Background: The femur is supplied princially by the diaphyseal nutrient artery which enters the bone throught the nutrient foramen. This supply is essential during the growing period, the early phases of ossification, and in different surgical procedures. The aim of present study was to examine the morphology and topography of the femur nutrient foramen to provide detalied data on such features.Methods: This was a cross-sectional-descriptive study in which we observed 50 femurs. We analysed the number and location of nutrient foramina, the length of the bone, the position of the nutrient foramen regarding to values of FI, correlation between number of nutrient foramen and length of femur, correlation between position of nutrient foramen and side of extremity to which femur belongs.Results: The double foramina were common in right (57.1%) and left (42.1%) femur, mostly located in medial lip of aspera line in right (64.3%) and on the lateral lip in left femur (68.4%), with statistically significant correlation, χ = 4.85; p = 0.03, p <0.05.  The foramina in left (89.5%) and right (96.4%) femur were commonly observed at their middle third, with no statistically significant correlation between position of foramen accordingly to Foraminal Index value and side of extremity on which femur belongs (p=0.56; p>0.05). There is positive correlation between length of right and left femur and number of foramina.Conclusions: The study provides data of the nutrient foramina on femur, which is helpful for clinicians to help preserve bone vascularization during surgery.

Videofluoroscopic swallow studies are widely used in clinical and research settings to assess swallow function and to determine physiological impairments, diet recommendations, and treatment goals for people with dysphagia. Videofluoroscopy can be used to analyze biomechanical events of swallowing, including hyoid bone displacement, to differentiate between normal and disordered swallow functions. Previous research has found significant associations between hyoid bone displacement and penetration/aspiration during swallowing, but the predictive value of hyoid bone displacement during swallowing has not been explored. The primary objective of this study was to build a model based on aspects of hyoid bone displacement during swallowing to predict the extent of airway penetration or aspiration during swallowing. Aspects of hyoid bone displacement from 1433 swallows from patients referred for videofluoroscopy were analyzed to determine which aspects predicted risk of penetration and aspiration according to the Penetration–Aspiration Scale. A generalized estimating equation incorporating components of hyoid bone displacement and variables shown to impact penetration and aspiration (such as age, bolus volume, and viscosity) was used to evaluate penetration and aspiration risk. Results indicated that anterior-horizontal hyoid bone displacement was the only aspect of hyoid bone displacement predictive of penetration and aspiration risk. Further research should focus on improving the model performance by identifying additional physiological swallowing events that predict penetration and aspiration risk. The model built for this study, and future modified models, will be beneficial for clinicians to use in the assessment and treatment of people with dysphagia, and for potentially tracking improvement in hyolaryngeal excursion resulting from dysphagia treatment, thus mitigating adverse outcomes that can occur secondary to dysphagia.

Abstract Built around the SMARDDA modules for magnetic field-line tracing [IEEE Tr. Plasma Sc. 42 (2014) 1932], the SMITER code package (SMARDDA for ITER) is a new graphical user interface (GUI) framework for power deposition mapping on tokamak plasma-facing components (PFC) in the full 3-D CAD geometry of the machine, taking as input a user-defined specification for parallel heat flux in the scrape-off layer (SOL) and a description of the equilibrium magnetic flux. The software package provides CAD model import and integration with the ITER Integrated Modelling and Analysis Suite (IMAS), parametric CAD components catalogue and modelling, CAD de-featuring for PFC surface extraction, meshing, visualization (using an integrated ParaView module), Python scripting and batch processing, storage in hierarchical data files, with several simulation cases in one study running in parallel and using message passing interface (MPI) for code speed-up. An integrated ParaView module can combine CAD geometry, magnetic field equilibrium, meshes and results for detailed setup analysis and a module is under development for full finite element computation of surface temperatures resulting from the power deposition patterns on 3-D PFCs. The code package has been developed for ITER, but can be deployed for similar modelling of any tokamak. This paper presents and discusses key features of this field-line tracing environment, demonstrates benchmarking against existing field-line tracing code and provides specific examples of power deposition mapping in ITER for different plasma configurations.

