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Introduction: The effect of statins on risk of heart failure (HF) hospitalization and lethal outcome remains dubious. Aim: To investigate whether statin therapy improves clinical outcomes in patients hospitalized for ischemic heart failure (HF), to compare the efficacy of lipophilic and hydrophilic statins and to investigate which statin subtype provides better survival and other outcome benefits. Material and Methods: Total amount of 155 patients in the study were admitted to the Clinic for Cardiology, Rheumatology and Vascular diseases in Clinical Center University of Sarajevo in the period from January 2014- December 2017. Inclusion criteria was HF caused by ischemic coronary artery disease upon admission. For each patient the following data were obtained: gender, age, comorbidities and medications on discharge. New York Heart Association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. The patients were followed for a period of two years. Outcome points were: rehospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure. Results: Overall, 58.9% of HF patients received statin therapy, with 33.9% patients receiving atorvastatin and 25.0% rosuvastatin therapy. The most frequent rehospitalization was in patients without statin therapy (66.7%), followed by patients on rosuvastatin (64.1%), and atorvastatin (13.2%), with statistically significant difference p = 0.001 between the groups. Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy, 12.8% in patients on rosuvastatin therapy and 3.8% in patients on atorvastatin therapy (p = 0.004). Conclusion: Lipophilic statin therapy is associated with substantially better long-term outcomes in patients with HF.

Title of Days of AMNuBiH 2018” and “SWEP 2018” is “Ethical Dilemmas in Science Editing and Publishing”. Why? If one wants to create a scientific work, must have on his mind that creating a scientific work requires creativity and openness, honesty, trust, and obeying the ethical principles for writing a scientific paper. While working on a an biomedical research involving human subjects medical workers should have on mind that it is the duty of the physician to remain the protector of the life and health of that person on whom biomedical research is being carried out. The World Medical Association (WMA) has developed the Declaration of Helsinki as a statement of ethical principles to provide guidance to physicians and other participants in medical research involving human subjects.

Abstract This research is aimed at determining the impact of supplementing extensively reared lambs with a limited amount of flax seed enriched-concentrate on the fatty acid profile of the lamb meat (omental fat depot). A total of 96 60-day old Pramenka breed lambs (23.85±3.98 kg live body weight; 60±10 days of age; 42 males and 54 females) raised on pasture with their dams were randomly divided in three experimental groups: control (CON) or extensive rearing group, which did not receive any supplementary feed; concentrate (CC) group, receiving 300 g of a conventional commercial concentrate feed per animal daily, and concentrate-flax seed (CC-FS) group, receiving 300 g/day of the concentrate supplemented with 5% of flax seed. After 60 days of experimental period, 10 lambs were selected (5 males and 5 females) from each group and slaughtered. Omental fat samples were taken and analyzed to determine their fatty acid profile. Significant (P>0.05) differences in the fatty acid profile between CON and CC groups were small. However, enrichment of the concentrate with 5% flax seed increased the percentages of PUFA and n-3 PUFA when compared to both CON and CC groups and thus slightly improved the nutritional characteristics of the omental fat. The effect of sex on the fatty acid profile was only observed for C20:4 n-6 and C20:5 n-3 (P < 0.05).

Aim: The aim of this article is to determine the possible correlation between the smoking habit and the incidence of basocellular skin cancer (BCC). Patients and methods: The prospective study, which lasted from June 2012 to June 2018, included subjects diagnosed with basocellular skin cancer (BCC). Respondents were divided into 3 groups. The first, group A (21 respondents), are respondents who smoke 20-35 cigarettes a day. The second, group B (19 respondents), consists of respondents who smoke 35-50 cigarettes a day. The third, group C (91 respondents), consist of non-smokers. Observed parameters are sex, age, current and previous smoking habits, including duration (total smoking year) and intensity (average number of cigarettes smoked per day), age at the start of smoking, and prolonged exposure to the sun. Results: No statistically significant relationship was found between smoking and BCC frequency. It was shown that with BCC of the skin was more affected those who did not smoke. There is no clear relationship between the duration of smoking and/or the amount of smoking and the development of BCC, and it follows that this relationship is not likely to be causative. A suggestive, but not significant, evidence of relationship between smoking and skin cancer is found at this time. Conclusion: Since it is a conglomerate of possible etiological factors, further research is needed to definitively clarify the effect of tobacco consumption on the development of BCC by monitoring a larger number of respondents over a longer period of time in large prospective studies. In any case, a possible association with skin cancer is a reason to avoid smoking.

