Transformations between amorphous and crystalline apatite mechanistically govern some of the most essential processes in bone metabolism, including biomineralization and bone remodeling. Fundamental understanding of this phase transition can help us gain control over the formation and dissolution of boney tissues in vivo and utilize that knowledge for various therapeutic ends. Crystallization of hydroxyapatite (HAp) and two tricalcium phosphate (TCP) polymorphs from the metastable precursor, amorphous calcium phosphate (ACP) was here studied kinetically and mechanistically using thermal analyses, X-ray diffraction and Fourier-transform infrared spectroscopy. Crystallization was detected in the differential thermal analysis as the exothermic peak at 639.5 °C at the slowest heating regimen of 5 °C min-1, while a combination of different kinetics models, including Augis-Bennett, Borchardt-Daniels, Johnson-Mehl-Avrami, Kissinger, Ozawa and Piloyan, yielded activation energies in the 435-450 kJ mol-1 range. Dehydrated ACP required a significant energy input to transform to HAp, thus indirectly proving the key role that structural water plays in this process in a biological setting. The phase transformation at high temperatures involved preformed nuclei and was solely due to their 3D growth, contrasting the edge-controlled nucleation derived earlier as the mechanism of growth in the solution. Crystallization was in both cases accompanied by the formation of needle-shape crystals of HAp through aggregation of ultrafine spherical units of ACP. Relationship between crystallinity and the heating rate was detected only for the initially amorphous structure, indicating a more intense and coherent lattice ordering process in annealed ACP than in HAp. Despite that, crystallization disobeyed the rule of inverse proportionality between the thermal energy required for the relaxation of defects and the level of strain, as the recovery rate of the initially poorly crystalline HAp was higher than that of ACP.

At the end of the 19th century in the Czech Republic a new way of physical exercise entitled the “Sokol” or “Tyrš” system appeared. It spread to all the countries where Slavs lived and thus arrived among the Serbs who lived on the territory of Bosnia and Herzegovina. A group of Serbs from Foča in 1893 tried to establish the Serbian Soko society but the Austro-Hungarian authorities did not allow it. The first Serbian gymnastic society on the territory of Bosnia and Herzegovina called “Obilić” was founded in 1904 in Mostar. Many educated people of that time participated in the work of the Soko organizations, among them the medical doctor Branko Čubrilović. The main subject of this paper is Branko Čubrilović and his connections with Serbian Sokolism and the aim is to highlight his role in the development of Serbian Sokolism, primarily in the areas of Bosnia and Herzegovina, as well as in other areas where Serbs lived. The authors used a historical method.

Introduction A fully portable infection is a public-health problem of great importance in most of the world. Infections that are transmitted by sexual contact make up a large group of diseases caused by various microorganisms: bacteria, viruses, parasites, fungi and protozoa. The most common sexually transmitted infections (PPIs) are: chlamydia, gonorrhea, Hepatitis B, AIDS, HPV infections, and others.Method The conducted research is a type of cross section study. In December of the month, 113 students of Foča SSC were interviewed from the first to the fourth year. The survey used an anonymous character questionnaire.Results 35.4% of respondents were sexually active. Young men are sexually considerably more active than girls (χ2 = 30,447; p = 0,000). The majority of sexually active students stated that the first sexual intercourse was at the age of 15 (10.6%). Men and girls have diametrically opposite attitudes to the age in which they consider optimal time to start sexual activity (χ2 = 20,252; p = 0,000). Students in the third and fourth grade have a significantly higher level of knowledge than students of the first and second (χ2 = 31,791; p = 0,000). Most students would continue to associate with a person who knows that she has one of sexually transmitted diseases (64.6%).Conclusion The results of this paper show that the sexual activity of the adolescents examined is not a mass phenomenon, but that the knowledge of pupils of the first and second grades is insufficient, and that there is a need for education of this target group, considering the importance of preserving the reproductive health of adolescents, which are the future of preserving the population.

ABSTRACT Introduction: Recipients of hematopoietic stem cell transplantation (HSCT) are exposed to numerous drugs in both pre- and post-transplantation period, which creates an opportunity for drug–drug interactions (DDIs); if clinically relevant DDIs happen, the risk of adverse treatment outcomes is increased. Areas covered: This review is focused on DDIs in recipients of HSCT that were observed and published as clinical trials, case series or case reports. Relevant publications were found by the systematic search of the following online databases: MEDLINE, SCOPUS, EBSCO, and SCINDEX. Expert opinion: The most important DDIs involve cytostatic or immunosuppressant drug on one side, and antimicrobial drugs on the other. The majority of clinically relevant interactions have pharmacokinetic character, involving drug metabolizing enzymes in the liver. Antifungal azoles inhibit metabolism of many cytostatic and immunosuppressant drugs at cytochromes and increase their plasma concentrations. Macrolide antibiotics and fluoroqunolones should be avoided in HSCT recipients, as they have much larger potential for DDIs than other antibiotic groups. HSCT recipients increasingly receive new immunomodulating drugs, and further observational studies are needed to reveal unsuspected DDIs with clinical relevance.

