This paper describes an approach introducing location intelligence using open-source software components as the solution for planning and construction of the airport infrastructure. As a case study, the spatial information system of the International Airport in Sarajevo is selected. Due to the frequent construction work on new terminals and the increase of existing airport capacities, as one of the measures for more efficient management of airport infrastructures, the development team has suggested to airport management to introduce location intelligence, meaning to upgrade the existing information system with a functional WebGIS solution. This solution is based on OpenGeo architecture that includes a set of spatial data management technologies used to create an online internet map and build a location intelligence infrastructure.

This article discusses the application of thermoelectric (TE) materials in building facade systems, which can be used to create active exterior enclosures. TEs are semiconductors that have the ability to produce a temperature gradient when electricity is applied, exploiting the Peltier effect, or to generate a voltage when exposed to a temperature gradient, utilizing the Seebeck effect. TEs can be used for heating, cooling, or electricity generation. In this research, heating and cooling applications of these novel systems were explored. We designed and constructed two prototypes, where one prototype was used to study integration of TE modules (TEMs) as stand-alone elements in the facade, and one prototype was used to explore integration of TEMs and heat sinks in facade assemblies. Both prototypes were tested for heating and cooling potential, using a thermal chamber to represent four different exterior environmental conditions (-18°C, -1°C, 16°C and 32°C). The interior ambient conditions were kept constant at room temperature. The supplied voltage to facade-integrated TEMs varied from 1 to 8 V. We measured temperature outputs of TEMs for all investigated thermal conditions using thermal imaging, which are discussed in this article. The results indicate that while stand-alone facade-integrated TEMs are not stable, addition of heat sinks improves their performance drastically. Facade-integrated TEMs with heatsinks showed that they would operate well in heating and cooling modes under varying exterior environmental conditions.