Introduction: An increase in nitric oxide (NO) synthesis concentration could help alleviate some pathological changes directly related to uremia. Aim: To investigate the concentration of nitric oxide in saliva of patients with terminal stage of chronic renal failure on hemodialysis and to investigate the effect of hemodialysis on concentration of nitric oxide in saliva of the patients with terminal stage of chronic renal failure on hemodialysis. Material and Methods: The study had a prospective character and included 60 respondents of both sexes, at age between 20 and 60 years. The control group included 30 healthy volunteers of both sexes (15 men and 15 women) of the same age, who were based on subjective and objective health status without any manifestations of pathophysiological changes. The group of patients with terminal stage of chronic renal failure on hemodialysis involved 30 patients of both sexes (15 men and 15 women). Inclusion criteria: hemodialysis duration more than 6 months and age between 20 and 60 years. Results: The amount of non-stimulated saliva collected during 15 minutes in patients with chronic renal failure was lower by 31.3% compared to the control group of healthy subjects (p<0.0001). Concentration of NO in saliva in patients with chronic renal failure was higher by 121% than in the control group (p<0.001). Concentration of NO in saliva in patients with chronic renal failure after hemodialysis was 121% lower than in the same subjects prior to hemodialysis (p<0.001). A statistically significant negative correlation (r=-0.381, p<0.05) was found between the hemodialysis duration in months and the level of NO in saliva of the patients with chronic renal failure prior to hemodialysis. There was no statistically significant correlation (r=-0.167, NS) between the hemodialysis duration in months and NO levels in saliva of the patients with chronic renal failure after hemodialysis treatment. Conclusion: Concentration of NO in saliva of the patients on hemodialysis was statistically significantly higher in relation to NO concentration in the saliva of healthy subjects and after hemodialysis was statistically significantly lower in relation to NO values prior to hemodialysis. Monitoring of changes in NO concentration dynamics in saliva of hemodialysis patients will probably be helpful in monitoring hemodialysis efficacy.

Dr. Karl (Karel) Bayer (Hradec Kralove, Czech Republic, January 23, 1850 - Sarajevo, April 12, 1914), was physician, specialist in Neuropsychiatry (Figure 1). He graduated elementary school and gymnasium in the town of Hradec Kralove (1-6). He graduated from the Faculty of Medicine at Charles University in Prague in 1876.

Acta Informatica Medica (www. actainformmed.org) is a peer-reviewed, open access journal which publish original articles, professional articles, reviews, viewpoints, and case studies, covering issues in Biomedical and Medical/Health informatics, published by the Academy of Medical Sciences of Bosnia and Herzegovina (www.amn. ba) (1). Acta Informatica Medica journal (Acta Inform Med) has founded in the year 1993 by Izet Masic and Zoran Ridjanovic, as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). This year Acta Informatica Medica has accepted as official journal of the European Federation for Medical Informatics ( www.efmi. org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 25 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. Also, we sent application for including Acta as official journal of International Medical Informatics Association (www.imia.org) and to Web of Science groups (exactly to The Emerging Sources Citation Index) and waiting result of the reviewing process. During the year 2018 in Acta Informatica Medica was published 58 papers (from total amount published papers, 76.9% was original papers), where it was more published original papers in the journal than in the year 2017 (Figure 1). The journal began with the practice to publish the articles of PhD students free of charge, and in that manner opened to this population, and began with the practice of populating biomedical information technology, both in Bosnia and Herzegovina and in the region. The journal opened to PhD students, and they embrace it through the official letter to the Editor, presenting their goals and problems. The purpose of the journal is availability in the future period, to those authors who are not able to pay a publishing fee (because the subscription fee should be secondary and the quality of the work at the first place) to publish their papers free of charge. The tendency for the future is to preserve the Open Access model, while enabling funding through the subscription and purchase of printed publications. The purpose of the journal is to continue the publishing of both its online and print edition, four times a year (ISSN: 0353-8109 (Print), ISSN: 1986-5988 (On-line)). The website of the journal is refreshed in 2018, revised by Editorial Board (new members were included) and regularly updated. The authors of the published articles in 2018 issues are from 11 countries and four continents. Acceptance rate in 2018 was 32.7% (Table 1). Scimagojr.com Index H (for 2017) for Acta Informatica Medica is 12, while scimagojr.com index (SJR) is 0.275 (2). On the aforementioned page, the total number of citations from the journal Acta Informatica Medica was 187 (it should be noted that the number is only from the journals that are covered by Scopus). Self-citation (the number of citations from a journal citing article to articles published by the same journal) was 7. For the period 2013-2017, the Google Scholar h5 index was 17 and the h5 median was the 28. The journal in its function and everyday work is Importance of “Acta Informatica Medica” Journal in Spreading of Biomedical Informatics Knowledge and Experiences in Scientific and Academic Community

Editor and Co-Editor of this journal was informed from anonymous reader that article which was published in Medical Archives in 2001 \'Psychotherapeutic Testimony by Refugees from Bosnia and Herzegovina: a Pilot Study\' (in Bosnian language) has been already published in \'American Journal of Psychiatry\' under the title \'Testimony Psychotherapy in Bosnian Refugees: a Pilot Study\', in 1998. (1, 2).

