Economic theory suggests that free capital flows increase the efficiency of the resource allocation and stimulate economic growth. Foreign direct investment (FDI) is seen as a remedy for all economic problems in countries that do not have a sufficient level of accumulation to start economic growth. According to economic criteria of Copenhagen, countries that are in the process of European integration should have a functioning market economy able to cope with competition and market forces within the European Union. The greatest expectations regarding the development of a competitive economy in the Southeast European (SEE) countries are precisely related to attraction and exploitation of the positive effects of FDI. This paper explores the impact of FDI on economic growth of the Central European (CE) countries and the SEE countries. The experience of the CE countries can be beneficial for the SEE countries following them in the process of European integration. The results show that FDI flows to the SEE region are significantly lower than to the CE region. Panel analysis has shown a statistically significant impact of FDI on economic growth inboth regions. However, in absolute terms the impact of FDI on economic growth inthe SEE region is almost negligible.

Epilepsy is a paroxysmal cerebral dysrhythmia defined by three important characteristics: the suddenness of the process, brain origin and the disorder of the rhythm of the electrical brain activity (1). Seizures (crises, ictus events, attacks) are common to all epilepsies. They include a variety of clinical manifestations or sudden episodes of disturbance of motor, sensibility, behaviour, perception, awareness or other psychic functions, autonomic and other regulations. The classification of seizures and epilepsy syndrome takes the central place in modern epileptology, although the classification process itself is as old as the study of epilepsy. The international classification, based mainly on the clinical form of seizure and the electroencephalographic findings, was adopted in 1981 and has been further modified. In 1989, ILAE (International League Against Epilepsy) adopted the International classification of epilepsies, epilepsy syndromes and disorders, which highlights the symptoms and signs that show the localization of initial cerebral dysfunction and its spread (2). In 2017, the ILAE released a new classification of seizure types, based upon the existing classification formulated in 1981. and its extension from 2010. The differences include the following: "partial seizures" become "focal"; consciousness is used as a classifier of focal seizures; terms such as „dyscognitive”, „simple partial”, „complex partial”, „psychic” and „secondary generalized” are eliminated; new focal seizures include automatisms, behavioural changes, hyperkinetic, autonomic, cognitive and emotional; atonic, clonic, epileptic spasms, myoclonic, and tonic seizures can be either focal or generalized phenomena; „focal seizure evolving to a bilateral tonic-clonic seizure” replace the term „secondary generalized seizure”; new generalized types of attack are absence with eyelid myoclonia, myoclonic absence, myoclonic-atonic and myoclonic-tonic-clonic and seizures of unknown onset (3). Biometeorology is an interdisciplinary science that studies the interaction system between living organisms and the environment. The biometerological warning, bioforecast, contain a description of the meteorological situation and announces the arrival of those weather conditions which may adversely affect human health in the next days. The goal of bioprognosis is the organization of preventive measures for the protection of the vulnerable groups health (4). Variations in biometeorological factors have an influence on the overall balance of the human body, as well as to changes in the condition of patients, primarily those with chronic diseases. Le Blanc and Mills (1932) stated that one of the oldest and best known disease whose association with climatic factors is mentioned, is epilepsy (5). Fluctuation in some climatic factors, e.g. air pressure, might influence one or more of the above mentioned factors, and thus lead to seizure. The purpose of this study was to determine the effect of atmospheric pressure on the specific seizure types frequency as well as on patient's subjective perception of the seizure "severity".

Millions of people across the globe suffer from swallowing difficulties, known as dysphagia, which can lead to malnutrition, pneumonia, and even death. Swallowing cervical auscultation, which has been suggested as a noninvasive screening method for dysphagia, has not been associated yet with any physical events. In this paper, we have compared the hyoid bone displacement extracted from the videofluoroscopy images of 31 swallows to the signal features extracted from the cervical auscultation recordings captured with a tri-axial accelerometer and a microphone. First, the vertical displacement of the anterior part of the hyoid bone is related to the entropy rate of the superior–inferior swallowing vibrations and to the kurtosis of the swallowing sounds. Second, the vertical displacement of the posterior part of the hyoid bone is related to the bandwidth of the medial–lateral swallowing vibrations. Third, the horizontal displacements of the posterior and anterior parts of the hyoid bone are related to the spectral centroid of the superior–inferior swallowing vibrations and to the peak frequency of the medial–lateral swallowing vibrations, respectively. At last, the airway protection scores and the command characteristics were associated with the vertical and horizontal displacements, respectively, of the posterior part of the hyoid bone. Additional associations between the patients’ characteristics and auscultations’ signals were also observed. The hyoid bone maximal displacement is a cause of swallowing vibrations and sounds. High-resolution cervical auscultation may offer a noninvasive alternative for dysphagia screening and additional diagnostic information.