Tobacco consumption continues to be behavior engaged in by a large percentage of Bosnia&Herzegovina (BiH) citizens. According to the official statistics, nearly half of the state’s adults, that is about 1,200,600 people, consume tobacco product on a daily bases. The state excise policy is one of the main available tool for reducing smoking prevalence because the cigarette prices are under direct impact of this policy. The specific excise on cigarettes introduced in BiH in 2009 and have increased every year so it was the main driver of cigarettes price growth. In order to provide research-based evidence for more effective tobacco taxation policies in BIH, in this paper we estimate price elasticity of demand for cigarettes using the macro level data for the period 2008 to 2017, on a semi-annual basis. The results have shown that increase in prices of cigarettes have statistically significant impact on cigarettes consumption, at significance level of 1%. The estimated price elasticity coefficient is in the range from -0.71 to -0.83, depends on the selected control variables used in the model. It means that increase in real cigarettes prices for 10% led to the decrease in cigarettes consumption in the range from 7.1% to 8.3%.

In this paper, the stress and strain analysis of common laminated wood seat shell is performed. Experimental stiffness evaluation is conducted by measuring displacement of the point on the backrest, and experimental stress analysis is carried out by tensometric measuring at the critical transition area from the seat to the backrest. Finite element analysis is carried out layer by layer with a “2D linear elastic model” for orthotropic materials. Good matching is found between numerical and experimental results of displacement. It is also shown that the results of the principal stress in the measurement points of the seat shell compare favourably with experimental data. The applied in-plane stress analysis of each individual veneer is not applicable for interlaminar stress calculations that are a significant factor in curved forms of laminated wood. Curved forms of laminated wood products require more complex numerical analysis, but the method can be used to achieve approximate data in early phase of product design.

Graphs are irregular structures which naturally account for data integrity, however, traditional approaches have been established outside Signal Processing, and largely focus on analyzing the underlying graphs rather than signals on graphs. Given the rapidly increasing availability of multisensor and multinode measurements, likely recorded on irregular or ad-hoc grids, it would be extremely advantageous to analyze such structured data as graph signals and thus benefit from the ability of graphs to incorporate spatial awareness of the sensing locations, sensor importance, and local versus global sensor association. The aim of this lecture note is therefore to establish a common language between graph signals, defined on irregular signal domains, and some of the most fundamental paradigms in DSP, such as spectral analysis of multichannel signals, system transfer function, digital filter design, parameter estimation, and optimal filter design. This is achieved through a physically meaningful and intuitive real-world example of geographically distributed multisensor temperature estimation. A similar spatial multisensor arrangement is already widely used in Signal Processing curricula to introduce minimum variance estimators and Kalman filters \cite{HM}, and by adopting this framework we facilitate a seamless integration of graph theory into the curriculum of existing DSP courses. By bridging the gap between standard approaches and graph signal processing, we also show that standard methods can be thought of as special cases of their graph counterparts, evaluated on linear graphs. It is hoped that our approach would not only help to demystify graph theoretic approaches in education and research but it would also empower practitioners to explore a whole host of otherwise prohibitive modern applications.

One of the first tasks in engineering embedded systems is the selection of the hardware; more specifically, the MicroController Units (MCUs). This selection is driven by business, technical, organizational, and legal constraints. Often, the hardware is delivered together with proprietary environments in which the software to be deployed has to be developed. This imposes architecturally significant constraints that are usually communicated inappropriately (in terms of time and format) to the engineering team. Examples are the usage of proprietary data types and programming language constructs (e.g., macros in C) and limitations to the reuse of existing software assets. To overcome this challenge, we propose an approach that has two main constituents: (i) the Embedded System Checklist, which aims at guiding the selection of MCUs according to the architecture constraints; and (ii) the Embedded System ESDT Dependency (SED) Architecture View, which connects the software design view with the technical view, describing hardware-related development environment limitations and their influences on the software architecture. We evaluated the application of these concepts in two industrial projects and show that making these dependencies transparent saves a lot of effort during software system development.