1. Schechter AL, Stern DF, Vaidyanathan L et al. The neu oncogene: an ERB-B-related gene encoding a 185,000-Mr tumour antigen. Nature 1984; 312(5994): 513–516. 2. Finkle D, Quan ZR, Asghari V et al. HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. Clin Cancer Res 2004; 10(7): 2499–2511. 3. Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235(4785): 177–182. 4. Mishra R, Hanker AB, Garrett JT. Genomic alterations of ERBB receptors in cancer: clinical implications. Oncotarget 2017; 8(69): 114371–114392. 5. Pillai RN, Behera M, Berry LD et al. HER2 mutations in lung adenocarcinomas: a report from the Lung Cancer Mutation Consortium. Cancer 2017; 123(21): 4099–4105. 6. Li BT, Ross DS, Aisner DL et al. HER2 amplification and HER2 mutation are distinct molecular targets in lung cancers. J Thorac Oncol 2016; 11(3): 414–419. 7. Liu L, Shao X, Gao W et al. The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data. J Thorac Oncol 2010; 5(12): 1922–1932. 8. Nakamura H, Saji H, Ogata A et al. Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in nonsmall cell lung cancer. Int J Cancer 2003; 103(1): 61–66. 9. Yoshizawa A, Sumiyoshi S, Sonobe M et al. HER2 status in lung adenocarcinoma: a comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations. Lung Cancer 2014; 85(3): 373–378. 10. Peters S, Stahel R, Bubendorf L et al. Trastuzumab emtansine (T-DM1) in patients with previously treated HER2-overexpressing metastatic nonsmall cell lung cancer: efficacy, safety, and biomarkers. Clin Cancer Res 2019; 25(1): 64–72. 11. Dong ZY, Zhang JT, Liu SY et al. EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer. Oncoimmunology 2017; 6(11): e1356145. 12. Li BT, Shen R, Buonocore D et al. Ado-trastuzumab emtansine for patients with HER2-mutant lung cancers: results from a Phase II Basket Trial. J Clin Oncol 2018; 36(24): 2532–2537. 13. Hotta K, Aoe K, Kozuki T et al. A phase II study of trastuzumab emtansine in HER2-positive non-small cell lung cancer. J Thorac Oncol 2018; 13(2): 273–279. 14. Mazières J, Barlesi F, Filleron T et al. Lung cancer patients with HER2 mutations treated with chemotherapy and HER2-targeted drugs: results from the European EUHER2 cohort. Ann Oncol 2016; 27(2): 281–286. 15. Langer CJ, Stephenson P, Thor A et al. Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group Study 2598. J Clin Oncol 2004; 22(7): 1180–1187. 16. Gatzemeier U, Groth G, Butts C et al. Randomized phase II trial of gemcitabine–cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol 2004; 15(1): 19–27. 17. Mazières J, Peters S, Lepage B et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 2013; 31(16): 1997–2003. 18. Hainsworth JD, Meric-Bernstam F, Swanton C et al. Targeted therapy for advanced solid tumors on the basis of molecular profiles: results from mypathway, an open-label, phase IIa multiple basket study. J Clin Oncol 2018; 36(6): 536–542. 19. Kris MG, Camidge DR, Giaccone G et al. Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors. Ann Oncol 2015; 26(7): 1421–1427. 20. Hyman DM, Piha-Paul SA, Won H et al. HER kinase inhibition in patients with HER2and HER3-mutant cancers. Nature 2018; 554(7691): 189–194. 21. Gandhi L, Besse B, Mazieres J et al. MA04.02 neratinib 6 temsirolimus in HER2-mutant lung cancers: an international, randomized phase II study. J Thoracic Oncol 2017; 12(1): S358–S359. 22. De Grève J, Moran T, Graas MP et al. Phase II study of afatinib, an irreversible ErbB family blocker, in demographically and genotypically defined lung adenocarcinoma. Lung Cancer 2015; 88(1): 63–69. 23. Smit EF, Peters S, Dziadziuszko R et al. A single-arm phase II trial of afatinib in pretreated patients with advanced NSCLC harboring a HER2 mutation: the ETOP NICHE trial. J Clin Oncol 2017; 35(Suppl 15): 9070. 24. Lai W-CV, Lebas L, Milia J et al. Afatinib in patients with metastatic HER2-mutant lung cancers: an international multicenter study. J Clin Oncol 2017; 35(Suppl 15): 9071. 25. Wang Y, Jiang T, Qin Z et al. HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib. Ann Oncol 2019; 30(3): 447–455. 26. de Melo Gagliato D, Jardim DL, Marchesi MS, Hortobagyi GN. Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2þ breast cancer. Oncotarget 2016; 7(39): 64431–64446. 27. Pauli C, Hopkins BD, Prandi D et al. Personalized. Cancer Discov 2017; 7(5): 462–477.

There has been significant progress in recent years aimed at the development of new analytical techniques for investigating structure-function relationships in hierarchically ordered materials. Inspired by these technological advances and the potential for applying these approaches to the study of construction materials from antiquity, we present a new set of high throughput characterization tools for investigating ancient Roman concrete, which like many ancient construction materials, exhibits compositional heterogeneity and structural complexity across multiple length scales. The detailed characterization of ancient Roman concrete at each of these scales is important for understanding its mechanics, resilience, degradation pathways, and for making informed decisions regarding its preservation. In this multi-scale characterization investigation of ancient Roman concrete samples collected from the ancient city of Privernum (Priverno, Italy), cm-scale maps with micron-scale features were collected using multi-detector energy dispersive spectroscopy (EDS) and confocal Raman microscopy on both polished cross-sections and topographically complex fracture surfaces to extract both bulk and surface information. Raman spectroscopy was used for chemical profiling and phase characterization, and data collected using EDS was used to construct ternary diagrams to supplement our understanding of the different phases. We also present a methodology for correlating data collected using different techniques on the same sample at different orientations, which shows remarkable potential in using complementary characterization approaches in the study of heterogeneous materials with complex surface topographies.

