to-peer (P2P) communication architectures for prosumers’ energy trading and sharing. The performances of common P2P protocols are evaluated under the stringent communication requirements of energy networks defined in IEEE 1547.3-2007. Simulation results show that the structured P2P protocol exhibits a reliability of 99.997% in peer discovery and message delivery whilst the unstructured P2P protocol yields 98%, both of which are consistent with the requirements of MG applications. These two architectures exhibit high scalability with a latency of 0.5 s at a relatively low bandwidth consumption, thus, showing promising potential in their adoption for prosumer to prosumer communication.

We present chest wall reconstruction with titanium mesh in a patient who underwent sternal resection due to solitary plasmacytoma (SP). A 35 year old female was admitted to The Thoracic Surgery Department of University Clinical Center Tuzla with pain and tender upper-sternal swelling.

When exploring the relationship between users and information systems, it is necessary to ascertain what impact the user's basic features have on their experience of the information systems they use in their work. Accordingly, this survey was conducted in the Government of Brcko within the district of Bosnia and Herzegovina, and within the Public company Brcko Municipality. The survey was conducted on 479 employees, while 261 employees completed the questionnaire developed for this research. When measuring the basic characteristics of the respondent’s gender was considered, as well as the work place, age, qualifications, their work experience and the amount of use of the information system weekly. When measuring the experience of using the information system, a modified model of performance of the information system was used. The SPSS 20.0 statistical software tool was applied during the testing of the proposed hypothesis, and the multivariate variance analysis (MANOVA) and the variance analysis (ANOVA) were used for the analysis. A factor analysis was used with the grouping of the proposed claims. The results obtained using this analysis show that in the modified model of success of the information system the statements were grouped into 4 factors. The hypothesis test results have shown that there is a significant statistical dependence on the use of information systems in almost all features of a user, except for the age of users where there is no statistical dependence. The results obtained from this research will contribute to a better understanding of how users experience information systems in their work and what basic features of the respondents affect the use of the system.

Design of Experiments (DOE) is statistical tool deployed in various types of system, process and product design, development and optimization. It is multipurpose tool that can be used in various situations such as design for comparisons, variable screening, transfer function identification, optimization and robust design. This paper explores historical aspects of DOE and provides state of the art of its application, guides researchers how to conceptualize, plan and conduct experiments, and how to analyze and interpret data including examples. Also this paper reveals that in past 20 years application of DOE have been growing rapidly in manufacturing as well as non-manufacturing industries. It was most popular tool in scientific areas of medicine, engineering, biochemistry, physics, computer science and counts about 50% of its applications compared to all other scientific areas.

The study aims to examine the euroization phenomenon in seven Western Balkan countries (Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Romania, Serbia and Macedonia) between 2000 and 2015 and a number of –specific challenges faced by the region. More precisely, the paper analyzes the impact of the latest global financial crisis on the extent of currency substitution persistency by exploring the trends before, in wake of the financial crisis, and after the financial crisis. The study employed several indicators as a proxy variable for measuring of the overall level of currency substitution or euroization and cross country analysis in selected countries (liability euroization,credit euroization and deposit euroization and asset substitution- overall euroization index). Finally, the study found that deposit euroisation, credit euroization, and liabilities euroization in seven Western Balkan countries is still high with relatively high degree of heterogeneity. In some countries of the Western Balkan region the process of euroisation was further intensified in spite of the consequences of the latest global financial crises, while in the other ones the crisis years were marked by the trend of de-euroisation. In overall, this study does not find any significant evidence on significantly increases or decreases in currency substitution at the region sub-samples. Finally,Student t-test results indicate that there is no significant difference in means of before, in wake and after the financial crises at level of Western Balkan region.

Over the past several decades, the relationship between tourism and economic growth, for both developing and developed countries, has been a popular issue of debate. Taking into account the fact that the tourism is an important sector in the world economy, the knowledge of the sign and size of the impact of tourism earnings on economic growth is of particular importance to policy makers. This paper aims to explore the impact of tourism earnings on economic growth. Panel data of 113 countries are used for the years that span from 1995 to 2015. The potential contribution of tourism to economic growth is analyzed within the conventional augmented Solow growth model. GMM method is employed to account for a dynamic phenomenon of economic growth. The obtained results indicate a significant positive impact of tourism on economic growth. Furthermore, the obtained results indicate that tourism-economic growth nexus differs among income disparity. The obtained findings imply that low-income countries should enhance their economic growth by strengthening their tourism industry.

The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. The Hh signaling pathway plays an important role in the embryonic development. It exerts its biological effects through a signaling cascade that culminates in a change of balance between activator and repressor forms of glioma-associated oncogene (Gli) transcription factors. The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor (Smo), Suppressor of fused homolog (Sufu), kinesin protein Kif7, protein kinase A (PKA), and cyclic adenosine monophosphate (cAMP). The activator form of Gli travels to the nucleus and stimulates the transcription of the target genes by binding to their promoters. The main target genes of the Hh signaling pathway are PTCH1, PTCH2, and GLI1. Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporadic cancers, such as basal cell carcinoma, medulloblastoma, pancreatic, breast, colon, ovarian, and small-cell lung carcinomas. The aberrant activation of the Hh signaling pathway is caused by mutations in the related genes (ligand-independent signaling) or by the excessive expression of the Hh signaling molecules (ligand-dependent signaling - autocrine or paracrine). Several Hh signaling pathway inhibitors, such as vismodegib and sonidegib, have been developed for cancer treatment. These drugs are regarded as promising cancer therapies, especially for patients with refractory/advanced cancers.