This paper aims to evaluate the trilateral relations between Turkey, Serbia, and Bosnia and Herzegovina. In the course of a proper evaluation of the growing dynamics of diplomatic relations between these three countries, it is important to assess relations at the presidential and ministerial levels. The research analyzes official statements, declarations, and agreements that envision the tripartite mechanism. Besides putting these official statements, declarations, and agreements into perspective, the research aims to assess the major implications, activities, and results of trilateral relations. It is significant to determine to what extent trilateral relations affect diplomatic relations, regional stability, regional cooperation, tourism, trade, and economic relations. This paper also aims to put the trilateral relations into perspective by explaining constructive and proactive Turkish foreign policy in the Balkans.

With great interest we have read the letter by De Giorgi et al. in which they express their disagreement with the conclusions of our study on the potential value of a Raman spectroscopy device in the clinical diagnosis of cutaneous melanoma. In our paper, we tested the diagnostic accuracy of Raman spectroscopy, expressed as sensitivity, specificity and number needed to treat, in a set of pigmented skin lesions that were deemed suspicious for melanoma by dermatologists. Whereas current clinical diagnosis and dermoscopy rely on recognition of morphological characteristics, Raman spectroscopy provides information about the molecular composition of pigmented skin lesions. Our results indicate that Raman spectroscopy constitutes a valuable diagnostic tool: all melanomas that were analyzed tested positive with Raman spectroscopy (sensitivity 100%), and the estimated number needed to treat was 2.7 (ratio between the number of lesions tested positive by Raman spectroscopy and the total confirmed melanoma). De Georgi et al. disagree with our conclusions which state that the diagnostic model based on Raman spectroscopy has enabled greater sensitivity and specificity in melanoma diagnosis, detecting all thin melanomas and reducing the number of unnecessary excisions by more than two-fold compared with the current clinical practice. They object to the fact that pigmented skin lesions were enrolled in the study after a dermatologist performed a clinical assessment and had excised lesions that were clinically suspicious for melanoma, and state that this does not reflect clinical practice. They furthermore state that such “lesion pre-selection frequently includes many melanomas that are easy to diagnose, and which often have an exceedingly high frequency of malignancies within the lesions examined, thus creating an “artificial” diagnostic setting compared to real practice”. De Giorgi et al. have misinterpreted the objective of our study and our data set. Our results are based on the use of Raman spectroscopy as an add-on to diagnose dermatologist-selected lesions. We do not want to by-pass the dermatologist. The selection of suspicious lesions by a dermatologist is part of the intended clinical practice. This must not be confused with a bias in the case series used. The sample set mostly consisted of difficult to classify lesions, including melanoma in situ and dysplastic nevi, deemed suspicious for melanoma based on visual inspection by dermatologists specialized in pigmented skin lesions. This selection of lesions was in line with the objective of our study; namely to investigate the diagnostic use of Raman spectroscopy as an adjunct technique to distinguish between melanoma and unnecessary diagnostic excisions. This is fully in line with the main conclusion drawn from the results regarding the diagnostic accuracy in an independent validation set, and the possible reduction of the number of unnecessary diagnostic excisions if the Raman instrument were used as an add-on to classify lesions considered suspicious by dermatologists. De Giorgi et al. also criticize the fact that amelanotic lesions were excluded from analysis. All lesions that were excised by the dermatologist for suspicion for melanoma were subjected to Raman spectroscopy. This included unpigmented lesions suspicious for amelanotic melanoma. After histopathological evaluation, the lesions diagnosed as non-melanocytic were excluded from analysis (basal cell carcinoma, seborrheic wart, lichenoid keratosis, dermatofibroma, haemangioma, scar), because the aim of the study at this stage was to distinguish between melanoma and non-melanoma melanocytic lesions. De Giorgi et al. furthermore state that only a melanoma left unexcised represents a clinically relevant false negative diagnosis and that in their experience this does not frequently occur, and likely limited to subjects harboring a clinically “featureless” tumor. We can only refer to the literature. The accuracy and reproducibility of melanocytic skin lesion diagnosis is poor, in particular among general practitioners, as has been demonstrated in several studies. More evidence-based studies are required to provide data about the role of Raman spectroscopy to improve clinical diagnosis of melanoma in different medical settings, including screening of inconspicuous melanocytic skin lesions. With this study we provide evidence that accurate diagnostic results can be obtained by Raman spectroscopy on pigmented skin lesions selected by dermatologists as suspicious for melanoma. We believe that these results represent an important step towards accurate clinical diagnosis of melanoma.