This paper deals with the Compressive Sensing implementation in the Face Recognition problem. Compressive Sensing is new approach in signal processing with a single goal to recover signal from small set of available samples. Compressive Sensing finds its usage in many real applications as it lowers the memory demand and acquisition time, and therefore allows dealing with huge data in the fastest manner. In this paper, the undersampled signal is recovered using the algorithm based on Total Variation minimization. The theory is verified with an experimental results using different percentage of signal samples.

Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C. ramosum, intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro, suggesting that the presence of C. ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity.

Heavy metals disturb the redox homeostasis of the plant cell. The indolamine hormone, melatonin, protects plants from oxidative damage by directly scavenging reactive oxygen species or by stimulating the activity of antioxidant enzymes. The antioxidative role of melatonin in the leaves of two medicinal plants, lemon balm (Melissa officinalis L.) and valerian (Valeriana officinalis L.) that were treated with increased concentrations of Zn and Cd 24 h after sowing at an open field, were investigated. The plants were treated with Zn, Cd, melatonin and a mixture of melatonin with the mentioned metals. Exogenously added melatonin increased the endogenous melatonin concentration in lemon balm leaves. However, in the valerian leaves, lower or the same endogenous melatonin level was detected. The significantly higher concentration of endogenous melatonin in both plants was measured after treatment with Zn. As the results showed, changes in superoxide dismutase (SOD) and peroxidase (POD) activities are species-specific and change depending on the plant development phase, and the type of treatment. Melatonin pretreatment induced alternation in SOD isoenzyme profiles and activities as well as POD activity in both plant species treated with heavy metals.

Aim To assess efficacy of omalizumab in moderate to severe asthma and notable factors affecting it, such as treatment compliance during the period of ten years. This retrospective, observational real life study is the first of this kind in the Gulf region and one of the worldwide rare long term omalizumab treatment studies. Methods The treatment for 35 patients started in 2008. Twenty patients (ongoing group) proceeded with treatment and were assessed annually until 2017. Reasons for treatment discontinuation in 15 patients (drop-out group) were also assessed. Results Before starting omalizumab the ongoing group of patients had history of ≥2 asthma exacerbations per year, which significantly decreased during the first year of the treatment (p<0.001), and for 14 (70%) patients ≤1 exacerbation stayed during the next 10 years. Since 2014 six (30%) patients had had ≥2 annual asthma exacerbations (p<0.05 in 2013; p<0.05 in 2014; p<0.001 in 2015; p<0.01 in 2016; p<0.001 in 2017). At the same time there was a significant drop in compliance index (CI) (p<0.0001). Conclusion To our knowledge this is the first 10-year study of compliance and effectiveness, which may help finalize some practical suggestions to improve CI in clinical practice and to note acceptable variation in CI. It is important to recognize factors that can possibly affect effectiveness of the treatment and identify the patients who will have the best benefit from a long term omalizumab treatment.

One of the major causes of ecological and environmental problems comes from the enormous number of discarded waste tires, which is directly connected to the exponential growth of the world’s population. In this paper, previous works carried out on the effects of partial or full replacement of aggregate in concrete with waste rubber on some properties of concrete were investigated. A database containing 457 mixtures with partial or full replacement of natural aggregate with waste rubber in concrete provided by different researchers was formed. This database served as the basis for investigating the influence of partial or full replacement of natural aggregate with waste rubber in concrete on compressive strength. With the aid of the database, the possibility of achieving reliable prediction of the compressive strength of concrete with tire rubber is explored using neural network modelling.

