Liposomes are spherical, biodegradable, and biocompatible vesicular systems. These vesicles are built from phospholipid double layers (membranes) surrounding the inner water phase. Liposomes are highly desirable as drug carriers because they can incorporate hydrophilic, hydrophobic and amphipathic drug substances (drugs). The physicochemical properties of liposomes such as size, charge, surface properties and encapsulation efficiency can highly influence their in vivo stability and kinetics. The aim of our study was to prepare liposomal dispersions and to determine the influence of cycles of high pressure homogenization on some parameters, such as vesicle size and polydispersity index (PDI). Higher homogenization pressures and repeated recirculation led to further reduction in vesicle diameter and heterogeneity. For preparing liposomal dispersions Phosal IP 40 and Phosal 75 SA were used (Lipoid, Germany). Liposomal dispersions were prepared according to the thin film hydration method. By sampling after each cycle, an estimate was made of how many cycles are needed for the dispersion to have satisfactory parameters (size and PDI). The size and PDI analysis of the liposomes were carried out by using Zetasizer (Nano series) ZS 90, Malvern Instruments. . High pressure homogenization was carried out in 10 cycles and based on the obtained liposome size values and PDI, was determined how many cycles are needed in the process of homogenization. With each cycle, the size of the liposomes decreased and PDI value was reduced. It has been observed that after 5 cycles of homogenization there is no significant decrease in the size of the liposomes and PDI. Therefore, in the further production of liposomes with active substances with these raw materials, is recommended to use only 5 cycles of homogenization

The inhibition of copper corrosion by Helichrysum italicum extract (HI) in simulated acid rain was investigated using electrochemical techniques. Results indicate an increase in corrosion inhibition efficiency with the HI extract concentration. The inhibitive process was assumed to occur via adsorption of the extract on the metal surface. The thermodynamic data indicated physical adsorption and followed the Freundlich isotherm. The effect of temperature on the copper corrosion was studied. The value of the activation energy confirmed physisorption of extract molecules on the copper surface. The concentration of Cu ions released into solution, measured by atomic absorption spectrometry, was in accordance with the electrochemical results.

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From the 18th century, the Industrial Revolutions led to the creation of a base for the development and progress of civilization and business. Different business models that relied on the new trends defined by the industrial revolutions significantly transformed the ecosystems of companies. This resulted in the accelerated development and entrance into the digital age, followed by the digitization of the environment and establishing a new system of values. Information and communication technologies are the backbone of the development and mapping of the physical domain into cyber-physical, leading to the emergence of new processes, knowledge, and skills that have been established in the context of Digital Transformation and the digital era. The key part of Digital transformation process is the Smart Systems concept, which is present in almost all industries and domains. Smart Agriculture is one of the most common applications of Smart Systems solutions. It aims to answer important questions regarding food production while, at the same time, taking care of the preservation of the environment, the health of the population and global development. In this paper, the key concepts of the digital transformation and smart systems are presented. In addition, the design and development of the GoGrow, commercial solution for smart agriculture is described. Keywords-Industry 4.0; Digital Transformation; Smart Systems; Smart Agriculture;