Objective: We present a 17-year-old boy with an incidentally diagnosed left adrenal ganglioneuroma during the diagnostic workup of alopecia areata. Clinical Presentation and Intervention: Laboratory investigations revealed vitamin D deficiency. Laparoscopic adrenalectomy was performed and ganglioneuroma was confirmed histologically. At follow-up, the vitamin D supplements improved the vitamin D levels followed by a gradual regression of alopecia areata. However, it recurred 18 months later despite the normal levels of serum vitamin D and no tumor recurrence. Conclusion: Further studies should reveal the relationship between alopecia areata and ganglioneuroma as well as the role of vitamin D in alopecia areata.

Constructed wetlands, as an alternative to conventional methods, are systemsdesigned on the basis of the application of natural purification processes that take placein watery and swampy overgrown habitats, with certain microbiological groups. In thewastewater treatment process various types of constructed wetlands can be combinedto achieve a higher efficiency of the purification.In this study, the removal effectiveness of the organic substances from municipalwastewater was monitored, using a horizontal pilot - scale constructed wetlandutilizing Typha latifolia and Phragmites australis. In addition to the measurement oforganic substances content through COD, BOD and KMnO4 consumption, and totaldissolved substances (TDS) in influent and effluent, microbiological sample analysis wasperformed, monitored by total number of coliform bacteria.The aim of this study was to calculate the effectiveness of removing organicsubstances from municipal wastewater, depending on the season, as well as theeffectiveness of eliminating total coliform bacteria.The results of one-year research have shown that the removal effectiveness ofthe organic substances from municipal wastewater, expressed as the chemical oxygendemand (COD), was the highest in summer - 87.82% ± 2.83%, and the lowest in thewinter - 64.51% ± 5.89%. During the study, effectiveness of elimination of total coliformbacteria was 97.88 ± 0.80% and total dissolved substances 71.27% .

In this paper, we strive to point out the special protection of children with developmental disabilities and invalids as victims of crime and violence, in accordance with international and national law. Through the analysis of the judgment of the European Court against Bosnia and Herzegovina, we want to point out the secondary victimization of such persons who have been mistreated by civil servants and responsible for the state of Bosnia and Herzegovina. In the law on civil servants, it is necessary to incorporate responsibility for the execution of secondary victims of victimization in a manner that is personally liable for these violations of citizens' rights and that the damages caused are borne by themselves and that they are removed from the civil service.

Victims and witnesses may be reluctant to give information and evidence because of perceived or actual intimidation or threats against themselves or members of their family. This concern may be exacerbated where people who come into contact with the criminal justice system are particularly vulnerable. For instance, by virtue of their age and developing levels of maturity, children require that special measures be taken to ensure that they are appropriately assisted and protected by criminal justice processes.Victims who receive appropriate and adequate care and support are more likely to cooperate with the criminal justice system in bringing perpetrators of crime to justice. However, inadequacies of criminal justice systems may mean that victims are not able to access the services they need and may even be re-victimized by the criminal justice system itself.