Aim To determine dietary habits of elementary school students in relation to a place of living and socio-economic status of the family. Methods A prospective study conducted in the Primary Health Center Zenica involved five family medicine teams in urban and five in rural settlement during 2015. Elementary school students aged 10-16 were interviewed by random selection using a questionnaire on the socio-economic status of parents and nutritional habits of adolescents. Results The survey involved 199 respondents, 103 from rural and 96 from urban area. There were significantly more pupils from employed parents who consumed non-carbonated drinks. Students from urban areas more likely consumed fruit every day than children from rural areas. More than half of the respondents did not or rarely consumed vegetables, in this case the village pupils, who consumed much less milk. It would be expected that rural students were more likely to consume fruits, vegetables and milk due to easier access to these foods in the countryside, but the results of this research did not confirm this assumption. Conclusion Changes in traditional family functioning (lower income, unemployment) could be linked with lifestyle changes (low consumption of fruits and vegetables, low consumption of milk both in rural and urban areas, consumption of carbonated drinks), especially in families in rural areas.

Introduction: Percutaneous transluminal angioplasty (PTA) is one of the treatment options for stenotic and obstructive lesions of the subclavian artery. Aim: To evaluate initial and long-term results of percutaneous transluminal angioplasty of subclavian artery lesions. Methods: During period February 2016 to December 2017, 26 patients (12 men and 14 women) with significant subclavian artery stenosis and occlusion were admitted and underwent PTA. All patients were symptomatic. All PTA procedures were performed with the patient under local anesthesia, through the femoral artery (n=22), brachial artery (n=4), or combined route (n=6). In 7 patients, we performed direct stenting, while in the other 15 patients we performed predilatation before stent implantation. The follow-up protocol consisted of regular clinical examinations in 1, 3, 6 and 12 months post-procedural, and annually thereafter with duplex ultrasound monitoring. Results: Initial technical success was achieved in 22 of 26 procedures (84.61%), 100% in stenotic lesions and 55.5 % in total occlusions. Fourth of nine occlusions could not be recanalized by PTA. These patients were managed surgically. The 30-day mortality rate was 0% for the entire group. No patients required reintervention for recurrence of symptoms and the stents remain patent at period of 12 months post-procedural. Conclusion: The minimal invasive technique, the markedly lower complication rate, the high long-term patency, patient’s comfort and the decreased hospital stay have made endovascular repair the primary choice of treatment in the majority of cases, especially in patients with stenotic lesions and high-risk patients. We consider PTA of subclavian artery stenotic/obstructive lesions should be the first therapeutic option.

Aim To compare the effect of neoadjuvant chemotherapy based on taxane and/or anthracycline to the extent of an objective response in female patients with unresectable breast cancer with evaluation of the toxic profile of applied chemotherapy. Methods One hundred patients with histologically verified breast cancer, treated with neoadjuvant chemotherapy were divided into two groups: a study group A (50 patients), who had received 4 to 6 cycles of taxane-based chemotherapy, and control group B (50 patients), who had received 4 to 6 cycles of anthracyclines-based chemotherapy. Pathohistological response was evaluated after tumour excision and axillary resection at the end of chemotherapy and it was defined as pathologic complete (pCR), partial (pPR), or no response (pNR). Toxic effects were evaluated and quantified by the Common Terminology Criteria for Adverse Events v4.0. Results After neoadjuvant chemotherapy, 8% of patients in the group A achieved pCR, 54% achieved pPR, while 38% of patients had no tumour response to applied chemotherapy. In the group B pCR was achieved in 6%, pPR in 42% of patients, while 51% of patients were pNR to the administered chemotherapy. Significant reduction of tumour mass was achieved in the group of patients treated with taxanes: 20.00 (7.75-30.25) vs. 13.50 (6.00-25.00) mm (p=0.024). Toxicity of chemotherapy in group A and group B was within the limits of grade 2. Conclusion The addition of taxane to anthracycline-based neoadjuvant chemotherapy in patients with breast cancer resulted in a significant reduction in tumour mass compared to the group of patients treated with anthracyclines, but without increasing the overall side effects.

Leishmania infantum causes potentially life-threatening disease in humans. To determine the extent of the animal reservoir for this pathogen in Bosnia and Herzegovina, we tested dogs and cats. We found that a large proportion of dogs were exposed to or infected with L. infantum, indicating endemicity in dogs and zoonotic risk for humans.