We address the problem of state estimation, attack isolation, and control for discrete-time Linear Time Invariant (LTI) systems under (potentially unbounded) actuator false data injection attacks. Using a bank of Unknown Input Observers (UIOs), each observer leading to an exponentially stable estimation error in the attack-free case, we propose an estimator that provides exponential estimates of the system state and the attack signals when a sufficiently small number of actuators are attacked. We use these estimates to control the system and isolate actuator attacks. Simulations results are presented to illustrate the performance of the results.

Modern technologies provide advanced knowledge and prepare students for lifelong learning. They affect both education and upbringing. Electronic learning is now inevitable. The main goal is to create a modern school through information technology, and to abandon the current traditional way of working. Electronic learning offers many learning advantages where we will point out some of its most important features in the paper, and we will give guidance on how to apply it through several tasks related to the attitudes and opinions of teachers and students about its use, better results, more motivation for learning and similar. We have come up with a result where students and teachers advocate learning through information technology in classroom teaching and want to apply them in their work.

The 677 C>T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C>T polymorphism of the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These results suggested that presence of the 677 C>T polymorphism of the LRP1 gene in our population should be a base for further case-control association or population genetics studies.

Introduction: Living conditions and socioeconomic status are the significant determinants of oral health. The research goal was to analyze the dietary habits of 12-year-old children in Sarajevo, Bosnia-Hercegovina. Another goal was to investigate the differences in food cariogenicity of children living under different socioeconomic conditions and to determine their relationship with the oral health. Materials and methods: The sample included 109 children, classified in groups of high, average and low socioeconomic status. Based on the survey and examination, data on nutrition and caries experience (DMFT index) were obtained. Results: There was a difference in dietary habits between children living under different conditions. Children of high socioeconomic status (SES) had a more favorable number of daily meals comparing to children of low socioeconomic status. The average DMFT index, as a measure of caries experience of 12-year-old children amounted 4.8(±3.2). Children of high socioeconomic status had significantly lower caries experience than those from average and low statuses (high SES DMFT 3,60±2,84SD vs. middle SES DMFT 5,28±3,83SD and low SES DMFT 5,47±2,53SD; p<0.05). Corresponding Author: Amila Zukanović Department of Preventive and Pediatric Dentistry School of Dental Medicine, University of Sarajevo Bolnička 4, 71 000 Sarajevo, Bosnia and Herzegovina e-mail: amila.zukanovic@hotmail.com Socioeconomic condition and dietary habits in relation to oral health in 12-year-old children from Sarajevo, Bosnia-Hercegovina

U članku je pružen pregled nastanka i razvoja organizacija Hrvatskog katoličkog pokreta i Katoličke akcije, jednog od najznačajnih događaja Crkve u Hrvata na početku 20. stoljeća. Članak je podijeljen na tri dijela koji korespondiraju s najvažnijim zbivanjima unutar tog razdoblja. To su stvaranje nove južnoslavenske države, razdoblje pseudoparlamentarizma u 20-im godinama prošlog stoljeća te posljednje desetljeće života Kraljevine SHS/Kraljevine Jugoslavije.

Abstract Aims There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after ‘recalibration’, a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied. Methods and results Using individual-participant data on 360 737 participants without CVD at baseline in 86 prospective studies from 22 countries, we compared the Framingham risk score (FRS), Systematic COronary Risk Evaluation (SCORE), pooled cohort equations (PCE), and Reynolds risk score (RRS). We calculated measures of risk discrimination and calibration, and modelled clinical implications of initiating statin therapy in people judged to be at ‘high’ 10 year CVD risk. Original risk algorithms were recalibrated using the risk factor profile and CVD incidence of target populations. The four algorithms had similar risk discrimination. Before recalibration, FRS, SCORE, and PCE over-predicted CVD risk on average by 10%, 52%, and 41%, respectively, whereas RRS under-predicted by 10%. Original versions of algorithms classified 29–39% of individuals aged ≥40 years as high risk. By contrast, recalibration reduced this proportion to 22–24% for every algorithm. We estimated that to prevent one CVD event, it would be necessary to initiate statin therapy in 44–51 such individuals using original algorithms, in contrast to 37–39 individuals with recalibrated algorithms. Conclusion Before recalibration, the clinical performance of four widely used CVD risk algorithms varied substantially. By contrast, simple recalibration nearly equalized their performance and improved modelled targeting of preventive action to clinical need.

ABSTRACT This paper chronicles the ongoing efforts of several groups of Bosnian activists, artists and academics, to create archives of the often forgotten, and nowadays variously threatened, heritage of political and social life during Yugoslav socialism. Postsocialist archives in other parts of Eastern Europe have typically been motivated by the need to ‘settle accounts’ with communism, understood in this context to be a totalitarian project. By contrast, these ongoing archiving efforts in the postwar and postsocialist Bosnia-Herzegovina, are created in order to recuperate and repurpose the unrealized potentials of Yugoslav socialism, and to use this history to reseed contemporary political imaginaries. I show how these post-Yugoslav activist-archives are working to recover a form of transformational historical subjectivity which seems profoundly necessary in the current political moment, marked by political disenchantment and the devastating effects of the postsocialist transition.