The use of nanotechnology in the diagnosis of diseases, treatment and monitoring of cancer patients has become a subject of study for the last 20 years. This paper presents brief overview of general characteristics, synthesis and application of dendrimers and quantum points in oncology. Dendrimers and quantum dots are nanostructures whose application in oncology is still being examined. QDs are used in magnetic resonance, wherein very well detect the location of tumor. Dendrimers are intensively tested, especially in cancer therapy. Dendrimers are intensively tested, especially in cancer therapy, because, due to their extremely small dimensions, they have the ability to pass through the mucous barriers and vascular pores, enabling safe delivery of the drug to the tumor cells.

After 21 post-war years Bosnia and Herzegovina (BiH) found itself in a “middle-income trap”. It is not classified into low income countries because workers and citizens do not accept low wages and low standard of living, nor does it fit into high income countries because those workers do not produce sophisticated products that ensure competitiveness, export and the basis for high wages and the standard of living. The development vision of BiH is to become a high income country. However, the state has neither suitable strategy nor policy.This paper represents a detailed research of multifaceted secondary sources (i.e. journal articles, government publications, internet sources, etc.), conducted in a cross-sectional time manner. By utilizing secondary sources of data we conducted our own calculations based on data from the World Bank, the Central Bank of Bosnia and Herzegovina and Agency for Statistics of Bosnia and Herzegovina.We hold that key sectors which would provide return to pre-crisis GDP growthrate of 6-7 percent per year, should be: financial system, diaspora and digitalizationof industry (with the introduction of suitable strategies and policies), each of whichwould contribute to GDP growth of two percent per year. The key agents of changeshould be the leaders of value chains (large-scale companies), cities-regions, gazellecompanies (fast growing small and medium size companies) and micro digital companies.

This paper analytically presents the factors of entrepreneurial intentions of students in Bosnia and Herzegovina (BiH). The research problem can be defined by the question whether today a university can be called an “entrepreneurial university” which educates, prepares and encourages students to start their own business as a career option independently? Do economic policies of small countries contribute to their significant role in encouraging entrepreneurship, and what are predictors of entrepreneurial intentions of students? The study was conducted on a sample of 351 students at the Faculty of Economics of the University of Banja Luka in April 2016, based on previously empirically verified questionnaire that measures the support of closer social environment (friends and family), self-efficacy and acceptability of entrepreneurship as a career, as well as the entrepreneurial intention, through three dimensions of time - starting a business immediately after the end of their formal academic education, within 5 years after graduation and in an indefinite moment in the future. The methods of descriptive statistics, factor and correlation analyses have been applied. The aim of the research is to determine the predictors of entrepreneurial intentions of students in small countries in transition in the case ofstudents from BiH at the early stage during their education and whether their entrepreneurialintentions are influenced by the economic policies through the constructionof entrepreneurial infrastructure institutions? The research results indicate theexistence of clearly defined and mutually comparable latent variables that can beidentified as factors of entrepreneurial intentions of students. Personal competenceand motivation of students are predictors of entrepreneurial intentions, which isnot the case with the “entrepreneurial university” and the institutional support forentrepreneurs who are beginners.

In conditions of significant high youth unemployment rates in the transition countries of Southeast Europe, the subject of special interest of public administration and the academic community is researching the connection between stimulating entrepreneurial activity and launching independent entrepreneurial ventures and self-employment. Also, the subjectof research interest is factors influencing the entrepreneurial affinities andintentions of youth, who are finishing the process of formal education andtrying to get involved in the world of work, either as employees or employers.The subject research was conducted on a purposive (deliberate)sample of 448 respondents in Croatia, Bosnia and Herzegovina (BiH) andSerbia, collected through online questionnaire, with the aim of comparingcareer aspirations of youth towards entrepreneurial and managerial jobs.The research is an extension of the interest of the academic community,complements the previous intense research from the region of SoutheastEurope and gives a scientific contribution by modifying and testingpreviously conducted empirical research in BiH and Croatia (Umihanić,Đonlagić Alibegović & Alfirević, 2018), extending the sample to Serbia,where significant research of this kind has not been conducted. The results,obtained by using descriptive statistics, analysis of variance (F-Test) andPost Hoc Fisher’s LSD test for testing research hypothesis, indicate thatthere are significant differences in the career orientation of the surveyedstudents between three observed countries. In Croatia and Serbia, the impactof society and national culture is neither favourable for entering entrepreneurship,nor for a managerial career. Attitudes are somewhat morefavourable in BiH, but not significantly more favourable in comparison toSerbia and Croatia.

