in broiler’s small intestine. Investigation were carried out on isolated smooth muscle of the circular and longitudinal layer of the broilers small intestine (strip dimension 3-4 mm x 2 cm). The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations were recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotonin (nonselective 5-HT agonist), 2-Me-5HT (5-HT3B agonist) and Y-25130-hydrochloride (selective 5-HT3B antagonist). The research established a presence of serotonergic 5HT3B type receptors within the smooth musculature of the small intestines of broilers (COBB 500). The 5HT3B type receptors were present in smooth muscles of duodenum, jejunum and ileum, especially in longitudinal smooth muscles since this layer reacted even to low serotonin concentration (10-6). Statistical tests of obtained results showed significant differences (p< 0.001) in responses related to muscle layers, applied concentrations and intestinal parts which were observed. In the light of these findings, we suggest that investigated substances may have considerable physiological and therapeutic implications in disturbed function of small intestine of broiler’s.

We analyze the spectrum of the massless Dirac operator on the 3-torus $\mathbb{T}^3$. It is known that it is possible to calculate this spectrum explicitly, that it is symmetric about zero and that each eigenvalue has even multiplicity. However, for a general oriented closed Riemannian 3-manifold $(M,g)$ there is no reason for the spectrum of the massless Dirac operator to be symmetric. Using perturbation theory, we derive the asymptotic formulae for the eigenvalues $\pm 1$ and prove that by the perturbation of the Euclidean metric on the 3-torus, it is possible to obtain spectral asymmetry of the massless Dirac operator in the axisymmetric case.

The paper aims to analyze the causal relationship between economic development and the high-technology export. Time-series annual data are collected for Turkey over the period running from 1990 to 2015. The motivation for the research was the fact that Turkey faces increasing trends in terms of economic development as well as in terms of high-technology export in the observed period. Various econometrics methods for time-series data are used in this paper to analyze the relationship between economic development and high-technology export. Initially, Johansen cointegration test is applied as well as Granger causality test. Moreover, this paper applies ARDL approach based on time-series data to explore the long-run causal linkages and short-run dynamics between the economic terms of interest. In order to test for the stability of the model, the impact of foreign direct investments is controlled. Johansen cointegration test indicates the cointegrating relationship between economic development and high-technology export. Moreover, Granger causality test reports a bidirectional relationship between economic terms of interest. In terms of ARDL model it is important to emphasize a significant positive long-run relationship that is reported between economic terms of interest in the initial model. However, the coefficient in the short-run is not reported to be significant. The extended model controls for the impact of foreign direct investments. The obtained results do not differ in sign and significance from the initial model. Therefore, the initial model can be considered stable.

As lutas dos indigenas brasileiros devem-se, em parte, a preservacao das suas terras contra fazendeiros e politicos. No caso dos Pankara, a adversidade levou-os ao reconhecimento etnico, a manutencao do territorio e ao direito de vivenciarem as suas praticas culturais na escola. Este estudo recorre ao ritual sagrado do tore, visando produzir um material educativo como organizador previo para o(a) educador(a) indigena negociar significados interculturais entre a sua propria cultura e o saber escolar institucionalizado. O objetivo do material produzido e aludir metaforicamente as idealizacoes geometricas de circulo e dos seus elementos com o saber nao indigena, e com isso despertar cultural e cientificamente o interesse de criancas pankara pelo saber matematico.

Organic layered charge-transfer salts κ -(BEDT-TTF) 2 X form highly frustrated lattices of molecular dimers in which strong correlations give rise to Mott insulating states situated close to the metal-to-insulator phase boundary. The salts κ -(BEDT-TTF) 2 Cu 2 (CN) 3 and κ -(BEDT-TTF) 2 Ag 2 (CN) 3 have been considered as prime candidates for a quantum spin liquid, while κ -(BEDT-TTF) 2 Cu[N(CN) 2 ]Cl has been suggested as a prototypical charge-order-driven antiferromagnet. In this paper, we summarize and discuss several key results, including some not reported previously, obtained in search to clarify the competition of these two ground states. The origin of anomalous dielectric response found at low temperatures in all three salts is also discussed. We conclude by pointing out the relevant new insights into the role of frustration and random disorder in the suppression of magnetic ordering and formation of the spin liquid state.