On December 8th of the year 2018 in Sarajevo held meeting “Days of AMNuBiH” - Days of Academy of Medical Sciences of Bosnia and Herzegovina, and The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP–2018). Venue of the both meetings were at hotel Holiday in Sarajevo (1).

The problem that is being addressed in this paper is to improve the services provided by company and achieve better communication between companies in the supply chain. Therefore, a qualitative assessment of service has been required. This service is characterized by a group of parameters, which are often inaccurately estimated values, as well as their importance for the evaluation system. This is often the result of assessor ́s uncertainty, variability of conditions, etc. Therefore, in the context of AM4SCM (Adaptive Model for Supply Chain Management) a mathematical model for evaluating the quality of services has been developed (FAM4QS Fuzzy Aggregation Method for Quality Service) which is based on the fuzzy arithmetic. Selection of different values for the degrees of fuzzy power mean, which are used for evaluation of parameters or groups of parameters of the system and the service, contributes to a better assessment and it is due to the varying nature of the parameters. The observed model was simulated on 17 supply chains on the territory of the Republic of Serbia. Service quality assessment is carried out based on data from the user requirements participants of supply chains binding the so-called fuzzy aggregation function.

The daily requirements and needs imposed on the executors of logistics services imply the need for a higher level of quality. In this, the proper execution of all sustainability processes and activities plays an important role. In this paper, a new methodology for improving the measurement of the quality of the service consisting of three phases has been developed. The first phase is the application of the Delphi method to determine the quality dimension ranking. After that, in the second phase, using the FUCOM (full consistency method), we determined the weight coefficients of the quality dimensions. The third phase represents determining the level of quality using the SERVQUAL (service quality) model, or the difference between the established gaps. The new methodology considers the assessment of the quality dimensions of a large number of participants (customers), on the one hand, and experts’ assessments on the other hand. The methodology was verified through the research carried out in an express post company. After processing and analyzing the collected data, the Cronbach alpha coefficient for each dimension of the SERVQUAL model for determining the reliability of the response was calculated. To determine the validity of the results and the developed methodology, an extensive statistical analysis (ANOVA, Duncan, Signum, and chi square tests) was carried out. The integration of certain methods and models into the new methodology has demonstrated greater objectivity and more precise results in determining the level of quality of sustainability processes and activities.

This paper shows a method to determine unknown angular accelerations of driving members of a planar mechanism with multiple degrees of freedom via partial mechanism reduction, assuming that driving loads are known for those driving members. Besides the partial reduction of mechanism, here we use the analysis of primary and secondary accelerations, as well as the principle of virtual displacements (virtual work). Using this method, a set of decoupled equations is obtained, which is an advantage when compared to classical methods, such as an application of generalized laws of dynamics, which result in a set of equations that are coupled. As an illustration of how to use the described method, an example is shown.

Introduction: The role of Radio frequent Generator (RF) has been extended from simple tumor ablation to routine hepatic resection. RF energy precoagulates the tissue and thus allows the closure of small blood vessels and bile ducts. The development of surgical techniques and modern technological advances have enabled liver resections to be significantly surgically better controlled in the sense of bleeding, and are more successful and safer for patients. The RF generator has its advantages and disadvantages and as such can be equally used in resective liver surgery. Aim: Display the intraoperative and postoperative complications among patients that had been subjected to liver resection using a RF generator (RF resection), compared to those that had been subjected to liver resection without the use of RF generators (classical liver resection methods of CC resection). Material and methods: The study included 60 patients of both sexes which had resective operative surgery or metastasectomy on the liver due to the basic process. The study was conducted at the Clinic for General and Abdominal Surgery of the Clinical Center of the University of Sarajevo in a four-year period. The study was designed as a comparative study of outcome and postoperative complications of surgical treatment, i.e. resective liver interventions using two operating techniques (RF–liver resection and Classical resection techniques on the liver). Results: The highest number of surgical procedures was due to colorectal cancer. A slightly smaller number was performed due to primary liver cancer and gallbladder cancer. The highest number of surgical interventions remain on non-anatomic resections. Smaller number remains to large resective operations. The length of hospitalization was significantly correlated with blood loss (r = 713 p = 0,000) and the average hospitalization time ranged from 10.5 to 53.3 days. Conclusion: We have shown that the use of RF generators does not significantly reduce intraoperative and postoperative complications. There is a justification for using both techniques for resection on the liver. The resective liver operation depends mostly on the personal stance and the surgeons training.