Abstract Detailed analysis of phenolic composition and antioxidant and antimicrobial activities of Verbascum glabratum subsp. bosnense (K. Malý) Murb., an endemic species of southeastern Dinaric Alps was performed for the first time. The phenolic composition measured via UHPLC-MS/MS of four extract with different polarity suggested this plant species is very rich in both phenolic acids and flavonoids. Ethanol extract was chemically the most versatile containing 12 compounds with quercitrin and rosmarinic acid as the majors, while water extracts were rich in 4-hydroxybenzoic acid, salicylic acid, morin, and apigenin. All extracts showed high antioxidant potential measured spectrophotometrically with IC50 values ranging 0.139 - 0.021 mg/mL. Antimicrobial testing using agar diffusion test showed that ethanol extract was the most potent against all tested organisms. Also, these activities are correlated with the content of phenolic compounds, which suggest they are active ingredients of the extracts. Graphical Abstract

1Department of Zoology, Faculty of Science, University of South Bohemia, České Budějovice 37005, Czech Republic 2Rangeland Sciences Department, Gansu Agricultural University, 730070, Lanzhou, China 3Department of Biology and Institute of Mountain Research & Development, Mekelle University, Mekelle, Ethiopia 4Wildlife Conservation Research Unit, Zoology, University of Oxford, The Recanati-Kaplan Centre, Tubney house, Tubney OX13 5QL, UK

background and purpose: Logging is an example of the strongest human influence on forest environment because it causes damages to the forest soil and residual trees. The damages that occur during logging are more frequent in the skidding phase compared to the felling and processing phase. Material and Methods: The research was conducted in mixed stands of fir and spruce in the area of eastern Bosnia and Herzegovina. Felling was conducted by chainsaw and extraction by animals, i.e. by two oxen. The following data were collected: tree species, diameter at breast height, pre-bunching zone (0-30 m or 30-60 m), presence of damages, presence of old damages, number of damages, type of damage, damage position and the size of damage. Results: Damages were recorded on 3.32% of residual trees. The average number of damages per damaged tree was 1.08. The same percentage share of damages was recorded on butt end and root collar (38.46%), while damages on root have a share of 23.08%. Stem damages were not recorded. The most common type of damage was debarked tree (61.54%), then squashed bark (23.08%) and debarked and damaged tree (15.38%). It was recorded that the size of damages varied between 60 and 570 cm2. The average size of damage was 222.54 cm2. Statistical analysis using χ2 test showed significant difference in the proportion of damaged trees among different pre-bunching methods, and did not show significant difference in the proportion of damaged trees between different pre-bunching zones. conclusions: It can be assumed that oxen logging causes insignificant damages to residual trees. The results of research will be used as a basis for future studies of residual trees’ damaging during wood skidding.

Introduction: The introduction of BRAF inhibitor vemurafenib significantly improvedoverall survival (OS) in metastatic melanoma patients.Aim of the Study: The purpose of this study was to determine OS and progressionfree survival (PFS) in patients with advanced metastatic melanoma treated withvemurafenib in the Oncology Clinic, University Clinical Centre of the Republic ofSrpska (UKC RS). The secondary goal is to determine the effect of elevated serumlactate dehydrogenase (LDH) on OS.Patients and Methods: We analysed patients that received vemurafenib in theApril 2015. until March 2018. They had pathohistologically confirmed B-RAF positivemetastatic melanoma. LDH values were measured at the start of the treatment.Results: A total of 16 patients were analyzed, with an average age of 53 years(37-78). A large number of patients at the start had multiple sites of metastases.Calculated OS in patients who received vemurafenib is 11.8 months (p=0,23), withstandard deviation (SD) 9.18. The calculated PFS is 9.5, SD 7,57. OS in patients withnormal LDH is 14.4 months, SD 10.73, and with elevated LDH is 8.4 months, SD4.9 (p=0.079).Conclusion: Use of vemurafenib resulted in an improvement in PFS, with improvedOS in patients with advanced BRAF-mutated melanoma. In patients with elevatedLDH OS was reduced. This shows that LDH is a good prognostic marker and thatwe should do it routinely for all patients with melanoma. This study has indicatedthe need for new diagnostic and therapeutic options for melanoma in Republic ofSrpska.