Milk fat is an important component in the forming of the cheese curd. It influences the firmness of the curd, as well as flavour of cheese and cheese yield. Therefore, in industrial cheesemaking standardisation of milk by adjusting the content of protein and milk fat to the optimal ratio of 0.9 : 1 is regularly carried. On contrary, it is not carried out in small scale dairy plant, which could result with reduced recovery of milk fat to cheese and due to that lesser financial profit. The aim of this study was to determine the effect of the milk standardisation on the recovery of milk fat to Skripavac cheese. In the small scale dairy plant, 10 batches of Skripavac cheese were produced. The milk of each batch was divided into three categories: milk for cheese production without standardisation (1) ; milk for cheese production with standardised ratio protein : fat = 0.9 : 1 by the addition of skimmed milk powder – SMP (2), and by skimming the part of milk fat (3). Standardisation of milk by the addition of SMP significantly increased the content of total solids, lactose (P<0.0001) and proteins (P<0.05) in whey. Addition of the SMP resulted in a significantly (P<0.05) higher recovery of milk fat to Skripavac cheese (76.88 %) compared to the treatment of skimming the part of the cream (71.52 %). Addition of SMP can provide the economic benefits in the production of traditional cheeses due to the better recovery of milk fat to cheese.

Introduction: satisfaction of patients has been frequently used as an indicator of quality in the healthcare sector. The analysis of patient satisfaction or experience in respect of hospital food is an important segment influencing the overall satisfaction with hospital services provided, and the study results should serve for the purpose of improving the service quality. Aim: to analyse patient satisfaction with hospital food services, evaluate the level of satisfaction in respect of food distribution, and give recommendations for improvement of hospital food quality. Materials and methods: the study included 300 patients hospitalized in the Clinical Centre of the University of Sarajevo (CCSU). The study used an anonymous, purposely designed questionnaire. The study was conducted in the period from 1 May to 31 August 2017. Results: the study related to patient satisfaction with hospital food services showed that the respondents were satisfied with hospital food in the majority of cases. Few respondents were unsatisfied with food provided from the central kitchen, specifically 5% of them; 25% of the respondents were unsatisfied with the nutritive value of the food, 6% of them were unsatisfied with the menu, and 10% of the respondents were unsatisfied with the dietary treatment. Conclusion: nutrition of patients during their hospital treatment has significant influence on the overall recovery and it significantly affects the overall satisfaction regarding patients’ treatment in hospital. Small number of the tested patients showed subjective perception in respect of nutritive value of the food and prescribed dietary regime.

Background: This study aimed to prospectively investigate the scholastic factors related to illicit drug misuse (IDM) and the initiation of IDM among older adolescents from Bosnia and Herzegovina. Methods: This 2-year prospective study included 436 participants (202 females), who were an average of 16 years old at the beginning of the study (baseline). The participants were tested at baseline and follow-up (20 months later). The predictors included variables of scholastic-achievement (grade point average, school absences, unexcused absences and behavioral grade). The criteria were: (i) IDM at baseline; (ii) IDM at follow-up; and (iii) initiation of IDM over the study course. Results: Logistic regression indicated increased odds of IDM in adolescents who were more frequent absent from school (baseline: Odds Ratio (OR): 3.73, 95% Confidence Interval (CI): 2.12–6.57; follow-up: OR: 2.91, 95% CI: 1.90–4.65). The lower grade point average and more unexcused absences were evidenced for adolescents who consumed drugs on follow-up (OR: 1.67, 95% CI: 1.11–2.51; OR: 1.74, 95% CI: 1.30–2.32 for grade point average and unexcused absences, respectively). Initiation of IDM was predicted by frequent absences from school (OR: 2.2, 95% CI: 1.3–3.8), and lower behavioral grades (OR: 1.9, 95% CI: 1.2–3.3). Conclusions: The findings confirmed strong correlations between scholastic failure and IDM. Absences from school and lower behavioral grades at baseline were predictive of the initiation of IDM in older adolescents.

We reported the first case of inoperative thymic adenocarcinoma successfully palliative treated by the double-stent procedure. In a patient who expressed stridor, computed tomography was done and necrotic mediastinal mass, which protrudes into a trachea, was demonstrated. Fiberoptic bronchoscopy showed tracheal infiltration and 70% stenosis; therefore, surgical resection was inapplicable. Recanalization with repeated argon plasma coagulation and debridement of necrotic mass was performed, followed by placement of the endotracheal stent, radiotherapy, and chemotherapy. After 1 year, the patient developed gastric aspiration and tracheoesophageal fistula; therefore, the esophageal stent was placed. The outcome was lethal, but the placement of endotracheal stent significantly increased a length of survival for the patient with invasive thymic adenocarcinoma.

The original version of this Article contained errors in the affiliations of the authors Ibrahim Numanagić and Thomas A. Courtade, which were incorrectly given as ‘Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA’ and ‘Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA’, respectively. Also, the hyperlink for the source code in the Data Availability section was incorrectly given as https://github.iu.edu/kzhu/assembltrie, which links to a page that is not publicly accessible. The source code is publicly accessible at https://github.com/kyzhu/assembltrie. Furthermore, in the PDF version of the Article, the right-hand side of Figure 3 was inadvertently cropped. These errors have now been corrected in both the PDF and HTML versions of the Article.

The original version of this Article contained errors in the affiliations of the authors Ibrahim Numanagić and Thomas A. Courtade, which were incorrectly given as ‘Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA’ and ‘Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA’, respectively. Also, the hyperlink for the source code in the Data Availability section was incorrectly given as https://github.iu.edu/kzhu/assembltrie, which links to a page that is not publicly accessible. The source code is publicly accessible at https://github.com/kyzhu/assembltrie. Furthermore, in the PDF version of the Article, the right-hand side of Figure 3 was inadvertently cropped. These errors have now been corrected in both the PDF and HTML versions of the Article.

Background Clustering of breast and colorectal cancer has been observed within some families and cannot be explained by chance or known high-risk mutations in major susceptibility genes. Potential shared genetic susceptibility between breast and colorectal cancer, not explained by high-penetrance genes, has been postulated. We hypothesized that yet undiscovered genetic variants predispose to a breast-colorectal cancer phenotype. Methods To identify variants associated with a breast-colorectal cancer phenotype, we analyzed genome-wide association study (GWAS) data from cases and controls that met the following criteria: cases (n = 985) were women with breast cancer who had one or more first- or second-degree relatives with colorectal cancer, men/women with colorectal cancer who had one or more first- or second-degree relatives with breast cancer, and women diagnosed with both breast and colorectal cancer. Controls (n = 1769), were unrelated, breast and colorectal cancer-free, and age- and sex- frequency-matched to cases. After imputation, 6,220,060 variants were analyzed using the discovery set and variants associated with the breast-colorectal cancer phenotype at P<5.0E-04 (n = 549, at 60 loci) were analyzed for replication (n = 293 cases and 2,103 controls). Results Multiple correlated SNPs in intron 1 of the ROBO1 gene were suggestively associated with the breast-colorectal cancer phenotype in the discovery and replication data (most significant; rs7430339, Pdiscovery = 1.2E-04; rs7429100, Preplication = 2.8E-03). In meta-analysis of the discovery and replication data, the most significant association remained at rs7429100 (P = 1.84E-06). Conclusion The results of this exploratory analysis did not find clear evidence for a susceptibility locus with a pleiotropic effect on hereditary breast and colorectal cancer risk, although the suggestive association of genetic variation in the region of ROBO1, a potential tumor suppressor gene, merits further investigation.

PurposeSentinel lymph node biopsy (SLNB) was introduced as a minimally invasive technique for nodal staging. Since associated morbidity is not negligible, it is highly relevant to pursue a more minimally invasive alternative. The purpose of this study was to prospectively evaluate the sensitivity of fine needle aspiration cytology (FNAC) with combined gamma probe and ultrasound (US) guidance in comparison with the gold standard histology of the sentinel node (SN) after SLNB for detecting metastasis.MethodsThe study was designed as a prospective, multicentre, open-label, single-arm trial enrolling patients with newly diagnosed cutaneous melanoma or breast cancer between May 2015 and August 2017. Sample radioactivity was measured using a Mini 900 scintillation monitor. After FNAC, all patients underwent SLNB. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated.ResultsAccrual was terminated early following an unplanned interim analysis indicating that a FNAC sensitivity of at least 80% could not be achieved. In total 58 patients of the originally planned 116 patients underwent FNAC with gamma probe and US guidance. There were no true-positive FNAC results, 14 false-negative results and one false-positive result, and thus the sensitivity, specificity, PPV and NPV of FNAC were 0%, 98%, 0% and 75%, respectively. At least 75% of the FNAC samples had a radioactivity signal higher than the background signal.ConclusionFNAC with gamma probe and US guidance is not able to correctly detect metastases in the SN and is therefore not able to replace SLNB. Gamma probe-guided US is a highly accurate method for correctly identifying the SN, which offers possibilities for future research.