Patient, a man, age of 66 years, was admitted to the Internal Department,Interventional Cardiology Department for chest pains by type of stable anginapectoris. CCS II. In ambulatory conditions he was made non-invasive diagnostics,and after a positive ergometric test, a decision was made that the patient beadmitted to the catheterization hall for invasive diagnosis and possible percutaneouscoronary intervention.

Introduction: Gastrectomy is one of the most common surgical methods for the treatment of gastric cancer, which basically destroys the mechanism and digestion chemistry. Reconstruction after gastrectomy attempts to optimize the antireflux and nutritive component of the postgastrectomic syndrome.Objective: To determine which reconstructive method after gastrectomy has the optimal synthesis of antireflux and nutritional components.Patients and Methods: 111 patients were treated for gastric malignancies at the Surgical Clinic of the University Clinical Center in Banja Luka, which were operated with the intention of achieving curability.Results: Based on Fisher’s exact probability test there is no statistically significant difference (p> 0.05) in mortality compared to the restoration of digestive continuity after gastrectomy. Reflux oesophagitis is the dominant modality of morbidity in omega-loop reconstruction (p <0.05). There is no statistically significant difference (p> 0.05) in late dumping syndrome in patients relative to individual gastric substitution options. In the Hunt-Lawrence-Rodino pouch reconstruction option, there is no statistically significant difference (p> 0.05) in the participation of individual modalities of meal quantity in relation to the condition before the disease or the modality of the nutritional status. .Conclusion: The results indicate the antireflux component of reconstruction Roux en Y and the advantage of the nutritive component in the loop modification (the creation of the Hunt-Lawrence-Rodino pouch).

For a young researcher, the best way to improve his skills and develop his research capabilities is to work in established research laboratories where he is enabled to learn modern techniques and how to attack the scientific problems. Today, we have easy communications, including computers and the internet, but direct interactions with the most experienced scientists are the best way for young scientist to advance his research capabilities. Ulf Svante von Euler, Swedish pharmacologist and physiologist presents the best example that illustrates how interaction of a young researcher with established scientists develop his research capabilities and become a well-known scientist1.When Ulf was seventeen (1922), he came in Stockholm to study medicine. As a student, he became interested in research, and in 1926 he attended the Twelfth International Congress of Physiologists in Stockholm where he heard lectures by I. P. Pavlov, E. H. Starling and other great scientists of the time. He also observed a historic demonstration by Otto Loewi on the existence of Vagusstoff in the frog’s heart, which would stimulate his own interest and research on mediators of nerve transmission. Prior to this demonstration, Loewi had published several papers on the nature of this chemical substance that slowed the heart, but not all of his research contemporaries were convinced. However, a successful demonstration at the Congress (repeated eighteen times) convinced all critics. Von Euler recalled that these experiments inspired his enduring interest in neurohumoral transmission.Initially, von Euler was influenced by several well-known Swedish scientists: G. Liljestrand (pharmacologist/physiologist), R. Fåraeus (a hematologist) and H. Theorell (a biochemist, who received the Nobel Prize for Medicine and Physiology in 1955). Ulf defended his doctoral dissertation in 1930 and became a professor of pharmacology. Then, he received a two-year scholarship for postdoctoral studies abroad that enabled him to improve his skills by working with several famous foreign researchers.The young Ulf von Euler made the most of this opportunity. He spent six months in Hampstead at Sir Henry Dale’s laboratory, two months in Birmingham with I. de Burgh Daly, eight months in Ghent with C. Heymans, and three months in Frankfurt with G. Embden. Later, in 1934, he returned to London for six months to work with A. Hill, primarily because Liljestrand advised him instead of pharmacology, rather to devote to physiology because at that time in Sweden this scientific discipline was more appreciated. Towards the end of 1937, he went back to Hampstead for five months to work again with Sir Henry Dale.